Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

Fischle, Wolfgang; Dequiedt, Franck; Hendzel, Michael J; Guenther, Matthew G; Lazar, Mitchell A; Voelter, Wolfgang; Verdin, Eric

doi:10.1016/s1097-2765(01)00429-4

Cited by 762Histone Deacetylase Inhibitors ResearchGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

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Fischle, Wolfgang, Dequiedt, Franck, Hendzel, Michael J, Guenther, Matthew G, Lazar, Mitchell A, Voelter, Wolfgang, Verdin, Eric·2002·Molecular Cell

DOI 10.1016/s1097-2765(01)00429-4

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Abstract

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression. The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered necessary and sufficient for enzymatic activity. Here, we show that the catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor N-CoR/SMRT. All experimental conditions leading to the suppression of HDAC4 binding to SMRT/N-CoR and to HDAC3 result in the loss of enzymatic activity associated with HDAC4. In vitro reconstitution experiments indicate that HDAC4 and other class II HDACs are inactive in the context of the SMRT/N-CoR-HDAC3 complex and do not contribute to its enzymatic activity. These observations indicate that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N-CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity.

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HDAC4 and -7 associate with HDAC3-SMRT/N-CoR complexes through their HDAC domains.
“In particular, HDAC4 and -7 were shown to associate with HDAC3-SMRT/N-CoR complexes through their HDAC domains (19,20).”
From Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases (2007) · cites this paper as [20]
Site-directed mutagenesis of conserved active site residues in HDAC4 failed to clarify whether the drop in overall deacetylase activity was caused by loss of intrinsic HDAC4 activity or loss of the associated HDAC3 complex.
“Site-directed mutagenesis of conserved active site residues in HDAC4 failed to clarify this point in that all HDAC4 mutants showing impaired deacetylase activity in vitro also lost the ability to interact with HDAC3-SMRT/N-CoR complexes (20).”
From Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases (2007) · cites this paper as [20]

Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works
Current protocols in molecular biology
Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,298 · see citing works
Histone acetylation in chromatin structure and transcription
Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884 · see citing works
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233 · see citing works
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
Kornberg, R. D., & Lorch, Y. (1999) · Cell · doi:10.1016/s0092-8674(00)81958-3 · Cited by 1,833 · see citing works
A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p
Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science · doi:10.1126/science.272.5260.408 · Cited by 1,829 · see citing works
Histone acetylation and transcriptional regulatory mechanisms
Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.5.599 · Cited by 1,815 · see citing works
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R., & Pavletich, N. P. (1999) · Nature · doi:10.1038/43710 · Cited by 1,714 · see citing works
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.
Osborn, L., Kunkel, S. L., & Nabel, G. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2336 · Cited by 1,642 · see citing works
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
Workman, J. L., & Kingston, R. E. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.545 · Cited by 1,129 · see citing works
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
Zhang, Y., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Bird, A., & Reinberg, D. (1999) · Genes & Development · doi:10.1101/gad.13.15.1924 · Cited by 1,103 · see citing works
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051 · see citing works
Chromatin Structure and Function
Nicolini, C. A. (1979) · Springer eBooks · doi:10.1007/978-1-4684-0973-4 · Cited by 1,030 · see citing works
[36] Eukaryotic gene transcription with purified components
Dignam, J. D., Martin, P. L., Shastry, B. S., & Roeder, R. G. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01039-3 · Cited by 963 · see citing works
Coactivator and corepressor complexes in nuclear receptor function
Xu, L., Glass, C. K., & Rosenfeld, M. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80021-5 · Cited by 897 · see citing works
Three proteins define a class of human histone deacetylases related to yeast Hda1p
Grozinger, C. M., Hassig, C. A., & Schreiber, S. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4868 · Cited by 770 · see citing works
Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3
Li, J., Wang, J., Wang, J., Nawaz, Z., Liu, J. M., Qin, J., & Wong, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4342 · Cited by 629 · see citing works
Histone deacetylases, transcriptional control, and cancer
Cress, W. D., & Seto, E. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 619 · see citing works
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
Rundlett, S. E., Carmen, A. A., Kobayashi, R., Bavykin, S. G., Turner, B. M., & Grunstein, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14503 · Cited by 618 · see citing works
The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611 · see citing works
Self-citation
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Grozinger, C. M., & Schreiber, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140199597 · Cited by 587 · see citing works
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578 · see citing works
HDAC4 deacetylase associates with and represses the MEF2 transcription factor
Miska, E. A., Karlsson, C., Langley, E., Nielsen, S. J., Pines, J., & Kouzarides, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5099 · Cited by 551 · see citing works
Chromatin disruption and modification
Wolffe, A. P., & Hayes, J. J. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.3.711 · Cited by 551 · see citing works
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
Guenther, M. G., Lane, W. S., Fischle, W., Verdin, E., Lazar, M. A., & Shiekhattar, R. (2000) · Genes & Development · doi:10.1101/gad.14.9.1048 · Cited by 489 · see citing works
Self-citation
BCoR, a novel corepressor involved in BCL-6 repressionPreprint
Huynh, K. D., Fischle, W., Verdin, E. M., & Bardwell, V. J. (2000) · Genes & Development · doi:10.1101/gad.14.14.1810 · Cited by 475 · see citing works
Self-citation
Untitled work
Ng (2000) · doi:10.1016/s0968-0004(00)01551-6 · Cited by 427 · see citing works
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repressionPreprint
Kao, H., Downes, M., Ordentlich, P., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.14.1.55 · Cited by 424 · see citing works
Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
Rundlett, S. E., Carmen, A. A., Suka, N., Turner, B. M., & Grunstein, M. R. (1998) · Nature · doi:10.1038/33952 · Cited by 411 · see citing works
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Y.-D., Perissi, V., Staszewski, L. M., Yang, W.-M., Krones, A., Glass, C. K., Rosenfeld, M. G., & Seto, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7202 · Cited by 378 · see citing works
A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
Hassig, C. A., Tong, J. K., Fleischer, T. C., Owa, T., Grable, P. G., Ayer, D. E., & Schreiber, S. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3519 · Cited by 365 · see citing works
Review: Chromatin Structural Features and Targets That Regulate Transcription
Wolffe, A. P., & Guschin, D. Y. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4217 · Cited by 350 · see citing works
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathwayPreprint
Huang, E. Y., Zhang, J., Miska, E. A., Guenther, M. G., Kouzarides, T., & Lazar, M. A. (2000) · Genes & Development · doi:10.1101/gad.14.1.45 · Cited by 325 · see citing works
Self-citation
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Underhill, C., Qutob, M. S., Yee, S.-P., & Torchia, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007864200 · Cited by 323 · see citing works
Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo
Kadosh, D., & Struhl, K. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5121 · Cited by 320 · see citing works
Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor
Hu, E., Chen, Z., Fredrickson, T., Zhu, Y., Kirkpatrick, R., Zhang, G.-F., Johanson, K., Sung, C.-M., Liu, R., & Winkler, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908988199 · Cited by 309 · see citing works
HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor
Wang, A. H., Bertos, N. R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H. H., Th’ng, J., Han, J., & Yang, X.-J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7816 · Cited by 294 · see citing works
Characterization of a human RPD3 ortholog, HDAC3
Emiliani, S., Fischle, W., Lint, C. M. V., Al-Abed, Y., & Verdin, E. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2795 · Cited by 292 · see citing works
Self-citation
Acetylation and chromosomal functions
Cheung, W. L., Briggs, S. D., & Allis, C. D. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00096-x · Cited by 290 · see citing works
Regulation of Histone Deacetylase 4 by Binding of 14-3-3 Proteins
Wang, A. H., Kruhlak, M. J., Wu, J., Bertos, N., Vezmar, M., Posner, B. I., Bazett‐Jones, D. P., & Yang, X. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6904-6912.2000 · Cited by 275 · see citing works
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo
Kadosh, D., & Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.6.797 · Cited by 234 · see citing works
Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo
Fischle, W., Dequiedt, F., Fillion, M., Hendzel, M. J., Voelter, W., & Verdin, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104935200 · Cited by 232 · see citing works
Self-citation
Chromatin Remodeling and the Control of Gene Expression
Wu, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28171 · Cited by 229 · see citing works
Identification of a New Family of Higher Eukaryotic Histone Deacetylases
Verdel, A., & Khochbin, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2440 · Cited by 227 · see citing works
A New Family of Human Histone Deacetylases Related toSaccharomyces cerevisiae HDA1p
Fischle, W., Emiliani, S., Hendzel, M. J., Nagase, T., Nomura, N., Voelter, W., & Verdin, E. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11713 · Cited by 225 · see citing works
Self-citation
Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm
Verdel, A., Curtet, S., Brocard, M.-P., Rousseaux, S., Lemercier, C., Yoshida, M., & Khochbin, S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00542-x · Cited by 224 · see citing works
The “Dark Side” of Chromatin Remodeling
Tyler, J. K., & Kadonaga, J. T. (1999) · Cell · doi:10.1016/s0092-8674(00)81530-5 · Cited by 223 · see citing works
MEF‐2 function is modified by a novel co‐repressor, MITR
Sparrow, D. B., Miska, E. A., Langley, E., Reynaud‐Deonauth, S., Kotecha, S., Towers, N., Spohr, G., Kouzarides, T., & Mohun, T. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5085 · Cited by 196 · see citing works
HDA1 and HDA3 Are Components of a Yeast Histone Deacetylase (HDA) Complex
Carmen, A. A., Rundlett, S. E., & Grunstein, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15837 · Cited by 188 · see citing works
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Kruhlak, M. J., Lever, M. A., Fischle, W., Verdin, E. M., Bazett‐Jones, D. P., & Hendzel, M. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.1.41 · Cited by 174 · see citing works
Self-citation
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Moazed, D. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00202-7 · Cited by 160 · see citing works
Identification of a nuclear domain with deacetylase activity.
Downes, M., Ordentlich, P., Hung, Y.-K., Alvarez, J. G., & Evans, R. M. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.19.10330 · Cited by 144 · see citing works
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5
Zhou, X., Richon, V. M., Rifkind, R. A., & Marks, P. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1056 · Cited by 120 · see citing works
Organization of Highly Acetylated Chromatin around Sites of Heterogeneous Nuclear RNA Accumulation
Hendzel, M. J., Kruhlak, M. J., & Bazett‐Jones, D. P. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2491 · Cited by 95 · see citing works
Self-citation
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Carmen, A. A., Griffin, P. R., Calaycay, J. R., Rundlett, S. E., Suka, Y., & Grunstein, M. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12356 · Cited by 87 · see citing works
Targeting of N‐CoR and histone deacetylase 3 by the oncoprotein v‐ErbA yields a chromatin infrastructure‐dependent transcriptional repression pathway
Urnov, F. D., Yee, J., Sachs, L. M., Collingwood, T. N., Bauer, A., Beug, H., Shi, Y., & Wolffe, A. P. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4074 · Cited by 77 · see citing works
Exploring the transcription–chromatin interface: Figure 1.Preprint
Jones, K. A., & Kadonaga, J. T. (2000) · Genes & Development · doi:10.1101/gad.14.16.1992 · Cited by 49 · see citing works
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Albini, S., Zakharova, V., & Ait‐Si‐Ali, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814879-2.00003-0 · Cited by 19 · see citing works
Transcriptional control within the three-dimensional context of nuclear architecture: Requirements for boundaries and direction
Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., McNeil, S. M., & Pockwinse, S. M. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1999)75:32+ · Cited by 9 · see citing works

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Ordovás, J. M., & Smith, C. E. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.104 · Cited by 402 · see citing works
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
Chemical mechanisms of histone lysine and arginine modifications
Smith, B. C., & Denu, J. M. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.06.005 · Cited by 390 · see citing works
Epigenetic mechanisms in drug addiction
Renthal, W. R., & Nestler, E. J. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.06.004 · Cited by 383 · see citing works
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Lobera, M., Madauss, K. P., Pohlhaus, D. T., Wright, Q. G., Trocha, M., Schmidt, D. R., Baloglu, E., Trump, R. P., Head, M. S., Hofmann, G. A., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1223 · Cited by 384 · see citing works
In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions
Miao, F., Gonzalo, I. T. G., Lanting, L. L., & Natarajan, R. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311786200 · Cited by 374 · see citing works
Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control
Bhaskara, S., Chyla, B., Amann, J. M., Knutson, S. K., Cortez, D., Sun, Z., & Hiebert, S. W. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.030 · Cited by 369 · see citing works
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
Montgomery, R. L., Potthoff, M. J., Haberland, M., Qi, X., Matsuzaki, S., Humphries, K. M., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35847 · Cited by 363 · see citing works
Regulation of histone deacetylase activities
Sengupta, N., & Seto, E. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20179 · Cited by 347 · see citing works
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
Kirsh, O., Seeler, J.-S., Pichler, A., Gast, A., Müller, S. P., Miska, E. A., Marion, M., Harel‐Bellan, A., Kouzarides, T., Melchior, F., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2682 · Cited by 328 · see citing works
Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration
Cho, Y., Sloutsky, R., Naegle, K. M., & Cavalli, V. (2013) · Cell · doi:10.1016/j.cell.2013.10.004 · Cited by 327 · see citing works
The role of corepressors in transcriptional regulation by nuclear hormone receptors.
Privalsky, M. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032802.155556 · Cited by 335 · see citing works
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain
Shen, S., Li, J., & Casaccia‐Bonnefil, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412101 · Cited by 320 · see citing works
Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain
Bottomley, M. J., Surdo, P. L., Giovine, P. D., Cirillo, A., Scarpelli, R., Ferrigno, F., JONES, P. G., Neddermann, P., Francesco, R. D., Steinkühler, C., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803514200 · Cited by 319 · see citing works
Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems
Williams, S. R., Aldred, M. A., Der Kaloustian, V. M., Halal, F., Gowans, G., McLeod, D. R., Zondag, S., Toriello, H. V., Magenis, R. E., & Elsea, S. H. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.011 · Cited by 302 · see citing works
The Potential of HDAC Inhibitors as Cognitive Enhancers
Gräff, J., & Tsai, L. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140216 · Cited by 297 · see citing works
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
Mottis, A., Mouchiroud, L., & Auwerx, J. (2013) · Genes & Development · doi:10.1101/gad.214023.113 · Cited by 297 · see citing works
Exercise-induced histone modifications in human skeletal muscle
McGee, S. L., Fairlie, E., Garnham, A. P., & Hargreaves, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181065 · Cited by 296 · see citing works
The functional interactome landscape of the human histone deacetylase family
Joshi, P., Greco, T. M., Guise, A. J., Luo, Y., Yu, F., Nesvizhskii, A. I., & Cristea, I. M. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.26 · Cited by 289 · see citing works
Regulation of distinct biological activities of the NF-?B transcription factor complex by acetylation
Chen, L., & Greene, W. C. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0469-0 · Cited by 275 · see citing works
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
Knutson, S. K., Chyla, B. J., Amann, J. M., Bhaskara, S., Huppert, S. S., & Hiebert, S. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.51 · Cited by 271 · see citing works
Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors
Antos, C. L., McKinsey, T. A., Dreitz, M., Hollingsworth, L. M., Zhang, C., Schreiber, K. L., Rindt, H., Gorczynski, R. J., & Olson, E. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303113200 · Cited by 269 · see citing works
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex
Vannini, A., Volpari, C., Gallinari, P., Jones, P., Mattu, M., Carfí, A., De Francesco, R., Steinkühler, C., & Di Marco, S. (2007) · The EMBO Reports · doi:10.1038/sj.embor.7401047 · Cited by 256 · see citing works
Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity
Schuetz, A., Min, J., Allali‐Hassani, A., Schapira, M., Shuen, M., Loppnau, P., Mazitschek, R., Kwiatkowski, N. P., Lewis, T. A., Maglathin, R. L., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707362200 · Cited by 261 · see citing works
Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3 + T-Regulatory Cells
de Zoeten, E. F., Wang, L., Butler, K. V., Beier, U. H., Akimova, T., Sai, H., Bradner, J. E., Mazitschek, R., Kozikowski, A. P., Matthias, P., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05155-11 · Cited by 257 · see citing works
Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation
Senese, S., Zaragoza, K., Minardi, S. P., Muradore, I., Ronzoni, S., Passafaro, A., Bernard, L., Draetta, G. F., Alcalay, M., Seiser, C., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00494-07 · Cited by 253 · see citing works
Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor
Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 247 · see citing works
Self-citation
A Hormone-Dependent Module Regulating Energy Balance
Wang, B., Moya, N., Niessen, S., Hoover, H. S., Mihaylova, M. M., Shaw, R. J., Yates, J. R., Fischer, W. H., Thomas, J. B., & Montminy, M. (2011) · Cell · doi:10.1016/j.cell.2011.04.013 · Cited by 242 · see citing works
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis
Alenghat, T., Osborne, L. C., Saenz, S. A., Kobuley, D. E., Ziegler, C. G. K., Mullican, S. E., Choi, I., Grunberg, S., Sinha, R., Wynosky-Dolfi, M. A., et al. (2013) · Nature · doi:10.1038/nature12687 · Cited by 248 · see citing works
Self-citation
Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle Differentiation
Zhang, C. L., McKinsey, T. A., & Olson, E. N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7302-7312.2002 · Cited by 246 · see citing works
Class IIa histone deacetylases: regulating the regulators
Martin, M., Kettmann, R., & Dequiedt, F. (2007) · Oncogene · doi:10.1038/sj.onc.1210613 · Cited by 243 · see citing works
Self-citation
Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation
Schroeder, T. M., Kahler, R. A., Li, X., & Westendorf, J. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403702200 · Cited by 244 · see citing works
Readers, Writers, and Erasers
Gillette, T. G., & Hill, J. A. (2015) · Circulation Research · doi:10.1161/circresaha.116.303630 · Cited by 239 · see citing works
Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression
Yang, X., & Seto, E. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00015-7 · Cited by 241 · see citing works
Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice
de Zoeten, E. F., Wang, L., Sai, H., DILLMANN, W. H., & Hancock, W. W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.10.037 · Cited by 236 · see citing works
HDAC4: Mechanism of Regulation and Biological Functions
Wang, Z., Qin, G., & Zhao, T. C. (2014) · Epigenomics · doi:10.2217/epi.13.73 · Cited by 239 · see citing works
Therapeutic potential for HDAC inhibitors in the heart
McKinsey, T. A. (2012) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134712 · Cited by 230 · see citing works
Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue
Galmozzi, A., Mitro, N., Ferrari, A., Gers, E., Gilardi, F., Godio, C., Cermenati, G., Gualerzi, A., Donetti, E., Rotili, D., et al. (2012) · Diabetes · doi:10.2337/db12-0548 · Cited by 236 · see citing works
The nuclear-envelope protein and transcriptional repressor LAP2β interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation
Somech, R., Shaklai, S., Geller, O., Amariglio, N., Simon, A. J., Rechavi, G., & Gal-Yam, E. N. (2005) · Journal of Cell Science · doi:10.1242/jcs.02521 · Cited by 223 · see citing works
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
Winbanks, C. E., Chen, J. L., Qian, H., Liu, Y., Bernardo, B. C., Beyer, C., Watt, K. I., Thomson, R. E., Connor, T., Turner, B. J., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211134 · Cited by 225 · see citing works
HDACs and HDAC inhibitors in colon cancer
Mariadason, J. M. (2008) · Epigenetics · doi:10.4161/epi.3.1.5736 · Cited by 226 · see citing works
Isoform-specific histone deacetylase inhibitors: The next step?
Balasubramanian, S., Verner, E. J., & Buggy, J. J. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.013 · Cited by 224 · see citing works
SMRT Derepression by the IκB Kinase α
Hoberg, J. E., Yeung, F., & Mayo, M. W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.010 · Cited by 220 · see citing works
Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA
Glaser, K. B., Li, J., Staver, M. J., Wei, R.-Q., Albert, D. H., & Davidsen, S. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.043 · Cited by 220 · see citing works
Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition
Guo, W., Shan, B., Klingsberg, R. C., Qin, X., & Lasky, J. A. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00128.2009 · Cited by 218 · see citing works
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
McGee, S. L., & Hargreaves, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0377-1 · Cited by 221 · see citing works
Histone deacetylase inhibitors as therapeutics for polyglutamine disorders
Butler, R. K., & Bates, G. P. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1989 · Cited by 212 · see citing works
HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21
Wilson, A. J., Byun, D.-S., Nasser, S., Murray, L. B., Ayyanar, K., Arango, D., Figueroa, M. E., Melnick, A. M., Kao, G. D., Augenlicht, L. H., et al. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0139 · Cited by 214 · see citing works
Rett syndrome: a neurological disorder with metabolic components
Kyle, S. M., Vashi, N., & Justice, M. J. (2018) · Open Biology · doi:10.1098/rsob.170216 · Cited by 213 · see citing works
HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis
Dequiedt, F., Kasler, H. G., Fischle, W., Kiermer, V., Weinstein, M., HERNDIER, B. G., & Verdin, E. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00109-2 · Cited by 212 · see citing works
Self-citation
Epigenetics and Cardiovascular Development
Chang, C., & Bruneau, B. G. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153242 · Cited by 202 · see citing works
The N-CoR/Histone Deacetylase 3 Complex Is Required for Repression by Thyroid Hormone Receptor
Ishizuka, T., & Lazar, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5122-5131.2003 · Cited by 202 · see citing works
Self-citation
Cys2His2 zinc finger protein family: Classification, functions, and major members
Razin, S., Borunova, V., Maksimenko, O., & Kantidze, O. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912030017 · Cited by 186 · see citing works
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo
You, S.-H., Lim, H., Sun, Z., Broache, M., Won, K., & Lazar, M. A. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2476 · Cited by 200 · see citing works
Self-citation
Histone deacetylases: structural determinants of inhibitor selectivity
Micelli, C., & Rastelli, G. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.01.007 · Cited by 196 · see citing works
Signaling chromatin to make muscle
McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00389-7 · Cited by 198 · see citing works
MEF2 transcription factors: developmental regulators and emerging cancer genes
Pon, J., & Marra, M. (2015) · OncoTarget · doi:10.18632/oncotarget.6223 · Cited by 182 · see citing works
Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity
Kato, H., Tamamizu‐Kato, S., & Shibasaki, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406320200 · Cited by 196 · see citing works
Class II a HDAC s – new insights into their functions in physiology and pathology
Parra, M. (2014) · FEBS Journal · doi:10.1111/febs.13061 · Cited by 194 · see citing works
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
Wang, L., de Zoeten, E. F., Greene, M. I., & Hancock, W. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd3031 · Cited by 186 · see citing works
Modulation of Smooth Muscle Gene Expression by Association of Histone Acetyltransferases and Deacetylases with Myocardin
Cao, D., Wang, Z., Zhang, C., Oh, J., Xing, W., Li, S., Richardson, J. A., Wang, D.-Z., & Olson, E. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.364-376.2005 · Cited by 185 · see citing works
Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT*
Liao, G., Chen, L.-Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J. C., Li, H., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206374200 · Cited by 207 · see citing works
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300
Hoberg, J. E., Popko, A. E., Ramsey, C. S., & Mayo, M. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.457-471.2006 · Cited by 181 · see citing works
The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma
Yuan, J., Yang, F., Chen, B.-F., Lu, Z. J., Huo, X., Zhou, W., Wang, F., & Sun, S. (2010) · Hepatology · doi:10.1002/hep.24606 · Cited by 180 · see citing works
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Kao, G. D., McKenna, W. G., Guenther, M. G., Muschel, R. J., Lazar, M. A., & Yen, T. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209065 · Cited by 178 · see citing works
Self-citation
Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1
Li, D., Yea, S., Li, S., Zhu, C. X., Narla, G., Banck, M. S., Laborda, J., Tan, S., Friedman, J. M., Friedman, S. L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500463200 · Cited by 177 · see citing works
Hyaluronic Acid Promotes Angiogenesis by Inducing RHAMM-TGFβ Receptor Interaction via CD44-PKCδ
Park, D., Kim, Y., Kim, H., Kim, K., Lee, Y., Choe, J., Hahn, J.-H., Lee, H., Jeon, J., Choi, C., et al. (2012) · Molecules and Cells · doi:10.1007/s10059-012-2294-1 · Cited by 178 · see citing works
Histone Deacetylase Inhibitors In The Treatment Of Cancer: Overview And Perspectives
Giannini, G., Cabri, W., Fattorusso, C., & Rodriquez, M. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.80 · Cited by 178 · see citing works
Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders
Pang, M., & Zhuang, S. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168385 · Cited by 173 · see citing works
Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor–induced Nur77 expression and apoptosis
Dequiedt, F., Lint, J. V., Lecomte, E., Duppen, V. V., Seufferlein, T. T. W., Vandenheede, J. R., Wattiez, R., & Kettmann, R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042034 · Cited by 171 · see citing works
Self-citation
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
Jia, H., Pallos, J., Jacques, V., Lau, A., Tang, B., Cooper, A. C., Syed, A., Purcell, J. M., Chen, Y., Sharma, S., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.016 · Cited by 170 · see citing works
Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells
Jamaladdin, S., Kelly, R. D., O’Regan, L., Dovey, O. M., Hodson, G. E., Millard, C. J., Portolano, N., Fry, A. M., Schwabe, J. W. R., & Cowley, S. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321330111 · Cited by 164 · see citing works
Physiological Roles of Class I HDAC Complex and Histone Demethylase
Hayakawa, T., & Nakayama, J. (2010) · BioMed Research International · doi:10.1155/2011/129383 · Cited by 165 · see citing works
Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors
Chen, L., Endler, A., & Shibasaki, F. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.12.103 · Cited by 164 · see citing works
Chromatin Remodeling in Cardiovascular Development and Physiology
Han, P., Hang, C. T., Yang, J., & Chang, C. (2011) · Circulation Research · doi:10.1161/circresaha.110.224287 · Cited by 165 · see citing works
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signalingPreprint
Ariyoshi, M., & Schwabe, J. W. R. (2003) · Genes & Development · doi:10.1101/gad.266203 · Cited by 163 · see citing works

The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611 · see citing works
Self-citation
Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo
Fischle, W., Dequiedt, F., Fillion, M., Hendzel, M. J., Voelter, W., & Verdin, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104935200 · Cited by 232 · see citing works
Self-citation
Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex
Hudson, G. M., Watson, P. J., Fairall, L., Jamieson, A. G., & Schwabe, J. W. R. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661058 · Cited by 56 · see citing works
Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor
Kim, G. S., Jung, H.-E., Kim, J., & Lee, Y. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132680 · Cited by 8 · see citing works
Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4
Park, S., Kim, G. S., Hwang, H.-J., Nam, T.-H., Park, H.-S., Song, J., Jang, T.-H., Lee, Y. C., & Kim, J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky926 · Cited by 36 · see citing works

Authors: Fischle, W., Dequiedt, F., Hendzel, M. J., Guenther, M. G., Lazar, M. A., Voelter, W., & Verdin, E.
Affiliations: University of California, San Francisco (US)
University of Alberta (CA)
University of Pennsylvania (US)
University of Tübingen (DE)
Corresponding author: Verdin, Eric
ORCID: Fischle, Wolfgang
Hendzel, Michael J
Guenther, Matthew G
Lazar, Mitchell A
Voelter, Wolfgang
Verdin, Eric
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2002-01
Volume: 9
Issue: 1
Pages: 45-57
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(01)00429-4
OpenAlex: W2052373759
Cited by: 754
References: 60
Citations by year: 2026: 16 · 2025: 20 · 2024: 26 · 2023: 12 · 2022: 32 · 2021: 23 · 2020: 31 · 2019: 39 · 2018: 29 · 2017: 34 · 2016: 33 · 2015: 43 · 2014: 42 · 2013: 46 · 2012: 41
FWCI: 9.99
Type: journal article
Language: en
Open access: bronze
doi.org
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www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4215 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
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Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Max Planck Institute for Plasma Physics (submittedVersion)
Open Repository and Bibliography (University of Liège) (submittedVersion)
Funders: National Institute of General Medical Sciences (R01GM051671, GM51671)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: histone deacetylase, class II HDACs, HDAC4, HDAC3, SMRT, NCoR, corepressors, protein complexes, transcriptional repression, gene expression regulation, repressors
MeSH terms: Histone Deacetylase 3, Amino Acid Sequence, DNA Mutational Analysis, DNA-Binding Proteins, Enzyme Activation, HeLa Cells, Histone Deacetylases, Humans, Molecular Sequence Data, Protein Binding, Repressor Proteins, Transcription, Genetic, Nuclear Receptor Co-Repressor 2

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Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

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