Cited by 2,287Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

The amazing osteocyte

Open access

Bonewald, Lynda F·2011·Journal of Bone and Mineral Research

Open this paper in CoChat — free account Open PDF

Abstract

The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell. The osteocyte is a source of soluble factors not only to target cells on the bone surface but also to target distant organs, such as kidney, muscle, and other tissues. This cell plays a role in both phosphate metabolism and calcium availability and can remodel its perilacunar matrix. Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment. As we age, these cells die, leaving behind empty lacunae that frequently micropetrose. In aged bone such as osteonecrotic bone, empty lacunae are associated with reduced remodeling. Inflammatory factors such as tumor necrosis factor and glucocorticoids used to treat inflammatory disease induce osteocyte cell death, but by different mechanisms with potentially different outcomes. Therefore, healthy, viable osteocytes are necessary for proper functionality of bone and other organs. © 2011 American Society for Bone and Mineral Research.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jbmr.320

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · cited 1×
“Sclerostin was thought to be a bone morphogenetic protein (BMP) antagonist but later was discovered to be involved in the Wnt pathway as an antagonist against lipoprotein receptor 5 (LRP5), a positive regulator of bone mass.((48,49)) Mechanical loading also has been reported to reduce sclerostin expression,((50)) as d…”
Background
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.115 · Cited by 1,318
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298
A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
Weinbaum, S., Cowin, S. C., & Zeng, Y. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90010-8 · Cited by 1,266
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199
Self-citation
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · cited 1×
“Mutations of SOST causes high bone mass in humans,((46)) as does deletion in mice.”
Background
Osteocytes, mechanosensing and Wnt signaling
Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076
Self-citation
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Poole, K. E. S., Van Bezooijen, R. L., Loveridge, N., Hamersma, H., Papapoulos, S. E., Löwik, C. W., & Reeve, J. (2005) · The FASEB Journal · doi:10.1096/fj.05-4221fje · Cited by 965

Flagged first, then by citations

Show all 107 references

Research works printed but not linked: 7

Parfitt, 1990, Bone. The Osteoblast and Osteocyte, 351
Guo, 2009, Mice with Targeted Deletion of E11/gp38 in Late Osteoblasts Have Reduced Canaliculi per Osteocyte Which May Be Responsible for The Enhanced Trabecular Bone Volume. FR0268, J Bone Min Res., S126
Qing, 2010, PTHR1 in Osteocytes Plays a Major role in Perilacunar Remodeling through the Activation of “Osteoclastic” Genes in Osteocytes, #1082J Bone Min Res., S25
Bonewald, 2007, Osteoporosis, 169
Qing, 2009, Osteocyte Perilacunar Remodeling Is Regulated Hormonally, but Not by Mechanical Unloading, Journal of Bone & Mineral Research., Mo0255
Potter, 2009, Raman spectroscopic characterization of bone tissue material properties around the osteocyte lacuna: effect of aging, J Bone Miner Res., Su0266
Xiao, 2009, Conditional deletion and/or disruption of Pkd1 in osteocytes results in a significant reduction in anabolic response to mechanical loading, J Bone Miner Res., #1042

Sorted by citations

Items 601–700 of 1,005

Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice
Wang, Y., Yan, Q., Zhao, Y., Liu, X. Z., Lin, S., Zhang, P., Ma, L., Lai, Y., Bai, X., Liu, C.-J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131692 · Cited by 44
Dentoalveolar Defects in the Hyp Mouse Model of X-linked Hypophosphatemia
Zhang, H., Chavez, M. B., Kolli, T. N., Tan, M. H., Fong, H. K., Chu, E. Y., Li, Y., Ren, X.-Z., Watanabe, K., Kim, D. G., et al. (2020) · Journal of Dental Research · doi:10.1177/0022034520901719 · Cited by 44
Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling
Bailey, K. N., Nguyen, J., Yee, C. S., Dole, N. S., Dang, A. C., & Alliston, T. N. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41548 · Cited by 47
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration
Tower, R. J., Busse, E., Jaramillo, J., Lacey, M., Hoffseth, K., Guntur, A. R., Simkin, J., & Sammarco, M. C. (2022) · eLife · doi:10.7554/elife.71542 · Cited by 43
Connexin 43 is a potential regulator in fluid shear stress‐induced signal transduction in osteocytes
Li, X., Liu, C., Li, P., Li, S., Zhao, Z., Chen, Y., Huo, B., & Zhang, D. (2013) · Journal of Orthopaedic Research® · doi:10.1002/jor.22448 · Cited by 43
Osteocyte Deficiency in Hip Fractures
Delgado‐Calle, J., Arozamena, J., García-Renedo, R. J., García‐Ibarbia, C., Pascual-Carra, M. A., González-Macías, J., & Riancho, J. A. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9522-0 · Cited by 43
Osteocytes exposed to far field of therapeutic ultrasound promotes osteogenic cellular activities in pre-osteoblasts through soluble factors
Fung, C.-H., Cheung, W., Pounder, N. M., Harrison, A. J., & Leung, K. (2014) · Ultrasonics · doi:10.1016/j.ultras.2014.02.003 · Cited by 43
Insights into the osteoblast precursor differentiation towards mature osteoblasts induced by continuous BMP-2 signaling
Zouani, O. F., Rami, L., Lei, Y., & Durrieu, M. (2013) · Biology Open · doi:10.1242/bio.20134986 · Cited by 43
Beneficial effects of δ-tocotrienol against oxidative stress in osteoblastic cells: studies on the mechanisms of action
Casati, L., Pagani, F., Limonta, P., Vanetti, C., Stancari, G., & Sibilia, V. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02047-9 · Cited by 43
Targeted nanomedicines for the treatment of bone disease and regeneration
Ordikhani, F., Zandi, N., Mazaheri, M., Luther, G. A., Ghovvati, M., Akbarzadeh, A., & Annabi, N. (2020) · Medicinal Research Reviews · doi:10.1002/med.21759 · Cited by 45
The Role of Irisin in Exercise-Mediated Bone Health
Liu, L., Guo, J., Chen, X., Tong, X., Xu, J., & Zou, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668759 · Cited by 43
Senescent cells: A therapeutic target for osteoporosis
Wang, T., Huang, S., & He, C. (2022) · Cell Proliferation · doi:10.1111/cpr.13323 · Cited by 47
Skeletal Adaptation to Intramedullary Pressure-Induced Interstitial Fluid Flow Is Enhanced in Mice Subjected to Targeted Osteocyte Ablation
Kwon, R. Y., Meays, D. R., Meilan, A. S., Jones, J. R., Miramontes, R., Kardos, N., Yeh, J.-C., & Frangos, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033336 · Cited by 45
Sympathetic Innervation Regulates Osteocyte‐Mediated Cortical Bone Resorption during Lactation
Guo, Q., Chen, N., Cheng, Q., Qi, C., Noller, K., Wan, M., Liu, X., Zhang, W., Cahan, P., & Cao, X. (2023) · Advanced Science · doi:10.1002/advs.202207602 · Cited by 49
Circadian Regulation of Bone Remodeling
Kikyo, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094717 · Cited by 43
Osteoclast‐like cells on deproteinized bovine bone mineral and biphasic calcium phosphate: light and transmission electron microscopical observations
Jensen, S. S., Gruber, R., Buser, D., & Bosshardt, D. D. (2014) · Clinical Oral Implants Research · doi:10.1111/clr.12376 · Cited by 42
Osteocyte death during orthodontic tooth movement in mice
Moin, S., Kalajzić, Ž., Utreja, A., Nihara, J., Wadhwa, S., Uribe, F. A., & Nanda, R. (2014) · The Angle Orthodontist · doi:10.2319/110713-813.1 · Cited by 42
Variation in osteocytes morphology vs bone type in turtle shell and their exceptional preservation from the Jurassic to the present
Cadena, E., & Schweitzer, M. H. (2012) · Bone · doi:10.1016/j.bone.2012.05.002 · Cited by 42
Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis
Karunaratne, A., Xi, L., Bentley, L., Sykes, D., BOYDE, A., Esapa, C. T., Terrill, N. J., Brown, S. D. M., Cox, R., Thakker, R. V., et al. (2015) · Bone · doi:10.1016/j.bone.2015.11.019 · Cited by 44
Aberrant miR‐145–5p/β‐catenin signal impairs osteocyte function in adolescent idiopathic scoliosis
Zhang, J., Chen, H., Leung, R. K., Choy, K. W., Lam, T. P., Ng, B. K. W., Qiu, Y., Feng, J. Q., Cheng, J. C. Y., & Lee, W. (2018) · The FASEB Journal · doi:10.1096/fj.201800281 · Cited by 42
Synthesis and Characterization of Poly(Vinyl Alcohol)-Chitosan-Hydroxyapatite Scaffolds: A Promising Alternative for Bone Tissue Regeneration
Pineda‐Castillo, S. A., Bernal-Ballén, A., Bernal-López, C., Segura-Puello, H. R., Nieto-Mosquera, D. L., Villamil-Ballesteros, A. C., Muñoz-Forero, D. M., & Münster, L. (2018) · Molecules · doi:10.3390/molecules23102414 · Cited by 42
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer
Wang, S., Pei, S., Wasi, M., Parajuli, A., Yee, A., You, L., & Wang, L. (2021) · Bone · doi:10.1016/j.bone.2021.116100 · Cited by 43
Mineralocorticoid receptor function in bone metabolism and its role in glucocorticoid-induced osteopenia
Fumoto, T., Ishii, K., Ito, M., Berger, S., Schütz, G., & Ikeda, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.149 · Cited by 41
Osteocyte function under compressive mechanical force
Takano‐Yamamoto, T. (2013) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2013.10.004 · Cited by 46
Osteocytes Produce Interferon-β as a Negative Regulator of Osteoclastogenesis
Hayashida, C., Ito, J., Nakayachi, M., Okayasu, M., Ohyama, Y., Hakeda, Y., & Sato, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.523811 · Cited by 41
Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton
Yorgan, T. A., Vollersen, N., Riedel, C., Jeschke, A., Peters, S., Busse, B., Amling, M., & Schinke, T. (2016) · Bone · doi:10.1016/j.bone.2016.04.012 · Cited by 41
Intraskeletal variation in human cortical osteocyte lacunar density: Implications for bone quality assessment
Hunter, R. L., & Agnew, A. M. (2016) · Bone Reports · doi:10.1016/j.bonr.2016.09.002 · Cited by 40
Mechanisms of bone response to injury
Dittmer, K. E., & Firth, E. C. (2017) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638716679861 · Cited by 41
Bone: A Fertile Soil for Cancer Metastasis
Coughlin, T. R., Romero-Moreno, R., Mason, D. E., Nystrom, L. M., Boerckel, J. D., Niebur, G. L., & Littlepage, L. E. (2017) · Current Drug Targets · doi:10.2174/1389450117666161226121650 · Cited by 41
microRNA Regulation of Skeletal Development
Sera, S. R., & Nieden, N. I. Z. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0379-7 · Cited by 41
Ex vivo replication of phenotypic functions of osteocytes through biomimetic 3D bone tissue construction
Sun, Q., Choudhary, S., Mannion, C. M., Kissin, Y., Zilberberg, J., & Lee, W. Y. (2017) · Bone · doi:10.1016/j.bone.2017.10.019 · Cited by 40
The regulatory roles of Notch in osteocyte differentiation via the crosstalk with canonical Wnt pathways during the transition of osteoblasts to osteocytes
Shao, J., Zhou, Y., & Xiao, Y. (2018) · Bone · doi:10.1016/j.bone.2018.01.010 · Cited by 41
Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program
Sánchez‐de‐Diego, C., Artigas, N., Pimenta-Lopes, C., Valer, J. A., Torrejón, B., Gama-Pérez, P., Villena, J. A., García-Rovés, P. M., Rosa, J. L., & Ventura, F. (2019) · iScience · doi:10.1016/j.isci.2019.04.015 · Cited by 41
microRNA‐Mediated Regulation of Bone Remodeling: A Brief Review
Liu, J., Dang, L., Wu, X., Li, D., Ren, Q., Lü, A., & Zhang, G. (2019) · JBMR Plus · doi:10.1002/jbm4.10213 · Cited by 41
Pulsed electromagnetic fields modify the adverse effects of glucocorticoids on bone architecture, bone strength and porous implant osseointegration by rescuing bone-anabolic actions
Cai, J., Shao, X., Yang, Q., Yang, Y., Yan, Z., Luo, E., Feng, X., & Jing, D. (2020) · Bone · doi:10.1016/j.bone.2020.115266 · Cited by 41
The molecular etiology and treatment of glucocorticoid-induced osteoporosis
Peng, C.-H., Lin, W.-Y., Yeh, K., Chen, I., Wu, W., & Lin, M. (2021) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_233_20 · Cited by 41
Osteoblasts, Osteoclasts, and Osteocytes: Unveiling Their Intimate-Associated Responses to Applied Orthodontic Forces
Lerner, U. H. (2012) · Seminars in Orthodontics · doi:10.1053/j.sodo.2012.06.002 · Cited by 49
Therapeutic Effect of Cistanoside A on Bone Metabolism of Ovariectomized Mice
Xu, X., Zhang, Z., Wang, W., Yao, H., & Ma, X. (2017) · Molecules · doi:10.3390/molecules22020197 · Cited by 42
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading
Zhao, D., Riquelme, M. A., Guda, T., Tu, C., Xu, H., Gu, S., & Jiang, J. X. (2022) · eLife · doi:10.7554/elife.74365 · Cited by 43
The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System
Dienes, B., Bazsó, T., Szabó, L. Z., & Csernoch, L. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076513 · Cited by 45
Inflammation and mechanical force‐induced bone remodeling
Jeon, H. H., Huang, X., Rojas, L., Sripinun, P., Lee, J., Hong, J. J., & Graves, D. T. (2024) · Periodontology 2000 · doi:10.1111/prd.12619 · Cited by 45
FGF23 in Acute and Chronic Illness
Schnedl, C., Fahrleitner‐Pammer, A., Pietschmann, P., & Amrein, K. (2015) · Disease Markers · doi:10.1155/2015/358086 · Cited by 40
TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk
van der Eerden, B. C. J., Oei, L., Roschger, P., Fratzl‐Zelman, N., Hoenderop, J. G. J., van Schoor, N. M., Pettersson, U., Schreuders‐Koedam, M., Uitterlinden, A. G., Albert Hofman, D., et al. (2013) · Bone · doi:10.1016/j.bone.2013.09.017 · Cited by 40
Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade
Dolan, E. B., Haugh, M. G., Voisin, M. C., Tallon, D., & McNamara, L. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119652 · Cited by 40
17β Estradiol regulation of connexin 43-based gap junction and mechanosensitivity through classical estrogen receptor pathway in osteocyte-like MLO-Y4 cells
Ren, J., Wang, X.-H., Wang, G.-C., & Wu, J. (2012) · Bone · doi:10.1016/j.bone.2012.12.004 · Cited by 40
Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes
Zhu, J. J., Siclari, V. A., Liu, F., Spatz, J., Chandra, A., Pajevic, P. D., & Qin, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050099 · Cited by 40
Parallel mechanisms suppress cochlear bone remodeling to protect hearing
Jáuregui, E. J., Akil, O., Acevedo, C., Hall‐Glenn, F., Tsai, B. S., Bale, H., Liebenberg, E. C., Humphrey, M. B., Ritchie, R. O., Lustig, L. R., et al. (2016) · Bone · doi:10.1016/j.bone.2016.04.010 · Cited by 40
Bone Cells Dynamics during Peri-Implantitis: a Theoretical Analysis
Fernandes, M. H., & Gomes, P. D. S. (2016) · Journal of Oral and Maxillofacial Research · doi:10.5037/jomr.2016.7306 · Cited by 44
Mammalian target of rapamycin as a therapeutic target in osteoporosis
Shen, G., Ren, H. J., Qiu, T., Zhang, Z., Zhao, W., Yu, X., Huang, J., Tang, J., Liang, D., Yao, Z., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26161 · Cited by 41
Assessing bone mineralisation in children with chronic kidney disease: what clinical and research tools are available?
Lalayiannis, A. D., Crabtree, N. J., Fewtrell, M. S., Biassoni, L., Milford, D. V., Ferro, C. J., & Shroff, R. C. (2019) · Pediatric Nephrology · doi:10.1007/s00467-019-04271-1 · Cited by 43
Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
Qin, L., Fu, X., Ma, J., Lin, M., Zhang, P., Wang, Y., Yan, Q., Tao, C., Liu, W., Tang, B. H., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01950-4 · Cited by 41
Receptor Activator of Nuclear Factor‐κB Ligand and Sclerostin Expression in Osteocytes of Alveolar Bone in Rats With Ligature‐Induced Periodontitis
Kim, J., Lee, D., Cha, J., Bak, E., & Yoo, Y. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140230 · Cited by 42
Marrow adiposity and hematopoiesis in aging and obesity: exercise as an intervention
Patel, V. S., Ete Chan, M., Rubin, J., & Rubin, C. T. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0424-1 · Cited by 39
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5
Zhao, D., Hua, R., Riquelme, M. A., Cheng, H., Guda, T., Xu, H., Gu, S., & Jiang, J. X. (2022) · Bone Research · doi:10.1038/s41413-022-00222-z · Cited by 43
Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration After Motor-Complete Spinal Cord Injury in Rats
Qin, W., Li, X., Peng, Y., Harlow, L. M., Ren, Y., Wu, Y., Li, J., Qin, Y., Sun, J., Zheng, S., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2864 · Cited by 39
Effect of Recent Spinal Cord Injury on Wnt Signaling Antagonists (Sclerostin and Dkk-1) and Their Relationship With Bone Loss. A 12-Month Prospective Study
Gifre, L., Vidal, J., Carrasco, J. L., Filella, X., Ruiz-Gaspà, S., Muxí, Á., Portell, E., Monegal, A., Guañabens, N., & Peris, P. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2423 · Cited by 41
The plastic nature of the human bone–periodontal ligament–tooth fibrous joint
Ho, S. P., Kurylo, M. P., Grandfield, K., Hurng, J. M., Herber, R., Ryder, M. I., Altoé, V., Aloni, S., Feng, J. Q., Webb, S. M., et al. (2013) · Bone · doi:10.1016/j.bone.2013.09.007 · Cited by 39
Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model
Boudenot, A., Presle, N., Uzbekov, R. E., Toumi, H., Pallu, S., & Lespessailles, É. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.05.020 · Cited by 39
Ex vivo 3D osteocyte network construction with primary murine bone cells
Sun, Q., Gu, Y., Zhang, W., Dziopa, L., Zilberberg, J., & Lee, W. (2015) · Bone Research · doi:10.1038/boneres.2015.26 · Cited by 41
Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression
Gupta, A., Anderson, H., Buo, A. M., Moorer, M. C., Ren, M., & Stains, J. P. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.04.014 · Cited by 39
Musculoskeletal health in newly diagnosed children with Crohn’s disease
Ward, L. M., Ma, J., Rauch, F., Benchimol, E. I., Hay, J., Leonard, M. B., Matzinger, M. A., Shenouda, N. F., Lentle, B. C., Cosgrove, H., et al. (2017) · Osteoporosis International · doi:10.1007/s00198-017-4159-0 · Cited by 39
Primary Human Osteocyte Networks in Pure and Modified Collagen Gels
Bernhardt, A., Weiser, E., Wolf, S., Vater, C., & Gelinsky, M. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0338 · Cited by 39
Senescent and apoptotic osteocytes and aging: Exercise to the rescue?
Sherk, V. D., & Rosen, C. J. (2019) · Bone · doi:10.1016/j.bone.2019.02.006 · Cited by 41
Aberrant activation of Wnt signaling pathway altered osteocyte mineralization
Zhou, Y., Lin, J., Shao, J., Zuo, Q., Wang, S., Wolff, A., Nguyen, D., Rintoul, L., Du, Z., Gu, Y., et al. (2019) · Bone · doi:10.1016/j.bone.2019.06.027 · Cited by 39
Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion
Clerin, V. M., Saito, H., Filipski, K. J., Nguyen, A. H., Garren, J. M., Kisucka, J., Reyes, M., & Jüppner, H. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135665 · Cited by 39
Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography
Haridy, Y., Osenberg, M., Hilger, A., Manke, I., Davesne, D., & Witzmann, F. (2021) · Science Advances · doi:10.1126/sciadv.abb9113 · Cited by 39
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography
Goff, E., Buccino, F., Bregoli, C., McKinley, J. P., Aeppli, B., Recker, R. R., Shane, E. J., Cohen, A., Kuhn, G. A., & Müller, R. (2021) · Bone · doi:10.1016/j.bone.2021.116094 · Cited by 41
Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice
Qin, L., He, T., Yang, D., Wang, Y., Li, Z., Yan, Q., Zhang, P., Chen, Z., Lin, S., Gao, H., et al. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.03.008 · Cited by 39
Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern
Dozzo, A., Galvin, A., Shin, J., Scalia, S., O’Driscoll, C. M., & Ryan, K. B. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01189-4 · Cited by 40
The osteocyte as a therapeutic target in the treatment of osteoporosis
Rochefort, G. Y. (2014) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x14523500 · Cited by 40
Biophysical Regulation of Stem Cell Differentiation
Govey, P. M., Loiselle, A. E., & Donahue, H. J. (2013) · Current Osteoporosis Reports · doi:10.1007/s11914-013-0138-3 · Cited by 39
Metabolic Health and Disease: A Role of Osteokines?
Shimonty, A., Bonewald, L. F., & Huot, J. R. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01093-0 · Cited by 41
Self-citation
Drug Delivery and Therapy Strategies for Osteoporosis Intervention
Ma, M., Zeng, H., Yang, P., Xu, J., Zhang, X., & He, W. (2023) · Molecules · doi:10.3390/molecules28186652 · Cited by 40
Ultrastructural evaluation of shrinkage artefacts induced by fixatives and embedding resins on osteocyte processes and pericellular space dimensions
Shah, F. A., Johansson, B. R., Thomsen, P., & Palmquist, A. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35287 · Cited by 38
The parathyroid hormone-regulated transcriptome in osteocytes: Parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function
John, H. C. S., Meyer, M. B., Benkusky, N. A., Carlson, A. H., Prideaux, M., Bonewald, L. F., & Pike, J. W. (2014) · Bone · doi:10.1016/j.bone.2014.11.010 · Cited by 39
Self-citation
Safety of Antidiabetic Therapies on Bone
Lecka‐Czernik, B. (2012) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-012-9129-7 · Cited by 38
Interleukin-1-induced acute bone resorption facilitates the secretion of fibroblast growth factor 23 into the circulation
Yamazaki, M., Kawai, M., Miyagawa, K., Ohata, Y., Tachikawa, K., Kinoshita, S., Nishino, J., Ozono, K., & Michigami, T. (2014) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-014-0598-2 · Cited by 38
The expression and function of microRNAs in bone homeostasis
Gao, B. (2015) · Frontiers in bioscience · doi:10.2741/4301 · Cited by 38
Measurement, variation, and scaling of osteocyte lacunae: a case study in birds
D’Emic, M. D., & Benson, R. (2013) · Bone · doi:10.1016/j.bone.2013.08.010 · Cited by 39
T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics
Brown, G. N., Leong, P. L., & Guo, X.-D. E. (2016) · Bone · doi:10.1016/j.bone.2016.04.018 · Cited by 41
3D micro structural analysis of human cortical bone in paired femoral diaphysis, femoral neck and radial diaphysis
Gauthier, R., Langer, M., Follet, H., Olivier, C., Gouttenoire, P.-J., Helfen, L., Rongièras, F., Mitton, D., & Peyrin, F. (2018) · Journal of Structural Biology · doi:10.1016/j.jsb.2018.08.006 · Cited by 38
Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment
Metzger, C. E., Narayanan, S. A., Phan, P. H., & Bloomfield, S. A. (2020) · npj Microgravity · doi:10.1038/s41526-020-00118-4 · Cited by 38
Functionalization of Electrospun Polycaprolactone Scaffolds with Matrix-Binding Osteocyte-Derived Extracellular Vesicles Promotes Osteoblastic Differentiation and Mineralization
Nieuwoudt, M., Woods, I., Eichholz, K. F., Martins, C., McSweeney, K., Shen, N., & Hoey, D. A. (2021) · Annals of Biomedical Engineering · doi:10.1007/s10439-021-02872-2 · Cited by 36
Immunohistochemical evidence for sclerostin during cementogenesis in mice
Lehnen, S. D. M., Götz, W., Baxmann, M., & Jäger, A. (2012) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2012.02.014 · Cited by 38
Osteocyte density in the peri‐implant bone of implants retrieved after different time periods (4 weeks to 27 years)
Piattelli, A., Artese, L., Penitente, E., Iaculli, F., Degidi, M., Mangano, C., Shibli, J. A., Coelho, P. G., Perrotti, V., & Iezzi, G. (2013) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33000 · Cited by 38
Changes in the spatial distribution of sclerostin in the osteocytic lacuno-canalicular system in alveolar bone due to orthodontic forces, as detected on multimodal confocal fluorescence imaging analyses
Nishiyama, Y., Matsumoto, T., Lee, J., Saitou, T., Imamura, T., Moriyama, K., Yamaguchi, A., & Iimura, T. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.08.013 · Cited by 38
Cell Sources for Human In vitro Bone Models
Ansari, S., Ito, K., & Hofmann, S. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00648-6 · Cited by 37
Osteocytes Serve as a Progenitor Cell of Osteosarcoma
Sottnik, J. L., Campbell, B., Mehra, R., Behbahani‐Nejad, O., Hall, C. L., & Keller, E. T. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24793 · Cited by 37
Premature loss of bone remodeling compartment canopies is associated with deficient bone formation: A study of healthy individuals and patients with cushing's syndrome
Jensen, P. R., Andersen, T. L., Søe, K., Hauge, E., Bollerslev, J., Amling, M., Barvencik, F., & Delaissé, J. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1490 · Cited by 39
Pore network microarchitecture influences human cortical bone elasticity during growth and aging
Bala, Y., Lefèvre, E., Roux, J.-P., Baron, C., Lasaygues, P., Pithioux, M., Kaftandjian, V., & Follet, H. (2016) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.05.018 · Cited by 37
Multiscale Modeling Provides Differentiated Insights to Fluid Flow-Driven Stimulation of Bone Cellular Activities
Estermann, S.-J., & Scheiner, S. (2018) · Frontiers in Physics · doi:10.3389/fphy.2018.00076 · Cited by 37
Irradiation‐induced osteocyte damage promotes HMGB1‐mediated osteoclastogenesis in vitro
He, F., Bai, J., Wang, J., Zhai, J., Tong, L., & Zhu, G. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28351 · Cited by 37
Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality
Milovanovic, P. D., & Busse, B. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00508-y · Cited by 36
Bone Matrix Levels of Dickkopf and Sclerostin are Positively Correlated with Bone Mass and Strength in Postmenopausal Osteoporosis
Ueland, T., Stilgren, L. S., & Bollerslev, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122896 · Cited by 39
Bioglass/carbonate apatite/collagen composite scaffold dissolution products promote human osteoblast differentiation
Ferreira, S. A., Young, G. R., Jones, J. R., & Rankin, S. M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111393 · Cited by 37
Osteocytes promote osteoclastogenesis via autophagy-mediated RANKL secretion under mechanical compressive force
Li, W., Zhao, J., Sun, W. S., Wang, H., Pan, Y., Wang, L., & Zhang, W. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108594 · Cited by 37
Inflammatory macrophages interrupt osteocyte maturation and mineralization via regulating the Notch signaling pathway
Wang, S., Xiao, L., Prasadam, I., Crawford, R., Zhou, Y., & Xiao, Y. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00530-4 · Cited by 39
Lipoprotein receptor–related protein 6 is required for parathyroid hormone–induced Sost suppression
Li, C., Wang, W., Xie, L., Luo, X., Cao, X., & Wan, M. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12750 · Cited by 37
Zoledronic Acid Acutely Increases Sclerostin Serum Levels in Women With Postmenopausal Osteoporosis
Catalano, A., Morabito, N., Basile, G., Brancatelli, S., Cucinotta, D., & Lasco, A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4039 · Cited by 36
Multipotential Stromal Cell Abundance in Cellular Bone Allograft: Comparison with Fresh Age-Matched Iliac Crest Bone and Bone Marrow Aspirate
Baboolal, T. G., Boxall, S., El-Sherbiny, Y. M., Moseley, T. A., Cuthbert, R. J., Giannoudis, P. V., McGonagle, D., & Jones, E. (2014) · Regenerative Medicine · doi:10.2217/rme.14.17 · Cited by 36

Authors: Bonewald, L. F.
Affiliations: University of Missouri–Kansas City (US)
Corresponding author: Bonewald, Lynda F
ORCID: Bonewald, Lynda F
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 2010-12-16
Volume: 26
Issue: 2
Pages: 229-238
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1002/jbmr.320
PMC: PMC3179345
OpenAlex: W2019582558
Cited by: 2,287
References: 107
Citations by year: 2026: 134 · 2025: 136 · 2024: 140 · 2023: 152 · 2022: 159 · 2021: 160 · 2020: 186 · 2019: 189 · 2018: 137 · 2017: 149 · 2016: 128 · 2015: 165 · 2014: 130 · 2013: 147 · 2012: 133
FWCI: 8.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (P01AR046798, RC2AR058962, AR 46798)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: osteocytes, bone remodeling, osteoclast regulation, phosphate metabolism, calcium availability, bone aging, TNF-α, glucocorticoids
MeSH terms: Animals, Bone and Bones, Calcium, Cell Survival, Glucocorticoids, Humans, Inflammation, Models, Biological, Osteocytes, Phosphates, Tumor Necrosis Factor-alpha, Bone Remodeling, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The amazing osteocyte

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks