Neural implementation of response selection in humans as revealed by localized effects of stimulus–response compatibility on brain activation
Open accessAbstract
Response selection, which involves choosing representations for appropriate motor behaviors given one's current situation, is a fundamental mental process central to a wide variety of human performance, yet the neural mechanisms underlying this mental process remain unclear. Research using nonhuman primates implicates ventral prefrontal and lateral premotor cortices in this process. In contrast, human neuroimaging research also highlights the role of dorsal prefrontal, anterior cingulate, and superior parietal cortices in response selection. This inconsistency may stem from the difficulty of isolating response selection within the constraints of cognitive subtraction methodology utilized in neuroimaging. We overcome this limitation by using an experimental procedure designed to selectively influence discrete mental processing stages and analyses that are less reliant on the assumptions of cognitive subtraction. We varied stimulus contrast to affect stimulus encoding and stimulus-response compatibility to affect response selection. Brain activation data suggest processing specific to response selection in superior parietal and dorsal prefrontal cortices, and not ventral prefrontal cortex. Anterior cingulate and lateral premotor cortices may also be involved in response selection, or these regions may mediate other response processes.
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The PMv and middle frontal gyrus regions observed in the present study are similar to regions observed in relation to response selection by Bunge et al. (2003) and Schumacher and D'Esposito (2002).
“The PMv and middle frontal gyrus regions observed in the present study are similar to regions observed in relation to response selection by Bunge et al. (2003) and Schumacher and D'Esposito (2002).”
From The Neural Correlates of Motor Skill Automaticity (2005) · cites this paper as Schumacher and D'Esposito, 2002
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- Authors
- Schumacher, E. H., & D'Esposito, M.
- Affiliations
- University of California, Berkeley (US)
- ORCID
- Schumacher, Eric H.
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2002-09-30
- Volume
- 17
- Issue
- 3
- Pages
- 193-201
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6871942
- OpenAlex
- W2087663053
- Cited by
- 90
- References
- 8
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2019: 3 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Centers for Disease Control and Prevention (HM12676)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- response selection, stimulus-response compatibility, stimulus contrast, dorsal prefrontal cortex, superior parietal cortex, anterior cingulate cortex, lateral premotor cortex, ventral prefrontal cortex, stimulus encoding
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Psychomotor Performance, Reaction Time
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