Reduced connectivity of the auditory cortex in patients with auditory hallucinations: A resting state functional magnetic resonance imaging study
Abstract
BACKGROUND: Previous research has reported auditory processing deficits that are specific to schizophrenia patients with a history of auditory hallucinations (AH). One explanation for these findings is that there are abnormalities in the interhemispheric connectivity of auditory cortex pathways in AH patients; as yet this explanation has not been experimentally investigated. We assessed the interhemispheric connectivity of both primary (A1) and secondary (A2) auditory cortices in n=13 AH patients, n=13 schizophrenia patients without auditory hallucinations (non-AH) and n=16 healthy controls using functional connectivity measures from functional magnetic resonance imaging (fMRI) data. METHOD: Functional connectivity was estimated from resting state fMRI data using regions of interest defined for each participant based on functional activation maps in response to passive listening to words. Additionally, stimulus-induced responses were regressed out of the stimulus data and the functional connectivity was estimated for the same regions to investigate the reliability of the estimates. RESULTS: AH patients had significantly reduced interhemispheric connectivity in both A1 and A2 when compared with non-AH patients and healthy controls. The latter two groups did not show any differences in functional connectivity. Further, this pattern of findings was similar across the two datasets, indicating the reliability of our estimates. CONCLUSIONS: These data have identified a trait deficit specific to AH patients. Since this deficit was characterized within both A1 and A2 it is expected to result in the disruption of multiple auditory functions, for example, the integration of basic auditory information between hemispheres (via A1) and higher-order language processing abilities (via A2).
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Gavrilescu et al. reported reductions in cross-hemisphere resting functional connectivity linking the primary and secondary auditory cortices in hallucinating patients when compared with nonhallucinating patients and healthy controls.
“Gavrilescu et al. (66) examined cross-hemisphere resting FC linking the primary and secondary auditory cortices and reported reductions in hallucinating patients when compared with nonhallucinating patients and healthy controls.”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [66]
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“Using RS fMRI, Gavrilescu and colleagues investigated interhemispheric connectivity in the primary and secondary auditory cortex in patients with and without AVH and healthy controls (Gavrilescu et al., 2010).”
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- Authors
- Gavrilescu, M., Rossell, S., Stuart, G. W., Shea, T. L., Innes-Brown, H., Henshall, K., McKay, C., Sergejew, A. A., Copolov, D., & Egan, G. F.
- Affiliations
- The University of Melbourne (AU)
- The Alfred Hospital (AU)
- Mental Health Research Institute (AU)
- University of Manchester (GB)
- Florey Institute of Neuroscience and Mental Health (AU)
- Corresponding author
- Gavrilescu, M.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-11-06
- Volume
- 40
- Issue
- 7
- Pages
- 1149-1158
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2101837615
- Cited by
- 121
- References
- 58
- Citations by year
- 2026: 2 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 4 · 2018: 12 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 14
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- auditory hallucinations, auditory cortex, interhemispheric connectivity, primary auditory cortex, secondary auditory cortex, schizophrenia, resting-state functional connectivity, auditory processing deficits, hemispheric integration
- MeSH terms
- Adult, Auditory Cortex, Female, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Models, Psychological, Nerve Net, Schizophrenia, Severity of Illness Index, Speech Perception, Vocabulary
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