The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Type III neuregulin‐1 promotes oligodendrocyte myelination
Abstract
The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of neuregulin‐1 (NRG1), a neuronal signal essential for Schwann cell differentiation and myelination. In contrast to Schwann cells, primary oligodendrocytes differentiate normally when cocultured with dorsal root ganglia (DRG) neurons deficient in type III NRG1. However, they myelinate type III NRG1‐deficient neurites poorly in comparison to wild type cultures. Type III NRG1 is not sufficient to drive oligodendrocyte myelination as sympathetic neurons are not myelinated even with lentiviral‐mediated expression of NRG1. Mice haploinsufficient for type III NRG1 are hypomyelinated in the brain, as evidenced by reduced amounts of myelin proteins and lipids and thinner myelin sheaths. In contrast, the optic nerve and spinal cord of heterozygotes are myelinated normally. Together, these results implicate type III NRG1 as a significant determinant of the extent of myelination in the brain and demonstrate important regional differences in the control of CNS myelination. They also indicate that oligodendrocyte myelination, but not differentiation, is promoted by axonal NRG1, underscoring important differences in the control of myelination in the CNS and peripheral nervous system (PNS). © 2007 Wiley‐Liss, Inc.
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Cites
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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
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“Finally, proteolytic activation of type III NRG1 on the axonal surface by the beta secretase BACE1 is required for proper myelination in both the PNS (Willem et al., 2006) and CNS (Hu et al., 2006).”
BackgroundBace1 modulates myelination in the central and peripheral nervous system
Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience · doi:10.1038/nn1797 · Cited by 608
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A central role for Necl4 (SynCAM4) in Schwann cell–axon interaction and myelination
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Cited by
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Myelination of the Nervous System: Mechanisms and Functions
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Oligodendrocytes: biology and pathology
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A critical period for social experience-dependent oligodendrocyte maturation and myelination
Makinodan, M., Rosen, K. M., Ito, S., & Corfas, G. (2012) · Science · doi:10.1126/science.1220845 · Cited by 922
Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
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Metadata
- Authors
- Taveggia, C., Thaker, P., Petrylak, A., Caporaso, G. L., Toews, A., Falls, D. L., Einheber, S., & Salzer, J. L.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2007-12-13
- Volume
- 56
- Issue
- 3
- Pages
- 284-293
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2031155687
- Cited by
- 193
- References
- 9
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taveggia, C., Thaker, P., Petrylak, A., Caporaso, G. L., Toews, A., Falls, D. L., Einheber, S., & Salzer, J. L. (2008). Type III neuregulin‐1 promotes oligodendrocyte myelination. Glia. https://doi.org/10.1002/glia.20612
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