The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Importance of disrupted intestinal barrier in inflammatory bowel diseases
Abstract
The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and ulcerative colitis (UC), involves the interaction between environmental factors in the intestinal lumen and inappropriate host immune responses in genetically predisposed individuals. The intestinal mucosal barrier has evolved to maintain a delicate balance between absorbing essential nutrients while preventing the entry and responding to harmful contents. In IBD, disruptions of essential elements of the intestinal barrier lead to permeability defects. These barrier defects exacerbate the underlying immune system, subsequently resulting in tissue damage. The epithelial phenotype in active IBD is very similar in CD and UC. It is characterized by increased secretion of chloride and water, leading to diarrhea, increased permeability via both the transcellular and paracellular routes, and increased apoptosis of epithelial cells. The main cytokine that seems to drive these changes is tumor necrosis factor alpha in CD, whereas interleukin (IL)-13 may be more important in UC. Therapeutic restoration of the mucosal barrier would provide protection and prevent antigenic overload due to intestinal "leakiness." Here we give an overview of the key players of the intestinal mucosal barrier and review the current literature from studies in humans and human systems on mechanisms underlying mucosal barrier dysfunction in IBD.
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Cites
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Cited by
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Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia
Vanheel, H., Vicario, M., Vanuytsel, T., Van Oudenhove, L., Martinez, C., Keita, Å. V., Pardon, N., Santos, J., Söderholm, J. D., Tack, J., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303857 · Cited by 424
Self-citationRole of microbiota-derived short-chain fatty acids in cancer development and prevention
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Metadata
- Authors
- Salim, S. Y., & Söderholm, J. D.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01
- Volume
- 17
- Issue
- 1
- Pages
- 362-381
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W1993753740
- Cited by
- 602
- References
- 33
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- closed
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