CoChat
Sign Up
Cited by 287

The DOI matches its Crossref record.

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

Howell, Brian W., Gertler, Frank B., Cooper, Jonathan A.·1997·The EMBO Journal
DOI 10.1093/emboj/16.1.121
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/emboj/16.1.121

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dab1 binds to the NPxY motif in the cytoplasmic domain of Apoer2 and undergoes transphosphorylation on tyrosine residues when receptors are clustered.

    “Dab1 binds to the NPxY motif in the cytoplasmic domain of Apoer2 and when the receptors are clustered, for example by interacting with Reelin, Dab1 undergoes transphosphorylation on tyrosine residues (Hiesberger et al., 1999; Howell et al., 1997).”

    From Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) · cites this paper as Howell et al., 1997

    The Abstract reports that mDab1 is tyrosine phosphorylated during mouse embryogenesis. The available text does not establish binding to the NPxY motif of Apoer2 or show that receptor clustering causes Dab1 transphosphorylation; it points to a PDF for the full text, so those details cannot be checked in this copy. (LLM, conf=0.79)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 88

  1. Afar DE, Goga A, McLaughlin J, Witte ON and Sawyers CL (1994) Differential complementation of Bcr–Abl point mutants with c‐Myc. Science, 264, 424–426. · DOI
  2. Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J and White R (1996) Sequence, genomic structure, and chromosomal assignment of human DOC‐2. Genomics, 33, 207–213. · DOI
  3. Alonso G, Koegl M, Mazurenko N and Courtneidge SA (1995) Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J Biol Chem, 270, 9840–9848. · DOI
  4. Anderson DJ (1989) The neural crest cell lineage problem: neuropoiesis? Neuron, 3, 1–12. · DOI
  5. Batzer AG, Blaikie P, Nelson K, Schlessinger J and Margolis B (1995) The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor. Mol Cell Biol, 15, 4403–4409. · DOI
  6. Beggs HE, Soriano P and Maness PF (1994) NCAM‐dependent neurite outgrowth is inhibited in neurons from fyn‐minus mice. J Cell Biol, 127, 825–833. · DOI
  7. Bennett RL and Hoffmann FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell–cell interactions. Development, 116, 953–966. · DOI
  8. Bixby JL and Harris WA (1991) Molecular mechanisms of axon growth and guidance. Annu Rev Cell Biol, 7, 117–159. · DOI
  9. Bork P and Margolis B (1995) A phosphotyrosine interaction domain. Cell, 80, 693–694. · DOI · Paper page
  10. Brown MT and Cooper JA (1996) Regulation, substrates, and functions of Src. Biochim Biophys Acta, 1287, 121–149.
  11. Callahan CA, Muralidhar MG, Lundgren SE, Scully AL and Thomas JB (1995) Control of neuronal pathway selection by a Drosophila receptor protein‐tyrosine kinase family member. Nature, 376, 171–174. · DOI
  12. Cobb BS, Schaller MD, Leu TH and Parsons JT (1994) Stable association of pp60src and pp59fyn with the focal adhesion‐associated protein tyrosine kinase, pp125fak. Mol Cell Biol, 14, 147–155.
  13. Cooper JA and MacAuley A (1988) Potential positive and negative autoregulation of p60c‐src by intermolecular autophosphorylation. Proc Natl Acad Sci USA, 85, 4232–4236. · DOI
  14. Cooper JA, Gould KL, Cartwright CA and Hunter T (1986) Tyr527 is phosphorylated in pp60c‐src: implications for regulation. Science, 231, 1431–1434. · DOI
  15. Desai CJ, Gindhart JG, Goldstein LSB and Zinn K (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell, 84, 599–609. · DOI
  16. Druker BJ, Mamon HJ and Roberts TM (1989) Oncogenes, growth factors, and signal transduction. New Engl J Med, 321, 1383–1391. · DOI
  17. Duyster J, Baskaran R and Wang JY (1995) Src homology 2 domain as a specificity determinant in the c‐Abl‐mediated tyrosine phosphorylation of the RNA polymerase II carboxyl‐terminal repeated domain. Proc Natl Acad Sci USA, 92, 1555–1559. · DOI
  18. Eck MJ, Dhe‐Paganon S, Trüb T, Nolte RT and Shoelson SE (1996) Structure of the IRS‐1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell, 85, 695–705. · DOI
  19. Edwards MK, Harris JF and McBurney MW (1983) Induced muscle differentiation in an embryonal carcinoma cell line. Mol Cell Biol, 3, 2280–2286.
  20. Feng S, Chen JK, Yu H, Simon JA and Schreiber SL (1994) Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3–ligand interactions. Science, 266, 1241–1247. · DOI · Paper page
  21. Fumagalli S, Totty NF, Hsuan JJ and Courtneidge SA (1995) A target for Src in mitosis. Nature, 368, 871–874. · DOI
  22. Gertler FB (1992) Genetic modifiers of the Drosophila abl mutant phenotype. Ph.D. Dissertation, University of Wisconsin‐Madison.
  23. Gertler FB, Bennett RL, Clark MJ and Hoffmann FM (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage‐sensitive interactions with disabled. Cell, 58, 103–113. · DOI · Paper page
  24. Gertler FB, Doctor JS and Hoffmann FM (1990) Genetic suppression of mutations in the Drosophila abl proto‐oncogene homolog. Science, 248, 857–860. · DOI
  25. Gertler FB, Hill KK, Clark MJ and Hoffmann FM (1993) Dosage‐sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate. Genes Dev, 7, 441–453. · DOI · Paper page
  26. Goldberg DJ and Wu DY (1995) Inhibition of formation of filopodia after axotomy by inhibitors of protein tyrosine kinases. J Neurobiol, 27, 553–560. · DOI
  27. Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P and Kandel ER (1992) Impaired long‐term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science, 258, 1903–1910. · DOI
  28. Henkemeyer MJ, Gertler FB, Goodman W and Hoffmann FM (1987) The Drosophila Abelson proto‐oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development. Cell, 51, 821–828. · DOI
  29. Henkemeyer M, West SR, Gertler FB and Hoffmann FM (1990) A novel tyrosine kinase‐independent function of Drosophila abl correlates with proper subcellular localization. Cell, 63, 949–960. · DOI
  30. Hill KK, Bedian V, Juang JL and Hoffmann FM (1995) Genetic interactions between the Drosophila abelson (Abl) tyrosine kinase and failed axon connections (Fax), a novel protein in axon bundles. Genetics, 141, 595–606. · DOI
  31. Hogan B, Beddington R, Costantini F and Lacy E (1994) Techniques for visualizing genes, gene products, and specialized cell types. In Manipulating the Mouse Embyro. A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 325–384.
  32. Hollenberg SM, Sternglanz R, Cheng PF and Weintraub H (1995) Identification of a new family of tissue‐specific basic helix–loop–helix proteins with a two‐hybrid system. Mol Cell Biol, 15, 3813–3822. · DOI
  33. Howell BW and Cooper JA (1994) Csk suppression of Src involves movement of Csk to sites of Src activity. Mol Cell Biol, 14, 5402–5411.
  34. Ignelzi MAJ, Miller DR, Soriano P and Maness PF (1994) Impaired neurite outgrowth of src‐minus cerebellar neurons on the cell adhesion molecule L1. Neuron, 12, 873–884. · DOI
  35. Jones‐Villeneuve EM, Rudnicki MA, Harris JF and McBurney MW (1983) Retinoic acid‐induced neural differentiation of embryonal carcinoma cells. Mol Cell Biol, 3, 2271–2279.
  36. Kavanaugh WM and Williams LT (1994) An alternative to SH2 domains for binding tyrosine‐phosphorylated proteins. Science, 266, 1862–1865. · DOI
  37. Kavanaugh WM, Turck CW and Williams LT (1995) PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science, 268, 1177–1179. · DOI
  38. Kozak M (1991) Structural features in eukaryotic mRNAs that modulate the initiation of translation. J Biol Chem, 266, 19867–19870. · DOI
  39. Kremer NE, D'Arcangelo G, Thomas SM, DeMarco M, Brugge JS and Halegoua S (1991) Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of Src and Ras actions. J Cell Biol, 115, 809–819. · DOI
  40. Krueger NX, Vanvactor D, Wan HI, Gelbart WM, Goodman CS and Saito H (1996) The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell, 84, 611–622. · DOI
  41. Kunkel TA, Roberts JD and Zakour RA (1987) Rapid and efficient site‐specific mutagenesis without phenotypic selection. Methods Enzymol, 154, 367–382. · DOI
  42. Kussick SJ, Basler K and Cooper JA (1993) Ras1‐dependent signaling by ectopically‐expressed Drosophila src gene product in the embryo and developing eye. Oncogene, 8, 2791–2803.
  43. Lai KM, Olivier JP, Gish GD, Henkemeyer M, McGlade J and Pawson T (1995) A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase. Mol Cell Biol, 15, 4810–4818. · DOI
  44. Lynch SA, Brugge JS and Levine JM (1986) Induction of altered c–src product during neural differentiation of embryonal carcinoma cells. Science, 234, 873–876. · DOI
  45. MacAuley A and Cooper JA (1988) The carboxy‐terminal sequence of p56lck can regulate p60c‐src. Mol Cell Biol, 8, 3560–3564.
  46. Maness PF (1992) Nonreceptor protein tyrosine kinases associated with neuronal development. Dev Neurosci, 14, 257–270.
  47. Maness PF, Shores CG and Ignelzi M (1990) Localization of the normal cellular src protein to the growth cone of differentiating neurons in brain and retina. Adv Exp Med Biol, 265, 117–125. · DOI
  48. Mayer BJ and Eck MJ (1995) SH3 domains: minding your p's and q's. Curr Biol, 5, 364–367. · DOI
  49. Mayer BJ, Jackson PK, Van Etten RA and Baltimore D (1992) Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo. Mol Cell Biol, 12, 609–618.
  50. McBurney MW, Jones‐Villeneuve EM, Edwards MK and Anderson PJ (1982) Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature, 299, 165–167. · DOI
  51. Miller AD, Miller DG, Garcia JV and Lynch CM (1993) Use of retroviral vectors for gene transfer and expression. Methods Enzymol, 217, 581–599. · DOI
  52. Mok SC, Wong KK, Chan RK, Lau CC, Tsao SW, Knapp RC and Berkowitz RS (1994) Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. Gynecol Oncol, 52, 247–252. · DOI · Paper page
  53. Mori S, Ronnstrand L, Yokote K, Engstrom A, Courtneidge SA, Claesson‐Welsh L and Heldin CH (1993) Identification of two juxtamembrane autophosphorylation sites in the PDGF beta‐receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J, 12, 2257–2264. · DOI
  54. O'Bryan JP, Songyang Z, Cantley L, Der CJ and Pawson T (1996) A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine‐binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci USA, 93, 2729–2734. · DOI
  55. Okada M, Howell BW, Broome MA and Cooper JA (1993) Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl‐terminal tyrosine. J Biol Chem, 268, 18070–18075. · DOI
  56. Pearson WR and Lipman DJ (1988) Improved tools for biological sequence comparison. Proc Natl Acad Sci USA, 85, 2444–2448. · DOI · Paper page
  57. Placzek M, Tessier‐Lavigne M, Jessell T and Dodd J (1990) Orientation of commissural axons in vitro in response to a floor plate‐derived chemoattractant. Development, 110, 19–30. · DOI
  58. Rudnicki MA and McBurney MW (1987) Cell culture methods and induction of differentiation of embryonal carcinoma cell lines. In Robertson,E. (ed.), Teratocarcinomas and Embryonic Stem Cells: A Practical Approach. IRL Press Limited, Oxford, UK, pp. 19–47.
  59. Sabe H, Hata A, Okada M, Nakagawa H and Hanafusa H (1994) Analysis of the binding of the Src homology 2 domain of Csk to tyrosine‐phosphorylated proteins in the suppression and mitotic activation of c‐Src. Proc Natl Acad Sci USA, 91, 3984–3988. · DOI
  60. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
  61. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR and Parsons JT (1994) Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2‐dependent binding of pp60src. Mol Cell Biol, 14, 1680–1688.
  62. Schneider C, Newman RA, Sutherland DR, Asser U and Greaves MF (1982) A one‐step purification of membrane proteins using a high efficiency immunomatrix. J Biol Chem, 257, 10766–10769. · DOI
  63. Seidel‐Dugan C, Meyer BE, Thomas SM and Brugge JS (1992) Effects of SH2 and SH3 deletions on the functional activities of wild‐type and transforming variants of c‐Src. Mol Cell Biol, 12, 1835–1845.
  64. Simon MA, Drees B, Kornberg T and Bishop JM (1985) The nucleotide sequence and the tissue‐specific expression of Drosophila c‐src. Cell, 42, 831–840. · DOI
  65. Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell, 77, 627–638. · DOI
  66. Songyang Z et al. (1993) SH2 domains recognize specific phosphopeptide sequences. Cell, 72, 767–778. · DOI
  67. Songyang Z et al. (1995a) Catalytic specificity of protein‐tyrosine kinases is critical for selective signalling. Nature, 373, 536–539. · DOI
  68. Songyang Z, Margolis B, Chaudhuri M, Shoelson SE and Cantley LC (1995b) The phosphotyrosine interaction domain of Shc recognizes tyrosine‐phosphorylated NPXY motif. J Biol Chem, 270, 14863–14866. · DOI
  69. Soriano P, Montgomery C, Geske R and Bradley A (1991) Targeted disruption of the c‐src proto‐oncogene leads to osteopetrosis in mice. Cell, 64, 693–702. · DOI
  70. Stainier DY and Gilbert W (1990) Pioneer neurons in the mouse trigeminal sensory system. Proc Natl Acad Sci USA, 87, 923–927. · DOI
  71. Stein PL, Lee H‐M, Rich S and Soriano P (1992) pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell, 70, 741–750. · DOI
  72. Taylor SJ and Shalloway D (1994) An RNA‐binding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature, 368, 867–871. · DOI
  73. Tessier‐Lavigne M (1995) Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell, 82, 345–348. · DOI
  74. Tybulewicz VLJ, Crawford CE, Jackson PK, Bronson RT and Mulligan RC (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c‐abl proto‐oncogene. Cell, 65, 1153–1163. · DOI
  75. Umemori H, Sato S, Yagi T, Aizawa S and Yamamoto T (1994) Initial events of myelination involve Fyn tyrosine kinase signalling. Nature, 367, 572–576. · DOI
  76. Vaessin H, Grell E, Wolff E, Bier E, Jan LY and Jan YN (1991) prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell, 67, 941–953. · DOI
  77. Vaillancourt RR, Heasley LE, Zamarripa J, Storey B, Valius M, Kazlauskas A and Johnson GL (1995) Mitogen‐activated protein kinase activation is insufficient for growth factor receptor‐mediated PC12 cell differentiation. Mol Cell Biol, 15, 3644–3653. · DOI
  78. van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S and Pawson T (1995) A conserved amino‐terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. Curr Biol, 5, 404–412. · DOI
  79. Vojtek AB and Cooper JA (1993) Identification and characterization of a cDNA encoding mouse CAP: a homolog of the yeast adenylyl cyclase associated protein. J Cell Sci, 105, 777–785. · DOI
  80. Vojtek AB and Hollenberg SM (1995) Ras–Raf interaction: two‐hybrid analysis. Methods Enzymol, 255, 331–342. · DOI
  81. Vojtek AB, Hollenberg SM and Cooper JA (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell, 74, 205–214. · DOI
  82. Waksman G et al. (1992) Crystal structure of the phosphotyrosine recognition domain SH2 of v‐src complexed with tyrosine‐phosphorylated peptides. Nature, 358, 646–653. · DOI
  83. Wilson R et al. (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C.elegans. Nature, 368, 32–38. · DOI
  84. Wu DY and Goldberg DJ (1993) Regulated tyrosine phosphorylation at the tips of growth cone filopodia. J Cell Biol, 123, 653–664. · DOI
  85. Xu XX, Yang WN, Jackowski S and Rock CO (1995) Cloning of a novel phosphoprotein regulated by colony‐stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem, 270, 14184–14191. · DOI · Paper page
  86. Yu H, Chen JK, Feng S, Dalgarno DC, Brauer AW and Schreiber SL (1994) Structural basis for the binding of proline‐rich peptides to SH3 domains. Cell, 76, 933–945. · DOI
  87. Zhou MM et al. (1995) Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature, 378, 584–592. · DOI
  88. Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trub T, Shoelson SE and Fesik SW (1996) Structural basis of IL‐4 receptor phosphopeptide recognition by the IRS‐1 PTB domain. Nature Struct Biol, 3, 388–393. · DOI

Cited by

Sorted by citations

Metadata

Authors
Howell, B. W., Gertler, F. B., & Cooper, J. A.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
1997-01-01
Volume
16
Issue
1
Pages
121-132
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/16.1.121
Cited by
287
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review