Roles of Trained Immunity in the Pathogenesis of Cholangiopathies: A Therapeutic Target
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Myeloid cells, i.e., monocytes and macrophages, play an important role in the pathogenesis of primary biliary cholangitis (PBC).
“Myeloid cells, i.e., monocytes and macrophages, represent a key component of innate and adaptive immune systems and play an important role in the pathogenesis of PBC.”
From A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression (2023) · cites this paper as [36]
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- Authors
- Yan, C., Koda, S., Wu, J., Zhang, B., Yu, Q., Netea, M. G., Tang, R., & Zheng, K.
- Affiliations
- Xuzhou Medical College (CN)
- University of Bonn (DE)
- Jiangsu Key Laboratory of Immunity and Metabolism,Department of Pathogenic Biology and Immunology,Laboratory of Infection and Immunity,Xuzhou Medical University,Xuzhou,People’s Republic of China
- Venue
- Hepatology
- Published
- 2020-10-25
- Volume
- 72
- Issue
- 5
- Pages
- 1838-1850
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- OpenAlex
- W3030731983
- Cited by
- 21
- References
- 91
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81702027, 81572019)
- China Postdoctoral Science Foundation (2018M640525)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- trained immunity, cholangiopathy, biliary tract diseases, pathogenesis, therapeutic target, innate immunity
- MeSH terms
- Adjuvants, Immunologic, Animals, B-Lymphocytes, BCG Vaccine, Bile Duct Diseases, Disease Models, Animal, Humans, Immunologic Memory, Killer Cells, Natural, Macrophages, Monocytes, T-Lymphocytes, Epigenesis, Genetic, Disease Resistance
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