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Cited by 53Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Relationship between astrocytic processes and “perineuronal nets” in rat neocortex.

Blümcke, Ingmar, Eggli, Peter, Celio, Marco R.·1995·Glia
DOI 10.1002/glia.440150205
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Abstract

"Perineuronal nets" (PNs) ensheath a subtype of inhibitory neurons in the mammalian neocortex. In the light of the proposal that PNs consist of glial processes, we have analyzed the relationship between intracellularly injected glial cells and PNs in the rat neocortex. Glial cells were injected iontophoretically with Lucifer Yellow in lightly fixed tissue slices and PNs were visualized with the lectin from Vicia villosa. Using confocal laser scanning microscopy, glial processes and PNs were identified as distinct structures. Lectin labeling was consistently associated with the extracellular space interposed between LY-labeling was consistently associated with the extracellular space interposed between LY-labeled astrocyte processes and neurons. Of the different types of glial cells injected, only the densely-ramifying protoplasmic astrocytes extended processes which could be traced to contact PNs. These protoplasmic astrocytes also sent out processes to adjacent neurons not ensheathed by PNs, and to capillaries. The present data strongly suggests that PNs do not consist of glial processes but rather support the idea that PNs represent specialized extracellular material interposed between the surface of some inhibitory interneurons and astrocytic processes.

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  • Astrocytes extend their processes into PNNs localized near the synapse.

    “Astrocytes extend their processes into PNNs localized near the synapse (Brückner et al., 1993; Blümcke et al., 1995), suggesting a tetrapartite synaptic organization involving ECM, pre/post synaptic sites and astrocytes (Dityatev and Rusakov, 2011; Smith et al., 2015) whose synergistic functions remain unexplored.”

    From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Blümcke et al., 1995

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Authors
Blümcke, I., Eggli, P., & Celio, M. R.
Affiliations
  • University of Fribourg (CH)
  • University of Bern (CH)
Corresponding author
Blümcke, Ingmar
ORCID
Venue
Glia
Publisher
Wiley
Published
1995-10
Volume
15
Issue
2
Pages
131-140
ISSN
  • 0894-1491 (ISSN-L)
  • 1098-1136
DOI
10.1002/glia.440150205
OpenAlex
W1979227386
Cited by
53
References
42
Citations by year
2025: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2013: 1 · 2012: 3
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3299 d)
Locations
  • Glia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
perineuronal nets, astrocytic processes, protoplasmic astrocyte, neocortex, inhibitory interneurons, extracellular matrix, glial processes, astrocyte-neuron interaction, rat brain
MeSH terms
Animals, Astrocytes, Cerebral Cortex, Extracellular Matrix, Immunohistochemistry, Isoquinolines, Nerve Net, Neuroglia, Rats, Inbred Strains, Microscopy, Confocal, Lectins, Rats, In Vitro Techniques

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