The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
The amazing osteocyte
Open accessAbstract
The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell. The osteocyte is a source of soluble factors not only to target cells on the bone surface but also to target distant organs, such as kidney, muscle, and other tissues. This cell plays a role in both phosphate metabolism and calcium availability and can remodel its perilacunar matrix. Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment. As we age, these cells die, leaving behind empty lacunae that frequently micropetrose. In aged bone such as osteonecrotic bone, empty lacunae are associated with reduced remodeling. Inflammatory factors such as tumor necrosis factor and glucocorticoids used to treat inflammatory disease induce osteocyte cell death, but by different mechanisms with potentially different outcomes. Therefore, healthy, viable osteocytes are necessary for proper functionality of bone and other organs. © 2011 American Society for Bone and Mineral Research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In fact, it has been recognized that these cells play numerous important functions in bone [8].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [8]
In the citing paper
“There is evidence that osteocytes act as mechanosensors and orchestrators of this bone remodeling process [5–8].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [8]
In the citing paper
“On the other hand, osteocyte markers including dentine matrix protein 1 (DMP1) and sclerostin are highly expressed [8, 62–64].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [8]
In the citing paper
“Upon mechanical stimulation, osteocytes produce several secondary messengers, for example, ATP, nitric oxide (NO), Ca2+, and prostaglandins (PGE2 and PGI2,) which influence bone physiology [8, 80].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [8]
In the citing paper
“Besides osteoclasts and osteoblasts, it has been demonstrated that osteocytes play key roles during the bone remodeling cycle [8].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [8]
In the citing paper
“The remaining osteoblasts (those on the bone trabecular endosteal and endocortical surfaces) might differentiate into BLCs, which are characterized by lower biosynthetic activity and a flat morphology, or they might remain embedded in the matrix, undergo the active process of osteocytogenesis,288 and become osteocytes (5%–20% of mature osteoblasts).”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [288]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · cited 1×
“Sclerostin was thought to be a bone morphogenetic protein (BMP) antagonist but later was discovered to be involved in the Wnt pathway as an antagonist against lipoprotein receptor 5 (LRP5), a positive regulator of bone mass.((48,49)) Mechanical loading also has been reported to reduce sclerostin expression,((50)) as d…”
BackgroundMechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.115 · Cited by 1,318
Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298
A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
Weinbaum, S., Cowin, S. C., & Zeng, Y. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90010-8 · Cited by 1,266
Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199
Self-citationIncreased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · cited 1×
“Mutations of SOST causes high bone mass in humans,((46)) as does deletion in mice.”
BackgroundOsteocytes, mechanosensing and Wnt signaling
Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076
Self-citationSclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Poole, K. E. S., Van Bezooijen, R. L., Loveridge, N., Hamersma, H., Papapoulos, S. E., Löwik, C. W., & Reeve, J. (2005) · The FASEB Journal · doi:10.1096/fj.05-4221fje · Cited by 965
Flagged first, then by citations
Research works printed but not linked: 7
- Parfitt, 1990, Bone. The Osteoblast and Osteocyte, 351
- Guo, 2009, Mice with Targeted Deletion of E11/gp38 in Late Osteoblasts Have Reduced Canaliculi per Osteocyte Which May Be Responsible for The Enhanced Trabecular Bone Volume. FR0268, J Bone Min Res., S126
- Qing, 2010, PTHR1 in Osteocytes Plays a Major role in Perilacunar Remodeling through the Activation of “Osteoclastic” Genes in Osteocytes, #1082J Bone Min Res., S25
- Bonewald, 2007, Osteoporosis, 169
- Qing, 2009, Osteocyte Perilacunar Remodeling Is Regulated Hormonally, but Not by Mechanical Unloading, Journal of Bone & Mineral Research., Mo0255
- Potter, 2009, Raman spectroscopic characterization of bone tissue material properties around the osteocyte lacuna: effect of aging, J Bone Miner Res., Su0266
- Xiao, 2009, Conditional deletion and/or disruption of Pkd1 in osteocytes results in a significant reduction in anabolic response to mechanical loading, J Bone Miner Res., #1042
Cited by
Sorted by citations
Items 1,001–1,005 of 1,005
Matsugaki, A., Matsuzaka, T., Murakami, A., Wang, P., & Nakano, T. (2020) · International Journal of Bioprinting · doi:10.18063/ijb.v6i4.293 · Cited by 22
Hongo, H., Hasegawa, T., Saito, M., Tsuboi, K., Yamamoto, T., Sasaki, M., Abe, M., Henrique Luiz de Freitas, P., Yurimoto, H., Udagawa, N., et al. (2020) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155420961375 · Cited by 12
Jadzic, J., Milovanovic, P., Tomanovic, N., Zivkovic, V., Djukic, D., Nikolic, S., Djuric, M., & Djonic, D. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02130-3 · Cited by 11
The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
Lungu, O., Toscani, D., Burroughs-Garcia, J., & Giuliani, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054893 · Cited by 10
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts
Lademann, F., Rijntjes, E., Köhrle, J., Tsourdi, E., Hofbauer, L. C., & Rauner, M. (2024) · Communications Biology · doi:10.1038/s42003-024-06227-0 · Cited by 8
Metadata
- Authors
- Bonewald, L. F.
- Affiliations
- University of Missouri–Kansas City (US)
- Corresponding author
- Bonewald, Lynda F
- ORCID
- Bonewald, Lynda F
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-16
- Volume
- 26
- Issue
- 2
- Pages
- 229-238
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC3179345
- OpenAlex
- W2019582558
- Cited by
- 2,287
- References
- 107
- Citations by year
- 2026: 134 · 2025: 136 · 2024: 140 · 2023: 152 · 2022: 159 · 2021: 160 · 2020: 186 · 2019: 189 · 2018: 137 · 2017: 149 · 2016: 128 · 2015: 165 · 2014: 130 · 2013: 147 · 2012: 133
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P01AR046798, RC2AR058962, AR 46798)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteocytes, bone remodeling, osteoclast regulation, phosphate metabolism, calcium availability, bone aging, TNF-α, glucocorticoids
- MeSH terms
- Animals, Bone and Bones, Calcium, Cell Survival, Glucocorticoids, Humans, Inflammation, Models, Biological, Osteocytes, Phosphates, Tumor Necrosis Factor-alpha, Bone Remodeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
