The DOI matches its Crossref record; 30 of the 33 references it cites were found in a registry or an index.
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
Open accessAbstract
Peroxisome proliferators are a diverse group of chemicals, including several hypolipidaemic drugs, that activate a nuclear hormone receptor termed the peroxisome proliferator activated receptor (PPAR). The peroxisomal enzyme acyl CoA oxidase (ACO) is the most widely used marker of peroxisome proliferator action. We have examined the 5' flanking region of the rat ACO gene for sequences that mediate the transcriptional effect of peroxisome proliferators and have identified an element located 570 bp upstream of the ACO gene that confers responsiveness to the hypolipidaemic peroxisome proliferator Wy-14,643. This peroxisome proliferator response element (PPRE) contains a direct repeat of the sequence motifs TGACCT and TGTCCT and binds PPAR. These data therefore indicate an important role of PPAR in mediating the action of peroxisome proliferators including the induction of ACO.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“PPAR␥ heterodimerizes with RXRs (Tugwood et al., 1992), and, during ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Tugwood et al., 1992
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“PPAR␥ heterodimerizes with RXRs (Tugwood et al., 1992), and, during ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Tugwood et al., 1992
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS
Berry, M. N., & Friend, D. S. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.43.3.506 · Cited by 4,407
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Self-citationUmesono, K., Murakami, K. K., Thompson, C. C., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90020-y · Cited by 1,688
Lazarow, P. B., & de Duve, C. (1976) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.73.6.2043 · Cited by 1,044
Nuclear receptors enhance our understanding of transcription regulation
Green, S., & Chambon, P. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90108-4 · Cited by 1,042
Self-citationIdentification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene
de Thé, H., Vivanco, M. D., Tiollais, P., Stunnenberg, H. G., & Dejean, A. (1990) · Nature · doi:10.1038/343177a0 · Cited by 991
Reddy, J. K., Lalvvai, N. D., & Farber, E. (1983) · Critical Reviews in Toxicology · doi:10.3109/10408448309029317 · Cited by 879
Steroid Receptor Family: Structure and Functions
Carson, M. A., Schrader, W. T., & O’Malley, B. W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-201 · Cited by 813
Research works printed but not linked: 4
- Lazarow,P.B. and de Duve,C. (1976) Proc. Natl. Acad. Sci. USA, 73, 2043-2046.
- Reddy,J.K. Goel,S.K., Nemali,M.R., Carrino,J.J., Laffler,T.G., Reddy,M.K., Sperbeck,S.J., Osumi,T., Hashimoto,T., Lalwani,N.D. and Rao,M.S. (1986) Proc. Natl. Acad. Sci. USA, 83, 1747-1751.
- Ausubel,F.M., Brent,R., Kingston,R.E., Moore,D.D., Seidman,J.G., Smith,J.A. and Struhl,K. (eds) (1990) Current Protocols in Molecular Biology. Wiley, New York.
- Green,S. (1991) Biochem. Pharmacol., in press.
Cited by
Sorted by citations
Items 101–200 of 898
Berthou, L., Duverger, N., Emmanuel, F., Langouët, S., Auwerx, J. H., Guillouzo, A., Fruchart, J., Rubin, E. M., Denèfle, P., Staels, B., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118687 · Cited by 251
Zhao, X., Zhang, Y., Strong, R., Grotta, J. C., & Aronowski, J. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600233 · Cited by 246
Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?
Cattley, R. C., DeLuca, J. G., Elcombe, C. R., Fenner-Crisp, P. A., Lake, B. G., Marsman, D. S., Pastoor, T. A., Popp, J. A., Robinson, D. E., Schwetz, B. A., et al. (1998) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1997.1163 · Cited by 244
Self-citationVu‐Dac, N., Schoonjans, K., Laine, B., Fruchart, J., Auwerx, J. H., & Staels, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47383-8 · Cited by 244
Regulation of Cytokine Expression by Ligands of Peroxisome Proliferator Activated Receptors
Cunard, R. A., Ricote, M., DiCampli, D., Archer, D. C., Kahn, D. A., Glass, C. K., & Kelly, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2795 · Cited by 238
Latruffe, N., & Vamecq, J. (1997) · Biochimie · doi:10.1016/s0300-9084(97)81496-4 · Cited by 235
Boergesen, M., Pedersen, T. Å., Gross, B. S., van Heeringen, S. J., Hagenbeek, D., Bindesbøll, C., Caron, S., Lalloyer, F., Steffensen, K. R., Nebb, H. I., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06175-11 · Cited by 242
Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.
Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J. H., & Wahli, W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31420-5 · Cited by 233
Zhang, B., Marcus, S. L., Sajjadi, F. G., Alvares, K., Reddy, J. K., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7541 · Cited by 233
Tachibana, K., Yamasaki, D., Ishimoto, K., & Doi, T. (2008) · PPAR Research · doi:10.1155/2008/102737 · Cited by 238
Chawla, A., & Lazar, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1786 · Cited by 230
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans
Guan, Y., Zhang, Y., Davis, L. S., & Breyer, M. D. (1997) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1997.273.6.f1013 · Cited by 223
Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis
Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00234-1 · Cited by 228
A Paradigm for Gene Regulation: Inflammation, NF-κB and PPAR
Vanden Berghe, W., Vermeulen, L., Delerive, P., De Bosscher, K., Staels, B., & Haegeman, G. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_22 · Cited by 222
Watkins, P. A. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00004-0 · Cited by 222
The Peroxisome Proliferator‐activated Receptors: Ligands and Activatorsa
FORMAN, B. M., Chen, J., & Evans, R. M. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb18621.x · Cited by 220
Yang, W.-L. (2001) · Carcinogenesis · doi:10.1093/carcin/22.9.1379 · Cited by 217
Fibrates, Glitazones, and Peroxisome Proliferator–Activated Receptors
Lalloyer, F., & Staels, B. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179689 · Cited by 226
Zhang, J., Zhang, F., Didelot, X., Bruce, K. D., Cagampang, F. R. A., Vatish, M., Hanson, M. A., Lehnert, H., Ceriello, A., & Byrne, C. D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-478 · Cited by 223
Mader, S., Chen, J. Y., Chen, Z., White, J. H., Chambon, P., & Gronemeyer, H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06196.x · Cited by 216
Diascro, D. D., Vogel, R. L., Johnson, T. E., Witherup, K. M., Pitzenberger, S. M., Rutledge, S. J., Prescott, D. J., Rodan, G. A., & Schmidt, A. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.1.96 · Cited by 211
PPARs and the Cardiovascular System
Hamblin, M., Chang, L., Fan, Y., Zhang, J., & Chen, Y. E. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2280 · Cited by 210
Echeverría, F., Ortíz, M., Valenzuela, R., & Videla, L. A. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.10.001 · Cited by 211
Immunological functions of leptin and adiponectin
Carbone, F., Rocca, C. L., & Matarese, G. (2012) · Biochimie · doi:10.1016/j.biochi.2012.05.018 · Cited by 213
Holden, P. R., & Tugwood, J. D. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0220001 · Cited by 200
Self-citationLysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation
Zhang, C., Baker, D. L., Yasuda, S., Makarova, N., Balázs, L., Johnson, L. R., Marathe, G. K., McIntyre, T. M., Xu, Y., Prestwich, G. D., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031619 · Cited by 201
Oxidized phospholipids activate PPARα in a phospholipase A2‐dependent manner
Delerive, P., Furman, C., Teissier, E., Fruchart, J., Duriez, P., & Staels, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01364-8 · Cited by 209
Lambe, K. G., & Tugwood, J. D. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0001u.x · Cited by 200
Self-citationCross-Talk between Fatty Acid and Cholesterol Metabolism Mediated by Liver X Receptor-
Tobin, K. A. R., Steineger, H. H., Alberti, S., Spydevold, Ø. S., Auwerx, J. H., Gustafsson, J.-Α., & Nebb, H. I. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.5.0459 · Cited by 195
Three Peroxisome Proliferator-Activated Receptor Isotypes from Each of Two Species of Marine Fish
Leaver, M. J., Boukouvala, E., Antonopoulou, E., Díez, A., Favre‐Krey, L., Ezaz, T., Bautista, J. M., Tocher, D. R., & Krey, G. D. (2005) · Endocrinology · doi:10.1210/en.2004-1638 · Cited by 198
Liver regeneration versus direct hyperplasia
Columbano, A., & Shinozuka, H. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.10.8751714 · Cited by 186
Jennewein, C., von Knethen, A., Schmid, T., & Brüne, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.066399 · Cited by 183
Molecular mechanisms of lysophosphatidic acid action
Tigyi, G., & Parrill, A. L. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00035-3 · Cited by 181
Aldridge, T. C., Tugwood, J. D., & Green, S. (1995) · Biochemical Journal · doi:10.1042/bj3060473 · Cited by 183
Self-citationJiang, G., Nepomuceno, L., Hopkins, K. J., & Sladek, F. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.5131 · Cited by 179
Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulation
Johnson, E. F., Palmer, C. N. A., Griffin, K. J., & Hsu, M. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.11.8836037 · Cited by 177
Zhu, Y., Qi, C., Calandra, C., Rao, M. S. R., & Reddy, J. K. (1996) · Europe PMC (PubMed Central) · Cited by 178
PPARα alleviates iron overload‐induced ferroptosis in mouse liver
Xing, G., Meng, L., Cao, S., Liu, S., Wu, J., Li, Q., Huang, W., & Zhang, L. (2022) · EMBO Reports · doi:10.15252/embr.202052280 · Cited by 179
Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes
Blaschke, F., Takata, Y., Caglayan, E., Law, R. E., & Hsueh, W. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191663.12164.77 · Cited by 176
PPAR: a mediator of peroxisome proliferator action
Green, S. (1995) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(95)00136-0 · Cited by 178
Self-citationp300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33435 · Cited by 180
Shibata, N., Motoi, Y., Tomiyama, H., Ohnuma, T., Kuerban, B., Tomson, K., Komatsu, M., Shimazaki, H., Hattori, N., & Arai, H. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000351419 · Cited by 171
Ellinghaus, P., Wolfrum, C., Assmann, G., Spener, F., & Seedorf, U. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2766 · Cited by 174
Marcus, S. L., Miyata, K., Zhang, B., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5723 · Cited by 172
Li, S., Liu, C., Li, N., Hao, T., Han, T., HILL, D. E., Vidal, M., & Lin, J. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.013 · Cited by 170
Varanasi, U., Chu, R., Huang, Q. M., Castellon, R., Yeldandi, A. V., & Reddy, J. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2147 · Cited by 169
Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure
Portilla, D., Dai, G., Peters, J. M., Gonzalez, F. J., Crew, M. D., & Proia, A. D. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.4.f667 · Cited by 168
Burgermeister, E., Chuderland, D., Hanoch, T., Meyer, M., Liscovitch, M., & Seger, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00601-06 · Cited by 162
Peters, J. M. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.1989 · Cited by 160
The Role of PPAR α Activation in Liver and Muscle
Burri, L., Thoresen, G. H., & Berge, R. K. (2010) · PPAR Research · doi:10.1155/2010/542359 · Cited by 173
Roduit, R., Morin, J., Massé, F., Segall, L., Roche, E., Newgard, C. B., Assimacopoulos‐Jeannet, F., & Prentki, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006001200 · Cited by 160
Auwerx, J. H., Schoonjans, K., Fruchart, J., & Staels, B. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05854-6 · Cited by 158
Peroxisome proliferator-activated receptors: finding the orphan a home
Green, S., & Wahli, W. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90294-1 · Cited by 160
Self-citationPhysiological functions of peroxisome proliferator-activated receptor β
Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161
Seo, Y. S., Kim, J. H., Jo, N. Y., Choi, K. M., Baik, S. H., Park, J., Kim, J. J., Byun, K. S., Bak, Y., Lee, C. H., et al. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04819.x · Cited by 155
The Peroxisome Proliferator-activated Receptor α (PPARα) Regulates Bile Acid Biosynthesis
Hunt, M. C., Yang, Y., Eggertsen, G., Carneheim, C., Gåfvels, M. E., Einarsson, C., & Alexson, S. E. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002782200 · Cited by 155
Mechanisms of transactivation by retinoic acid receptors
Stunnenberg, H. G. (1993) · BioEssays · doi:10.1002/bies.950150504 · Cited by 155
Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
Larter, C. Z., & Farrell, G. C. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.11.030 · Cited by 155
Laurent, G., de Boer, V. C. J., Finley, L. W. S., Sweeney, M. O., Lu, H., Schug, T. T., Cen, Y., Jeong, S. M., Li, X., Sauve, A. A., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00087-13 · Cited by 158
Louet, J., Chatelain, F., Decaux, J., Park, E. A., Kohl, C., Pineau, T., Girard, J. R., & Pégorier, J. P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540189 · Cited by 154
Role of the Conjugated Linoleic Acid in the Prevention of Cancer
Lee, K. W., Lee, H. J., Cho, H. Y., & Kim, Y. J. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490911800 · Cited by 154
The peroxisome proliferator activated receptor regulates malic enzyme gene expression.
Castelein, H., Gulick, T., Declercq, P. E., Mannaerts, G. P., Moore, D. D., & Baes, M. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47083-4 · Cited by 153
Khan, S. A., & Heuvel, J. P. V. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00098-6 · Cited by 153
PPAR Tissue Distribution and Interactions with Other Hormone‐Signaling Pathwaysa
Lemberger, T., Braissant, O., Juge-Aubry, C. E., KELLER, H., Saladin, R., Staels, B., Auwerx, J. H., Burger, A., Meier, C. A., & Wahli, W. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb18619.x · Cited by 156
Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrier
Lim, D. C., & Pack, A. I. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.12.003 · Cited by 158
Kallwitz, E. R., McLachlan, A., & Cotler, S. J. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.22 · Cited by 152
Blanquart, C., Barbier, O., Fruchart, J., Staels, B., & Glineur, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110598200 · Cited by 133
Peroxisome Proliferator‐activated Receptors: Stuctures and Function
Tugwood, J. D., Aldridge, T. C., Lambe, K. G., MACDONALD, N., & Woodyatt, N. J. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb18620.x · Cited by 145
Self-citationRuyter, B., Andersen, Ø., Dehli, A., Farrants, A. Ö., Gjøen, T., & Thomassen, M. S. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00080-5 · Cited by 150
Steineger, H. H., Sørensen, H. N., Tugwood, J. D., Skrede, S., Spydevold, Ø. S., & Gautvik, K. M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.0967b.x · Cited by 144
Self-citationGervois, P. P., Delannoy, S., Fadel, A., Dubois, G., Kosykh, V., Fruchart, J., Najïb, J., Laudet, V., & Staels, B. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.3.0248 · Cited by 156
Lefebvre, A., Peinado‐Onsurbe, J., Leitersdorf, I., Briggs, M. R., Paterniti, J. R., Fruchart, J., Fiévet, C., Auwerx, J. H., & Staels, B. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.9.1756 · Cited by 143
Gervois, P. P., Pineda‐Torra, I., Chinetti, G., Grötzinger, T., Dubois, G., Fruchart, J., Fruchart‐Najib, J., Leitersdorf, E., & Staels, B. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0341 · Cited by 150
Uemura, T., Goto, T., Kang, M., Mizoguchi, N., Hirai, S., Lee, J.-Y., Nakano, Y., Shono, J., Hoshino, S., Taketani, K., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125591 · Cited by 143
Altered PPARγ expression and activation after transient focal ischemia in rats
Victor, N., Wanderi, E. W., Gamboa, J. L., Zhao, X., Aronowski, J. A., Deininger, K. M., Lust, W. D., Landreth, G. E., & Sundararajan, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05037.x · Cited by 143
Biochemistry of peroxisomes in health and disease
Singh, I. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006883229684 · Cited by 146
9-cis retinoic acid signaling: changing partners causes some excitement.Preprint
Leblanc, B. P., & Stunnenberg, H. G. (1995) · Genes & Development · doi:10.1101/gad.9.15.1811 · Cited by 146
Gao, Z., He, Q., Peng, B., Chiao, P. J., & Ye, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507784200 · Cited by 141
Fruchart, J.-C., Santos, R. D., Aguilar-Salinas, C., Aikawa, M., Al Rasadi, K., Amarenco, P., Barter, P. J., Ceska, R., Corsini, A., Després, J.-P., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0864-7 · Cited by 140
Roberts, R. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.43 · Cited by 140
Karpichev, I. V., & Small, G. M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6560 · Cited by 143
PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes
Martin, G., Schoonjans, K., Staels, B., & Auwerx, J. H. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00315-8 · Cited by 138
Heinlein, C. A., Ting, H., Yeh, S., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16147 · Cited by 135
Imakado, S., Bickenbach, J. R., Bundman, D. S., Rothnagel, J. A., Attar, P., Wang, X. J., Walczak, V., Wisniewski, S., Pote, J., & Gordon, J. S. (1995) · Genes & Development · doi:10.1101/gad.9.3.317 · Cited by 137
Peroxisome Proliferator-Activated Receptors (PPARs) and the Human Skin
Sertznig, P., Seifert, M., Tilgen, W., & Reichrath, J. (2008) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200809010-00002 · Cited by 135
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15901 · Cited by 139
Regulation of stearoyl‐CoA desaturase expression
Ntambi, J. M., Miyazaki, M., & Dobrzyń, A. (2004) · Lipids · doi:10.1007/s11745-004-1331-2 · Cited by 136
Peroxisome proliferator-activated receptor-$gamma; ligands as cell-cycle modulators
Theocharis, S., Margeli, A. P., Vielh, P. R., & Kouraklis, G. P. (2004) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2004.04.004 · Cited by 138
Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3)
Pibiri, M., Ledda‐Columbano, G. M., Cossu, C., Simbula, G., Menegazzi, M., Shinozuka, H., & Columbano, A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0416com · Cited by 135
Dietary polyunsaturated fatty acid regulation of gene transcription
Jump, D. Β., Clarke, S. D., Thelen, A. P., Liimatta, M. B., Ren, B., & Badin, M. V. (1996) · Progress in Lipid Research · doi:10.1016/s0163-7827(96)00007-0 · Cited by 133
Fernyhough, M. E., Okine, E. K., Hausman, G., VIERCK, J. L., & Dodson, M. V. (2007) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2007.05.001 · Cited by 133
Djouadi, F., Brandt, J. M., Weinheimer, C. J., Leone, T. C., Gonzalez, F. J., & Kelly, D. P. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(99)80009-x · Cited by 133
Bogazzi, F., Hudson, L. D., & Nikodem, V. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32624-8 · Cited by 133
Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice
Rosa, A. O., Kaster, M. P., Binfaré, R. W., Morales, S., Martı́n-Aparicio, E., Navarro-Rico, M. L., Martı́nez, A., Medina, M., Garcı́a, A. G., López, M. G., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.020 · Cited by 132
Peroxisome Proliferator-Activated Receptor γ: Implications for Cardiovascular Disease
Hsueh, W. A., & Bruemmer, D. (2004) · Hypertension · doi:10.1161/01.hyp.0000113626.76571.5b · Cited by 129
Belury, M. A., Moya-Camarena, S. Y., Liu, K.-L., & Heuvel, J. P. V. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00093-4 · Cited by 130
Bishop‐Bailey, D., & Wray, J. A. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(03)00003-0 · Cited by 131
Role of adiponectin in the regulation of carbohydrate and lipid metabolism.
Karbowska, J., & Kochan, Z. (2006) · PubMed · Cited by 126
Dalen, K. T., Ulven, S. M., Arntsen, B. M., Solaas, K., & Nebb, H. I. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500459-jlr200 · Cited by 129
Heuvel, J. P. V. (1999) · Journal of Nutrition · doi:10.1093/jn/129.2.575s · Cited by 126
Metadata
- Authors
- Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S.
- Venue
- The EMBO Journal
- Published
- 1992-02-01
- Volume
- 11
- Issue
- 2
- Pages
- 433-439
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC556472
- OpenAlex
- W98247596
- Cited by
- 895
- References
- 33
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 16 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 24 · 2013: 27 · 2012: 16
- FWCI
- 20.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- peroxisome proliferator-activated receptors, peroxisome proliferators, acyl-CoA oxidase, peroxisome proliferator response element, 5'-flanking region, transcriptional regulation, Wy-14,643, hypolipidaemic drugs
- MeSH terms
- Animals, Anticholesteremic Agents, Base Sequence, Binding Sites, Cell Line, Humans, Kinetics, Methylation, Microbodies, Molecular Sequence Data, Oligodeoxyribonucleotides, Oxidoreductases, Plasmids, Promoter Regions, Genetic, Pyrimidines, Repetitive Sequences, Nucleic Acid, Transfection, Chloramphenicol O-Acetyltransferase, Baculoviridae, Acyl-CoA Oxidase, Fatty Acid Desaturases, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
