Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant
Open accessAbstract
Rationale Ayahuasca is a South American psychoactive plant tea which contains the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and monoamine-oxidase inhibitors that render DMT orally active. Previous investigations with ayahuasca have highlighted a psychotropic effect profile characterized by enhanced introspective attention, with individuals reporting altered somatic perceptions and intense emotional modifications, frequently accompanied by visual imagery. Despite recent advances in the study of ayahuasca pharmacology, the neural correlates of acute ayahuasca intoxication remain largely unknown.Objectives To investigate the effects of ayahuasca administration on regional cerebral blood flow.Methods Fifteen male volunteers with prior experience in the use of psychedelics received a single oral dose of encapsulated freeze-dried ayahuasca equivalent to 1.0 mg DMT/kg body weight and a placebo in a randomized double-blind clinical trial. Regional cerebral blood flow was measured 100-110 min after drug administration by means of single photon emission tomography (SPECT).Results Ayahuasca administration led to significant activation of frontal and paralimbic brain regions. Increased blood perfusion was observed bilaterally in the anterior insula, with greater intensity in the right hemisphere, and in the anterior cingulate/frontomedial cortex of the right hemisphere, areas previously implicated in somatic awareness, subjective feeling states, and emotional arousal. Additional increases were observed in the left amygdala/parahippocampal gyrus, a structure also involved in emotional arousal.Conclusions The present results suggest that ayahuasca interacts with neural systems that are central to interoception and emotional processing and point to a modulatory role of serotonergic neurotransmission in these processes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The increased right side perfusion after Ayahuasca and the right side hypermetabolism after psilocybin seem at odds with the right side hypoperfusion after mescaline.
“This increased right side perfusion after Ayahuasca [141] and the right side hypermetabolism after psilocybin [137] seem at odds with the right side hypoperfusion after mescaline [140].”
From Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans. (2021) · cites this paper as [141]
The magnitude of the CBF response in depression patients was distinctly less than that in the study of healthy volunteers by Riba et al.
“While similar in distribution, the magnitude of the CBF response in depression patients was distinctly less than that in the study of healthy volunteers by Riba et al. [141].”
From Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans. (2021) · cites this paper as [141]
In a group of 15 healthy males with previous hallucinogen experience, authentic Ayahuasca at a dose of 1 mg DMT/kg provoked bilateral activations of perfusion in the anterior insula (more pronounced in the right hemisphere), along with activation in the right anterior cingulate/frontomedial cortex, and the left amygdala.
“A group of 15 healthy males with previous hallucinogen experience had perfusion SPECT scans before and after receiving authentic Ayahuasca at a dose of 1 mg DMT (9)/kg [141]. In contrast to results for mescaline, the Ayahuasca treatment provoked bilateral activations of perfusion in the anterior insula (which were more pronounced in the right hemisphere), along with activation in the right”
From Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans. (2021) · cites this paper as [141]
These activations coincided with distinct increases in score in a hallucinogen rating scale.
“These activations coincided with distinct increases in score in a hallucinogen rating scale.”
From Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans. (2021) · cites this paper as [141]
Enhanced activation of the ACC and other prefrontal regions was observed in novice and experienced meditators and as a result of ayahuasca administration.
“For example, enhanced activation of the ACC and other prefrontal regions was observed in novice and experienced meditators (120–122), and as a result of ayahuasca administration (33, 63).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [63]
Ayahuasca's anti-depressive potential has been demonstrated in pilot studies and replicated in a randomised controlled trial on patients with treatment-resistant depression.
“Similarly, ayahuasca's anti-depressive potential has been demonstrated in pilot studies and replicated in a RCT on patients with treatment-resistant depression (33, 36, 63).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [63]
The Volunteers and Study design sections describe a randomized ayahuasca-versus-placebo study in 15 volunteers that excluded people with a history of psychiatric disorders. The Subjective effects section reports acute positive mood and euphoria, not an antidepressant outcome. Our copy does not report the claimed pilot studies or a trial in patients with treatment-resistant depression (searched: depression, antidepressant, treatment-resistant depression). (LLM, conf=0.76)
Experimental — accuracy not yet measuredRiba et al. (2006) SPECT showed increased brain activity bilaterally in the anterior insula, in the fronto-medial cortical anterior cingulate of the right hemisphere, and in the left amygdala after ayahuasca ingestion.
“Riba’s group (Riba et al., 2006) conducted single-photon emission computed tomography to reveal the brain areas affected by ayahuasca ingestion. Increased activity was recorded bilaterally in the anterior insula, in the fronto-medial cortical anterior cingulate of the right hemisphere and the left amygdala.”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Riba et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502 · see citing works
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 2× · see citing works
“Recent research has shown bilateral insular and cingulate activation in tasks requiring interoceptive attention, with the right anterior insula specifically subserving explicit awareness of bodily processes (Critchley et al. 2004).”
BackgroundContributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556 · see citing works
Subcortical and cortical brain activity during the feeling of self-generated emotions
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L. B., Parvizi, J., & Hichwa, R. D. (2000) · Nature Neuroscience · doi:10.1038/79871 · Cited by 2,117 · see citing works
Looking for Spinoza: Joy, Sorrow, and the Feeling Brain
Gross, H. S. (2004) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000130139.70393.da · Cited by 2,053 · see citing works
Looking for Spinoza : Joy, Sorrow, and the Feeling Brain
Damásio, A. R. (2003) · Dominican Scholar (Dominican University of California) · Cited by 1,879 · see citing works
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722 · see citing works
Meditation experience is associated with increased cortical thickness
Lazar, S. W., Kerr, C. E., Wasserman, R. H., Gray, J. R., Greve, D. N., Treadway, M. T., McGarvey, M., Quinn, B. T., Dusek, J. A., Benson, H., et al. (2005) · NeuroReport · doi:10.1097/01.wnr.0000186598.66243.19 · Cited by 1,698 · see citing works
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
Vollenweider, F. X., Vollenweider-Scherpenhuyzen, M. F. I., Bäbler, A., Vogel, H., & Hell, D. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00024 · Cited by 1,018 · see citing works
Martin, W. R., Sloan, J. W., SAPIRA, J. D., & Jasinski, D. R. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971122part1245 · Cited by 945 · see citing works
Neuroanatomical correlates of externally and internally generated human emotion
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.918 · Cited by 711 · see citing works
Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020022002 · Cited by 453 · see citing works
Vollenweider, F. X., Leenders, K. L., Øye, I., Hell, D., & Angst, J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00042-9 · Cited by 413 · see citing works
McKenna, D. J., Towers, G. H. N., & Abbott, F. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90003-5 · Cited by 398 · see citing works
Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049882 · Cited by 390 · see citing works
Self-citationDamásio, A. R. (2003) · Cited by 381 · see citing works
Titeler, M., Lyon, R. A., & Glennon, R. A. (1988) · Psychopharmacology · doi:10.1007/bf00176847 · Cited by 343 · see citing works
Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil.
GROB, C. S., McKENNA, D. J., CALLAWAY, J. C., BRITO, G. S., NEVES, E. S., OBERLAENDER, G., SAIDE, O. L., LABIGALINI, E., TACLA, C., MIRANDA, C. T., et al. (1996) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199602000-00004 · Cited by 338 · see citing works
McKenna, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.03.002 · Cited by 321 · see citing works
Pharmacokinetics of Hoasca alkaloids in healthy humans
Callaway, J. C., McKenna, D. J., Grob, C. S., Brito, G. S., Raymon, L. P., Poland, R. E., Andrade, E. O., Andrade, E. O., & Mash, D. C. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00168-8 · Cited by 318 · see citing works
Riba, J., Rodríguez-Fornells, A., Urbano, G., Morte, A., Antonijoan, R., Montero, M., Callaway, J. C., & Barbanoj, M. J. (2001) · Psychopharmacology · doi:10.1007/s002130000606 · Cited by 303 · see citing works
Self-citationDose-Response Study of N,N-Dimethyltryptamine in Humans
Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020009001 · Cited by 291 · see citing works
Flesh of the Gods : The Ritual Use of Hallucinogens
Furst, P. T. (1972) · Cited by 258 · see citing works
The Botany and Chemistry of Hallucinogens
Reynolds, T., Schultes, R. E., & Hofmann, A. A. (1974) · Kew Bulletin · doi:10.2307/4108565 · Cited by 255 · see citing works
Gouzoulis-Mayfrank, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00089-x · Cited by 219 · see citing works
Hallucinogens and dissociative agents naturally growing in the United States
Halpern, J. H. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.03.003 · Cited by 219 · see citing works
Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes
McKenna, D. J., Repke, D. B., Lo, L., & Peroutka, S. J. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90001-8 · Cited by 195 · see citing works
The Botany and Chemistry of Hallucinogens.
Lipp, F. J., Schultes, R. E., & Hofmann, A. (1981) · Brittonia · doi:10.2307/2806315 · Cited by 193 · see citing works
Buckholtz, N. S., & Boggan, W. O. (1977) · Biochemical Pharmacology · doi:10.1016/0006-2952(77)90007-7 · Cited by 185 · see citing works
Hermle, L., Fünfgeld, M., Oepen, G., Botsch, H., Borchardt, D., Gouzoulis, E., Fehrenbach, R. A., & Spitzer, M. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90059-9 · Cited by 183 · see citing works
Plants of the Gods: Origins of Hallucinogenic Use
Brenan, J. P. M., Schultes, R. E., & Hofmann, A. (1980) · Kew Bulletin · doi:10.2307/4110029 · Cited by 154 · see citing works
Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex
Pierce, P. A., & Peroutka, S. J. (1989) · Psychopharmacology · doi:10.1007/bf00443425 · Cited by 152 · see citing works
Notes of a Botanist on the Amazon & Andes
Wallace, A. R. (2016) · Cited by 129 · see citing works
Visionary Vine: Hallucinogenic Healing in the Peruvian Amazon
de Ríos, M. D. (1972) · Medical Entomology and Zoology · Cited by 107 · see citing works
Notes of a Botanist on the Amazon and Andes
Spruce, R. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107252646 · Cited by 89 · see citing works
Psychometric assessment of the Hallucinogen Rating Scale☆
Riba, J., Rodrı́guez-Fornells, A., Strassman, R. J., & Barbanoj, M. J. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00175-7 · Cited by 88 · see citing works
Self-citationPlatelet serotonin uptake sites increased in drinkers ofayahuasca
Callaway, J. C., Airaksinen, M. M., McKenna, D. J., Brito, G. S., & Grob, C. S. (1994) · Psychopharmacology · doi:10.1007/bf02245347 · Cited by 81 · see citing works
5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens
Rabin, R. A., Regina, M. J., Doat, M., & Winter, J. C. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00720-1 · Cited by 58 · see citing works
Spanish version of the 49-item short form of the Addiction Research Center Inventory (ARCI)
Lamas, X., Farré, M., Llorente, M., & Camı́, J. (1994) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)90075-2 · Cited by 55 · see citing works
Check, E. (2004) · Nature · doi:10.1038/429126a · Cited by 53 · see citing works
Nosing in on the emotional brain
Hamann, S. B. (2003) · Nature Neuroscience · doi:10.1038/nn0203-106 · Cited by 53 · see citing works
Tromboni, M. (2003) · Mana · doi:10.1590/s0104-93132003000200011 · Cited by 31 · see citing works
Labate, B. C., Araújo, W. S., & da Ayahuasca, C. S. O. U. R. (2003) · Tipití/Tipiti · Cited by 23 · see citing works
Brown, C. (2004) · The New Scientist · Cited by 4 · see citing works
Kotler, S. (2005) · PsycEXTRA Dataset · doi:10.1037/e592272007-012 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Melton L (2004) Dream drug or demon brew. New Sci 182 (2453):42-43
Cited by
Sorted by citations
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works
Gasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000113 · Cited by 750 · see citing works
The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future
Carhart-Harris, R. L., & Goodwin, G. M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.84 · Cited by 706 · see citing works
Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders
Vollenweider, F. X., & Preller, K. H. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0367-2 · Cited by 570 · see citing works
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Carhart-Harris, R. L., Roseman, L., Bolstridge, M., Demetriou, L., Pannekoek, J. N., Wall, M. B., Tanner, M., Kaelen, M., McGonigle, J., Murphy, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13282-7 · Cited by 587 · see citing works
Osório, F. D. L., Sanches, R. F., Macedo, L. R., dos Santos, R. G., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2015) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2014-1496 · Cited by 488 · see citing works
Sanches, R. F., de Lima Osório, F., dos Santos, R. G., Macedo, L. R. H., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000436 · Cited by 466 · see citing works
The pharmacology of lysergic acid diethylamide: A review
Passie, T., Halpern, J. H., Stichtenoth, D. O., Emrich, H. M., & Hintzen, A. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00059.x · Cited by 455 · see citing works
Palhano-Fontes, F., Andrade, K. C., Tofoli, L. F., Santos, A. C., Crippa, J. A. S., Hallak, J. E. C., Ribeiro, S., & de Araujo, D. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118143 · Cited by 454 · see citing works
Doss, M. K., Považan, M., Rosenberg, M. D., Sepeda, N. D., Davis, A. K., Finan, P. H., Smith, G. S., Pekar, J. J., Barker, P. B., Griffiths, R. R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01706-y · Cited by 356 · see citing works
Andersen, K. A. A., Carhart‐Harris, R., Nutt, D. J., & Erritzoe, D. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13249 · Cited by 347 · see citing works
Psychiatry & the psychedelic drugs. Past, present & future
Rucker, J. J. H., Iliff, J., & Nutt, D. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.040 · Cited by 343 · see citing works
Recent advances in the neuropsychopharmacology of serotonergic hallucinogens
Halberstadt, A. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.016 · Cited by 312 · see citing works
“Similar patterns of brain activation were found in subjects administered ayahuasca as part of a SPECT study (Riba et al., 2006).”
BackgroundBouso, J. C., González, D., Fondevila, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C., Alcázar-Córcoles, M. Á., Araújo, W. S., Barbanoj, M. J., Fábregas, J. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042421 · Cited by 313 · see citing works
Self-citationdos Santos, R. G., Osório, F. L., Crippa, J. A. S., Riba, J., Zuardi, A. W., & Hallak, J. E. C. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316638008 · Cited by 306 · see citing works
Phenomenology, Structure, and Dynamic of Psychedelic States
Preller, K. H., & Vollenweider, F. X. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_459 · Cited by 282 · see citing works
Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates
Barrett, F. S., & Griffiths, R. R. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_474 · Cited by 273 · see citing works
Mason, N. L., Kuypers, K. P. C., Müller, F., Reckweg, J., Tse, D. H. Y., Toennes, S. W., Hutten, N. R. P. W., Jansen, J. F. A., Stiers, P., Feilding, A., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0718-8 · Cited by 258 · see citing works
Smigielski, L., Scheidegger, M., Kometer, M., & Vollenweider, F. X. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.009 · Cited by 248 · see citing works
The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization
Frecska, E., Bokor, P., & Winkelman, M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00035 · Cited by 242 · see citing works
Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion.
de Araujo, D. B., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., de Martinis, B. S., Crippa, J. A., Hallak, J. E. C., & Santos, A. C. (2012) · Human Brain Mapping · doi:10.1002/hbm.21381 · Cited by 239 · see citing works
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
SANTOS, R. G. D., Bouso, J. C., Alcázar‐Córcoles, M. Á., & Hallak, J. E. C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1511424 · Cited by 228 · see citing works
Ayahuasca: pharmacology, neuroscience and therapeutic potential
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.002 · Cited by 226 · see citing works
Assessment of addiction severity among ritual users of ayahuasca.
Fábregas, J. M., González, D., Fondevila, S., Cutchet, M., Fernández, X., Barbosa, P. C. R., Alcázar-Córcoles, M. Á., Barbanoj, M. J., Riba, J., & Bouso, J. C. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.03.024 · Cited by 227 · see citing works
Self-citationBouso, J. C., Palhano-Fontes, F., Rodríguez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., & Riba, J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.008 · Cited by 218 · see citing works
Soler, J., Elices, M., Franquesa, A., Barker, S., Friedlander, P., Feilding, A., Pascual, J. C., & Riba, J. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4162-0 · Cited by 209 · see citing works
Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking
Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L., & Ramaekers, J. G. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4377-8 · Cited by 201 · see citing works
Sampedro, F., de la Fuente Revenga, M., Valle, M., Roberto, N., Domínguez-Clavé, E., Elices, M., Luna, L. E., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., et al. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx036 · Cited by 200 · see citing works
Models of psychedelic drug action: modulation of cortical-subcortical circuits
Doss, M. K., Madden, M. B., Gaddis, A., Nebel, M. B., Griffiths, R. R., Mathur, B. N., & Barrett, F. S. (2021) · Brain · doi:10.1093/brain/awab406 · Cited by 198 · see citing works
Hamill, J., Hallak, J. E. C., Dursun, S. M., & Baker, G. B. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180125095902 · Cited by 182 · see citing works
Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting
Prochazkova, L., Lippelt, D. P., Colzato, L. S., Kuchar, M., Sjoerds, Z., & Hommel, B. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5049-7 · Cited by 177 · see citing works
Valle, M., Maqueda, A. E., Rabella, M., Rodríguez-Pujadas, A., Antonijoan, R. M., Romero, S., Alonso, J. F., Mañanas, M. À., Barker, S., Friedlander, P., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.012 · Cited by 173 · see citing works
Self-citationAyahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies
SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316689030 · Cited by 168 · see citing works
SANTOS, R. G. D., Osório, F. D. L., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1701 · Cited by 163 · see citing works
Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers
Murphy-Beiner, A., & Soar, K. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05445-3 · Cited by 135 · see citing works
Morales-Garcia, J. A., Calleja-Conde, J., Lopez-Moreno, J. A., Alonso-Gil, S., Sanz-SanCristobal, M., Riba, J., & Perez-Castillo, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01011-0 · Cited by 138 · see citing works
Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
Müller, F., Lenz, C., Dolder, P. C., Lang, U. E., Schmidt, A., Liechti, M. E., & Borgwardt, S. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12818 · Cited by 137 · see citing works
Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca
SANTOS, R. G. D., Valle, M., Bouso, J. C., Nomdedeu, J. F., Rodrı́guez-Espinosa, J., McIlhenny, E. H., Barker, S. A., Barbanoj, M. J., & Riba, J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31823607f6 · Cited by 136 · see citing works
Self-citationdos Santos, R. G., Balthazar, F. M., Bouso, J. C., & Hallak, J. E. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116652578 · Cited by 125 · see citing works
Ecstatic epileptic seizures: a potential window on the neural basis for human self-awareness.
Picard, F., & Craig, A. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.09.013 · Cited by 115 · see citing works
Adverse effects of ayahuasca: Results from the Global Ayahuasca Survey
Bouso, J. C., Andión, Ó., Sarris, J. J., Scheidegger, M., Tófoli, L. F., Opaleye, E. S., Schubert, V., & Perkins, D. (2022) · PLOS Global Public Health · doi:10.1371/journal.pgph.0000438 · Cited by 118 · see citing works
Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior
McMorris, T., Harris, R. C., Howard, A. N., Langridge, G., Hall, B., Corbett, J., Dicks, M., & Hodgson, C. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.024 · Cited by 115 · see citing works
Acute biphasic effects of ayahuasca.
Schenberg, E. E., Alexandre, J. F. M., Filev, R., Cravo, A. M., Sato, J. R., Muthukumaraswamy, S. D., Yonamine, M., Waguespack, M., Lomnicka, I., Barker, S. A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137202 · Cited by 111 · see citing works
dos Santos, R. G., & Hallak, J. E. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.001 · Cited by 111 · see citing works
Jiménez-Garrido, D. F., Gómez-Sousa, M., Ona, G., Dos Santos, R. G., Hallak, J. E. C., Alcázar-Córcoles, M. Á., & Bouso, J. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-61169-x · Cited by 110 · see citing works
Classic Psychedelic Drugs: Update on Biological Mechanisms
Vollenweider, F. X., & Smallridge, J. W. (2022) · Pharmacopsychiatry · doi:10.1055/a-1721-2914 · Cited by 112 · see citing works
McCulloch, D. E.-W., Knudsen, G. M., Barrett, F. S., Doss, M. K., Carhart-Harris, R. L., Rosas, F. E., Deco, G., Kringelbach, M. L., Preller, K. H., Ramaekers, J. G., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104689 · Cited by 108 · see citing works
Classical hallucinogens and neuroimaging: A systematic review of human studies
dos Santos, R. G., Osório, F. L., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.026 · Cited by 107 · see citing works
Allen, P. J., D’Anci, K. E., Kanarek, R. B., & Renshaw, P. F. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.160 · Cited by 106 · see citing works
Psychological and neuropsychological assessment of regular hoasca users
Barbosa, P. C. R., Strassman, R. J., da Silveira, D. X., Areco, K., Hoy, R., Pommy, J., Thoma, R., & Bogenschutz, M. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.09.003 · Cited by 105 · see citing works
WINSTOCK, A. R., Kaar, S. J., & Borschmann, R. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113513852 · Cited by 104 · see citing works
Soler, J., Elices, M., Dominguez-Clavé, E., Pascual, J. C., Feilding, A., Navarro-Gil, M., García-Campayo, J., & Riba, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00224 · Cited by 102 · see citing works
Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow
Lewis, C. R., Preller, K. H., Kraehenmann, R., Michels, L., Staempfli, P., & Vollenweider, F. X. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.07.020 · Cited by 102 · see citing works
Pic‐Taylor, A., da Motta, L. G., de Morais, J. A., Melo, W., Santos, A. D. F. A., Campos, L. A., Mortari, M. R., von Zuben, M. V., & Caldas, E. D. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.05.004 · Cited by 102 · see citing works
Serotonergic psychedelics temporarily modify information transfer in humans.
Alonso, J. F., Romero, S., Mañanas, M. À., & Riba, J. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv039 · Cited by 101 · see citing works
Self-citationPsychedelic therapy in the treatment of addiction: the past, present and future
Zafar, R. R., Siegel, M., Harding, R., Barba, T., Agnorelli, C., Suseelan, S., Roseman, L., Wall, M. B., Nutt, D., & Erritzøe, D. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1183740 · Cited by 108 · see citing works
Caudevilla, F., Jordi Riba, A., Ventura, M., González, D., Farré, M., Barbanoj, M. J., & Bouso, J. C. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111431752 · Cited by 97 · see citing works
Self-citationBouso, J. C., Fábregas, J. M., Antonijoan, R. M., Rodríguez-Fornells, A., & Riba, J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3167-9 · Cited by 96 · see citing works
Jauregui, X., Clavo, Z. M., Jovel, E. M., & Pardo‐de‐Santayana, M. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.01.042 · Cited by 95 · see citing works
Jordi Riba, A., McIlhenny, E. H., Valle, M., Bouso, J. C., & Barker, S. A. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1344 · Cited by 93 · see citing works
Nunes, A. A., SANTOS, R. G. D., Osório, F. D. L., Sanches, R. F., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2016.1188225 · Cited by 91 · see citing works
Gregorio, D. D., Enns, J. P., Núñez, N. A., Posa, L., & Gobbi, G. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.07.008 · Cited by 92 · see citing works
Inserra, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00330 · Cited by 91 · see citing works
Ayahuasca Improves Self-perception of Speech Performance in Subjects With Social Anxiety Disorder
SANTOS, R. G. D., Osório, F. D. L., Rocha, J. M., Rossi, G. N., Bouso, J. C., Rodrigues, L. S., Silveira, G. D. O., Yonamine, M., & Hallak, J. E. C. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001428 · Cited by 91 · see citing works
Frecska, E., Móré, C. E., Vargha, A., & Luna, L. E. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.703099 · Cited by 87 · see citing works
Safety and Side Effects of Ayahuasca in Humans—An Overview Focusing on Developmental Toxicology
SANTOS, R. G. D. (2013) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2013.763564 · Cited by 87 · see citing works
Kiraga, M. K., Mason, N. L., Uthaug, M. V., van Oorsouw, K. I. M., Toennes, S. W., Ramaekers, J. G., & Kuypers, K. P. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.721537 · Cited by 85 · see citing works
Perkins, D., Schubert, V., Šimonová, H., Tófoli, L. F., Bouso, J. C., Horák, M., Coelho, N. L. G., & Sarris, J. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.623979 · Cited by 77 · see citing works
A review on research and evaluation methods for investigating self-transcendence
Kitson, A., Chirico, A., Gaggioli, A., & Riecke, B. E. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.547687 · Cited by 76 · see citing works
Impulsivity and executive functions in polysubstance-using rave attenders
Verdejo‐García, A., Sánchez-Fernández, M. D. M., Alonso-Maroto, L. M., Fernández‐Calderón, F., Perales, J. C., Lozano, O. M., & Pérez-Garcı́a, M. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1833-8 · Cited by 73 · see citing works
Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers
Barbanoj, M. J., Jordi Riba, A., Clos, S., Giménez, S., Grasa, E., & Romero, S. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0963-0 · Cited by 75 · see citing works
Self-citationNew World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca
McKenna, D. J., & Jordi Riba, A. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_472 · Cited by 69 · see citing works
Genuine and drug-induced synesthesia: A comparison
Sinke, C., Halpern, J. H., Zedler, M., Neufeld, J., Emrich, H. M., & Passie, T. (2012) · Consciousness and Cognition · doi:10.1016/j.concog.2012.03.009 · Cited by 59 · see citing works
Modulatory effects of ayahuasca on personality structure in a traditional framework
Netzband, N., Ruffell, S., Linton, S., Tsang, W., & Wolff, T. J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05601-0 · Cited by 58 · see citing works
Ayahuasca: Uses, Phytochemical and Biological Activities
Estrella-Parra, E. A., Almanza-Pérez, J. C., & Alarcón-Aguilar, F. J. (2019) · Natural Products and Bioprospecting · doi:10.1007/s13659-019-0210-5 · Cited by 56 · see citing works
SANTOS, R. G. D., & Hallak, J. E. C. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.053 · Cited by 56 · see citing works
Psilocybin for Trauma-Related Disorders
Khan, A. J., Bradley, E., O’Donovan, A., & Woolley, J. (2022) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2022_366 · Cited by 55 · see citing works
Perkins, D., Pagni, B. A., Sarris, J. J., Barbosa, P. C. R., & Chenhall, R. D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.884703 · Cited by 55 · see citing works
Psychedelic pleasures: An affective understanding of the joys of tripping
Bøhling, F. (2017) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2017.07.017 · Cited by 55 · see citing works
The Pharmacology of Visual Hallucinations in Synucleinopathies
Russo, M., Carrarini, C., Dono, F., Rispoli, M. G., Pietro, M. D., Stefano, V. D., Ferri, L., Bonanni, L., Sensi, S. L., & ONOFRJ, M. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01379 · Cited by 56 · see citing works
Identification of N,N‐dimethyltryptamine and β‐carbolines in psychotropic ayahuasca beverage
Gambelunghe, C., Aroni, K., Rossi, R., Moretti, L. D., & Bacci, M. (2008) · Biomedical Chromatography · doi:10.1002/bmc.1023 · Cited by 52 · see citing works
Ictal alterations of consciousness during ecstatic seizures
Picard, F., & Kurth, F. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.09.036 · Cited by 51 · see citing works
Lysergic acid diethylamide: a drug of ‘use’?
Das, S., Barnwal, P., Ramasamy, A., Sen, S., & Mondal, S. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316640440 · Cited by 50 · see citing works
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects
Ruffell, S., Crosland‐Wood, M., Palmer, R., Netzband, N., Tsang, W., Weiss, B., Gandy, S., Cowley‐Court, T., Halman, A., McHerron, D., et al. (2023) · Psychiatry and Clinical Neurosciences Reports · doi:10.1002/pcn5.146 · Cited by 54 · see citing works
Bouso, J. C., Pedrero-Pérez, E. J., Gandy, S., & Alcázar-Córcoles, M. Á. (2016) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2545 · Cited by 48 · see citing works
Rocha, J. M., Rossi, G. N., Osório, F. D. L., Bouso, J. C., Silveira, G. D. O., Yonamine, M., Campos, A. C., Bertozi, G., Hallak, J. E. C., & SANTOS, R. G. D. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001396 · Cited by 47 · see citing works
A Critical Evaluation of Reports Associating Ayahuasca with Life-Threatening Adverse Reactions
SANTOS, R. G. D. (2013) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2013.785846 · Cited by 47 · see citing works
Ayahuasca’s Antidepressant Effects Covary with Behavioral Activation as Well as Mindfulness
Mian, M. N., Altman, B. R., & Earleywine, M. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1674428 · Cited by 46 · see citing works
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.
Cumming, P., Scheidegger, M., Dornbierer, D., Palner, M., Quednow, B. B., & Martin-Soelch, C. (2021) · Molecules · doi:10.3390/molecules26092451 · Cited by 43 · see citing works
Ayahuasca's therapeutic potential: What we know – and what not
Maia, L. O., Daldegan‐Bueno, D., Wießner, I., de Araújo, D. B., & Tófoli, L. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.10.008 · Cited by 47 · see citing works
The pharmacological interaction of compounds in ayahuasca: a systematic review
Ruffell, S., Netzband, N., Bird, C., Young, A. H., & Juruena, M. F. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0884 · Cited by 45 · see citing works
Rocha, J. M., Osório, F. D. L., Crippa, J. A. S., Bouso, J. C., Rossi, G. N., Hallak, J. E. C., & SANTOS, R. G. D. (2019) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125319845774 · Cited by 43 · see citing works
Eleftheriou, M. E., & Thomas, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.707057 · Cited by 39 · see citing works
“For example, enhanced activation of the ACC and other prefrontal regions was observed in novice and experienced meditators (120–122), and as a result of ayahuasca administration (33, 63).”
BackgroundRelational Processes in Ayahuasca Groups of Palestinians and Israelis
Roseman, L., Ron, Y., Saca, A., Ginsberg, N. L., Luan, L. X., Karkabi, N., Doblin, R., & Carhart-Harris, R. L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.607529 · Cited by 43 · see citing works
N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
James, E., Keppler, J., Robertshaw, T. L., & Sessa, B. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2835 · Cited by 43 · see citing works
Ayahuasca as a Candidate Therapy for PTSD
Nielson, J. L., & Megler, J. D. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_3 · Cited by 40 · see citing works
Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2021) · Molecules · doi:10.3390/molecules26051397 · Cited by 40 · see citing works
Ayahuasca and the Treatment of Drug Addiction
Bouso, J. C., & Jordi Riba, A. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_6 · Cited by 40 · see citing works
Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up
SANTOS, R. G. D., Sanches, R. F., Osório, F. D. L., & Hallak, J. E. C. (2018) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000149 · Cited by 37 · see citing works
- Authors
- Riba, J., Romero, S., Grasa, E., Mena, E., Carrió, I., & Barbanoj, M. J.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Venue
- Psychopharmacology
- Published
- 2006-03-31
- Volume
- 186
- Issue
- 1
- Pages
- 93-98
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2103583518
- Cited by
- 241
- References
- 48
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 8 · 2023: 25 · 2022: 21 · 2021: 24 · 2020: 16 · 2019: 9 · 2018: 14 · 2017: 15 · 2016: 20 · 2015: 14 · 2014: 11 · 2013: 9 · 2012: 12
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by-nc-nd)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- UPCommons institutional repository (Universitat Politècnica de Catalunya) (submittedVersion, cc-by-nc-nd)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ayahuasca, N,N-dimethyltryptamine, monoamine oxidase inhibitors, regional cerebral blood flow, frontal cortex activation, paralimbic system, anterior insula, anterior cingulate cortex, amygdala, parahippocampal gyrus, interoception, emotional processing, serotonergic neurotransmission
- MeSH terms
- Adult, Affect, Brain, Double-Blind Method, Euphoria, Humans, Male, Psychotropic Drugs, Tomography, Emission-Computed, Single-Photon, Plant Preparations, Banisteriopsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
