Acute and long-lasting changes in extracellular-matrix chondroitin-sulphate proteoglycans induced by injection of chondroitinase ABC in the adult rat brain
Abstract
Lattice-like perineuronal accumulations of extracellular-matrix proteoglycans have been shown to develop during postnatal maturation and to persist throughout life as perineuronal nets (PNs) in many brain regions. However, the dynamics of their reorganization in adults are as yet unknown. The aim of the present study was to examine the capability of PNs for reconstitution after experimental destruction and to search for possible consequences of extracellular-matrix degradation for neurons and glial cells. The changes were induced by single intracortical injections of Proteus vulgaris chondroitinase ABC and studied after postinjection periods of 1 day to 5 months. The N-acetylgalactosamine-binding Wisteria floribunda agglutinin (WFA), an antibody against chondroitin-sulphate proteoglycans, three antibodies recognizing initial chondroitin or chondroitin-sulphate moieties ('stubs') of proteoglycan core proteins, an antibody against the hyaluronan-binding protein component of versican, and biotinylated hyaluronectin, which binds to hyaluronan, were used as cytochemical markers. One day postinjection, the WFA-binding sites and hyaluronan were shown to be almost completely removed within a circumscribed digestion zone. The staining of different core-protein components revealed only fragments of PNs. These changes were found to be partly compensated 4 weeks after injection of chondroitinase ABC. After 8 and 12 weeks postinjection, the cytochemical and structural characteristics as well as the area-specific distribution patterns of PNs were progressively reconstituted. At 5 months postinjection, they could not be distinguished from those in untreated tissue. In contrast to such transient changes, a diffuse chondroitin-sulphate proteoglycan immunoreactivity persisted in the neuropil. Loss of neurons or alterations of their structure as well as reactions of glial cells were not observed. We conclude from this study that PNs, enzymatically destroyed in the adult rat brain, can be completely reconstituted, but the restoration of their extracellular-matrix components needs several months.
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After ChABC injection into the rat frontal or occipital cortex, matrix components significantly re-established only after 4 weeks.
“Injections of ChABC into the rat frontal or occipital cortex resulted in the erasure of PNs within 1 day followed by the significant re-establishment of matrix components only after 4 weeks and the rebuilding of PNs only after 5 months (Brückner et al., 1998).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Brückner et al., 1998
After ChABC injection into the rat frontal or occipital cortex, perineuronal nets rebuilt only after 5 months.
“Injections of ChABC into the rat frontal or occipital cortex resulted in the erasure of PNs within 1 day followed by the significant re-establishment of matrix components only after 4 weeks and the rebuilding of PNs only after 5 months (Brückner et al., 1998).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Brückner et al., 1998
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- Authors
- Brückner, G., Bringmann, A., Härtig, W., Köppe, G., Delpech, B., & Brauer, K.
- Affiliations
- Leipzig University (DE)
- Centre Henri Becquerel (FR)
- Venue
- Experimental Brain Research
- Published
- 1998-08-10
- Volume
- 121
- Issue
- 3
- Pages
- 300-310
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W2071526203
- Cited by
- 162
- References
- 57
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 3 · 2012: 6
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01 HD-23144)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- perineuronal nets, chondroitin sulfate proteoglycans, chondroitinase ABC, extracellular matrix degradation, hyaluronic acid, versican, Wisteria floribunda agglutinin, glial cells, neurons, adult rat brain, intracortical injection
- MeSH terms
- Age Factors, Animals, Brain Chemistry, Cerebral Cortex, Chondroitin Sulfates, Extracellular Matrix, Male, Microinjections, Nerve Regeneration, Neuroglia, Neuronal Plasticity, Neurons, Proteoglycans, Biomarkers, Chondroitin ABC Lyase, Rats, Long-Evans, Rats
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