Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice
Open accessAbstract
The global prevalence of obesity-induced liver disease (nonalcoholic fatty liver disease; NAFLD) is rising. Suggested causes include a role for in utero influences of maternal obesity compounded by the availability of energy-dense foods throughout postnatal life. Using a physiologically relevant model, we investigated the role of the innate immune system in liver injury induced by maternal obesity followed by a postnatal obesogenic diet. Female C57BL/6J mice were fed a standard or obesogenic diet before and throughout pregnancy and during lactation. Female offspring were weaned onto a standard or obesogenic diet at 3 weeks postpartum. Biochemical and histological indicators of dysmetabolism, NAFLD and fibrosis, analysis of profibrotic pathways, liver innate immune cells, and reactive oxygen species (ROS) were investigated at 3, 6, and 12 months. Female offspring exposed to a postweaning obesogenic diet (OffCon-OD) demonstrated evidence of liver injury, which was exacerbated by previous exposure to maternal obesity (OffOb-OD), as demonstrated by raised alanine aminotransferase, hepatic triglycerides, and hepatic expression of interleukin (IL)-6, tumor necrosis factor alpha, transforming growth factor beta, alpha smooth muscle actin, and collagen (P < 0.01). Histological evidence of hepatosteatosis and a more-robust NAFLD phenotype with hepatic fibrosis was observed at 12 months in OffOb-OD. A role for the innate immune system was indicated by increased Kupffer cell numbers with impaired phagocytic function and raised ROS synthesis (P < 0.01), together with reduced natural killer T cells and raised interleukin (IL)-12 and IL-18. Conclusion: Maternal obesity in the context of a postnatal hypercalorific obesogenic diet aggressively programs offspring NAFLD associated with innate immune dysfunction, resulting in a comprehensive phenotype that accurately reflects the human disease. (HEPATOLOGY 2013)
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Maternal obesity induced hepatic steatosis in the offspring.
“a number of studies showed that maternal obesity induced greater adiposity and obesity [95,96,97,98] as well as hepatic steatosis [95,96,99] in the offspring.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [96]
The Results report that maternal obesity exacerbated hepatic fat accumulation in offspring fed a postweaning obesogenic diet. The Discussion also says offspring of obese dams weaned onto standard chow had similar hepatic triglyceride content and histological steatosis to controls. The claim omits this important postnatal-diet qualification. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMaternal obesity induced greater adiposity and obesity in the offspring.
“a number of studies showed that maternal obesity induced greater adiposity and obesity [95,96,97,98] as well as hepatic steatosis [95,96,99] in the offspring.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [96]
Several studies have reported hyperlipidemia in offspring of maternal obesity, including elevated free fatty acids, plasma triacylglycerol and reduced total and HDL cholesterol, though one study did not observe alterations in plasma lipids.
“Several of these studies have reported hyperlipidemia [96,100], including elevated free fatty acids, plasma triacylglycerol and reduced total and HDL cholesterol in the offspring, though one study did not observe alterations in plasma lipids [101].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [96]
The citation to this paper is attached to the assertion that one study found no alterations in plasma lipids. The Materials and Methods section (page unavailable) says plasma was assayed for ALT, while triglycerides were measured in liver tissue. The Results and Discussion discuss hepatic triglycerides, not unchanged plasma lipids; searches for plasma lipid and cholesterol findings found no supporting passage. (LLM, conf=0.76)
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- Authors
- Mouralidarane, A., Soeda, J., Visconti-Pugmire, C., Samuelsson, A.-M., Pombo, J., Maragkoudaki, X., Butt, A., Saraswati, R., Novelli, M., Fusai, G., Poston, L., Taylor, P. D., & Oben, J. A.
- Affiliations
- King's College London (GB)
- The Royal Free Hospital (GB)
- University College London (GB)
- National Health Service (GB)
- Corresponding author
- Oben, Jude A.
- Venue
- Hepatology
- Published
- 2013-07
- Volume
- 58
- Issue
- 1
- Pages
- 128-138
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1969470394
- Cited by
- 145
- References
- 33
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 16 · 2017: 12 · 2016: 15 · 2015: 13 · 2014: 10 · 2013: 10
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- British Heart Foundation (FS/10/003/28163)
- Biotechnology and Biological Sciences Research Council (BB/H008845/1)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- maternal obesity, non-alcoholic fatty liver disease, offspring programming, innate immune dysregulation, obesogenic diet, Kupffer cells, NKT cells, reactive oxygen species, liver fibrosis, hepatic steatosis, IL-12, IL-18, postnatal diet, liver injury
- MeSH terms
- Animals, Dietary Fats, Fatty Liver, Female, Immunity, Innate, Liver, Liver Diseases, Mice, Inbred C57BL, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Mice, Non-alcoholic Fatty Liver Disease
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