Vasculature reconstruction of decellularized liver scaffolds via gelatin‐based re‐endothelialization
Abstract
Decellularized liver scaffolds based liver engineering is a promising approach toward developing functional liver surrogates. However, a major obstacle to long‐term transplantation is the hemocompatibility of the bioengineered liver surrogates. One approach to improve the hemocompatibility of engineered liver surrogates is re‐endothelialization. In the current study, immortalized endothelial cells were perfused for re‐endothelialization of decellularized rat liver scaffolds. When compared to the media‐based perfusion approach, gelatin hydrogels‐based perfusion significantly increased the number of cells that were retained in the decellularized liver scaffolds and the vascular lumen coverage ratio. Endothelial cells were lining along the vasculatures of the decellularized liver scaffolds and actively proliferating. Re‐endothelialization improved the blood retention ability of the liver scaffold vasculatures. Doppler ultrasound detected active blood flows within the re‐endothelialized liver scaffold transplants 8 days post‐transplantation. Our results strengthened the feasibility of developing bioengineered liver surrogates utilizing decellularized liver scaffolds. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 392–402, 2019.
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The endothelial layer reduces the risk of blood coagulation and protects the hepatocytes from shear stress resulting from blood flow outside the vascular spaces.
“This endothelial layer reduces the risk of blood coagulation and protects the hepatocytes from shear stress resulting from blood flow outside the vascular spaces [9,10,108,168].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [108]
Perfusing endothelial cells in gelatin hydrogel significantly increases retention of injected endothelial cells within decellularized liver scaffolds, resulting in a higher vascular lumen perimeter coverage ratio compared to perfusing ECs in RPMI medium.
“They reported a significant increase in the retention of injected endothelial cells within the decellularized liver scaffolds, resulting in a higher vascular lumen perimeter coverage ratio compared to perfusing ECs in Roswell Park Memorial Institute (RPMI) medium.”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [108]
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- Authors
- Meng, F., Almohanna, F., Altuhami, A., Assiri, A. M., & Broering, D.
- Affiliations
- King Faisal Specialist Hospital & Research Centre (SA)
- Department of Comparative Medicine King Faisal Specialist Hospital and Research Centre Riyadh, 11211 Saudi Arabia
- Corresponding author
- Meng, Fanwei
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2018-12-03
- Volume
- 107
- Issue
- 2
- Pages
- 392-402
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2903311567
- Cited by
- 31
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 2
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- King Faisal Specialist Hospital and Research Centre
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- decellularized liver scaffold, re-endothelialization, gelatin hydrogel, hemocompatibility, blood retention, Doppler ultrasound, rat liver
- MeSH terms
- Animals, Biocompatible Materials, Gelatin, Liver, Liver Transplantation, Rats, Sprague-Dawley, Neovascularization, Physiologic, Tissue Engineering, Endothelial Cells, Cell Proliferation, Rats, Tissue Scaffolds
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