The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Brain dopamine is associated with eating behaviors in humans
Abstract
OBJECTIVE: Eating behavior in humans is influenced by variables other than just hunger-satiety including cognitive restraint, emotional distress, and sensitivity to food stimuli. We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables. METHODS: We used the Dutch Eating Behavior Questionnaire (DEBQ) to measure Restraint, Emotionality, and Externality in 10 subjects. We correlated DEBQ scores with brain DA levels. Positron emission tomography and [(11)C]raclopride uptake were used to measure baseline D(2) receptors (neutral stimulation) and to assess changes in extracellular DA to food stimulation (display of food). RESULTS: Restraint was correlated with DA changes with food stimulation (higher restraint, greater responsivity), emotionality was negatively correlated with baseline D(2) receptors (higher emotionality, lower D(2) receptors), whereas externality was not. These correlations were significant in the dorsal but not in the ventral striatum. DISCUSSION: These results provide evidence that DA in the dorsal striatum is involved with the restraint and emotionality components regulating eating behavior and that these two dimensions reflect different neurobiologic processes.
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“This group has also previously reported that D2 receptor availability in the striatum of healthy controls modulates eating behavior, where low D2 receptor binding correlated with a greater tendency to eat when exposed to stress (Volkow et al., 2003).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Volkow et al., 2003
Citations
Cites
Predictive reward signal of dopamine neurons
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Fisher, R. A. (1915) · Biometrika · doi:10.1093/biomet/10.4.507 · Cited by 2,230
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Self-citationLogan, J., Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., HITZEMANN, R. J., Bendriem, B., Gatley, S. J., et al. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.127 · Cited by 1,481
Self-citationFisher, R. A. (1915) · Biometrika · doi:10.2307/2331838 · Cited by 1,334
Restrained and unrestrained eating1
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Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · cited 2×
“linearly related to extracellular DA in animal experiments (Breier et al., 1997), the precise relationship with synaptic DA is not understood (Laruelle, 2000).”
BackgroundBlum, K., Braverman, E. R., Holder, J. M., Lubar, J. F., Monastra, V. J., Miller, D., Lubar, J. O., Chen, T. J. H., & Comings, D. E. (2000) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2000.10736099 · Cited by 998
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review
Laruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944
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How emotions affect eating: a five-way model
Macht, M. (2008) · Appetite · doi:10.1016/j.appet.2007.07.002 · Cited by 1,396
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Telang, F. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0107 · Cited by 809
Self-citationStice, E., Spoor, S., Bohon, C., Veldhuizen, M. G., & Small, D. M. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013600 · Cited by 779
The dopamine theory of addiction: 40 years of highs and lows
Nutt, D., Lingford-Hughes, A. R., Erritzøe, D., & Stokes, P. R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3939 · Cited by 696
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Thanos, P. K., Logan, J., Alexoff, D., Ding, Y.-S., Wong, C., Ma, Y., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.002 · Cited by 573
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Metadata
- Authors
- Volkow, N. D., Wang, G., Maynard, L., Jayne, M., Fowler, J. S., Zhu, W., Logan, J., Gatley, S. J., Ding, Y., Wong, C., & Pappas, N.
- Affiliations
- Brookhaven National Laboratory (US)
- Stony Brook University (US)
- Corresponding author
- Volkow, Nora D.
- Venue
- International Journal of Eating Disorders
- Publisher
- Wiley
- Published
- 2003-02-25
- Volume
- 33
- Issue
- 2
- Pages
- 136-142
- ISSN
- 0276-3478 (ISSN-L)
- 1098-108X
- OpenAlex
- W1987913422
- Cited by
- 235
- References
- 33
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 3 · 2017: 9 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 19
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Eating Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da009490-08)
- National Institute on Drug Abuse (DA 09490-01, DA-06278, R01DA006278)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- dopamine, dietary habits, food motivation, cognitive restraint, emotionality, dopamine D2 receptor, dorsal striatum, ventral striatum, food stimulation
- MeSH terms
- Adult, Cerebellum, Corpus Striatum, Dopamine, Feeding Behavior, Female, Humans, Male, Surveys and Questionnaires, Tomography, Emission-Computed, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride
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