Role of serotonin in psychiatric and somatic comorbidities of attention-deficit/hyperactivity disorder: a systematic literature review
Open accessAbstract
INTRODUCTION: Serotonin is a well-established modulator of various neuropsychological processes, as well as organ and endocrine functioning, and metabolism and homeostasis. Serotonin has been implicated in the neurobiology of attention-deficit/hyperactivity disorder (ADHD). Herein, the evidence for a serotonergic link between psychiatric and somatic comorbidities associated with ADHD was evaluated. METHODS: A systematic literature review was conducted of the published literature to identify comorbidities proven to co-occur with ADHD and determine whether there was any serotonergic pathophysiology associated with these comorbidities. The average grade of serotonergic evidence was calculated and plotted alongside the volume of publications for each identified comorbidity. The date of the last search was 7 March 2024. RESULTS: One hundred eighty-two individual comorbidities commonly occurring in ADHD populations were identified; 135 (74.2 %) had evidence for serotonergic pathophysiology, including 91 psychiatric and 44 somatic conditions. The grade of evidence for a serotonergic role in the pathophysiology of a given comorbidity was generally medium to high or high. CONCLUSIONS: Findings indicate that serotonin plays a key role, alongside dopamine and norepinephrine, in ADHD neurobiology. Serotonin involvement in physiological functioning suggests that dysregulation is likely to generate a broad spectrum of clinical manifestations, which may account for the unique presentation of neuropsychiatric behaviors and comorbidities found in patients with ADHD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The serotonergic system has been implicated in ADHD, particularly in relation to impulsivity and high rates of comorbid mood and anxiety disorders.
“The serotonergic (5-HT) system has also been implicated, particularly in relation to impulsivity and the high rates of comorbid mood and anxiety disorders”
From ADHD in Adulthood: Clinical Presentation, Comorbidities, and Treatment Perspectives (2025) · cites this paper as [71]
Cites
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n71 · Cited by 108,283 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · cited 1× · see citing works
“…was registered with the international prospective register of systematic reviews, PROSPERO (CRD42024526906), and the review processes were conducted following the guidelines of the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) (Page et al., 2021; Liberati et al., 2009).”
The well-built clinical question: A key to evidence-based decisions
(1995) · ACP Journal Club · doi:10.7326/acpjc-1995-123-3-a12 · Cited by 2,931 · see citing works
Faraone, S. V., Banaschewski, T., Coghill, D., Zheng, Y., Biederman, J., Bellgrove, M. A., Newcorn, J. H., Gignac, M., Al Saud, N. M., Manor, I., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.022 · Cited by 1,545 · cited 1× · see citing works
“Individuals with ADHD have reduced quality of life (Faraone et al., 2021) and are at increased risk of impaired daily functioning (academic or occupational) (Varrasi et al., 2023), antisocial behavior and substance abuse (Retz et al., 2021; Van de Glind et al., 2020), a range of psychiatric and…”
Self-citationAttention-deficit/hyperactivity disorder
Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga-Barke, E. J. S., Tannock, R., & Franke, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.20 · Cited by 1,479 · see citing works
Self-citationFaraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Self-citationMeader, N., King, K., Llewellyn, A., Norman, G., Brown, J., Rodgers, M., Moe-Byrne, T., Higgins, J., Sowden, A., & Stewart, G. B. (2014) · Systematic Reviews · doi:10.1186/2046-4053-3-82 · Cited by 560 · see citing works
Dopamine and Cognitive Control in Prefrontal Cortex
Ott, T., & Nieder, A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.12.006 · Cited by 530 · see citing works
Logue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477 · see citing works
The Roles of Serotonin in Neuropsychiatric Disorders
Pourhamzeh, M., Moravej, F. G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R. T., Ahadi, R., & Joghataei, M. T. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01064-9 · Cited by 384 · see citing works
Attention-deficit/hyperactivity disorder
Faraone, S. V., Bellgrove, M. A., Brikell, I., Cortese, S., Hartman, C. A., Hollis, C., Newcorn, J. H., Philipsen, A., Polanczyk, G. V., Rubia, K., et al. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00495-0 · Cited by 355 · see citing works
Self-citationBeyond a neurotransmitter: The role of serotonin in inflammation and immunity
Wu, H., Denna, T., Storkersen, J., & Gerriets, V. A. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.06.015 · Cited by 348 · see citing works
Critical Involvement of Dopaminergic Neurotransmission in Impulsive Decision Making
van Gaalen, M. M., van Koten, R. C., Schoffelmeer, A. N. M., & Vanderschuren, L. J. M. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.005 · Cited by 338 · see citing works
The complex role of serotonin and 5-HT receptors in chronic pain
Bardin, L. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328349aae4 · Cited by 270 · see citing works
Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review
Instanes, J. T., Klungsøyr, K., Halmøy, A., Fasmer, O. B., & Haavik, J. (2018) · Journal of Attention Disorders · doi:10.1177/1087054716669589 · Cited by 232 · see citing works
Choi, W.-S., Woo, Y. S., Wang, S.-M., Lim, H. K., & Bahk, W.-M. (2022) · PLOS ONE · doi:10.1371/journal.pone.0277175 · Cited by 221 · see citing works
ADHD and the Prefrontal Cortex
Arnsten, A. F. T. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.018 · Cited by 220 · see citing works
Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill
Káňová, M., & Kohout, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094837 · Cited by 200 · see citing works
Prevalence of ADHD and Its Comorbidities in a Population-Based Sample
Mohammadi, M.-R., Zarafshan, H., Khaleghi, A., Ahmadi, N., Hooshyari, Z., Mostafavi, S.-A., Ahmadi, A., Alavi, S.-S., Shakiba, A., & Salmanian, M. (2021) · Journal of Attention Disorders · doi:10.1177/1087054719886372 · Cited by 194 · see citing works
Johnson, K. A., Robertson, I. H., Barry, E., Mulligan, A., Dáibhis, A., Daly, M., Watchorn, A., Gill, M., & Bellgrove, M. A. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01936.x · Cited by 192 · see citing works
Serotonin and Mental Disorders: A Concise Review on Molecular Neuroimaging Evidence
Lin, S., Lee, L.-T., & Yang, Y. K. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.3.196 · Cited by 177 · see citing works
Hooijmans, C. R., de Vries, R. B. M., Ritskes-Hoitinga, M., Rovers, M. M., Leeflang, M. M., IntHout, J., Wever, K. E., Hooft, L., de Beer, H., Kuijpers, T., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0187271 · Cited by 176 · see citing works
Basal ganglia and language: phonology modulates dopaminergic release
Tettamanti, M., Moro, A., Messa, C., Moresco, R. M., Rizzo, G., Carpinelli, A., Matarrese, M., Fazio, F., & Perani, D. (2005) · Neuroreport · doi:10.1097/00001756-200503150-00018 · Cited by 146 · see citing works
The skin as a mirror of the soul: exploring the possible roles of serotonin
Nordlind, K., Azmitia, E. C., & Slominski, A. T. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00670.x · Cited by 131 · see citing works
ADHD Pharmacotherapy and Mortality in Individuals With ADHD
Li, L., Zhu, N., Zhang, L., Kuja‐Halkola, R., D'Onofrio, B. M., Brikell, I., Lichtenstein, P., Cortese, S., Larsson, H., & Chang, Z. (2024) · JAMA · doi:10.1001/jama.2024.0851 · Cited by 131 · see citing works
Retz, W., Ginsberg, Y., Turner, D., Barra, S., Retz‐Junginger, P., Larsson, H., & Asherson, P. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.025 · Cited by 128 · see citing works
Does serotonin deficit mediate susceptibility to ADHD?
Banerjee, E., & Nandagopal, K. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.02.001 · Cited by 125 · see citing works
An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder
da Silva, B. S., Grevet, E. H., Silva, L. C. F., Ramos, J. K. N., Rovaris, D. L., & Bau, C. H. D. (2023) · Discover Mental Health · doi:10.1007/s44192-022-00030-1 · Cited by 125 · see citing works
Role of 5-HT receptors in neuropathic pain: potential therapeutic implications
Liu, Q. Q., Yao, X. X., Gao, S. H., Li, R., Li, B. J., Yang, W., & Cui, R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104949 · Cited by 124 · see citing works
Kaushanskaya, M., Park, J. S., Gangopadhyay, I., Davidson, M. M., & Weismer, S. E. (2017) · Journal of Speech Language and Hearing Research · doi:10.1044/2016_jslhr-l-15-0310 · Cited by 123 · see citing works
ADHD in Children and Adults: Diagnosis and Prognosis
Leffa, D. T., Caye, A., & Rohde, L. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_329 · Cited by 117 · see citing works
Fifty years on: Serotonin and depression
Jauhar, S., Cowen, P. J., & Browning, M. D. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231161813 · Cited by 109 · see citing works
The role of ADHD associated genes in neurodevelopment
Dark, C., Homman-Ludiye, J., & Bryson-Richardson, R. J. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.023 · Cited by 101 · see citing works
Aznar, S., & Hervig, M. E.-S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.008 · Cited by 95 · see citing works
Bralten, J., Franke, B., Waldman, I., Rommelse, N., Hartman, C., Asherson, P., Banaschewski, T., Ebstein, R. P., Gill, M., Miranda, A., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.08.020 · Cited by 93 · see citing works
Self-citationNeuroimmune Pathophysiology in Asthma
Pavón-Romero, G. F., Serrano-Pérez, N. H., García-Sánchez, L., Jiménez, F. R., & Teran, L. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663535 · Cited by 91 · see citing works
Shokrkon, A., & Nicoladis, E. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.848696 · Cited by 91 · see citing works
Amiri, S., Farhang, S., Ghoreishizadeh, M. A., Malek, A., & Mohammadzadeh, S. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1274 · Cited by 85 · see citing works
Irrelevant stimulus processing in ADHD: catecholamine dynamics and attentional networks
Aboitiz, F., Ossandón, T., Zamorano, F. J., Palma, B. A., & Carrasco, X. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00183 · Cited by 79 · see citing works
Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety
Hao, S., Shi, W., Liu, W., Chen, Q., & Zhuo, M. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1122381 · Cited by 79 · see citing works
Enge, S., Fleischhauer, M., Lesch, K., Reif, A., & Strobel, A. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.09.038 · Cited by 77 · see citing works
Azizi, S. A. (2020) · The Neuroscientist · doi:10.1177/1073858420974336 · Cited by 76 · see citing works
Attention Network Test in adults with ADHD - the impact of affective fluctuations
Lundervold, A. J., Adólfsdóttir, S., Halleland, H. B., Halmøy, A., Plessen, K. J., & Haavik, J. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-27 · Cited by 72 · see citing works
Genetic liability to ADHD and substance use disorders in individuals with ADHD
Wimberley, T., Agerbo, E., Horsdal, H. T., Ottosen, C., Brikell, I., Als, T. D., Demontis, D., Børglum, A. D., Nordentoft, M., Mors, O. N., et al. (2019) · Addiction · doi:10.1111/add.14910 · Cited by 70 · see citing works
Akmatov, M. K., Ermakova, T., & Bätzing, J. (2021) · Journal of Attention Disorders · doi:10.1177/1087054719865779 · Cited by 68 · see citing works
Linking neurogenetics and individual differences in language learning: the dopamine hypothesis.
Wong, P. C. M., Morgan-Short, K., Ettlinger, M., & Zheng, J. (2012) · Cortex · doi:10.1016/j.cortex.2012.03.017 · Cited by 67 · see citing works
Andersson, A., Tuvblad, C., Chen, Q., Du Rietz, E., Cortese, S., Kuja‐Halkola, R., & Larsson, H. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13233 · Cited by 56 · see citing works
Raghanti, M. A., Edler, M. K., Stephenson, A. R., Wilson, L. J., Hopkins, W. D., Ely, J. J., ERWIN, J. M., Jacobs, B., Hof, P. R., & Sherwood, C. C. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23937 · Cited by 49 · see citing works
Modulating role of serotonergic signaling in sleep and memory
Vaseghi, S., Arjmandi-Rad, S., Eskandari, M., Ebrahimnejad, M., Kholghi, G., & Zarrindast, M. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00339-8 · Cited by 49 · see citing works
Frimpong-Manson, K., Ortiz, Y. T., McMahon, L. R., & Wilkerson, J. L. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1355281 · Cited by 48 · see citing works
Marta Ribasés, A., Mitjans, M., Hartman, C. A., Artigas, M. S., Demontis, D., Larsson, H., Ramos‐Quiroga, J. A., Kuntsi, J., Faraone, S. V., Ad, B., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105313 · Cited by 47 · see citing works
Self-citationVarrasi, S., Boccaccio, F. M., Guerrera, C. S., Platania, G. A., Pirrone, C., & Castellano, S. (2022) · Education Sciences · doi:10.3390/educsci13010037 · Cited by 46 · see citing works
Baranova, A., Chandhoke, V., Cao, H.-B., & Zhang, F.-Q. (2023) · General Psychiatry · doi:10.1136/gpsych-2022-100996 · Cited by 45 · see citing works
Vanicek, T., Kutzelnigg, A., Philippe, C., Sigurdardottir, H. L., James, G. M., Hahn, A., Kranz, G. S., Höflich, A., Kautzky, A., Traub-Weidinger, T., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23418 · Cited by 44 · see citing works
Hou, Y.-W., Xiong, P., Gu, X., Huang, X., Wang, M., & Wu, J. (2018) · Current Medical Science · doi:10.1007/s11596-018-1912-3 · Cited by 41 · see citing works
Mota, N. R., Poelmans, G., Klein, M., Torrico, B., Fernàndez‐Castillo, N., Cormand, B., Reif, A., Franke, B., & Vásquez, A. A. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0592-4 · Cited by 41 · see citing works
A practical guide to preclinical systematic review and meta-analysis
Soliman, N., Rice, A. S. C., & Vollert, J. (2020) · Pain · doi:10.1097/j.pain.0000000000001974 · Cited by 40 · see citing works
Serotonergic regulation of energy metabolism in peripheral tissues
Choi, W., Moon, J. H., & Kim, H. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0546 · Cited by 37 · see citing works
Norepinephrine system at the interface of attention and reward
Zhang, Y., Chen, Y., Xin, Y., Peng, B., & Liu, S. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110751 · Cited by 36 · see citing works
Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder
Sudre, G. P., Gildea, D. E., Shastri, G. G., Sharp, W. S., Jung, B., Xu, Q., Auluck, P. K., Elnitski, L. L., Baxevanis, A. D., Marenco, S., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01844-9 · Cited by 32 · see citing works
Filipe, M. G., Veloso, A. S., & Frota, S. (2023) · Brain Sciences · doi:10.3390/brainsci13030470 · Cited by 32 · see citing works
Biederman, J., Lindstén, A., Sluth, L. B., Petersen, M. L., Ettrup, A., Eriksen, H. F., & D, M. F. M. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119832538 · Cited by 30 · see citing works
Ma, S. L., Chen, L. H., Lee, C., Lai, K. Y. C., Hung, S., Tang, C.-P., Ho, T., Shea, C. K., Mo, F. Y. M., Mak, T. S. H., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.649588 · Cited by 29 · see citing works
Jespersen, C., Lauritsen, M. P., Frøkjær, V. G., & Schroll, J. B. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001396.pub4 · Cited by 29 · see citing works
A Clinical Review on Paroxetine and Emerging Therapies for the Treatment of Vasomotor Symptoms
David, P. S., Smith, T. L., Nordhues, H. C., & Kling, J. M. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s282396 · Cited by 27 · see citing works
Méndez-Freije, I., Areces, D., & Rodríguez, C. (2023) · Children · doi:10.3390/children11010014 · Cited by 26 · see citing works
van de Glind, G., Brynte, C., Skutle, A., Kaye, S., Konstenius, M., Levin, F., Mathys, F., Demetrovics, Z., Moggi, F., Ramos-Quiroga, J., et al. (2020) · European Addiction Research · doi:10.1159/000508870 · Cited by 23 · see citing works
Reappraising the role of dopamine in adolescent risk-taking behaviorPreprint
França, T. F. A., & Pompéia, S. (2022) · doi:10.1016/j.neubiorev.2023.105085 · Cited by 22 · see citing works
Koller, D., Mitjans, M., Kouakou, M. R., Friligkou, E., Cabrera‐Mendoza, B., Deak, J. D., Llonga, N., Pathak, G. A., Stiltner, B., Løkhammer, S., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115758 · Cited by 22 · see citing works
Attention-Deficit/Hyperactivity Disorder
Beauchaine, T. P., Hinshaw, S. P., Ahmad, S. I., & Hinshaw, S. P. (2015) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199324675.013.17 · Cited by 20 · see citing works
Katsarou, D. V., Efthymiou, E., Kougioumtzis, G. Α., Sofologi, M., & Theodoratou, M. (2024) · Children · doi:10.3390/children11070841 · Cited by 19 · see citing works
The Role of Language in the Social and Academic Functioning of Children With ADHD
Jepsen, I., Brynskov, C., Thomsen, P. H., Rask, C., de López, K. M. J., & Lambek, R. (2024) · Journal of Attention Disorders · doi:10.1177/10870547241266419 · Cited by 11 · see citing works
Chatterjee, M., Saha, S., Sinha, S., & Mukhopadhyay, K. (2022) · World Journal of Pediatrics · doi:10.1007/s12519-022-00614-5 · Cited by 10 · see citing works
Disrupted waiting behavior in ADHD: exploring the impact of reward availability and predictive cues
Furukawa, E., Alsop, B., Alves, H., Vorderstrasse, V., Carrasco, K., Chuang, C.-C., & Tripp, G. (2022) · Child Neuropsychology · doi:10.1080/09297049.2022.2068518 · Cited by 9 · see citing works
Physiology and pharmacology of nausea and vomiting
Denholm, L., & Gallagher, G. (2024) · Anaesthesia & intensive care medicine · doi:10.1016/j.mpaic.2024.06.019 · Cited by 7 · see citing works
Reimherr, F. W., Gift, T. E., Steans, T. A., Reimherr, M. L., Rosenberg, L. I., Wilson, M., & Marchant, B. K. (2022) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001592 · Cited by 6 · see citing works
Köhler, R., Lichenstein, S. D., Cheng, R. H., Holmes, A. J., Bzdok, D., Pearlson, G. D., & Yip, S. W. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.02.998 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 79 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
ADHD in Adulthood: Clinical Presentation, Comorbidities, and Treatment Perspectives
Bogdańska-Chomczyk, E., Majewski, M. K., & Kozłowska, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211020 · Cited by 15 · see citing works
“The serotonergic (5-HT) system has also been implicated, particularly in relation to impulsivity and the high rates of comorbid mood and anxiety disorders [71].”
Faraone, S. V., Ward, C. L., Boucher, M., Elbekai, R. H., & Brunner, E. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2552324 · Cited by 8 · see citing works
Self-citationA comprehensive overview of the biological foundations of ADHD
Folego-Temoteo, I., Lima, Y. C., Grevet, E. H., Vidor, M. V., Tavares, M. E., da Silva, B. S., Bau, C. H. D., & Rovaris, D. L. (2026) · Bioscience Reports · doi:10.1042/bsr20254061 · Cited by 1 · see citing works
Potential treatments for attention-deficit/hyperactivity disorder: a focus on Phase III trials
Ferahkaya, H., & Bi̇lgi̇ç, A. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2566257
Pelz, M., Janušonis, S., & Handy, G. (2026) · SIAM Journal on Life Sciences · doi:10.1137/25m1827852
Griffioen, G., Tangen, Ä., Veldman, E. R., Svensson, J. E., Tiger, M., Nord, M., Andersson, M., Sorjonen, K., Varrone, A., Halldin, C., et al. (2026) · EJNMMI Research · doi:10.1186/s13550-026-01435-7
Chai, W., Liu, Z., Xu, J., Liu, J., Chen, X., Pei, R., Cera, N., Zhang, X., & Dong, M. (2026) · International Journal of Impotence Research · doi:10.1038/s41443-026-01288-7
Centanafadine (Simtriyo): a triple monoamine reuptake inhibitor for ADHD
Han, J., Jiang, C., Pruitt, A. A., Yu, Y., & Jiang, J. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.08.011
Ward, C. L., Oberdhan, D., Jin, N., Skubiak, T., van Stralen, J., Mattingly, G. W., & Childress, A. C. (2026) · Journal of Attention Disorders · doi:10.1177/10870547261483444
Self-citationNew and emerging therapeutics and molecular targets for attention-deficit hyperactivity disorder
Haavik, J. (2026) · Expert opinion on therapeutic targets · doi:10.1080/14728222.2026.2747529
- Authors
- Faraone, S. V., Ward, C. L., Boucher, M., Elbekai, R., & Brunner, E.
- Affiliations
- SUNY Upstate Medical University (US)
- Otsuka Pharmaceutical Development & Commercialization, Inc. (United States) (US)
- Otsuka Canada Pharmaceutical Inc. (Canada) (CA)
- Otsuka (United States) (US)
- Corresponding author
- Faraone, Stephen V.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2025-09
- Volume
- 176
- Pages
- 106275
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W4412055753
- Cited by
- 10
- References
- 79
- Citations by year
- 2026: 7 · 2025: 3
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Otsuka Pharmaceutical Development and Commercialization Inc
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- serotonin, attention deficit hyperactivity disorder, psychiatric comorbidity, somatic comorbidity, dopamine, norepinephrine
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Mental Disorders, Humans, Serotonin, Comorbidity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
