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The direct examination of three-dimensional bone architecture in vitro by computed tomography
Abstract
We describe a new method for the direct examination of three-dimensional bone structure in vitro based on high-resolution computed tomography (CT). Unlike clinical CT, a three-dimensional reconstruction array is created directly, rather than a series of two-dimensional slices. All structural indices commonly determined from two-dimensional histologic sections can be obtained nondestructively from a large number of slices in each of three orthogonal directions. This permits a comprehensive description of structural variation within a specimen and greatly facilitates the study of structural anisotropy. A measure of three-dimensional connectivity (Euler number/tissue volume) has been determined for the first time in human cancellous bone and shown to correlate with several two-dimensional histomorphometric indices. The method has the potential for overcoming many of the limitations of current approaches to the study of bone architecture at the microscopic level.
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Cited by
van Rietbergen, B., Weinans, H., Huiskes, R., & Odgaard, A. (1995) · Journal of Biomechanics · doi:10.1016/0021-9290(95)80008-5 · Cited by 865
Yadav, V. K., Oury, F., Suda, N., Liu, Z.-W., Gao, X.-B., Confavreux, C., Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.051 · Cited by 661
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Paulus, M. J., Gleason, S. S., Kennel, S. J., Hunsicker, P. R., & Johnson, D. K. (2000) · Neoplasia · doi:10.1038/sj.neo.7900069 · Cited by 490
Sornay-Rendu, E., Boutroy, S., Munoz, F., & Delmas, P. D. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061206 · Cited by 454
Carbonare, L. D., Arlot, M. E., Chavassieux, P. M., Roux, J. P., Portero, N. R., & Meunier, P. J. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.97 · Cited by 309
Lee, K.-W., Wang, S., Fox, B. C., Ritman, E. L., Yaszemski, M. J., & Lu, L. (2007) · Biomacromolecules · doi:10.1021/bm060834v · Cited by 292
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050815 · Cited by 216
Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., & Guo, X. E. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060716 · Cited by 207
Age‐related variations in the microstructure of human tibial cancellous bone
Ding, M., Odgaard, A., Linde, F., & Hvid, I. (2002) · Journal of Orthopaedic Research · doi:10.1016/s0736-0266(01)00132-2 · Cited by 186
Finite Element Method (FEM), Mechanobiology and Biomimetic Scaffolds in Bone Tissue Engineering
Boccaccio, A., Ballini, A., Pappalettere, C., Tullo, D., Cantore, S., & Desiate, A. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.112 · Cited by 178
Gradient collagen/nanohydroxyapatite composite scaffold: development and characterization
Liu, C., Han, Z., & Czernuszka, J. T. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.09.022 · Cited by 109
Local strain and damage mapping in single trabeculae during three-point bending tests
Jungmann, R., Szabo, M. E., Schitter, G., Yue-Sing Tang, R., Vashishth, D., Hansma, P. K., & Thurner, P. J. (2011) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2010.12.009 · Cited by 57
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Metadata
- Authors
- Feldkamp, L. A., Goldstein, S. A., Parfitt, M. A., Jesion, G., & Kleerekoper, M.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-02-01
- Volume
- 4
- Issue
- 1
- Pages
- 3-11
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2159591750
- Cited by
- 1,071
- References
- 0
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
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