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ATR–Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

Fujinaka, Y., Matsuoka, K., Iimori, M., Tuul, M., Sakasai, R., Yoshinaga, K., Saeki, H., Morita, M., Kakeji, Y., Gillespie, D. A., et al. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.11.005 · Cited by 27 · see citing works

N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells

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Double-strand breaks: When DNA repair events accidentally meet

藤井, 慎., Sobol, R. W., & Fuchs, R. P. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103303 · Cited by 26 · see citing works

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Ganesa, S., Sule, A. D., Sundaram, R. K., & Bindra, R. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-09614-x · Cited by 25 · see citing works

Celebrating DNA’s Repair Crew

Kunkel, T. A. (2015) · Cell · doi:10.1016/j.cell.2015.11.028 · Cited by 22 · see citing works

Mismatch repair-dependent metabolism of O 6 -methylguanine-containing DNA in Xenopus laevis egg extracts

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Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

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Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions

Tsaalbi‐Shtylik, A., Ferrás, C., Pauw, B., Hendriks, G., Temviriyanukul, P., Carlée, L., Calléja, F. M. G. R., van Hees‐Stuivenberg, S., Akagi, J., Iwai, S., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201408017 · Cited by 19 · see citing works

DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH)

Kemp, M. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.788406 · Cited by 17 · see citing works

Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-mCpG-Np95-Dnmt1 Axis

Wang, K.-Y., Chen, S. C.-C., Tsai, S., & Shen, C.-K. J. (2016) · Scientific Reports · doi:10.1038/srep37490 · Cited by 16 · see citing works

Claspin: From replication stress and DNA damage responses to cancer therapy

Azenha, D., Lopes, M. C., & Martins, T. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.10.007 · Cited by 13 · see citing works

Multiple ATR-Chk1 Pathway Proteins Preferentially Associate with Checkpoint-Inducing DNA Substrates

Yilmaz, S., Sancar, A., & Kemp, M. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022986 · Cited by 12 · see citing works

BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation

Justice, J., Needham, J. M., Verhalen, B., Jiang, M., & Thompson, S. R. (2022) · Journal of Virology · doi:10.1128/jvi.02028-21 · Cited by 8 · see citing works

OZF is a Claspin‐interacting protein essential to maintain the replication fork progression rate under replication stress

Feu, S., Unzueta, F., Llopis, A., Semple, J. I., Ercilla, A., Guaita‐Esteruelas, S., Jaumot, M., Freire, R., & Agell, N. (2020) · The FASEB Journal · doi:10.1096/fj.201901926r · Cited by 7 · see citing works

Accidental Encounter of Repair Intermediates in Alkylated DNA May Lead to Double-Strand Breaks in Resting Cells

藤井, 慎., & Fuchs, R. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158192 · Cited by 7 · see citing works

Cellular response to alkylating agent MNNG is impaired in STAT 1‐deficients cells

Koon, L. A., Lesage, D., Lemadre, E., Souissi, I., Fagard, R., Varin‐Blank, N., Fabre, E. E., & Schischmanoff, P. O. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12887 · Cited by 7 · see citing works

Interaction studies of muts and mutl with DNA containing the major cisplatin lesion and its mismatched counterpart under equilibrium and nonequilibrium conditions

Sedletska, Y., Culard, F., Midoux, P., & Malinge, J. (2013) · Biopolymers · doi:10.1002/bip.22232 · Cited by 5 · see citing works

Major Differences between Tumor and Normal Human Cell Fates after Exposure to Chemotherapeutic Monofunctional Alkylator

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Molecular Mechanisms and Functions of DNA Mismatch Repair

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DNA Mismatch Repair in Mammals

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Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPNPreprint

Hunter, J. E., Butterworth, J. A., Sellier, H., Luli, S., Floudas, A., Moore, A. J., Thomas, H. D., Campbell, K. J., Kenneth, N. S., Chiremba, R. T., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/358291 · Cited by 4 · see citing works

Replication across O6-methylguanine activates futile cycling of DNA mismatch repair attempts assisted by the chromatin-remodelling enzyme Smarcad1

Shigenobu-Ueno, K., Sakamoto, R., Kanatsu, E., Kawasoe, Y., & Takahashi, T. S. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvaf007 · Cited by 2 · see citing works

Claspin and Cancer: Where Are We Now?

Azenha, D., & Martins, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188828 · Cited by 2 · see citing works

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability

Simo‐Cheyou, E. R., Boni, J., Boulais, J., Carpio, E. P., Malina, A., Sherill-Rofe, D., Luo, V. M., Gonçalves, C., Bagci, H., Maters, A., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010495 · Cited by 2 · see citing works

FANCD2 counteracts O6-methylguanine-induced mismatch repair-dependent apoptosis

Morita, S., Fujikane, R., Uechi, Y., Matsuura, T., & Hidaka, M. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09682-4 · Cited by 2 · see citing works

DNA Alterations in Lynch Syndrome

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Cellular Responses to DNA Damage

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DNA mismatch repair in mammals

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Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicityPreprint

Ashour, M. E., Krekeler, E., Bhowmik, M. C., Kantar, H., Tsao, N., Herrera-Montávez, C., Tsai, M.-S., Zaher, M. S., Kadyrova, L. Y., Kadyrov, F. A., et al. (2026) · Genes & Development · doi:10.1101/gad.353661.126 · Cited by 1 · see citing works

ATR as a Therapeutic Target

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When mismatch repair met translesion synthesis

Tsaalbi‐Shtylik, A., Jansen, J. G., & de Wind, N. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1063288

DNA Damage Response Pathways in Cancer Predisposition and Progression

Ashour, M. E., El-Shafie, L., & El‐Khamisy, S. F. (2014) · Cancer metastasis · doi:10.1007/978-3-319-12136-9_3

Beta Actin Antibody Review and FAQs

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Biochemical and Cellular Studies of Human MSH2 ATPase Domain Mutants Support the Molecular Switch Model of Mismatch Repair In Vivo

Brown, G. D. (2014) · OpenCommons at University of Connecticut (University of Connecticut)

Hereditary CRC Syndromes

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Targeting ATR for Cancer Therapy: Profile and Expectations for ATR Inhibitors

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Understanding the biological functions of POPX2 phosphatase through its interactome

Kim, P. (2019) · doi:10.32657/10356/136952

Phospho-regulation of the DNA Damage Response Kinase ATR

Nam, E. A. (2011)

Regulation of the ATR Pathway in the Replication Stress Response

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MutS and DNA Function as a Clamp Loader for the MutL Sliding Clamp During Mismatch RepairPreprint

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Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence

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Induction d'un processus d'instabilité des microsatellites du génome dans des modèles murin et cellulaire : intérêt physiopathologique et clinique

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A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint

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Redundant mispair excision mechanisms in eukaryotic DNA mismatch repair

Putnam, C. D., & Kolodner, R. D. (2026) · Nucleus · doi:10.1080/19491034.2026.2741514

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR‐Chk1 pathway

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ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts

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Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1

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MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

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Mismatch repair-dependent G₂ checkpoint induced by low doses of S_N1 type methylating agents requires the ATR kinase

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