Behavior‐driven arc expression is reduced in all ventral hippocampal subfields compared to CA1, CA3, and dentate gyrus in rat dorsal hippocampus
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Anatomical connectivity and lesion studies reveal distinct functional heterogeneity along the dorsal-ventral axis of the hippocampus. The immediate early gene Arc is known to be involved in neural plasticity and memory and can be used as a marker for cell activity that occurs, for example, when hippocampal place cells fire. We report here, that Arc is expressed in a greater proportion of cells in dorsal CA1, CA3, and dentate gyrus (DG), following spatial behavioral experiences compared to ventral hippocampal subregions (dorsal CA1 = 33%; ventral CA1 = 13%; dorsal CA3 = 23%; ventral CA3 = 8%; and dorsal DG = 2.5%; ventral DG = 1.2%). The technique used here to obtain estimates of numbers of behavior-driven cells across the dorsal-ventral axis, however, corresponds quite well with samples from available single unit recording studies. Several explanations for the two- to-threefold reduction in spatial behavior-driven cell activity in the ventral hippocampus can be offered. These include anatomical connectivity differences, differential gain of the self-motion signals that appear to alter the scale of place fields and the proportion of active cells, and possibly variations in the neuronal responses to non-spatial information within the hippocampus along its dorso-ventral axis.
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The most dorsal clusters in CA1, CA3, and SUB show higher activity-dependent gene expression than ventral clusters.
“the most dorsal clusters in CA1, CA3 and SUB show high levels of activity-dependent gene expression compared to the ventral part”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Chawla et al., 2018
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Self-citationSeizure-Induced Arc mRNA Expression Thresholds in Rat Hippocampus and Perirhinal Cortex
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Self-citationThe dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway
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Self-citation
- Authors
- Chawla, M. K., Sutherland, V. L., Olson, K., McNaughton, B. L., & Barnes, C. A.
- Affiliations
- University of Arizona (US)
- National Institute of Environmental Health Sciences (US)
- University of Lethbridge (CA)
- Corresponding author
- Barnes, C. A.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2018-01-10
- Volume
- 28
- Issue
- 2
- Pages
- 178-185
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC5777901
- OpenAlex
- W2775830737
- Cited by
- 49
- References
- 65
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 10 · 2021: 12 · 2020: 4 · 2019: 8 · 2018: 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Evelyn F. McKnight Brain Research Foundation (AG09219, MH060123, NSF1631465)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Arc expression, ventral hippocampus, dorsal-ventral axis, spatial behavior, place cells, hippocampal subfields, CA1, CA3, dentate gyrus, neuroplasticity, self-motion signals
- MeSH terms
- Analysis of Variance, Animals, Cytoskeletal Proteins, Gene Expression Regulation, Hippocampus, Male, Nerve Tissue Proteins, Neurons, Rats, Inbred F344, RNA, Messenger, Spatial Behavior, Microscopy, Confocal, Rats
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