The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Adipose mesenchymal stem cell‐derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β‐catenin signaling in cutaneous wound healing
Abstract
Cutaneous wounds, a type of soft tissue injury, are difficult to heal in aging. Differentiation, migration, proliferation, and apoptosis of skin cells are identified as key factors during wound healing processes. Mesenchymal stem cells have been documented as possible candidates for wound healing treatment because their use could augment the regenerative capacity of many tissues. However, the effects of exosomes derived from adipose‐derived stem cell (ADSC‐exos) on cutaneous wound healing remain to be carefully elucidated. In this present study, HaCaT cells were exposed to hydrogen peroxide (H 2 O 2) for the establishment of the skin lesion model. Cell Counting Kit‐8 assay, migration assay, and flow cytometry assay were conducted to detect the biological function of ADSC‐exos in skin lesion model. Finally, the possible mechanism was further investigated using Western blot assay. The successful construction of the skin lesion model was confirmed by results of the enhanced cell apoptosis of HaCaT cells induced by H 2 O 2, the increased Bax expression and decreased Bcl‐2 expression. CD9 and CD63 expression evidenced the existence of ADSC‐exos. The results of functional experiments demonstrated that ADSC‐exos could prompt cell proliferation and migration of HaCaT cells, and repress cell apoptosis of HaCaT cells. In addition, the activation of Wnt/β‐catenin signaling was confirmed by the enhanced expression of β‐catenin at the protein level. Collectively, our findings suggest that ADSC‐exos play a positive role in cutaneous wound healing possibly via Wnt/β‐catenin signaling. Our study may provide new insights into the therapeutic target for cutaneous wound healing.
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Cites
HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing
Zhang, B., Wang, M., Gong, A., Zhang, X., Wu, X., Zhu, Y., Shi, H., Wu, L., Zhu, W., Qian, H., et al. (2015) · Stem Cells · doi:10.1002/stem.1771 · Cited by 792
Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis
Lichtman, M. K., Otero‐Vinas, M., & Falanga, V. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12398 · Cited by 626
Exosomes: New players in cell–cell communication
Bang, C., & Thum, T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.007 · Cited by 505
Toh, W. S., Lai, R. C., Hui, J. H. P., & Lim, S. K. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2016.11.008 · Cited by 502
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Age-Related Aspects of Cutaneous Wound Healing: A Mini-Review
Sgonc, R., & Gruber, J. (2013) · Gerontology · doi:10.1159/000342344 · Cited by 288
Beta‐catenin regulates wound size and mediates the effect of TGF‐beta in cutaneous healing
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Salivary Exosomes: Emerging Roles in Systemic Disease
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Cited by
Hong, P., Yang, H., Wu, Y., Li, K., & Tang, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1358-y · Cited by 269
Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”
Trzyna, A., & Banaś-Ząbczyk, A. (2021) · Biomolecules · doi:10.3390/biom11060878 · Cited by 201
Ma, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155
Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09877-6 · Cited by 139
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy
Wang, Y., Huo, Y., Zhao, C., Liu, H., Shao, Y., Zhu, C., An, L., Chen, X., & Chen, Z. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.02.015 · Cited by 84
Metadata
- Authors
- Ma, T., Fu, B., Yang, X., Xiao, Y., & Pan, M.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2019-01-25
- Volume
- 120
- Issue
- 6
- Pages
- 10847-10854
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2913512544
- Cited by
- 253
- References
- 27
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, T., Fu, B., Yang, X., Xiao, Y., & Pan, M. (2019). Adipose mesenchymal stem cell‐derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β‐catenin signaling in cutaneous wound healing. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.28376
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