The DOI matches its Crossref record; 40 of the 43 references it cites were found in a registry or an index.
Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion.
Open accessAbstract
The hallucinogenic brew Ayahuasca, a rich source of serotonergic agonists and reuptake inhibitors, has been used for ages by Amazonian populations during religious ceremonies. Among all perceptual changes induced by Ayahuasca, the most remarkable are vivid "seeings." During such seeings, users report potent imagery. Using functional magnetic resonance imaging during a closed-eyes imagery task, we found that Ayahuasca produces a robust increase in the activation of several occipital, temporal, and frontal areas. In the primary visual area, the effect was comparable in magnitude to the activation levels of natural image with the eyes open. Importantly, this effect was specifically correlated with the occurrence of individual perceptual changes measured by psychiatric scales. The activity of cortical areas BA30 and BA37, known to be involved with episodic memory and the processing of contextual associations, was also potentiated by Ayahuasca intake during imagery. Finally, we detected a positive modulation by Ayahuasca of BA 10, a frontal area involved with intentional prospective imagination, working memory and the processing of information from internal sources. Therefore, our results indicate that Ayahuasca seeings stem from the activation of an extensive network generally involved with vision, memory, and intention. By boosting the intensity of recalled images to the same level of natural image, Ayahuasca lends a status of reality to inner experiences. It is therefore understandable why Ayahuasca was culturally selected over many centuries by rain forest shamans to facilitate mystical revelations of visual nature.
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“The ayahuasca-produced stimulation of the primary visual cortex was comparable to the effect of natural images with the eyes open.”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as de Araujo et al. (2012)
In the citing paper
“Using functional magnetic resonance imaging technique de Araujo et al. (2012) found that ayahuasca induces a robust activation of occipital, temporal, and frontal areas during a closed-eyes imagery task.”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as de Araujo et al. (2012)
In the citing paper
“The consumption of the brew activated an extended network in the brain (that has previously been correlated to visual perception, memory and intention) in which the Brodmann areas BA10, BA17, BA30, and BA37 play a central role.”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as de Araujo et al. (2012)
In the citing paper
“Moreover, this effect correlated significantly with the occurrence of perceptual changes measured by rating scales.”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as de Araujo et al. (2012)
Citations
Cites
Kosslyn, S. M., Ganis, G., & Thompson, W. L. (2001) · Nature Reviews Neuroscience · doi:10.1038/35090055 · Cited by 1,894
Bar, M. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1476 · Cited by 1,613
Brain areas underlying visual mental imagery and visual perception: an fMRI study
Ganis, G., Thompson, W. L., & Kosslyn, S. M. (2004) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2004.02.012 · Cited by 765
The Role of Area 17 in Visual Imagery: Convergent Evidence from PET and rTMS
Kosslyn, S. M., Pascual‐Leone, Á., Félician, O., Camposano, S. E., Keenan, J. P., L., W., Thompson, Ganis, G., Sukel, K. E., & Alpert, N. M. (1999) · Science · doi:10.1126/science.284.5411.167 · Cited by 756
Kosslyn, S. M. (1990) · Cited by 702
Kalina Christoff, A., & Gabrieli, J. D. E. (2000) · Psychobiology · doi:10.3758/bf03331976 · Cited by 697
When the Brain Loses Its Self: Prefrontal Inactivation during Sensorimotor Processing
Goldberg, I. I., Harel, M., & Malach, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.015 · Cited by 593
Distributed Neural Systems for the Generation of Visual Images
Ishai, A., Ungerleider, L. G., & Haxby, J. V. (2000) · Neuron · doi:10.1016/s0896-6273(00)00168-9 · Cited by 579
Allen, P., Larøi, F., McGuire, P. K., & Aleman, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.07.012 · Cited by 579 · cited 2×
“The nonprimary visual areas strongly modulated by Ayahuasca (BA7, BA18, and BA19) are known to be activated during psychopathological hallucinations [Allen et al., 2008] as well as during normal dreaming, within rapid-eye-movement (REM) sleep [Braun et al., 1998; Wehrle et al., 2007].”
BackgroundBrain regions involved in prospective memory as determined by positron emission tomography
Burgess, P. W., Quayle, A., & Frith, C. D. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00149-4 · Cited by 575
When is early visual cortex activated during visual mental imagery?
Kosslyn, S. M., & Thompson, W. L. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.5.723 · Cited by 515
Braun, A. R., Balkin, T. J., Wesensten, N. J., Gwadry, F., Carson, R. E., Varga, M., Baldwin, P., Belenky, G., & Herscovitch, P. (1998) · Science · doi:10.1126/science.279.5347.91 · Cited by 474
A functional MRI study of mental image generation
D’Esposito, M., Detre, J. A., Aguirre, G. K., Stallcup, M., Alsop, D. C., Tippet, L. J., & Farah, M. J. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(96)00121-2 · Cited by 449
Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049882 · Cited by 390
Richardson, A. (1969) · Springer eBooks · doi:10.1007/978-3-662-37817-5 · Cited by 312
Riba, J., Rodríguez-Fornells, A., Urbano, G., Morte, A., Antonijoan, R., Montero, M., Callaway, J. C., & Barbanoj, M. J. (2001) · Psychopharmacology · doi:10.1007/s002130000606 · Cited by 303
Addis, D. R., & Schacter, D. L. (2007) · Hippocampus · doi:10.1002/hipo.20405 · Cited by 275
Common Mechanisms of Visual Imagery and Perception
Ishai, A., & Sagi, D. (1995) · Science · doi:10.1126/science.7792605 · Cited by 256
Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant
Riba, J., Romero, S., Grasa, E., Mena, E., Carrió, I., & Barbanoj, M. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0358-7 · Cited by 241
Reopening the Mental Imagery Debate: Lessons from Functional Anatomy
Mellet, E., Petit, L., Mazoyer, B., Denis, M., & Tzourio, N. (1998) · NeuroImage · doi:10.1006/nimg.1998.0355 · Cited by 237 · cited 2×
“VC 2011 Wiley Periodicals, Inc.”
Decoding Individual Episodic Memory Traces in the Human Hippocampus
Chadwick, M. J., Hassabis, D., Weiskopf, N., & Maguire, E. A. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.053 · Cited by 235
Wehrle, R., Kaufmann, C., Wetter, T. C., Holsboer, F., Auer, D. P., Pollmächer, T., & Czisch, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05314.x · Cited by 224
SANTOS, R. G. D., Landeira-Fernández, J., Strassman, R. J., Motta, V., & Cruz, A. P. D. M. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.04.012 · Cited by 212
Buckholtz, N. S., & Boggan, W. O. (1977) · Biochemical Pharmacology · doi:10.1016/0006-2952(77)90007-7 · Cited by 185
Receptive fields in human visual cortex mapped with surface electrodes
Yoshor, D., Bosking, W. H., Ghose, G. M., & Maunsell, J. H. R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl138 · Cited by 152
Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
Smith, R. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00110-5 · Cited by 147
Reliability and validity of a Portuguese version of the Young Mania Rating Scale
Vilela, J. A. A., Crippa, J. A. S., Del‐Ben, C. M., & Loureiro, S. R. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000900019 · Cited by 141
Self-citationRiba, J., Anderer, P., Morte, A., Urbano, G., Jané, F., Saletu, B., & Barbanoj, M. J. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01609.x · Cited by 125
Amplifying Phenomenal Information: Toward a Fundamental Theory of ConsciousnessPreprint
Gabora, L. M. (1999) · arXiv (Cornell University) · doi:10.48550/arxiv.adap-org/9911003 · Cited by 125
Theta Oscillations and Human Navigation: A Magnetoencephalography Study
de Araújo, D. B., Baffa, O., & Wakai, R. T. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902317205339 · Cited by 111
Turner, M., Simons, J. S., Gilbert, S. J., Frith, C., & Burgess, P. W. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.12.029 · Cited by 97
Crippa, J. A. S., Sanches, R. F., Hallak, J. E. C., Loureiro, S. R., & Zuardi, A. W. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.00185.x · Cited by 90
Self-citationLinden, D. E. J., Kallenbach, U., Heinecke, A., Singer, W., & Goebel, R. (1999) · Perception · doi:10.1068/p2820 · Cited by 88
Denis, M. (1991) · Medical Entomology and Zoology · Cited by 68
Brain activation patterns during memory of cognitive agency
Vinogradov, S., Luks, T. L., Simpson, G. V., Schulman, B. J., Glenn, S., & Wong, A. E. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.058 · Cited by 57
Identifying directed links in large scale functional networks: application to brain fMRI
Cecchi, G., Rao, A. R., Centeno, M. V., Baliki, M. N., Apkarian, A. V., & Chialvo, D. R. (2007) · BMC Cell Biology · doi:10.1186/1471-2121-8-s1-s5 · Cited by 43
Self-citationAltered states and the study of consciousness: The case of Ayahuasca
Shanon, B. (2003) · The Journal of mind and behavior · Cited by 26
Petit-Taboué, M.-C., Landeau, B., Barré, L., Onfroy, M.-C., Noël, M.-H., & Baron, J. (1999) · PubMed · Cited by 19
Psychological explanations and knowledge-dependent processes
Pylyshyn, Z. W. (1981) · Cognition · doi:10.1016/0010-0277(81)90056-1 · Cited by 15
Prado, D. A., Pinto, J. P., Crippa, J. A. S., Santos, A. C., Ribeiro, S. T. G., Araújo, D., Zuardi, A. W., Chaves, C., & Hallak, J. E. C. (2009) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(09)70469-9 · Cited by 9
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- 10.1126/science.284.5411.167 · DOI
- Shanon B, 2002, Ayahuasca visualizations‐A structural typology, J Conscious Stud, 9, 3
Cited by
Sorted by citations
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762
REBUS and the anarchic brain: Toward a unified model of the brain action of psychedelics
Carhart-Harris, R. L., & Friston, K. J. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.017160 · Cited by 1,180
Neural correlates of the LSD experience revealed by multimodal neuroimaging
Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., Tagliazucchi, E., Schenberg, E. E., Nest, T., Orban, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518377113 · Cited by 859
Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., Mota-Rolim, S. A., Osório, F. L., Sanches, R., dos Santos, R. G., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291718001356 · Cited by 852
Self-citationGasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000113 · Cited by 750
Metadata
- Authors
- de Araujo, D. B., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., de Martinis, B. S., Crippa, J. A., Hallak, J. E. C., & Santos, A. C.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- IBM Research - Thomas J. Watson Research Center (US)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Universidade Federal do Rio de Janeiro (BR)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2011-09-16
- Volume
- 33
- Issue
- 11
- Pages
- 2550-2560
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6870240
- OpenAlex
- W2035391615
- Cited by
- 239
- References
- 43
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 26 · 2023: 39 · 2022: 13 · 2021: 25 · 2020: 18 · 2019: 15 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 6
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Financiadora de Estudos e Projetos
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Keywords
- ayahuasca, hallucinations, visual imagery, serotonergic agonists, primary visual cortex, episodic memory, brain networks, shamanic rituals, mystical experience, hallucinogenic effects
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Hallucinations, Hallucinogens, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Banisteriopsis, Young Adult
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