Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Brochard, V., Combadière, B., Prigent, A., Laouar, Y., Perrin, A., Beray-Berthat, V., Bonduelle, O., Alvarez-Fischer, D., Callebert, J., Launay, J.-M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36470 · Cited by 1,172 · see citing works

Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

Kortekaas, R., Leenders, K. L., van Oostrom, J. C. H., Vaalburg, W., Bart, J., Willemsen, A. T. M., & Hendrikse, N. H. (2005) · Annals of Neurology · doi:10.1002/ana.20369 · Cited by 733 · see citing works

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

Schulz-Schaeffer, W. J. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0711-0 · Cited by 627 · see citing works

Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in <scp>A</scp> lzheimer's Disease

Sengillo, J. D., Winkler, E. A., Walker, C. T., Sullivan, J. S., Johnson, M., & Zlokovic, B. V. (2013) · Brain Pathology · doi:10.1111/bpa.12004 · Cited by 553 · see citing works

Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport

Freundt, E. C., Maynard, N., Clancy, E. K., Roy, S., Bousset, L., Sourigues, Y., Covert, M. W., Melki, R., Kirkegaard, K., & Brahic, M. (2012) · Annals of Neurology · doi:10.1002/ana.23747 · Cited by 370 · see citing works

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1039-8 · Cited by 354 · see citing works

The neostriatal mosaic: III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems

Gerfen, C. R., Baimbridge, K. G., & Thibault, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-12-03935.1987 · Cited by 340 · see citing works

6-Hydroxydopamine-induced alterations in blood-brain barrier permeability

Carvey, P. M., Zhao, C. H., Hendey, B., Lum, H., Trachtenberg, J., Desai, B. S., Snyder, J., Zhu, Y. G., & Ling, Z. D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04281.x · Cited by 218 · see citing works

Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies

Marui, W., Iseki, E., Nakai, T., Miura, S., Kato, M., Uéda, K., & Kosaka, K. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00006-0 · Cited by 161 · see citing works

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease

Pisani, V., Stefani, A., Pierantozzi, M., Natoli, S., Stanzione, P., Franciotta, D., & Pisani, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-188 · Cited by 158 · see citing works

Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia

Ohlin, K. E., Francardo, V., Lindgren, H. S., Sillivan, S. E., O’Sullivan, S. S., Luksik, A. S., Vassoler, F. M., Lees, A. J., Konradi, C. L., & Cenci, M. A. (2011) · Brain · doi:10.1093/brain/awr165 · Cited by 140 · see citing works

Severe Blood–Brain Barrier Disruption and Surrounding Tissue Injury

Chen, B., Friedman, B., Cheng, Q., Tsai, P. S., Schim, E., Kleinfeld, D., & Lyden, P. D. (2009) · Stroke · doi:10.1161/strokeaha.109.551341 · Cited by 122 · see citing works

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

Tanji, K., Mori, F., Mimura, J., Itoh, K., Kakita, A., Takahashi, H., & Wakabayashi, K. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0676-z · Cited by 102 · see citing works

Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration

Rosidi, N. L., Zhou, J., Pattanaik, S., Wang, P., Jin, W., Brophy, M., Olbricht, W. L., Nishimura, N., & Schaffer, C. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026612 · Cited by 87 · see citing works

Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease

Woulfe, J., Gray, M. T., Gray, D. A., Muñoz, D. G., & Middeldorp, J. M. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.02.031 · Cited by 64 · see citing works

Functional architecture of the mammalian striatum: Mouse vascular and striosome organization and their anatomic relationships

Breuer, O., Lawhorn, C., Miller, T., Smith, D. M., & Brown, L. L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.029 · Cited by 21 · see citing works

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609 · see citing works

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123 · see citing works

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Pajares, M., I. Rojo, A., Manda, G., Boscá, L., & Cuadrado, A. (2020) · Cells · doi:10.3390/cells9071687 · Cited by 779 · see citing works

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

Takata, F., Nakagawa, S., Matsumoto, J., & Dohgu, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.661838 · Cited by 651 · see citing works

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Booth, H. D. E., Hirst, W. D., & Wade-Martins, R. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.001 · Cited by 633 · see citing works

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588 · see citing works

Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis

Zhao, Z., Ning, J., Bao, X.-Q., Shang, M., Ma, J., Li, G., & Zhang, D. (2021) · Microbiome · doi:10.1186/s40168-021-01107-9 · Cited by 616 · see citing works

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Xie, J., Shen, Z., Anraku, Y., Kataoka, K., & Chen, X. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119491 · Cited by 604 · see citing works

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.13 · Cited by 527 · see citing works

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

Fiorentino, M., Sapone, A., Senger, S., Camhi, S. S., Kadzielski, S. M., Buie, T. M., Kelly, D. L., Cascella, N., & Fasano, A. (2016) · Molecular Autism · doi:10.1186/s13229-016-0110-z · Cited by 494 · see citing works

What does plasma CRP tell us about peripheral and central inflammation in depression?

Felger, J. C., Haroon, E., Patel, T. A., Goldsmith, D. R., Wommack, E. C., Woolwine, B. J., Le, N.-A., Feinberg, R., Tansey, M. G., & Miller, A. H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0096-3 · Cited by 448 · see citing works

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Lochhead, J. J., Yang, J., Ronaldson, P. T., & Davis, T. P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00914 · Cited by 445 · see citing works

Age-associated Physiological and Pathological Changes at the Blood-Brain Barrier: A Review

Erdő, F., Denes, L., & de Lange, E. (2017) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1177/0271678x16679420 · Cited by 426 · see citing works

Microglia and astrocyte dysfunction in parkinson's disease

Kam, T., Hinkle, J. T., Dawson, T. M., & Dawson, V. L. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105028 · Cited by 399 · see citing works

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha, S., Liu, H., Li, H., Li, H., Wong, K.-L., & All, A. H. (2024) · ACS Nano · doi:10.1021/acsnano.3c10674 · Cited by 378 · see citing works

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

Dudvarski Stankovic, N., Teodorczyk, M., Ploen, R., Zipp, F., & Schmidt, M. H. H. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1524-y · Cited by 301 · see citing works

Blood–brain barrier leakage is increased in parkinson’s disease

Al-Bachari, S., Naish, J. H., Parker, G. J. M., Emsley, H. C. A., & Parkes, L. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.593026 · Cited by 263 · see citing works

Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

Michinaga, S., & Koyama, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030571 · Cited by 263 · see citing works

Sepsis-Associated Encephalopathy and Blood-Brain Barrier Dysfunction

Gao, Q., & Hernandes, M. S. (2021) · Inflammation · doi:10.1007/s10753-021-01501-3 · Cited by 266 · see citing works

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases

Chen, L., Shen, Q., Liu, Y., Zhang, Y., Sun, L., Ma, X., Song, N., & Xie, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02071-0 · Cited by 271 · see citing works

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Pediaditakis, I., Kodella, K. R., Manatakis, D., Le, C. Y., Hinojosa, C. D., Tien-Street, W., Manolakos, E., Vekrellis, K., Hamilton, G., Ewart, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-021-26066-5 · Cited by 174 · see citing works

The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

Tran, S. M.-S., & Mohajeri, M. H. (2021) · Nutrients · doi:10.3390/nu13030732 · Cited by 207 · see citing works

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

Haileselassie, B., Joshi, A. U., Minhas, P. S., Mukherjee, R., Andreasson, K. I., & Mochly‐Rosen, D. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1689-8 · Cited by 203 · see citing works

Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease

Houser, M. C., Chang, J., Factor, S. A., Molho, E., Zabetian, C. P., Hill‐Burns, E. M., Payami, H., Hertzberg, V., & Tansey, M. G. (2018) · Movement Disorders · doi:10.1002/mds.27326 · Cited by 200 · see citing works

Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies

Zhang, X., Tang, B., & Guo, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00392-8 · Cited by 205 · see citing works

Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities

Araújo, B., Caridade-Silva, R., Soares-Guedes, C., Martins‐Macedo, J., Gomes, E. D., Monteiro, S., & Teixeira, F. G. (2022) · Cells · doi:10.3390/cells11182908 · Cited by 197 · see citing works

Lipid nanoparticle-mediated drug delivery to the brain

Khare, P., Edgecomb, S. X., Hamadani, C. M., Tanner, E. E. L., & S Manickam, D. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114861 · Cited by 187 · see citing works

Neuron-Astrocyte Interactions in Parkinson’s Disease

Miyazaki, I., & Asanuma, M. (2020) · Cells · doi:10.3390/cells9122623 · Cited by 186 · see citing works

Parkinson's Disease: A Multisystem Disorder

Costa, H. N., Esteves, A. R., Empadinhas, N., & Cardoso, S. M. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00934-6 · Cited by 191 · see citing works

Targeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson’s Disease Rat Model

Arab, H. H., Safar, M. M., & Shahin, N. N. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00722 · Cited by 180 · see citing works

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

Copas, A. N. M., McComish, S. F., Fletcher, J. M., & Caldwell, M. A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.666737 · Cited by 175 · see citing works

Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism

Anandhan, A., Jacome, M. S., Lei, S., Hernández-Franco, P., Pappa, A., Panayiotidis, M. I., Powers, R., & Franco, R. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.009 · Cited by 161 · see citing works

Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells

Garretti, F., Agalliu, D., Arlehamn, C. S. L., Sette, A., & Sulzer, D. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00303 · Cited by 162 · see citing works

Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy

Lau, K., Kotzur, R., & Richter, F. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00430-z · Cited by 165 · see citing works

The immune system in Parkinson's disease: what we know so far

Roodveldt, C., Bernardino, L. I., Çakmak, Ö. Ö., Dragić, M., Fladmark, K. E., Ertan, S., Aktaş, B., Pita, C., Ciglar, L., Garraux, G., et al. (2024) · Brain · doi:10.1093/brain/awae177 · Cited by 148 · see citing works

Leaky brain in neurological and psychiatric disorders: Drivers and consequences

Morris, G., Fernandes, B. S., Puri, B. K., Walker, A. J., Carvalho, A. F., & Berk, M. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418796955 · Cited by 144 · see citing works

Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics

Pan, Y., & Nicolazzo, J. A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.009 · Cited by 131 · see citing works

Infectious Etiologies of Parkinsonism: Pathomechanisms and Clinical Implications

Limphaibool, N., Iwanowski, P. S., Holstad, M. J. V., Kobylarek, D., & Kozubski, W. P. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00652 · Cited by 130 · see citing works

Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

Elabi, O. F., Gaceb, A., Carlsson, R., Padel, T., Soylu-Kucharz, R., Cortijo, I., Li, W., Li, J., & Paul, G. (2021) · Scientific Reports · doi:10.1038/s41598-020-80889-8 · Cited by 127 · see citing works

Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo

Bok, E., Chung, Y. C., Kim, K., Baik, H. H., Shin, W.-H., & Jin, B. K. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0111-4 · Cited by 125 · see citing works

The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease

Jacquet, A. D. R., Alpaugh, M., Denis, H. L., Tancredi, J. L., Boutin, M., Decaestecker, J., Beauparlant, C., Herrmann, L., Saint-Pierre, M., Parent, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39038-8 · Cited by 114 · see citing works

The blood–brain barriers: novel nanocarriers for central nervous system diseases

Liu, J., Wang, T., Dong, J., & Lu, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03247-8 · Cited by 124 · see citing works

Astrocytic <scp>VEGFA</scp> : An essential mediator in blood–brain‐barrier disruption in Parkinson's disease

Lan, G., Wang, P., Chan, R. B., Liu, Z., Yu, Z., Liu, X., Yang, Y., & Zhang, J. (2022) · Glia · doi:10.1002/glia.24109 · Cited by 122 · see citing works

Updates on immunity and inflammation in Parkinson disease pathology

Joshi, N., & Singh, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24185 · Cited by 118 · see citing works

Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway

Yang, Y.-L., Cheng, X., Li, W.-H., Liu, M., Wang, Y.-H., & Du, G.-H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030491 · Cited by 116 · see citing works

Gut Vibes in Parkinson's Disease: The Microbiota‐Gut‐Brain Axis

Bullich‐Vilarrubias, C., Keshavarzian, A., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2019) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12840 · Cited by 116 · see citing works

Plasma Short‐Chain Fatty Acids in Patients With Parkinson's Disease

Shin, C., Lim, Y., Lim, H., & Ahn, T. (2020) · Movement Disorders · doi:10.1002/mds.28016 · Cited by 116 · see citing works

Annexin A1 restores Aβ1‐42‐induced blood–brain barrier disruption through the inhibition of RhoA‐ ROCK signaling pathway

Park, J., Baik, S. H., Han, S., Cho, H. J., Choi, H., Kim, H. J., Choi, H., Lee, W., Kim, D. K., & Mook‐Jung, I. (2016) · Aging Cell · doi:10.1111/acel.12530 · Cited by 115 · see citing works

The Relevance of Insulin Action in the Dopaminergic System

Fiory, F., Perruolo, G., Cimmino, I., Cabaro, S., Pignalosa, F. C., Miele, C., Bèguinot, F., Formisano, P., & Oriente, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00868 · Cited by 114 · see citing works

Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro

Dohgu, S., Takata, F., Matsumoto, J., Kimura, I., Yamauchi, A., & Kataoka, Y. (2019) · Microvascular Research · doi:10.1016/j.mvr.2019.03.005 · Cited by 112 · see citing works

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Razzak, R. A., Florence, G. J., & Gunn‐Moore, F. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123108 · Cited by 115 · see citing works

Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort

Lee, H., Myung, W., Kim, D. K., Kim, S. E., Kim, C. T., & Kim, H. (2017) · Scientific Reports · doi:10.1038/srep44741 · Cited by 114 · see citing works

Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders

Xiao, M., Xiao, Z. J., Yang, B., Lan, Z., & Fang, F. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00764 · Cited by 112 · see citing works

Microglial interactions with the neurovascular system in physiology and pathology

Zhao, X., Eyo, U. B., Murugan, M., & Wu, L. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22576 · Cited by 109 · see citing works

Mast Cells in Neurodegenerative Disease

Jones, M. K., Nair, A. A., & Gupta, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00171 · Cited by 109 · see citing works

Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease

Sankowski, B., Księżarczyk, K., Raćkowska, E., Szlufik, S., Koziorowski, D., & Giebułtowicz, J. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.10.038 · Cited by 105 · see citing works

Paraquat exposure and Parkinson’s disease: A systematic review and meta-analysis

Tangamornsuksan, W., Lohitnavy, O., Sruamsiri, R., Chaiyakunapruk, N., Scholfield, C. N., Reisfeld, B., & Lohitnavy, M. (2018) · Archives of Environmental & Occupational Health · doi:10.1080/19338244.2018.1492894 · Cited by 103 · see citing works

The associations between Parkinson’s disease and cancer: the plot thickens

Feng, D. D., Cai, W., & Chen, X. M. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0043-z · Cited by 103 · see citing works

Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

Wu, J. R., Hernández, Y. M., Miyasaki, K. F., & Kwon, E. J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114820 · Cited by 103 · see citing works

The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders

Costea, L., Mészáros, Á., Bauer, H., Bauer, H., Traweger, A., Wilhelm, I., Farkas, A. E., & Krizbai, I. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215472 · Cited by 98 · see citing works

Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit

Paul, G., & Elabi, O. F. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.853372 · Cited by 96 · see citing works

The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies

Dithmer, S., Blasig, I. E., Fraser, P. A., Qin, Z., & Haseloff, R. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115601 · Cited by 99 · see citing works

The Role of Neurovascular System in Neurodegenerative Diseases

Ahmad, A., Patel, V., Xiao, J., & Khan, M. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02023-z · Cited by 94 · see citing works

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells

Wu, Y., Sonninen, T.-M., Peltonen, S., Koıstınaho, J., & Lehtonen, Š. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147710 · Cited by 88 · see citing works

Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease

Chen, Q.-Q., Haikal, C., Li, W., & Li, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00218 · Cited by 88 · see citing works

The impact of brain iron accumulation on cognition: A systematic review

Spence, H., McNeil, C. J., & Waiter, G. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240697 · Cited by 91 · see citing works

Glucose metabolism impairment in Parkinson’s disease

Dai, C., Tan, C., Zhao, L., Liang, Y., Liu, G., Liu, H., Zhong, Y., Liu, Z., Mo, L., Liu, X., et al. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110672 · Cited by 89 · see citing works

The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions

Kerkis, I., da Silva, Á. R. D. B. P., & Araldi, R. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1400533 · Cited by 89 · see citing works

The Relationship between the Blood-Brain-Barrier and the Central Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors

Dong, M., Wen, S., & Zhou, L. (2022) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s375559 · Cited by 90 · see citing works

From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum

Ouellette, J., & Lacoste, B. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.749026 · Cited by 87 · see citing works

Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective

Yi, S., Wang, L., Wang, H., Ho, M. S.-C., & Zhang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314753 · Cited by 90 · see citing works

Gut-first Parkinson’s disease is encoded by gut dysbiome

Muñoz, M., Candeias, E., Melo-Marques, I., Esteves, A. R., Maranha, A., Magalhães, J. D., Carneiro, D. R., Sant’Anna, M., Pereira-Santos, A. R., Abreu, A. E., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00766-0 · Cited by 88 · see citing works

Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease

Kip, E., & Parr‐Brownlie, L. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101618 · Cited by 88 · see citing works

Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis

Fang, X. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1096271 · Cited by 84 · see citing works

Stomaching the Possibility of a Pathogenic Role for <i>Helicobacter pylori</i> in Parkinson’s Disease

McGee, D. J., Lu, X.-H., & Disbrow, E. A. (2018) · Journal of Parkinson’s Disease · doi:10.3233/jpd-181327 · Cited by 86 · see citing works

Mitochondrial Oxidative Stress in Brain Microvascular Endothelial Cells: Triggering Blood-Brain Barrier Disruption.

Wang, Y., Wu, J., Wang, J.-X., He, L.-X., Lai, H., Zhang, T., Wang, X., & Li, W. (2023) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2023.01.007 · Cited by 80 · see citing works

Could Alzheimer’s Disease Originate in the Periphery and If So How So?

Morris, G., Berk, M., Maes, M. H. J., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1092-y · Cited by 83 · see citing works

Ferroptosis and Iron Homeostasis: Molecular Mechanisms and Neurodegenerative Disease Implications

Abdukarimov, N., Kokabi, K., & Kunz, J. (2025) · Antioxidants · doi:10.3390/antiox14050527 · Cited by 83 · see citing works

Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model

Ruan, Z., Zhang, D., Huang, R., Sun, W., Hou, L., Zhao, J., & Wang, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052793 · Cited by 82 · see citing works

Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

Jeon, M.-T., Kim, K.-S., Kim, E. S., Lee, S., Kim, J., Hoe, H.-S., & Kim, D.-G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101333 · Cited by 76 · see citing works

Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic

Duan, W.-X., Wang, F., Liu, J., & Liu, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01123-9 · Cited by 78 · see citing works

The Blood–Brain Barrier: Composition, Properties, and Roles in Brain HealthPreprint

Lacoste, B., Prat, A., Andrade, M. F., & Gu, C. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041422 · Cited by 79 · see citing works

Basal lamina changes in neurodegenerative disorders

Nguyen, B., Bix, G., & Yao, Y. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00502-y · Cited by 75 · see citing works

Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels

Bogorad, M. I., DeStefano, J. G., Linville, R. M., Wong, A. D., & Searson, P. C. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19855875 · Cited by 72 · see citing works

Age-dependent changes at the blood-brain barrier. A Comparative structural and functional study in young adult and middle aged rats

Bors, L. A., Tóth, K., Tóth, E. Z., Bajza, Á., Csorba, A., Szigeti, K., Máthé, D., Perlaki, G., Orsi, G., Tóth, G. K., et al. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.03.001 · Cited by 75 · see citing works

Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson’s Disease

Kuštrimović, N. Z., Marino, F., & Cosentino, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666181009161048 · Cited by 74 · see citing works

Selenium at the Neural Barriers: AReview

Solovyev, N. D., Drobyshev, E. J., Blume, B., & Michalke, B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.630016 · Cited by 74 · see citing works

Intestinal Inflammation and Parkinson’s Disease

Li, Y., Chen, Y., Jiang, L., Zhang, J., Tong, X., Chen, D., & Le, W. (2021) · Aging and Disease · doi:10.14336/ad.2021.0418 · Cited by 74 · see citing works

α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function

Kuan, W., Bennett, N. K., He, X., Skepper, J. N., Martynyuk, N., Wijeyekoon, R., Moghe, P. V., Williams‐Gray, C. H., & Barker, R. A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.003 · Cited by 73 · see citing works

GLP-1 receptor agonists for Parkinson's disease

Mulvaney, C. A., Duarte, G. S., Handley, J. D., Evans, D. J., Menon, S., Wyse, R. K. H., & Emsley, H. C. A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012990.pub2 · Cited by 69 · see citing works

Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?

Armentero, M., Cerri, S., & Blandini, F. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00232 · Cited by 70 · see citing works

Addressing Blood–Brain Barrier Impairment in Alzheimer’s Disease

Sharma, C., Woo, H., & Kim, S. R. (2022) · Biomedicines · doi:10.3390/biomedicines10040742 · Cited by 69 · see citing works

Pre-conditioning with Remote Photobiomodulation Modulates the Brain Transcriptome and Protects Against MPTP Insult in Mice

Ganeshan, V., Skladnev, N. V., Kim, J. Y., Mitrofanis, J., Stone, J., & Johnstone, D. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.050 · Cited by 67 · see citing works

B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights

Ahn, J. J., Abu-Rub, M., & Miller, R. H. (2021) · Cells · doi:10.3390/cells10071605 · Cited by 65 · see citing works

Breaking barriers: exploring mechanisms behind opening the blood–brain barrier

Stamp, M. E. M., Halwes, M. E., Nisbet, D. R., & Collins, D. J. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00489-2 · Cited by 67 · see citing works

Unique signatures of stress-induced senescent human astrocytes

Simmnacher, K., Krach, F., Schneider, Y., Alecu, J. E., Mautner, L., Klein, P., Roybon, L., Prots, I., Xiang, W., & Winner, B. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113466 · Cited by 63 · see citing works

Emerging role of S100B protein implication in Parkinson’s disease pathogenesis

Angelopoulou, E., Paudel, Y. N., & Piperi, C. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03673-x · Cited by 62 · see citing works

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives

Bogale, T. A., Faustini, G., Longhena, F., Mitola, S. M. F., Pizzi, M., & Bellucci, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.611761 · Cited by 59 · see citing works

Identification of mechanisms leading to blood-brain barrier dysfunction in Parkinson's disease

Lehtonen, Š., Sonninen, T.-M., Koskuvi, M., Shakirzyanova, A., Oksanen, M., Lagarkova, M. A., Киселев, С. Л., Puttonen, K. A., Tavi, P., & Koıstınaho, J. (2018) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.wcp2018.0_po4-1-124

Blood-brain Barrier Dysfunction in Parkinson’s Disease: Mechanisms and Emerging Therapeutic Strategies

Singh, G., & Aran, K. R. (2026) · Current Neurovascular Research · doi:10.2174/0115672026434365260113100943

Blood–brain barrier leakage is increased in parkinson’s disease

Al-Bachari, S., Naish, J. H., Parker, G. J. M., Emsley, H. C. A., & Parkes, L. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.593026 · Cited by 263 · see citing works

Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy

Lau, K., Kotzur, R., & Richter, F. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00430-z · Cited by 165 · see citing works

Disruption of the blood-brain barrier in parkinson's disease: curse or route to a cure?

Lee, H. (2014) · Frontiers in bioscience · doi:10.2741/4206 · Cited by 96 · see citing works