Cited by 286Neural and Behavioral Psychology StudiesPrimate Behavior and EcologyNeurotransmitter Receptor Influence on Behavior

Functional MRI of macaque monkeys performing a cognitive set-shifting task

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Nakahara, Kiyoshi, Hayashi, Toshihiro, Konishi, Seiki, Miyashita, Yasushi·2002·Science

Abstract

Functional brain organization of macaque monkeys and humans was directly compared by functional magnetic resonance imaging. Subjects of both species performed a modified Wisconsin Card Sorting Test that required behavioral flexibility in the form of cognitive set shifting. Equivalent visual stimuli and task sequence were used for the two species. We found transient activation related to cognitive set shifting in focal regions of prefrontal cortex in both monkeys and humans. These functional homologs were located in cytoarchitectonically equivalent regions in the posterior part of ventrolateral prefrontal cortex. This comparative imaging provides insights into the evolution of cognition in primates.

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Crossref · 10.1126/science.1067653

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Authors
Nakahara, K., Hayashi, T., Konishi, S., & Miyashita, Y.
Affiliations
  • Department of Physiology,
  • The University of Tokyo (JP)
  • National Institute for Physiological Sciences (JP)
Corresponding author
Miyashita, Yasushi
Venue
Science
Published
2002-02-22
Volume
295
Issue
5559
Pages
1532-1536
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2051511819
Cited by
286
References
27
Citations by year
2026: 7 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 12 · 2021: 8 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 14
FWCI
11.52
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
functional homology, macaque, human brain, prefrontal cortex, ventrolateral prefrontal cortex, behavioral flexibility, Wisconsin Card Sorting Test, cognitive evolution, comparative neuroanatomy, cytoarchitecture
MeSH terms
Animals, Brain Mapping, Cognition, Cues, Humans, Macaca, Magnetic Resonance Imaging, Neuropsychological Tests, Parietal Lobe, Photic Stimulation, Psychomotor Performance, Echo-Planar Imaging, Prefrontal Cortex

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