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The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
Open accessAbstract
Peroxisome proliferators are a diverse group of chemicals, including several hypolipidaemic drugs, that activate a nuclear hormone receptor termed the peroxisome proliferator activated receptor (PPAR). The peroxisomal enzyme acyl CoA oxidase (ACO) is the most widely used marker of peroxisome proliferator action. We have examined the 5' flanking region of the rat ACO gene for sequences that mediate the transcriptional effect of peroxisome proliferators and have identified an element located 570 bp upstream of the ACO gene that confers responsiveness to the hypolipidaemic peroxisome proliferator Wy-14,643. This peroxisome proliferator response element (PPRE) contains a direct repeat of the sequence motifs TGACCT and TGTCCT and binds PPAR. These data therefore indicate an important role of PPAR in mediating the action of peroxisome proliferators including the induction of ACO.
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“PPAR␥ heterodimerizes with RXRs (Tugwood et al., 1992), and, during ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Tugwood et al., 1992
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In the citing paper
“PPAR␥ heterodimerizes with RXRs (Tugwood et al., 1992), and, during ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Tugwood et al., 1992
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Metadata
- Authors
- Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S.
- Venue
- The EMBO Journal
- Published
- 1992-02-01
- Volume
- 11
- Issue
- 2
- Pages
- 433-439
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC556472
- OpenAlex
- W98247596
- Cited by
- 895
- References
- 33
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 16 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 24 · 2013: 27 · 2012: 16
- FWCI
- 20.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- peroxisome proliferator-activated receptors, peroxisome proliferators, acyl-CoA oxidase, peroxisome proliferator response element, 5'-flanking region, transcriptional regulation, Wy-14,643, hypolipidaemic drugs
- MeSH terms
- Animals, Anticholesteremic Agents, Base Sequence, Binding Sites, Cell Line, Humans, Kinetics, Methylation, Microbodies, Molecular Sequence Data, Oligodeoxyribonucleotides, Oxidoreductases, Plasmids, Promoter Regions, Genetic, Pyrimidines, Repetitive Sequences, Nucleic Acid, Transfection, Chloramphenicol O-Acetyltransferase, Baculoviridae, Acyl-CoA Oxidase, Fatty Acid Desaturases, Rats
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