The interplay between vitamin C and thyroid
Open accessAbstract
INTRODUCTION: Vitamin C (ascorbic acid) is a water-soluble vitamin, that plays a key role in the prevention and treatment of scurvy. As vitamin C is an antioxidant and thyroid function may be affected and may affect vitamin C levels, for the first time, we aimed to provide a detailed review of all human studies evaluating the different roles of vitamin C in the thyroid gland. Thyroid cancers, goitre, Graves' disease and other causes of hyperthyroidism and hypothyroidism were the conditions discussed in this study. Furthermore, vitamin C addition to other medications such as levothyroxine was also reviewed. METHODS: In this study, we reviewed the relevant literature regarding the association between vitamin C and thyroid diseases using original studies from PubMed, Scopus, Embase, and Web of Science. RESULTS: In this review, we found anti-cancer effects for intravenous (IV) administration of vitamin C in addition to the beneficial effects of using it in combination with radiotherapy and chemotherapy. As autoimmune diseases affect some antioxidant markers, some studies reported a significant difference in blood vitamin C levels in patients with autoimmune thyroid diseases such as Graves' disease. Despite many studies evaluating the effects of IV administration of vitamin C in mentioned diseases, there is a lack of evidence for oral consumption of vitamin C. CONCLUSIONS: To conclude, there is a lack of evidence, especially clinical trials, for the therapeutic effects of vitamin C on thyroid diseases; however, promising results were reported in some studies in the literature.
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Vitamin C co-administration may increase LT4 absorption, especially in patients with gastrointestinal issues.
“Co-administration with vitamin C may increase LT4 absorption, particularly, in patients with gastrointestinal issues.89,90”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [90]
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Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?
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Anti-Ferroptosis: A Promising Therapeutic Method for Thyroid Cancer
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Effect of micronutrients on the risk of Graves’ disease: a Mendelian randomization study
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- Authors
- Farasati Far, B., Behnoush, A. H., Ghondaghsaz, E., Habibi, M. A., & Khalaji, A.
- Affiliations
- Department of Chemistry Iran University of Science and Technology Tehran Iran
- Tehran University of Medical Sciences (IR)
- University of British Columbia (CA)
- University of Tehran (IR)
- Corresponding author
- Khalaji, Amirmohammad
- Venue
- Endocrinology, Diabetes & Metabolism
- Publisher
- Wiley
- Published
- 2023-05-29
- Volume
- 6
- Issue
- 4
- Pages
- e432-e432
- ISSN
- 2398-9238 (ISSN-L)
- PMC
- PMC10335618
- OpenAlex
- W4378640266
- Cited by
- 23
- References
- 84
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 10 · 2023: 4
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Endocrinology Diabetes & Metabolism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, thyroid dysfunction, thyroid cancer, goiter, Graves' disease, hyperthyroidism, hypothyroidism, levothyroxine, intravenous vitamin C, antioxidants, autoimmune thyroid disease, radiotherapy, chemotherapy
- MeSH terms
- Antioxidants, Ascorbic Acid, Graves Disease, Humans, Thyroid Diseases, Vitamins
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