Modulating functional connectivity patterns and topological functional organization of the human brain with transcranial direct current stimulation
Open accessAbstract
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects might be caused by stimulation-induced alterations of functional cortical network connectivity. We aimed to investigate the impact of tDCS on cortical network function through functional connectivity and graph theoretical analysis. Single recordings in healthy volunteers with 62 electroencephalography channels were acquired before and after 10 min of facilitatory anodal tDCS over the primary motor cortex (M1), combined with inhibitory cathodal tDCS of the contralateral frontopolar cortex, in resting state and during voluntary hand movements. Correlation matrices containing all 62 pairwise electrode combinations were calculated with the synchronization likelihood (SL) method and thresholded to construct undirected graphs for the θ, α, β, low-γ and high-γ frequency bands. SL matrices and undirected graphs were compared before and after tDCS. Functional connectivity patterns significantly increased within premotor, motor, and sensorimotor areas of the stimulated hemisphere during motor activity in the 60-90 Hz frequency range. Additionally, tDCS-induced significant intrahemispheric and interhemispheric connectivity changes in all the studied frequency bands. In summary, we show for the first time evidence for tDCS-induced changes in brain synchronization and topological functional organization.
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Functional neuroimaging studies have demonstrated modulation not only of the site of stimulation but also of functionally interconnected (sub)cortical regions.
“Functional neuroimaging studies have furthermore demonstrated modulation not only of the site of stimulation but also of functionally interconnected (sub)cortical regions (Polanía et al., 2011)”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Polanía et al., 2011
The Figure 7 discussion reports that tDCS changed synchronization beyond the stimulated motor area, including premotor and sensorimotor cortical areas. It describes effects on cortico-subcortical network functions as something the observed changes “might be” evidence for, rather than demonstrating modulation of subcortical regions. (LLM, conf=0.86)
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“Functional neuroimaging studies have furthermore demonstrated modulation not only of the site of stimulation but also of functionally interconnected (sub)cortical regions (Polanía et al., 2011), which makes it useful for targeting networks such as fronto-striatal systems in ADHD.”
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- Authors
- Polanía, R., Nitsche, M. A., & Paulus, W.
- Affiliations
- University of Göttingen (DE)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2011-07-08
- Volume
- 32
- Issue
- 8
- Pages
- 1236-1249
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6870160
- OpenAlex
- W2009053711
- Cited by
- 434
- References
- 57
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 18 · 2023: 24 · 2022: 28 · 2021: 35 · 2020: 29 · 2019: 35 · 2018: 29 · 2017: 43 · 2016: 33 · 2015: 28 · 2014: 23 · 2013: 32 · 2012: 21
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- GRO (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Rose Foundation for Communities and the Environment
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- transcranial direct current stimulation, functional connectivity, brain network topology, primary motor cortex, frontopolar cortex, cortical excitability, brain synchronization, interhemispheric connectivity, intrahemispheric connectivity, hand movement, gamma oscillations, graph theory
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Electric Stimulation, Electroencephalography, Female, Humans, Male, Movement, Nerve Net, Evoked Potentials, Motor
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