Cited by 49Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Behavior‐driven arc expression is reduced in all ventral hippocampal subfields compared to CA1, CA3, and dentate gyrus in rat dorsal hippocampus

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Chawla, M. K., Sutherland, V. L., Olson, K., McNaughton, B. L., Barnes, C. A.·2018·Hippocampus

Abstract

Anatomical connectivity and lesion studies reveal distinct functional heterogeneity along the dorsal-ventral axis of the hippocampus. The immediate early gene Arc is known to be involved in neural plasticity and memory and can be used as a marker for cell activity that occurs, for example, when hippocampal place cells fire. We report here, that Arc is expressed in a greater proportion of cells in dorsal CA1, CA3, and dentate gyrus (DG), following spatial behavioral experiences compared to ventral hippocampal subregions (dorsal CA1 = 33%; ventral CA1 = 13%; dorsal CA3 = 23%; ventral CA3 = 8%; and dorsal DG = 2.5%; ventral DG = 1.2%). The technique used here to obtain estimates of numbers of behavior-driven cells across the dorsal-ventral axis, however, corresponds quite well with samples from available single unit recording studies. Several explanations for the two- to-threefold reduction in spatial behavior-driven cell activity in the ventral hippocampus can be offered. These include anatomical connectivity differences, differential gain of the self-motion signals that appear to alter the scale of place fields and the proportion of active cells, and possibly variations in the neuronal responses to non-spatial information within the hippocampus along its dorso-ventral axis.

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Authors
Chawla, M. K., Sutherland, V. L., Olson, K., McNaughton, B. L., & Barnes, C. A.
Affiliations
  • University of Arizona (US)
  • National Institute of Environmental Health Sciences (US)
  • University of Lethbridge (CA)
Corresponding author
Barnes, C. A.
Venue
Hippocampus
Publisher
Wiley
Published
2018-01-10
Volume
28
Issue
2
Pages
178-185
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
OpenAlex
W2775830737
Cited by
49
References
65
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 10 · 2021: 12 · 2020: 4 · 2019: 8 · 2018: 3
FWCI
2.36
Type
journal article
Language
en
Open access
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Evelyn F. McKnight Brain Research Foundation (AG09219, MH060123, NSF1631465)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Arc expression, ventral hippocampus, dorsal-ventral axis, spatial behavior, place cells, hippocampal subfields, CA1, CA3, dentate gyrus, neuroplasticity, self-motion signals
MeSH terms
Analysis of Variance, Animals, Cytoskeletal Proteins, Gene Expression Regulation, Hippocampus, Male, Nerve Tissue Proteins, Neurons, Rats, Inbred F344, RNA, Messenger, Spatial Behavior, Microscopy, Confocal, Rats

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