Gradient collagen/nanohydroxyapatite composite scaffold: development and characterization
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This paper reports an in situ diffusion method for the fabrication of compositionally graded collagen/nanohydroxyapatite (HA) composite scaffold. The method is diffusion based and causes the precipitation of nano-HA crystallites in situ. A collagen matrix acts as a template through which calcium ions (Ca(2+)) and phosphate ions (PO4(3-)) diffuse and precipitate a non-stoichiometric HA. It was observed that needle-like prismatic nano-HA crystallites (about 2 x 2 x 20 nm) precipitated in the interior of the collagen template onto the collagen fibrils. Chemical and microstructural analysis revealed a gradient of the Ca to P ratio across the width of the scaffold template, resulting in the formation of a Ca-rich side and a Ca-depleted side of scaffold. The Ca-rich side featured low porosity and agglomerates of the nano-HA crystallites, while the Ca-depleted side featured higher porosity and nano-HA crystallites integrated with collagen fibrils to form a porous network structure.
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A collagen/nano-HA scaffold was Ca-rich with an interconnected porous structure and facilitated cell attachment and proliferation.
“A Ca-rich scaffold with interconnected porous structure was developed which facilitates cell attachment and proliferation.[111]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [111]
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Collagen–hydroxyapatite composite scaffolds for tissue engineering
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“Hydroxyapatite (HAp), a nanoparticle extensively investigated in the context of orthopedic grafts (Liu et al., 2009; Zandi et al., 2010; Ravichandran et al., 2012), is the prevailing subject of study in relation to bone regeneration.”
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“The pore sizes of the foams used for cell seeding in this study were around 200 mm, and Liu et al. (2009) reported that large pores support the transport of nutrients and removal of wastes, but also cause low attachment efficiency and intracellular signalling.”
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“…scaffolds providing appropriate chemical and physical (such as porosity, stiffness, and topology) cues can build up a microenvironment, the so-called niche, which may trigger a selective cellular differentiation and matrix formation (Liu et al., 2009; Pennesi et al., 2011; Scaglione et al., 2011).”
BackgroundElectrolytic Deposition of Collagen/HA Composite on Post HA∕TiO[sub 2] Coated Ti6Al4V Implant Alloy
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“…with an adequate amount of carbonate substitution ~Murugan & Ramakrishna, 2005!. Scaffolds based on inorganic and organic substances such as hydroxyapatite and collagen have been constructed ~Zhang et al., 2003; Kikuchi et al., 2004; Kamakura et al., 2007; Yunoki et al., 2007; Liu et al., 2009!.”
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Nanoparticles for Dental Materials
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- Authors
- Liu, C., Han, Z., & Czernuszka, J. T.
- Affiliations
- University of Oxford (GB)
- Jilin University (CN)
- Corresponding author
- Liu, Chaozong
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 5
- Issue
- 2
- Pages
- 661-669
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2059421614
- Cited by
- 109
- References
- 45
- Citations by year
- 2024: 3 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 16
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust (074486)
- University of Oxford
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- gradient scaffolds, calcium phosphate precipitation, collagen fibrils, porous scaffolds, scaffold porosity
- MeSH terms
- Animals, Cattle, Collagen, Hydrogen-Ion Concentration, Spectrum Analysis, Tomography, X-Ray Computed, X-Rays, Durapatite, Microscopy, Electron, Transmission, Nanoparticles
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