Astrocytic VEGFA : An essential mediator in blood–brain‐barrier disruption in Parkinson's disease

Parkinson disease

Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415 · see citing works

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452 · see citing works

TEER Measurement Techniques for In Vitro Barrier Model Systems

Srinivasan, B., Kolli, A. R., Esch, M. B., Abaci, H. E., Shuler, M. L., & Hickman, J. J. (2015) · SLAS TECHNOLOGY · doi:10.1177/2211068214561025 · Cited by 2,166 · see citing works

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00682-7 · Cited by 1,266 · see citing works

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

Islam, M. T. (2016) · Neurological Research · doi:10.1080/01616412.2016.1251711 · Cited by 989 · see citing works

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

Wilhelm, B. G., Mandad, S., Truckenbrodt, S., Kröhnert, K., Schäfer, C., Rammner, B., Koo, S. J., Claßen, G. A., Krauss, M., Haucke, V., et al. (2014) · Science · doi:10.1126/science.1252884 · Cited by 770 · see citing works

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

Argaw, A. T., Asp, L., Zhang, J., Navrazhina, K., Pham, T., Mariani, J. N., Mahase, S., Dutta, D. J., Seto, J., Kramer, E. G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60842 · Cited by 733 · see citing works

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

Nakagawa, S., Deli, M. A., Kawaguchi, H., Shimizudani, T., Shimono, T., Kittel, Á., Tanaka, K., & Niwa, M. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.002 · Cited by 728 · see citing works

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

Shi, M., Liu, C., Cook, T. J., Bullock, K. M., Zhao, Y., Ginghina, C., Li, Y., Aro, P., Dator, R., He, C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1314-y · Cited by 676 · see citing works

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

Argaw, A. T., Gurfein, B. T., Zhang, Y., Zameer, A., & John, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808698106 · Cited by 666 · see citing works

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

Halliday, M. R., Rege, S. V., Ma, Q., Zhao, Z., Miller, C. A., Winkler, E. A., & Zlokovic, B. V. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.44 · Cited by 649 · see citing works

Permeability Studies on In Vitro Blood–Brain Barrier Models: Physiology, Pathology, and Pharmacology

Deli, M. A., Ábrahám, C. S., Kataoka, Y., & Niwa, M. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1377-8 · Cited by 643 · see citing works

Glial influence on the blood brain barrier

Alvarez, J. I., Katayama, T., & Prat, A. (2013) · Glia · doi:10.1002/glia.22575 · Cited by 542 · see citing works

Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease

Braak, H., Sastre, M., & Del Tredici, K. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0244-3 · Cited by 462 · see citing works

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

Cabezas, R., Ávila, M. F., González, J., El-Bachá, R. D. S., Báez-Jurado, E., García‐Segura, L. M., Jurado-Coronel, J. C., Capani, F., Cardona‐Gómez, G. P., & Barreto, G. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00211 · Cited by 453 · see citing works

NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains

Wakabayashi, K., Hayashi, S., Yoshimoto, M., Kudo, H., & Takahashi, H. (2000) · Acta Neuropathologica · doi:10.1007/pl00007400 · Cited by 439 · see citing works

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409 · see citing works

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

Bodner, C. R., Dobson, C. M., & Bax, A. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.05.066 · Cited by 370 · see citing works

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

Gu, X., Long, C.-X., Sun, L., Xie, C., Lin, X. Z., & Cai, H. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-12 · Cited by 341 · see citing works

Alpha-synuclein oligomers: a new hope

Bengoa‐Vergniory, N., Roberts, R. F., Wade‐Martins, R., & Alegre‐Abarrategui, J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1755-1 · Cited by 335 · see citing works

Establishment and functional characterization of an in vitro model of the blood–brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes

Gaillard, P. J., Voorwinden, L. H., Nielsen, J. L., Aa, I., Atsumi, R., Engman, H., Ringbom, C., de Boer, A. G., & Breimer, D. D. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00123-8 · Cited by 332 · see citing works

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Perni, M., Galvagnion, C., Maltsev, A. S., Meisl, G., Müller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610586114 · Cited by 296 · see citing works

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Matsumoto, J., Stewart, T., Sheng, L., Li, N., Bullock, K. M., Song, N., Shi, M. Y., Banks, W. A., & Zhang, J. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0470-4 · Cited by 294 · see citing works

Barrier function in the peripheral and central nervous system—a review

Reinhold, A., & Rittner, H. L. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1920-8 · Cited by 279 · see citing works

Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

Michinaga, S., & Koyama, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030571 · Cited by 263 · see citing works

Hydrocortisone Reinforces the Blood–Brain Barrier Properties in a Serum Free Cell Culture System

Hoheisel, D., Nitz, T., Franke, H., Wegener, J., Hakvoort, A., Tilling, T., & Galla, H. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.8051 · Cited by 260 · see citing works

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

Bartels, A. L., Willemsen, A., Kortekaas, R., de Jong, B. M., de Vries, R., de Klerk, O., van Oostrom, J. C. H., Portman, A. T., & Leenders, K. L. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0030-y · Cited by 258 · see citing works

Impaired blood–brain/spinal cord barrier in ALS patients

Garbuzova-Davis, S. N., Hernandez‐Ontiveros, D. G., Rodrigues, M. C. O., Haller, E. M., Frisina-Deyo, A. J., Mirtyl, S., Sallot, S. A., Saporta, S., Borlongan, C. V., & Sanberg, P. R. (2012) · Brain Research · doi:10.1016/j.brainres.2012.05.056 · Cited by 240 · see citing works

SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes

Giles, F. J., Stopeck, A., Silverman, L. R., Lancet, J. E., Cooper, M. A., Hannah, A. L., Cherrington, J. M., O'Farrell, A. M., Yuen, H. A., Louie, S. G., et al. (2003) · Blood · doi:10.1182/blood-2002-10-3023 · Cited by 201 · see citing works

Caffeine protects against MPTP‐induced blood‐brain barrier dysfunction in mouse striatum

Chen, X., Lan, X., Roche, I., Liu, R., & Geiger, J. D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05697.x · Cited by 189 · see citing works

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

Chapouly, C., Argaw, A. T., Horng, S. H., Castro, K., Zhang, J., Asp, L., Loo, H., Laitman, B. M., Mariani, J. N., Farber, R. S., et al. (2015) · Brain · doi:10.1093/brain/awv077 · Cited by 184 · see citing works

α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease

Sorrentino, Z. A., Giasson, B. I., & Chakrabarty, P. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01977-2 · Cited by 181 · see citing works

Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head

Liu, B., & Neufeld, A. H. (2000) · Glia · doi:10.1002/(sici)1098-1136(200004)30:2 · Cited by 177 · see citing works

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease

Pisani, V., Stefani, A., Pierantozzi, M., Natoli, S., Stanzione, P., Franciotta, D., & Pisani, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-188 · Cited by 158 · see citing works

Electrical resistance of a capillary endothelium.

Crone, C. G., & Christensen, O. (1981) · The Journal of General Physiology · doi:10.1085/jgp.77.4.349 · Cited by 157 · see citing works

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

Henkel, J. S., Beers, D. R., Wen, S., Bowser, R., & Appel, S. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a41228 · Cited by 153 · see citing works

Blood–brain barrier disruption induces <i>in vivo</i> degeneration of nigral dopaminergic neurons

Rite, I., Machado, A., Cano, J., & Venero, J. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04567.x · Cited by 147 · see citing works

Dissociation of Metabolic and Neurovascular Responses to Levodopa in the Treatment of Parkinson's Disease

Hirano, S., Asanuma, K., Ma, Y., Tang, C., Feigin, A., DHAWAN, V. M., Carbon, M., & Eidelberg, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0582-08.2008 · Cited by 142 · see citing works

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease

Pienaar, I. S., Lee, C. H., Elson, J. L., McGuinness, L., Gentleman, S. M., Kalaria, R. N., & Dexter, D. T. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.006 · Cited by 125 · see citing works

Signals for the induction of nitric oxide synthase in astrocytes

Saha, R. N., & Pahan, K. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.007 · Cited by 123 · see citing works

Pentosan polysulfate protects brain endothelial cells against bacterial lipopolysaccharide-induced damages

Veszelka, S., Pásztói, M., Farkas, A. E., Krizbai, I. A., Dung, N. T. K., Niwa, M., Ábrahám, C. S., & Deli, M. A. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.08.006 · Cited by 110 · see citing works

Spreading depolarizations trigger caveolin‐1–dependent endothelial transcytosis

Sadeghian, H., Lacoste, B., Qin, T., Toussay, X., Rosa, R. C. D. L., Oka, F., Chung, D. Y., Takizawa, T., Gu, C., & Ayata, C. (2018) · Annals of Neurology · doi:10.1002/ana.25298 · Cited by 107 · see citing works

Distinct Region-Specific α-Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration

Tsika, E., Moysidou, M., Guo, J., Cushman-Nick, M., Gannon, P. J., Sandaltzopoulos, R., Giasson, B. I., Krainc, D., Ischiropoulos, H., & Mazzulli, J. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4977-09.2010 · Cited by 99 · see citing works

Adrenomedullin regulates blood–brain barrier functions in vitro

Kis, B., Deli, M. A., Kobayashi, H., Ábrahám, C. S., Yanagita, T., Kaiya, H., Isse, T., Nishi, R., Gotoh, S., Kangawa, K., et al. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00055 · Cited by 95 · see citing works

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Chavarría, C., Rodríguez-Bottero, S., Quijano, C., Cassina, P., & Souza, J. M. (2018) · Biochemical Journal · doi:10.1042/bcj20180297 · Cited by 82 · see citing works

Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression

Jangula, A., & Murphy, E. J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.058 · Cited by 76 · see citing works

Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat

Yang, S., Chen, Y., Deng, X., Jiang, W., Li, B., Fu, Z., Du, M.-X., & Ding, R. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9990-y · Cited by 76 · see citing works

Murine in vitro model of the blood–brain barrier for evaluating drug transport

Shayan, G., Choi, Y. S., Shusta, E. V., Shuler, M. L., & Lee, K. H. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.11.005 · Cited by 73 · see citing works

Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis

Sheng, L., Stewart, T., Yang, D., Thorland, E., Soltys, D., Aro, P., Khrisat, T., Xie, Z., Li, N., Liu, Z., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00983-w · Cited by 56 · see citing works

Delayed Administration of BQ788, an ET B Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood–Brain Barrier Function and a Reduction of Cerebral Edema in Mice

Michinaga, S., Kimura, A., Hatanaka, S., Minami, S., Asano, A., Ikushima, Y., Matsui, S., Toriyama, Y., Fujii, M., & Kōyama, Y. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5421 · Cited by 52 · see citing works

Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson’s Disease via a Vitamin D Receptor-Dependent Pathway

Kim, H., Shin, J., Lee, Y., Yun, S. P., Maeng, H., & Lee, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228538 · Cited by 47 · see citing works

SU5416, a VEGF Receptor Inhibitor and Ligand of the AHR, Represents a New Alternative for Immunomodulation

Mezrich, J. D., Nguyen, L. P., Kennedy, G., Nukaya, M., Fechner, J. H., Zhang, X., Xing, Y., & Bradfield, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044547 · Cited by 40 · see citing works

Optimization of endothelial cell growth in a murine in vitro blood–brain barrier model

Wuest, D., & Lee, K. H. (2011) · Biotechnology Journal · doi:10.1002/biot.201100189 · Cited by 37 · see citing works

The blood-brain barrier in aging and neurodegeneration

Knox, E. G., Aburto, M. R., Clarke, G., Cryan, J. F., & O’Driscoll, C. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01511-z · Cited by 738 · see citing works

Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis

Aburto, M. R., & Cryan, J. F. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00890-0 · Cited by 391 · see citing works

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00557-1 · Cited by 201 · see citing works

Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

Andjelkovic, A. V., Situ, M., Citalán‐Madrid, A. F., Stamatovic, S. M., Xiang, J., & Keep, R. F. (2023) · Stroke · doi:10.1161/strokeaha.122.040578 · Cited by 175 · see citing works

Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy

Lau, K., Kotzur, R., & Richter, F. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00430-z · Cited by 165 · see citing works

The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases

Zang, X., Chen, S., Zhu, J., Ma, J., & Zhai, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.872134 · Cited by 139 · see citing works

Blood-brain barrier disruption: a culprit of cognitive decline?

Che, J., Sun, Y., Deng, Y., & Zhang, J. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00563-3 · Cited by 103 · see citing works

Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit

Paul, G., & Elabi, O. F. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.853372 · Cited by 97 · see citing works

Blood–brain barrier endothelial cells in neurodegenerative diseases: Signals from the “barrier”

Yuan, Y., Sun, J., Dong, Q., & Cui, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1047778 · Cited by 86 · see citing works

Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway

Xie, Z., Zhang, M., Luo, Y., Jin, D., Guo, X., Yang, W., Zheng, J., Zhang, H., Zhang, L., Deng, C., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0309 · Cited by 80 · see citing works

The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders

Wu, Y., Bogale, T. A., Koıstınaho, J., Pizzi, M., Rõlova, T., & Bellucci, A. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02696-z · Cited by 81 · see citing works

Waste clearance shapes aging brain health

Jiang-Xie, L.-F., Drieu, A., & Kipnis, J. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.017 · Cited by 63 · see citing works

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis

Wang, P., Lan, G., Xu, B., Yu, Z., Tian, C., Lei, X., Meissner, W. G., Feng, T., Yang, Y., & Zhang, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00372-y · Cited by 63 · see citing works

Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays

Wang, Y., Du, W., Hu, X., Yu, X., Guo, C., Jin, X., & Wang, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.009 · Cited by 56 · see citing works

The blood-brain barrier, a key bridge to treat neurodegenerative diseases

Hang, Z., Zhou, L., Xing, C., Wen, Y., & Du, H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102070 · Cited by 45 · see citing works

Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease

Долгачева, Л. П., Зинченко, В. П., & Goncharov, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113043 · Cited by 41 · see citing works

Glial cells: an important switch for the vascular function of the central nervous system

Gao, L., Pan, X., Zhang, J. H., & Xia, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1166770 · Cited by 35 · see citing works

Blood-brain Barrier and Neurovascular Unit Dysfunction in Parkinson's Disease: From Clinical Insights to Pathogenic Mechanisms and Novel Therapeutic Approaches

Khor, S. L. Q., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230330093829 · Cited by 35 · see citing works

The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications

Ceci, C., Lacal, P. M., Barbaccia, M. L., Mercuri, N. B., Graziani, G., & Ledonne, A. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107101 · Cited by 35 · see citing works

Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders

McLoughlin, C. D., Nevins, S., Stein, J. B., Khakbiz, M., & Lee, K. (2024) · Small Science · doi:10.1002/smsc.202400232 · Cited by 38 · see citing works

The Impact of the Blood–Brain Barrier and Its Dysfunction in Parkinson’s Disease: Contributions to Pathogenesis and Progression

Iqbal, M. K., Khan, B., Hifsa, H., YuXuan, G., Mujahid, M., Kiyani, M. M., Khan, H. R., & Bashir, S. (2024) · ACS Omega · doi:10.1021/acsomega.4c06546 · Cited by 34 · see citing works

Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases

Jiménez, A., Estudillo, E., Guzmán‐Ruiz, M. A., Herrera, N., Victoria-Acosta, G., Cortés-Malagón, E. M., & López-Ornelas, A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030281 · Cited by 34 · see citing works

VEGF Paradoxically Reduces Cerebral Blood Flow in Alzheimer’s Disease Mice

Ali, M., & Bracko, O. (2022) · Neuroscience Insights · doi:10.1177/26331055221109254 · Cited by 30 · see citing works

The role of VEGF in Cancer angiogenesis and tumorigenesis: Insights for anti-VEGF therapy

Shi, Z., Kuai, M., Li, B., Akowuah, C. F., Wang, Z., Pan, Y., Tang, M., Yang, X., & Lü, P. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156908 · Cited by 33 · see citing works

Peripheral proteinopathy in neurodegenerative diseases

Xu, B., Lei, X., Yang, Y., Yu, J., Chen, J., Xu, Z., Ye, K., & Zhang, J. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-024-00461-6 · Cited by 30 · see citing works

Overview of blood-brain barrier dysfunction in methamphetamine abuse

Pang, L., & Wang, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114478 · Cited by 29 · see citing works

Reactive astrocytes associated with prion disease impair the blood brain barrier

Kushwaha, R., Li, Y., Makarava, N., Pandit, N. P., Molesworth, K., Birukov, K. G., & Baskakov, I. V. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106264 · Cited by 28 · see citing works

Inflammatory Blood Biomarkers Are Associated with Long-Term Clinical Disease Severity in Parkinson’s Disease

Hepp, D. H., van Wageningen, T. A., Kuiper, K. L., van Dijk, K. D., Oosterveld, L. P., Berendse, H. W., & van de Berg, W. D. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914915 · Cited by 26 · see citing works

A Focus on Astrocyte Contribution to Parkinson’s Disease Etiology

Prunell, G., & Olivera‐Bravo, S. (2022) · Biomolecules · doi:10.3390/biom12121745 · Cited by 26 · see citing works

Taurochenodeoxycholic acid activates autophagy and suppresses inflammatory responses in microglia of MPTP-induced Parkinson’s disease mice via AMPK/mTOR, AKT/NFκB and Pink1/Parkin signaling pathways mediated by Takeda G protein-coupled receptor 5

Ni, C., Wang, L., Bai, Y., Huang, F., Shi, H., Wu, H., Wu, X., & Huang, J. L. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.053 · Cited by 25 · see citing works

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease

Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 24 · see citing works

Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy

Wang, J., Liu, Y., Wu, Y., Yang, K., Yang, K., Yan, L., & Feng, L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176141 · Cited by 23 · see citing works

Emergence of the brain-border immune niches and their contribution to the development of neurodegenerative diseases

Tan, L. Y., Cunliffe, G., Hogan, M. P., Yeo, X. Y., Oh, C., Jin, B., Kang, J., Park, J., Kwon, M., Kim, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1380063 · Cited by 22 · see citing works

The role of macrophage plasticity in neurodegenerative diseases

Ma, H., Zhu, M., Chen, M., Li, X., & Feng, X. (2024) · Biomarker Research · doi:10.1186/s40364-024-00624-7 · Cited by 24 · see citing works

α-Synuclein pathology from the body to the brain: so many seeds so close to the central soil

Yang, Y., & Zhang, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.387967 · Cited by 24 · see citing works

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

He, Y., Qu, M., Yu, L., He, L., Lu, Y., Hong, J., Sun, M., Yang, H., Mi, W., Guo, H., et al. (2026) · MedComm · doi:10.1002/mco2.70712 · Cited by 24 · see citing works

Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson’s disease

Guan, Q., Liu, W., Mu, K., Hu, Q., Xie, J., Cheng, L., & Wang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.992505 · Cited by 21 · see citing works

Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood–Brain Barrier

Cogill, S. A., Lee, J.-H., Jeon, M., Kim, D.-G., & Chang, Y. (2024) · Cells · doi:10.3390/cells13100789 · Cited by 20 · see citing works

Cooperation between neurovascular dysfunction and Aβ in Alzheimer’s disease

Wang, N., Yang, X., Zhao, Z., Liu, D., Wang, X., Tang, H., Zhong, C., Chen, X., Chen, W. K., & Meng, Q. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1227493 · Cited by 20 · see citing works

3‐HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes

Chen, J., Shi, G., Yu, L., Shan, W., Sun, J., Guo, A., Wu, J., Tang, T., Zhang, X., & Wang, Q. (2025) · Advanced Science · doi:10.1002/advs.202412667 · Cited by 20 · see citing works

Inhibiting astrocyte connexin‐43 hemichannels blocks radiation‐induced vesicular VEGF‐A release and blood–brain barrier dysfunction

Schumacher, S., Tahiri, H., Ezan, P., Rouach, N., Witschas, K., & Leybaert, L. (2023) · Glia · doi:10.1002/glia.24460 · Cited by 20 · see citing works

Unlocking the potential of low-molecular-weight (Poly)phenol metabolites: Protectors at the blood-brain barrier frontier

Marques, D., Moura-Louro, D., Silva, I. P., Matos, S., dos Santos, C. N., & Figueira, I. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105836 · Cited by 20 · see citing works

Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61)

Lau, K., Porschen, L. T., Richter, F., & Gericke, B. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106298 · Cited by 18 · see citing works

On-chip modeling of physiological and pathological blood-brain barrier microenvironment for studying glial responses to neuroinflammation

Zeng, Y.-L., Du, Y., Xu, X., Wang, Y., Yu, S., Liu, T., Luo, S., Xiang, X., Liu, W., Chen, Y.-C., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101947 · Cited by 17 · see citing works

Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study

Albert, K., Kälvälä, S., Hakosalo, V., Syvänen, V., Krupa, P., Niskanen, J., Peltonen, S., Sonninen, T.-M., & Lehtonen, Š. (2022) · Biomedicines · doi:10.3390/biomedicines10102649 · Cited by 15 · see citing works

Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases

García, F., & Heiman, M. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00799-z · Cited by 14 · see citing works

Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines

Hasan, I., Roy, S., Guo, B., & Chang, C. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300058 · Cited by 14 · see citing works

Contribution of Direct Cerebral Vascular Transport in Brain Substance Clearance

Wen, Q., Wang, H., Haacke, E. M., Jiang, Q., & Hu, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0426 · Cited by 14 · see citing works

In vivo evidence of increased vascular endothelial growth factor in patients with major depressive disorder

Li, K., Wang, K., Xu, S., Xie, X., Tang, Y., Zhang, L., & Liu, Z. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.073 · Cited by 14 · see citing works

TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy

Jeon, M., Cogill, S. A., Kim, K., Kim, Y.-J., Kim, H., Lee, C.-Y., Kim, S., Son, S., Kim, J.-Y., Lee, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116001 · Cited by 13 · see citing works

Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease

Šaponjić, J., Mejı́as, R., Nikolovski, N., Dragić, M., Canak, A., Papoutsopoulou, S., Özdemir, Y., Fladmark, K. E., Ntavaroukas, P., Muluk, N. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084330 · Cited by 13 · see citing works

VEGFA mediates blood–brain barrier disruption in Parkinson disease

Wood, H. B. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00594-6 · Cited by 13 · see citing works

Hyperglycemia-induced blood-brain barrier dysfunction: Mechanisms and therapeutic interventions

Chen, C., Xu, X., Lu, J., Xiang, Y., Shi, L., & Liu, D. (2025) · Microvascular Research · doi:10.1016/j.mvr.2025.104820 · Cited by 14 · see citing works

Evolving insights into erythrocytes in synucleinopathies.

Yang, Y., Nie, X.-Q., Wang, Y.-J., Sun, J., Gao, X., & Zhang, J. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.06.005 · Cited by 12 · see citing works

Microglia, Astrocytes, and Oligodendrocytes in Parkinson’s Disease: Neuroinflammatory Crosstalk and Emerging Therapeutic Strategies

Kędzia, D., Galita, G., Majsterek, I., & Rozpędek‐Kamińska, W. (2026) · Biomolecules · doi:10.3390/biom16010156 · Cited by 11 · see citing works

Transcriptome sequencing and network pharmacology-based approach to reveal the effect and mechanism of Ji Chuan Jian against Parkinson’s disease

Wu, Y., Bai, Y., Lu, Y., Zhang, Z., Zhao, Y., Huang, S., Tang, L., Liang, Y., Hu, Y., & Xu, C. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03999-6 · Cited by 11 · see citing works

The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria

Mwikali, K., Mwangi, S., Pance, A., Ochola‐Oyier, L. I., Kariuki, S. M., Newton, C. R. J. C., Bejon, P., Rayner, J. C., & Abdi, A. I. (2024) · Science Advances · doi:10.1126/sciadv.adl2256 · Cited by 11 · see citing works

Machine learning approaches for neurological disease prediction: A systematic review

Fatima, A., & Masood, S. (2024) · Expert Systems · doi:10.1111/exsy.13569 · Cited by 10 · see citing works

VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway

Zhang, X., Liu, T., Ma, Z., Li, G., Ding, N., Wang, Z., Guan, Y., Zhang, Y., Liu, L., & Chen, X. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06388-4 · Cited by 9 · see citing works

Development of Brain Permeable Drugs and Novel Strategies to Overcome the Brain Barriers for Treatment Purposes

Chauhan, A., & Jain, S. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128386983250410092649 · Cited by 9 · see citing works

Repositioning of receptor tyrosine kinase inhibitors

Mansour, H. M., & El-Khatib, A. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18677-6.00010-5 · Cited by 9 · see citing works

Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model

Bluhm, A., Schrempel, S., Schilling, S., von Hörsten, S., Schulze, A., Roßner, S., & Hartlage‐Rübsamen, M. (2022) · Biomolecules · doi:10.3390/biom12071006 · Cited by 8 · see citing works

Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression

Liu, S., Feng, A., & Li, Z. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05010-4 · Cited by 8 · see citing works

Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment

Zang, Z., Yang, F., Qu, L., Ge, M., Tong, L., Xue, L., Sun, X., & Hai, Y. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1640389 · Cited by 8 · see citing works

Stress-induced regional characteristics of the blood-brain barrier

Zhou, M.-Y., Xie, F., Zhao, Y. F., Wang, X., Sun, Z., & Qian, L. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111548 · Cited by 7 · see citing works

Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease

Ding, X., Chen, Y., Zhang, X., Duan, Y., Yuan, G., & Liu, C. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102457 · Cited by 7 · see citing works

Neurovascular dysfunction in the development and progression of neuroinflammatory diseases

Gowdy, J., Ahn, J. J., Miller, R. H., & Islam, Y. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1741928 · Cited by 8 · see citing works

Increased ocular plasma cells induce damaging α-synuclein+ microglia in autoimmune uveitis

Li, M., Feng, M., Liu, T., Duan, S., Man, X., Yuan, X., Wang, L., Sun, Y., Wei, X., Fu, Q., et al. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.02.007 · Cited by 6 · see citing works

VEGFA induces anxiety and depression-like behaviors in post-stroke mice by regulating the permeability of the blood–brain barrier

Gou, Y., Zhang, J., Liu, H., Zhu, C., Song, X., Geng, S., Peng, Q., Jin, S., Wang, X., Xiao, Y., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.06.056 · Cited by 5 · see citing works

Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases

Chen, Y., Sun, X., Xi, Y., Luo, Z., Lai, H., Zhu, D., Zhang, Y., Xu, F., Li, J., Zhou, J., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.10.016 · Cited by 8 · see citing works

Tight Junction Regulation in Blood–Brain Barrier Integrity and Neurological Diseases

Nguyen, T. H., Pham, T. K. A., Tran, T. T. T., Trinh, K. N., Dhananjayan, S. S., Bui, A. T. T., Kim, N. D. T., Ho, H. H. N., Rai, A., Lee, C.-W., et al. (2026) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-25-00078 · Cited by 5 · see citing works

Impaired neuronal activity as a potential factor contributing to the underdeveloped cerebrovasculature in a young Parkinson’s disease mouse model

Jeong, J.-Y., Lee, H. J., Kim, N., Li, Y., Rah, J., & Oh, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-49900-w · Cited by 5 · see citing works

Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease

Li, W., Yang, J.-H., Liu, L., Ding, S., Yu, B., Jiang, L., Yan, N., & Liu, H.-D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1580029 · Cited by 5 · see citing works

Association between red cell distribution width/serum albumin ratio and Parkinson’s disease

Li, M., Xu, Y. Y., Huang, Z. J., Ye, L., & Chen, C. (2025) · European journal of medical research · doi:10.1186/s40001-025-02707-z · Cited by 4 · see citing works

A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies

Estrella, L. D., Sveeggen, T. M., de la Guardia, G., Cacho, J., Stauch, K. L., & Bagher, P. (2025) · npj Microgravity · doi:10.1038/s41526-025-00540-6 · Cited by 3 · see citing works

Intranasally administered muse cells attenuate neurodegeneration in Parkinson’s disease

Lu, Z., Ren, S., Wang, B., Shao, L., Zhang, Y., Wu, H., Mu, X., & Wang, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07401-6 · Cited by 3 · see citing works

Insights into receptor tyrosine kinases signaling in neurodegenerative disorders

Randhawa, P. K., Jaggi, A. S., & Bali, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18677-6.00001-4 · Cited by 3 · see citing works

Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin

Sharma, A., Feng, L., Muresanu, D. F., Tian, Z. R., Lafuente, J. V., Buzoianu, A. D., Nozari, A., Bryukhovetskiy, I., Manzhulo, I., Wiklund, L., et al. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.05.009 · Cited by 3 · see citing works

Neurogliovascular alterations in brain pathologies across lifespan

Daigle, B., Bevilacqua, L. M., Noël, V. P., Lebel, M., Côté, D. C., Lévesque, L., & Ménard, C. (2024) · Glial health research. · doi:10.1016/j.ghres.2024.100004 · Cited by 4 · see citing works

Multimodal Imaging of Blood–Brain Barrier Dysfunction in Parkinson's Disease: From Pathological Mechanisms to Therapeutic Opportunities

Lu, Z., Yin, H., Xiang, P., Yi, X., Tian, X., & Gong, Q. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70237 · Cited by 3 · see citing works

Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticityPreprint

Thomas, W. R., Richter, T. A., O’Neil, E. T., Baldoni, C., Corthals, A., von Elverfeldt, D., Nieland, J. D., Dechmann, D. K. N., Hunter, R. G., & Dávalos, L. M. (2024) · eLife · doi:10.7554/elife.100788 · Cited by 3 · see citing works

Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticityPreprint

Thomas, W. R., Richter, T. A., O’Neil, E. T., Baldoni, C., Corthals, A., von Elverfeldt, D., Nieland, J. D., Dechmann, D. K. N., Hunter, R. G., & Dávalos, L. M. (2024) · eLife · doi:10.7554/elife.100788.1 · Cited by 3 · see citing works

Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity

Thomas, W. R., Richter, T. A., O’Neil, E. T., Baldoni, C., Corthals, A., von Elverfeldt, D., Nieland, J. D., Dechmann, D. K. N., Hunter, R. G., & Dávalos, L. M. (2025) · eLife · doi:10.7554/elife.100788.3 · Cited by 2 · see citing works

Understanding the Crossing of Blood–Brain Barrier Using Nanocarriers: Current Trends and the Role of Physiologically Based Pharmacokinetic Modeling

Nazeer, A. A., & Ahn, S. (2025) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2025.3580172 · Cited by 2 · see citing works

Material considerations for delivering therapeutics across the blood–brain barrier

Zoba, A. N., & Tringides, C. M. (2025) · APL Materials · doi:10.1063/5.0284305 · Cited by 2 · see citing works

Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium

Mauser, H. D., Keyzer, T. E., Surma, J. M., Alexander, N. G., Cutts, W. D., Hathcock, S. F., Lackey, K., Lam, D. W., Thornton, J. A., Vollmuth, N., et al. (2025) · Virulence · doi:10.1080/21505594.2025.2564281 · Cited by 2 · see citing works

Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson’s disease vascular alterations

Alim, A., Baek, Y., Lee, M., & Paek, J. (2026) · Communications Engineering · doi:10.1038/s44172-025-00581-5 · Cited by 4 · see citing works

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Jiang, Z., Qin, Y., Luo, B., Bai, F., Liu, J., Ma, L., He, S., Chen, R., Wang, Y., Liu, S., et al. (2026) · Advanced Science · doi:10.1002/advs.202520239 · Cited by 2 · see citing works

Peripheral immunochemical considerations in Parkinson disease: sources, targets and crosstalk mechanisms

Castegna, A., Laera, L., Moda, P., Miglietta, S., D’Agostino, M., Ruggiero, M., Cianciulli, A., Filannino, F. M., Porro, C., Butterfield, D. A., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08102-4 · Cited by 2 · see citing works

Butylphthalide may inhibit blood–brain barrier disruption through complement-related pathways to alleviate cognitive impairment in epileptic mice

Zhao, L., Chen, S., Jin, X., Zhuang, W., Liu, Q., Xiao, Y., & Xu, H. (2025) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.110251 · Cited by 2 · see citing works

Immunity in Parkinson's disease – The role of innate responses

Iyengar, A. S., Dunkley, P. R., & Dickson, P. W. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578716 · Cited by 3 · see citing works

Identification of candidate biomarkers and pathways associated with multiple sclerosis using bioinformatics and next generation sequencing data analysisPreprint

Vastrad, B. M., Pattanashetti, S., & Vastrad, C. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.05.570305 · Cited by 2 · see citing works

Potential Molecular Mechanism of Guishao Pingchan Recipe in the Treatment of Parkinson’s Disease Based on Network Pharmacology and Molecular Docking

Tan, L.-J., Yu, Y., Fang, Z.-H., Zhang, J.-L., Huang, H., & Liu, H. (2022) · Natural Product Communications · doi:10.1177/1934578x221118486 · Cited by 1 · see citing works

Transgenic A53T Mice Have Astrocytic α‐Synuclein Aggregates in Dopamine and Striatal Regions

Peat, C., Prasad, A. A., Finkelstein, D. I., Sue, C. M., Johnston, J. A., Parish, C. L., Thompson, L. H., Kirik, D., & Halliday, G. M. (2026) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.70097 · Cited by 1 · see citing works

Parkinson's disease: A chronic systemic inflammatory disorder

Khan, H., & Benskey, M. J. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-21992-4.00006-3 · Cited by 1 · see citing works

Neuronal titration of Snca via enhancer disruption mitigates disease onset in a Parkinson's disease mouse model

Boyd, R. J., Kho, A. R., McClymont, S. A., Loftus, S. K., Ko, H. S., & McCallion, A. S. (2026) · Brain · doi:10.1093/brain/awag007 · Cited by 1 · see citing works

RNA-seq analysis reveals altered gene expression profiles in HMEC-1 cells overexpressing KRAS gene associated with brain arteriovenous malformation

Yuan, K., Zhao, Y., Zhang, H., Wang, K., Zhou, Y., Chen, Y., Chen, X., Zhao, Y., & Hao, Q. (2026) · Chinese Neurosurgical Journal · doi:10.1186/s41016-026-00427-9 · Cited by 1 · see citing works

Interconnected roles of astrocytes and the blood–brain barrier in Parkinson’s disease: pathological evidence, mechanistic insights, and knowledge gaps

Stoll, A. C., & Harms, A. S. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1765195 · Cited by 1 · see citing works

Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson’s Disease

Yao, W., Liu, L., Wang, J., Chen, S., Zhang, C., Liao, R., Wang, Y., Ou, K., Jiang, L., Yu, Y., et al. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01738-2 · Cited by 1 · see citing works

VEGFA mediates blood–brain barrier disruption in Parkinson disease

Wood, H. B. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00594-6 · Cited by 13 · see citing works

Interconnected roles of astrocytes and the blood–brain barrier in Parkinson’s disease: pathological evidence, mechanistic insights, and knowledge gaps

Stoll, A. C., & Harms, A. S. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1765195 · Cited by 1 · see citing works

In response to monomeric α-synuclein, brain pericytes release inflammatory cytokines to impair brain endothelial barrier

Dohgu, S., Takata, F., Matsumoto, J., Kimura, I., Yamauchi, A., & Kataoka, Y. (2018) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.wcp2018.0_po1-1-28

Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61)

Lau, K., Porschen, L. T., Richter, F., & Gericke, B. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106298 · Cited by 18 · see citing works

Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro

Dohgu, S., Takata, F., Matsumoto, J., Kimura, I., Yamauchi, A., & Kataoka, Y. (2019) · Microvascular Research · doi:10.1016/j.mvr.2019.03.005 · Cited by 112 · see citing works