Cited by 898Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid MetabolismNuclear Receptors and Signaling

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The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene

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Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, W.L., Green, S.·1992·The EMBO Journal

DOI 10.1002/j.1460-2075.1992.tb05072.xPMC PMC556472

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Abstract

Peroxisome proliferators are a diverse group of chemicals, including several hypolipidaemic drugs, that activate a nuclear hormone receptor termed the peroxisome proliferator activated receptor (PPAR). The peroxisomal enzyme acyl CoA oxidase (ACO) is the most widely used marker of peroxisome proliferator action. We have examined the 5' flanking region of the rat ACO gene for sequences that mediate the transcriptional effect of peroxisome proliferators and have identified an element located 570 bp upstream of the ACO gene that confers responsiveness to the hypolipidaemic peroxisome proliferator Wy-14,643. This peroxisome proliferator response element (PPRE) contains a direct repeat of the sequence motifs TGACCT and TGTCCT and binds PPAR. These data therefore indicate an important role of PPAR in mediating the action of peroxisome proliferators including the induction of ACO.

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Authors: Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1992-02-01
Volume: 11
Issue: 2
Pages: 433-439
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1992.tb05072.x
PMC: PMC556472
OpenAlex: W98247596
Cited by: 895
References: 33
Citations by year: 2026: 5 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 16 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 24 · 2013: 27 · 2012: 16
FWCI: 20.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: peroxisome proliferator-activated receptors, peroxisome proliferators, acyl-CoA oxidase, peroxisome proliferator response element, 5'-flanking region, transcriptional regulation, Wy-14,643, hypolipidaemic drugs
MeSH terms: Animals, Anticholesteremic Agents, Base Sequence, Binding Sites, Cell Line, Humans, Kinetics, Methylation, Microbodies, Molecular Sequence Data, Oligodeoxyribonucleotides, Oxidoreductases, Plasmids, Promoter Regions, Genetic, Pyrimidines, Repetitive Sequences, Nucleic Acid, Transfection, Chloramphenicol O-Acetyltransferase, Baculoviridae, Acyl-CoA Oxidase, Fatty Acid Desaturases, Rats

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The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene

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