Task demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains
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Abstract Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val158met, DAT, BDNF val66met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA samples and received Visual and Spatial WM training paired with tDCS (sham, 1, 1.5, 2 mA). After one session of tDCS, significant group differences in WM performance were predicted by COMT val158met status. One month after training, there was a significant interaction of tDCS intensity, COMT genotype, and WM task. Specifically, val/val homozygotes benefited most from 1.5 mA tDCS on Visual WM and from 1 mA tDCS on Spatial WM. For met/met homozygotes, 2 mA resulted in significantly poorer performance compared to 1.5 mA on Spatial WM. While this pattern was observed with relatively small sample sizes, these data indicate that variations in COMT val158met may predict the nature of WM improvement after initial and longitudinal tDCS. This contributes to our understanding of the underlying mechanism by which tDCS affects behaviour.
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The Val108/158Met polymorphism of the COMT gene is associated with differential tDCS effects on executive functions.
“Particularly, the Val108/158Met polymorphism of the catechol-O-methyltransferase (COMT) gene that regulates the dopamine metabolism [17] is associated with differential tDCS effects on executive functions [16,18].”
From Dynamic DNA methylation changes in the COMT gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation (2021) · cites this paper as [18]
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- Authors
- Stephens, J. A., Jones, K. T., & Berryhill, M. E.
- Affiliations
- Kennedy Krieger Institute (US)
- University of Nevada, Reno (US)
- Corresponding author
- Stephens, Jaclyn A.
- Venue
- Scientific Reports
- Published
- 2017-10-18
- Volume
- 7
- Issue
- 1
- Pages
- 13463-13463
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5647397
- OpenAlex
- W2764096619
- Cited by
- 43
- References
- 119
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 1
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1632738)
- National Institutes of Health (1632738)
- National Eye Institute (R15EY022775)
- National Institute of General Medical Sciences (P20GM103650)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007414)
- Office of Experimental Program to Stimulate Competitive Research (NSF 1632738, 1632738)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- transcranial direct current stimulation, working memory training, COMT Val158Met polymorphism, older adults, executive function, visual working memory, spatial working memory, genetic moderators, cognitive enhancement
- MeSH terms
- Aged, Analysis of Variance, Catechol O-Methyltransferase, Female, Genotype, Humans, Learning, Male, Memory, Short-Term, Middle Aged, Polymorphism, Genetic, Time Factors, Amino Acid Substitution, Transcranial Direct Current Stimulation
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