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Cited by 8

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

c‐fos elimination compensates for disabled‐2 requirement in mouse extraembryonic endoderm development

Yang, Dong‐Hua, Smith, Elizabeth R., Cai, Kathy Qi, Xu, Xiang‐Xi·2009·Developmental Dynamics
DOI 10.1002/dvdy.21856PMC PMC2743073
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Abstract

Disabled‐2 (Dab2) is expressed in primitive endoderm cells as they are differentiating from the inner cell mass and dab2 deficiency in mice results in lethality at E5.5–E6.5 due to the disorganization of the endoderm layers. Here we show that Dab2 suppresses c‐Fos expression in endoderm cells. A morphological normal primitive endoderm layer was observed in putative E5.5 dab2 (−/−):c‐fos (−/−) embryos, indicating that the primitive endoderm defect due to the loss of Dab2 is rescued by deletion of the c‐fos gene. The lethality of the double knockout embryos was delayed until E9.5–E10.5 and the defective embryos failed to undergo organogenesis. We conclude that Dab2 plays a role in epithelial organization by suppression of c‐Fos expression and suggest that unsuppressed c‐Fos can lead to disruption of primitive endoderm epithelial organization, yet an additional dab2 function is required for later organogenesis. Developmental Dynamics 238:514–523, 2009. © 2009 Wiley‐Liss, Inc.

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  • A role of Dab2 in suppressing Ras/MAPK activation accounts for embryonic development and several physiological phenotypes observed in Dab2 null mice.

    “Indeed, a role of Dab2 in suppressing Ras/MAPK activation accounts for embryonic development (Yang et al., 2009) and several physiological phenotypes observed in Dab2 null mice (Tao et al., 2014, 2016b).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Yang et al., 2009

    The Results and Discussion (page not provided) link Dab2-mediated suppression of c-Fos to extraembryonic endoderm organization and show that eliminating c-fos partially rescues early embryonic lethality. They do not establish that Dab2 suppresses Ras/MAPK activation; the Discussion instead describes regulation of activated MAPK’s nuclear entry as an untested hypothesis and identifies an additional c-Fos-independent requirement in development. The separate claim about physiological phenotypes is cited to Tao et al., not this paper. (LLM, conf=0.88)

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  • A suppressive activity of Dab2 was observed on the MAPK downstream effector c-Fos expression.

    “Additionally, a suppressive activity of Dab2 was observed on the MAPK downstream effector, the expression of c-Fos”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Yang et al., 2009

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Citations

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Research works printed but not linked: 36

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Metadata

Authors
Yang, D., Smith, E. R., Cai, K. Q., & Xu, X.
Venue
Developmental Dynamics
Publisher
Wiley
Published
2009-02-02
Volume
238
Issue
3
Pages
514-523
ISSN
  • 1058-8388
  • 1097-0177
DOI
10.1002/dvdy.21856
PMC
PMC2743073
Cited by
8
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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