Histone deacetylase dHDAC4 is involved in segmentation of the Drosophila embryo and is regulated by gap and pair‐rule genes
Abstract
Summary: Histone deacetylases (HDACs) are catalytic subunits of multiprotein complexes that are targeted to specific promoters through their interaction with different transcriptional repressors causing silencing of the corresponding genes. This study describes the isolation of dHDAC4, a novel, catalytically active class II Drosophila histone deacetylase, and the analysis of its role in embryonic development. In early embryos, dHDAC4 is expressed in several phases. Initial ubiquitous expression becomes localized to an anterior domain, then evolves into a pair‐rule‐like and finally into a segment‐polarity‐like pattern. Suppression of dHDAC4 during early embryogenesis by double‐stranded RNA interference led to segmentation defects. Analysis of dHDAC4 expression in gap and pair‐rule gene mutants demonstrated that hunchback, knirps, and giant activate, while even‐skipped suppresses dHDAC4 expression. These data revealed dHDAC4 involvement in the segmentation regulatory pathway and suggested complex transcriptional regulation as a potential mechanism that controls its expression. genesis 35:31–38, 2003. © 2002 Wiley‐Liss, Inc.
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Invertebrates like Caenorhabditis elegans and Drosophila melanogaster conserve the canonical Y and should retain canonical HDAC catalytic activity.
“Invertebrates like Caenorhabditis elegans and Drosophila melanogaster conserve the canonical Y and, accordingly, should retain canonical HDAC catalytic activity as suggested previously (25,26).”
From Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases (2007) · cites this paper as [26]
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BindingDB (2012) · UC San Diego · doi:10.7270/q2c82b5x
- Authors
- Zeremski, M., Stricker, J. R., Fischer, D., Zusman, S. B., & Cohen, D.
- Corresponding author
- Cohen, Dalia
- Venue
- genesis
- Publisher
- Wiley
- Published
- 2002-11-19
- Volume
- 35
- Issue
- 1
- Pages
- 31-38
- ISSN
- 1526-954X (ISSN-L)
- 1526-968X
- OpenAlex
- W1987705500
- Cited by
- 17
- References
- 40
- Citations by year
- 2020: 6 · 2014: 1 · 2013: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- genesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- histone deacetylase, class II HDACs, gap genes, pair-rule genes, hunchback, knirps, giants, even-skipped, transcriptional regulation, segment polarity, gene expression patterning, RNA interference
- MeSH terms
- Amino Acid Sequence, Animals, Cells, Cultured, Drosophila, Genes, Regulator, Histone Deacetylases, Humans, Molecular Sequence Data, Transcription, Genetic, Gene Expression, Sequence Homology, Amino Acid, Gene Expression Regulation, Developmental, RNA Interference
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