The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719

The Steroid and Thyroid Hormone Receptor Superfamily

Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

Berry, M. N., & Friend, D. S. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.43.3.506 · Cited by 4,407

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

Umesono, K., Murakami, K. K., Thompson, C. C., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90020-y · Cited by 1,688

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

Lazarow, P. B., & de Duve, C. (1976) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.73.6.2043 · Cited by 1,044

Nuclear receptors enhance our understanding of transcription regulation

Green, S., & Chambon, P. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90108-4 · Cited by 1,042

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

de Thé, H., Vivanco, M. D., Tiollais, P., Stunnenberg, H. G., & Dejean, A. (1990) · Nature · doi:10.1038/343177a0 · Cited by 991

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

Reddy, J. K., Lalvvai, N. D., & Farber, E. (1983) · Critical Reviews in Toxicology · doi:10.3109/10408448309029317 · Cited by 879

Steroid Receptor Family: Structure and Functions

Carson, M. A., Schrader, W. T., & O’Malley, B. W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-201 · Cited by 813

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,115

Untitled work

(1998) · PubMed · Cited by 2,737

The mechanisms of action of PPARs

Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., & Evans, R. M. (1992) · Nature · doi:10.1038/358771a0 · Cited by 1,746

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,402

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Xu, C., Li, C. Y.-T., & Kong, A. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,310

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

Lluis Fajas, A., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A., Saladin, R., Najib, J., Laville, M., Fruchart, J., Deeb, S. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18779 · Cited by 1,188

PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

Schoonjans, K., Peinado‐Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., & Auwerx, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00918.x · Cited by 1,173

Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring

Lillycrop, K. A., Phillips, E. S., Jackson, A. A., Hanson, M. A., & Burdge, G. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1382 · Cited by 1,139

Molecular Cues to Implantation

Dey, S. K., Lim, H. J., Das, S. K., Reese, J., Paria, B. C., Daikoku, T., & Wang, H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0020 · Cited by 1,120

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

He, T., Chan, T. A.-T., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,083

The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

Schoonjans, K., Staels, B., & Auwerx, J. H. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00066-5 · Cited by 1,045

International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

Michalik, L., Auwerx, J. H., Berger, J. P., Chatterjee, K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O’Rahilly, S., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.5 · Cited by 1,022

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

Keller, H., Dreyer, C., Medin, J. A., Mahfoudi, A., Ozato, K., & Wahli, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2160 · Cited by 944

Emerging roles of PPARS in inflammation and immunity

Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 926

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

Bougarne, N., Weyers, B., Desmet, S. J., Deckers, J., Ray, D. W., Staels, B., & De Bosscher, K. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00064 · Cited by 898

Retinoids in Embryonal Development

Ross, S. A., McCaffery, P. J. A., Dräger, U. C., & Luca, L. M. D. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1021 · Cited by 866

Orphan Nuclear Receptors: From Gene to Function

Giguère, V. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0378 · Cited by 871

Multiplicity generates diversity in the retinoic acid signalling pathways

Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

Glass, C. K. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-391 · Cited by 820

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 858

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

Lemberger, T., Desvergne, B., & Wahli, W. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.335 · Cited by 709

Embryo Implantation

Carson, D. D., Bagchi, I. C., Dey, S., Enders, A. C., Fazleabas, A. T., Lessey, B. A., & Yoshinaga, K. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9767 · Cited by 690

Integrated physiology and systems biology of PPARα

Kersten, S. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.002 · Cited by 701

Peroxisome proliferator-activated receptors in inflammation control

Delerive, P., Fruchart, J., & Staels, B. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690453 · Cited by 755

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdeltaPreprint

Lim, H. J., Gupta, R. A., Ma, W., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., & Dey, S. K. (1999) · Genes & Development · doi:10.1101/gad.13.12.1561 · Cited by 588

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782

The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.

Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 567

Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications

Mirza, A. Z., Althagafi, I. I., & Shamshad, H. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.067 · Cited by 563

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

Yoon, M. J., Lee, G. Y., Chung, J.-J., Ahn, Y. H., Hong, S. H., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1322 · Cited by 546

Control of Macrophage Activation and Function by PPARs

Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531

β-Oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: A century of continued progress

Kunau, W. H. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(95)00011-9 · Cited by 516

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus

Wolfrum, C., Borrmann, C. M., Börchers, T., & Spener, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051619898 · Cited by 506

Peroxisome Proliferator-Activated Receptor Activators Inhibit Thrombin-Induced Endothelin-1 Production in Human Vascular Endothelial Cells by Inhibiting the Activator Protein-1 Signaling Pathway

Delerive, P., Martin‐Nizard, F., Chinetti, G., Trottein, F., Fruchart, J., Najïb, J., Duriez, P., & Staels, B. (1999) · Circulation Research · doi:10.1161/01.res.85.5.394 · Cited by 509

A New Orphan Member of the Nuclear Hormone Receptor Superfamily That Interacts with a Subset of Retinoic Acid Response Elements

Baes, M. I., Gulick, T., Choi, H.-S., Martinoli, M., Simha, D., & Moore, D. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1544 · Cited by 496

Central Role of Pparα–Dependent Hepatic Lipid Turnover in Dietary Steatohepatitis in Mice

Ip, E., Farrell, G. C., Robertson, G., Hall, P., Kirsch, R., & Leclercq, I. (2003) · Hepatology · doi:10.1053/jhep.2003.50307 · Cited by 476

Differential activation of adipogenesis by multiple PPAR isoforms.Preprint

Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 480

Nuclear Receptor Signaling and Cardiac Energetics

Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 474

Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ

Tontonoz, P., Hu, E., & Spiegelman, B. M. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80025-5 · Cited by 462

Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

Gervois, P. P., Fruchart, J., Delerive, P., & Staels, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004045200 · Cited by 459

Peroxisome proliferator activated receptor-alpha expression in human liver.

Palmer, C. N., Hsu, M. H., Griffin, K. J., Raucy, J. L., & Johnson, E. F. (1998) · PubMed · Cited by 448

N-3 polyunsaturated fatty acid regulation of hepatic gene transcription

Jump, D. B. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ffaf6a · Cited by 443

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Tateishi, K., Okada, Y., Kallin, E. M., & Zhang, Y. (2009) · Nature · doi:10.1038/nature07777 · Cited by 442

Neuroinflammatory processes in Alzheimer’s disease

Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

Sastre, M., Klockgether, T., & Heneka, M. T. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.014 · Cited by 426

Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2

Bishop‐Bailey, D., & Hla, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17042 · Cited by 420

Peroxisome Proliferator Activated Receptor-α Expression in Human Liver

Palmer, C. N. A., Hsu, M.-H., Griffin, K. J., Raucy, J. L., & Johnson, E. F. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.14 · Cited by 494

Protein Import into Peroxisomes and Biogenesis of the Organelle

Subramani, S. E. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.002305 · Cited by 415

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

Staels, B., Vu-Dac, N., Kosykh, V. A., Saladin, R., Fruchart, J. C., Dallongeville, J., & Auwerx, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117717 · Cited by 410

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410

Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

Greene, M. E., Blumberg, B., McBride, O. W., Yi, H., Kronquist, K. E., Kwan, K. W., Hsieh, L., Greene, G. L., & Nimer, S. D. (1995) · Europe PMC (PubMed Central) · Cited by 399

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.

Vu‐Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J., Staels, B., & Auwerx, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118118 · Cited by 403

Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα

Moya-Camarena, S. Y., Heuvel, J. P. V., Blanchard, S. G., Leesnitzer, L. M., & Belury, M. A. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33384-8 · Cited by 401

The role and regulation of the peroxisome proliferator activated receptor alpha in human liver

Kersten, S., & Stienstra, R. (2017) · Biochimie · doi:10.1016/j.biochi.2016.12.019 · Cited by 405

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

Gearing, K. L., Göttlicher, M., Teboul, M., Widmark, E., & Gustafsson, J.-Α. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1440 · Cited by 400

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter

Schoonjans, K., 渡辺, 光., Suzuki, H., Mahfoudi, A., Krey, G. D., Wahli, W., Grimaldi, P. A., Staels, B., Yamamoto, T. T., & Auwerx, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19269 · Cited by 393

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491

PPARα: Energy Combustion, Hypolipidemia, Inflammation and Cancer

Pyper, S. R., Viswakarma, N., Yu, S., & Reddy, J. K. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08002 · Cited by 395

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

Rodríguez, J. C., Gil‐Gómez, G., Hegardt, F. G., & Haro, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32234-2 · Cited by 378

DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements

Juge-Aubry, C. E., Pernin, A., Favez, T., Burger, A., Wahli, W., Meier, C. A., & Desvergne, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25252 · Cited by 385

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis

Hegardt, F. G. (1999) · Biochemical Journal · doi:10.1042/bj3380569 · Cited by 375

Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503839103 · Cited by 373

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

Zhu, Y., Alvares, K., Huang, Q. M., Rao, M. S. R., & Reddy, J. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74184-2 · Cited by 373

Peroxisome Proliferator-Activated Receptors

Schiffrin, E. L., Amiri, F., Benkirane, K., Iglarz, M., & Diep, Q. N. (2003) · Hypertension · doi:10.1161/01.hyp.0000084370.74777.b6 · Cited by 370

Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

Omiecinski, C. J., Heuvel, J. P. V., Perdew, G. H., & Peters, J. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq338 · Cited by 385

Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes

Amri, E., Bonino, F., Ailhaud, G. P., Abumrad, N. A., & Grimaldi, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2367 · Cited by 375

Conjugated linoleic acid modulates hepatic lipid composition in mice

Belury, M. A., & Kempa-Steczko, A. (1997) · Lipids · doi:10.1007/s11745-997-0025-0 · Cited by 367

Peroxisome proliferator‐activated receptors in the cardiovascular system

Bishop‐Bailey, D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703149 · Cited by 365

Cytoplasmic fatty acid-binding proteins: Their structure and genes

Veerkamp, J. H., & Maatman, R. G. H. J. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(94)00005-7 · Cited by 352

Xenobiotic-inducible Transcription of Cytochrome P450 Genes

Denison, M. S., & Whitlock, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18175 · Cited by 354

Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA

IJpenberg, A., Jeannin, E., Wahli, W., & Desvergne, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20108 · Cited by 363

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338

Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

Hertz, R., Bishara-Shieban, J., & Bar‐Tana, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13470 · Cited by 340

The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

Yoon, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.004 · Cited by 336

Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

Lemberger, T., Saladin, R., Vázquez‐Carrera, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., & Auwerx, J. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1764 · Cited by 326

PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-12.2012 · Cited by 326

MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation

Zhou, J., Wang, K.-C., Wu, W., Subramaniam, S., Shyy, J. Y.-J., Chiu, J., Li, J. Y.-S., & Chien, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107052108 · Cited by 325

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

Ashby, J., Brady, A. M., Elcombe, C. R., ELLIOTT, B. M., Ishmael, J., Odum, J., Tugwood, J. D., Kettle, S., & Purchase, I. F. H. (1994) · Human & Experimental Toxicology · doi:10.1177/096032719401300201 · Cited by 314

Conjugated linoleic acid and obesity control: efficacy and mechanisms

Wang, Y. W., & Jones, P. J. H. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802641 · Cited by 312

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41738-3 · Cited by 306

Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver to Suppress Body Fat Accumulation

Kondo, T., Kishi, M., Fushimi, T., & Kaga, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900470c · Cited by 301

The cytochrome P450 4 (CYP4) family

Simpson, A. E. C. M. (1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(96)00246-7 · Cited by 298

Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease

Guan, Y., & Breyer, M. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00766.x · Cited by 292

Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells

Meade, E. A., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8328 · Cited by 292

Fatty Acid Flip-Flop in Phospholipid Bilayers Is Extremely Fast

Kamp, F., Zakim, D., Zhang, F., Noy, N., & Hamilton, J. A. (1995) · Biochemistry · doi:10.1021/bi00037a034 · Cited by 292

Nuclear Receptors and Their Selective Pharmacologic Modulators

Burris, T. P., Solt, L. A., Wang, Y., Crumbley, C., Banerjee, S., Griffett, K., Lundåsen, T., Hughes, T., & Kojetin, D. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006833 · Cited by 304

Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)

Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G. D., & Wahli, W. (1993) · Biology of the Cell · doi:10.1016/s0248-4900(05)80176-5 · Cited by 292

Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors

DiRenzo, J., Söderström, M., Kurokawa, R., Ogliastro, M.-H., Ricote, M., Ingrey, S., Hörlein, A., Rosenfeld, M. G., & Glass, C. K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2166 · Cited by 288

Novel Sequence Determinants in Peroxisome Proliferator Signaling

Palmer, C. N. A., Hsu, M., Griffin, K. J., & Johnson, E. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.16114 · Cited by 282

Hepatic peroxisome proliferation in rodents and its significance for humans

Bentley, P., Calder, I. C., Elcombe, C. R., GRASSO, P., Stringer, D. A., & Wiegand, H.-J. (1993) · Food and Chemical Toxicology · doi:10.1016/0278-6915(93)90225-n · Cited by 271

Identification of a Functional Peroxisome Proliferator-responsive Element in the Murine Fatty Acid Transport Protein Gene

Frohnert, B. I., Hui, T. Y., & Bernlohr, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.3970 · Cited by 265

Atherogenic Diet and Minimally Oxidized Low Density Lipoprotein Inhibit Osteogenic and Promote Adipogenic Differentiation of Marrow Stromal Cells

Parhami, F., Jackson, S. M., Tintut, Y., Le, V. L., Balucan, J. P., Territo, M., & Demer, L. L. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2067 · Cited by 259

Identification of a Functional Peroxisome Proliferator-Activated Receptor Response Element in the Rat Catalase Promoter

Girnun, G. D., Domann, F. E., Moore, S. A., & Robbins, M. E. C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0020 · Cited by 259

Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα

Tahri-Joutey, M., Andreoletti, P., Surapureddi, S., Nasser, B., Cherkaoui‐Malki, M., & Latruffe, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168969 · Cited by 273

Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.

Miller, C. W., & Ntambi, J. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9443 · Cited by 259

Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di(2-ethylhexyl)phthalate (DEHP) in Peroxisome Proliferator-Activated Receptorα-Null Mice

Ward, J. M., Peters, J. M., Perella, C. M., & Gonzalez, F. J. (1998) · Toxicologic Pathology · doi:10.1177/019262339802600208 · Cited by 253

Identification of a Peroxisome Proliferator-responsive Element Upstream of the Human Peroxisomal Fatty Acyl Coenzyme A Oxidase Gene

Varanasi, U., Chu, R., Huang, Q. M., Castellon, R., Yeldandi, A. V., & Reddy, J. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2147 · Cited by 169

Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter

Lambe, K. G., Woodyatt, N. J., Macdonald, N., Chevalier, S., & Roberts, R. A. (1999) · Toxicology Letters · doi:10.1016/s0378-4274(99)00151-4 · Cited by 60

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

Osumi, T., Wen, J., & Hashimoto, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91645-s · Cited by 197

ResearchArticle Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene

Liu, Y., Fumoto, T., Motojima, K., Yamaguchi, T., Hirose, F., & Osumi, T. (2006)

Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.

Zhang, B., Marcus, S. L., Sajjadi, F. G., Alvares, K., Reddy, J. K., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7541 · Cited by 233