Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET: Serotonin Transporter in ADHD Revealed by PET
Open accessAbstract
Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BP ND ) in patients with ADHD and to assess associations of SERT BP ND between the brain regions. 25 medication-free patients with ADHD (age ± SD; 32.39 ± 10.15; 10 females) without any psychiatric comorbidity and 25 age and sex matched healthy control subjects (33.74 ± 10.20) were measured once with PET and the highly selective and specific radioligand [ 11 C]DASB. SERT BP ND maps in nine a priori defined ROIs exhibiting high SERT binding were compared between groups by means of a linear mixed model. Finally, adopted from structural and functional connectivity analyses, we performed correlational analyses using regional SERT binding potentials to examine molecular interregional associations between all selected ROIs. We observed significant differences in the interregional correlations between the precuneus and the hippocampus in patients with ADHD compared to healthy controls, using SERT BP ND of the investigated ROIs (P ND and age in the ADHD and the healthy control group, we confirmed an age-related decline in brain SERT binding in the thalamus and insula (R 2 = 0.284, R 2 = 0.167, Ps < 0.05; Bonferroni corrected). The results show significantly different interregi…
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In adults, significant differences in serotonin transporter interregional correlations between the precuneus and hippocampus have been reported in adults with ADHD compared with controls without ADHD.
“In adults, significant differences in 5-HT transporter interregional correlations between the precuneus and hippocampus have been reported in adults with ADHD compared with controls without ADHD (225).”
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- Authors
- Vanicek, T., Kutzelnigg, A., Philippe, C., Sigurdardottir, H. L., James, G. M., Hahn, A., Kranz, G. S., Höflich, A., Kautzky, A., Traub-Weidinger, T., Hacker, M., Wadsak, W., Mitterhauser, M., Kasper, S., & Lanzenberger, R.
- Affiliations
- Medical University of Vienna (AT)
- Division of Nuclear Medicine; Department of Biomedical Imaging and Image-Guided Therapy; Medical University of Vienna; Austria
- Corresponding author
- Lanzenberger, Rupert
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2016-10-22
- Volume
- 38
- Issue
- 2
- Pages
- 792-802
- ISSN
- 1065-9471 (ISSN-L)
- PMC
- PMC6867013
- OpenAlex
- W2547185200
- Cited by
- 44
- References
- 17
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 3
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Biogen
- Novartis Pharmaceuticals Corporation
- Endocyte
- Deutsche Forschungsgemeinschaft
- Austrian Science Fund
- Bundesministerium für Gesundheit
- Oesterreichische Nationalbank (13675)
- Servier
- H. Lundbeck A/S
- Neuraxpharm
- AOP Orphan
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- serotonin transporter, attention deficit hyperactivity disorder, precuneus, hippocampus, functional connectivity
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Brain, Female, Humans, Male, Psychiatric Status Rating Scales, Linear Models, Case-Control Studies, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins, Young Adult
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