Individual histone deacetylases in Drosophila modulate transcription of distinct genes
Abstract
Lysine residues on the N-terminal tails of histones in chromatin are the primary targets of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in eukaryotes. Regulation of histone acetylation by these two classes of enzymes plays significant roles in controlling transcriptional activity in cells. Eukaryotic organisms have several different HDACs, but the biological roles of each HDAC are still not clear. To understand the physiological functions of HDACs, we characterized six different Drosophila HDACs, including Rpd3, HDAC3, HDAC4, HDAC6-S, HDAC6-L, and Sir2, by developmental expression pattern, transcriptional profiles of target genes, and sensitivity to HDAC inhibitors. We found that each HDAC has a distinct temporal expression pattern and regulates transcription of a unique set of genes. Furthermore, we demonstrated differential sensitivity of HDACs to inhibitors. These results show that each individual HDAC plays different roles in regulating genes involved in various biological processes.
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Invertebrates like Caenorhabditis elegans and Drosophila melanogaster conserve the canonical Y and should retain canonical HDAC catalytic activity.
“Invertebrates like Caenorhabditis elegans and Drosophila melanogaster conserve the canonical Y and, accordingly, should retain canonical HDAC catalytic activity as suggested previously (25,26).”
From Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases (2007) · cites this paper as [25]
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- Authors
- Cho, Y., Griswold, A., Campbell, C., & Min, K.-T.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Min, Kyung-Tai
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 86
- Issue
- 5
- Pages
- 606-617
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W1965804460
- Cited by
- 71
- References
- 62
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- histone deacetylase, Drosophila, histone acetylation, transcriptional regulation, Rpd3, HDAC3, HDAC4, HDAC6, Sir2, histone deacetylase inhibitors, developmental gene expression, chromatin regulation
- MeSH terms
- Animals, Chromatin, Drosophila, Enzyme Inhibitors, Gene Expression Regulation, Histone Deacetylases, Histones, Transcription, Genetic, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction
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