Cited by 117Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsSexual Differentiation and Disorders

Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report

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Cherrier, Monique M., Craft, Suzanne, Matsumoto, Alvin H.·2003·Journal of Andrology

Abstract

ABSTRACT: This study prospectively examined changes in cognition in hypogonadal men given testosterone (T) or older hypogonadal men given dihydrotestosterone (DHT) gel. A battery of cognitive tests assessing verbal and spatial memory, language, and attention was administered at baseline (prior to medication) and again at days 90 and 180 of treatment for men receiving T gel and at baseline and days 30 and 90 of treatment for men receiving DHT gel. For men receiving T gel, circulating total T and estradiol (E 2) were significantly raised compared with baseline, and a significant improvement in verbal memory was observed. For men receiving DHT gel, serum DHT levels increased and T levels decreased significantly compared with baseline, and a significant improvement in spatial memory was observed. The results suggest that beneficial changes in cognition can occur in hypogonadal men using T replacement levels and DHT treatment, and these changes in cognition can be reliably measured during a relative steady‐state dose level. Further, our results suggest that aromatization of T to E 2 may regulate verbal memory in men, whereas nonaromatizable androgens may regulate spatial memory.

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Authors
Cherrier, M. M., Craft, S., & Matsumoto, A. H.
Affiliations
University of Washington (US)
Corresponding author
Cherrier, Monique M.
Venue
Journal of Andrology
Publisher
Wiley
Published
2003-07-08
Volume
24
Issue
4
Pages
568-576
ISSN
  • 0196-3635 (ISSN-L)
  • 1939-4640
OpenAlex
W1661237936
Cited by
117
References
82
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 6
FWCI
3.46
Type
journal article
Language
en
Open access
Locations
  • Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG00858)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
testosterone replacement therapy, dihydrotestosterone, hypogonadism, cognitive function, verbal memory, spatial memory, estradiol, aromatization, androgens, attention, language
MeSH terms
Adult, Aged, Androgens, Attention, Cognition, Humans, Hypogonadism, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Space Perception, Dihydrotestosterone, Testosterone, Verbal Learning

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