Functional MRI of macaque monkeys performing a cognitive set-shifting task
Open accessAbstract
Functional brain organization of macaque monkeys and humans was directly compared by functional magnetic resonance imaging. Subjects of both species performed a modified Wisconsin Card Sorting Test that required behavioral flexibility in the form of cognitive set shifting. Equivalent visual stimuli and task sequence were used for the two species. We found transient activation related to cognitive set shifting in focal regions of prefrontal cortex in both monkeys and humans. These functional homologs were located in cytoarchitectonically equivalent regions in the posterior part of ventrolateral prefrontal cortex. This comparative imaging provides insights into the evolution of cognition in primates.
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The same cognitive tasks employed in human psychophysical studies can be used in neurophysiological studies with NHPs.
“The same cognitive tasks employed in human psychophysical studies can be used in neurophysiological studies with NHPs (e.g. [78]).”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [78]
Bilateral inferior frontal gyrus activations have been reported during set-shifting.
“Bilateral inferior frontal gyrus activations have been reported during set-shifting.35-37”
From Cognitive inflexibility and frontal–cortical activation in pediatric obsessive–compulsive disorder (2010) · cites this paper as [37]
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- Authors
- Nakahara, K., Hayashi, T., Konishi, S., & Miyashita, Y.
- Affiliations
- Department of Physiology,
- The University of Tokyo (JP)
- National Institute for Physiological Sciences (JP)
- Corresponding author
- Miyashita, Yasushi
- Venue
- Science
- Published
- 2002-02-22
- Volume
- 295
- Issue
- 5559
- Pages
- 1532-1536
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051511819
- Cited by
- 286
- References
- 27
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 12 · 2021: 8 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 14
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
- pure.teikyo.jp
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- functional homology, macaque, human brain, prefrontal cortex, ventrolateral prefrontal cortex, behavioral flexibility, Wisconsin Card Sorting Test, cognitive evolution, comparative neuroanatomy, cytoarchitecture
- MeSH terms
- Animals, Brain Mapping, Cognition, Cues, Humans, Macaca, Magnetic Resonance Imaging, Neuropsychological Tests, Parietal Lobe, Photic Stimulation, Psychomotor Performance, Echo-Planar Imaging, Prefrontal Cortex
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