Cited by 236Eating Disorders and BehaviorsNeurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

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Brain dopamine is associated with eating behaviors in humans

Volkow, Nora D., Wang, Gene‐Jack, Maynard, Laurence, Jayne, Millard, Fowler, Joanna S., Zhu, Wei, Logan, Jean, Gatley, S. John, Ding, Yu‐Shin, Wong, Christopher, Pappas, Naomi·2003·International Journal of Eating Disorders

DOI 10.1002/eat.10118

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Abstract

OBJECTIVE: Eating behavior in humans is influenced by variables other than just hunger-satiety including cognitive restraint, emotional distress, and sensitivity to food stimuli. We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables. METHODS: We used the Dutch Eating Behavior Questionnaire (DEBQ) to measure Restraint, Emotionality, and Externality in 10 subjects. We correlated DEBQ scores with brain DA levels. Positron emission tomography and [(11)C]raclopride uptake were used to measure baseline D(2) receptors (neutral stimulation) and to assess changes in extracellular DA to food stimulation (display of food). RESULTS: Restraint was correlated with DA changes with food stimulation (higher restraint, greater responsivity), emotionality was negatively correlated with baseline D(2) receptors (higher emotionality, lower D(2) receptors), whereas externality was not. These correlations were significant in the dorsal but not in the ventral striatum. DISCUSSION: These results provide evidence that DA in the dorsal striatum is involved with the restraint and emotionality components regulating eating behavior and that these two dimensions reflect different neurobiologic processes.

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Authors: Volkow, N. D., Wang, G., Maynard, L., Jayne, M., Fowler, J. S., Zhu, W., Logan, J., Gatley, S. J., Ding, Y., Wong, C., & Pappas, N.
Affiliations: Brookhaven National Laboratory (US)
Stony Brook University (US)
Corresponding author: Volkow, Nora D.
ORCID: Volkow, Nora D.
Wang, Gene‐Jack
Zhu, Wei
Logan, Jean
Ding, Yu‐Shin
Wong, Christopher
Venue: International Journal of Eating Disorders
Publisher: Wiley
Published: 2003-02-25
Volume: 33
Issue: 2
Pages: 136-142
ISSN: 0276-3478 (ISSN-L)
1098-108X
DOI: 10.1002/eat.10118
OpenAlex: W1987913422
Cited by: 235
References: 33
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 3 · 2017: 9 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 19
FWCI: 11.39
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Eating Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01da009490-08)
National Institute on Drug Abuse (DA 09490-01, DA-06278, R01DA006278)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: dopamine, dietary habits, food motivation, cognitive restraint, emotionality, dopamine D2 receptor, dorsal striatum, ventral striatum, food stimulation
MeSH terms: Adult, Cerebellum, Corpus Striatum, Dopamine, Feeding Behavior, Female, Humans, Male, Surveys and Questionnaires, Tomography, Emission-Computed, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride

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Brain dopamine is associated with eating behaviors in humans

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