Cited by 4,930Immune cells in cancerCardiac Fibrosis and RemodelingPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

Macrophage plasticity, polarization, and function in health and disease

Open access

Shapouri‐Moghaddam, Abbas, Mohammadian, Saeed, Vazini, Hossein, Taghadosi, Mahdi, Esmaeili, Seyed‐Alireza, Mardani, Fatemeh, Seifi, Bita, Mohammadi, Asadollah, Afshari, Jalil T., Sahebkar, Amirhossein·2018·Journal of Cellular Physiology

DOI 10.1002/jcp.26429PMC PMC13482560

Open this paper in CoChat — free account

Abstract

Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro‐inflammatory and polarized by lipopolysaccharide (LPS) either alone or in association with Th1 cytokines such as IFN‐γ, GM‐CSF, and produce pro‐inflammatory cytokines such as interleukin‐1β (IL‐1β), IL‐6, IL‐12, IL‐23, and TNF‐α; and 2) Alternatively activated or M2 macrophages, which are anti‐inflammatory and immunoregulatory and polarized by Th2 cytokines such as IL‐4 and IL‐13 and produce anti‐inflammatory cytokines such as IL‐10 and TGF‐β. M1 and M2 macrophages have different functions and transcriptional profiles. They have unique abilities by destroying pathogens or repair the inflammation‐associated injury. It is known that M1/M2 macrophage balance polarization governs the fate of an organ in inflammation or injury. When the infection or inflammation is severe enough to affect an organ, macrophages first exhibit the M1 phenotype to release TNF‐α, IL‐1β, IL‐12, and IL‐23 against the stimulus. But, if M1 phase continues, it can cause tissue damage. Therefore, M2 macrophages secrete high amounts of IL‐10 and TGF‐β to suppress the inflammation, contribute to tissue repair, remodeling, vasculogenesis, and retain homeostasis. In this review, we first discuss the basic biology of macrophages including origin, differentiation and activation, tissue distribution, plasticity and polarization, migration, antigen presentation capacity, cytokine and chemokine production, metabolism, and involvement of microRNAs in macrophage polarization and function. Secondly, we discuss the protective and pathogenic role of the macrophage subsets in normal and pathological pregnancy, anti‐microbial defense, anti‐tumor immunity, metabolic disease and obesity, asthma and allergy, atherosclerosis, fibrosis, wound healing, and autoimmunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jcp.26429

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Macrophage phenotypic plasticity in atherosclerosis: The associated features and the peculiarities of the expression of inflammatory genes
Chistiakov, D. A., Bobryshev, Y. V., Nikiforov, N. G., Elizova, N. V., Sobenin, I. A., & Orekhov, A. N. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.055 · Cited by 184
Retracted
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 14×
“…by displaying processed antigens in associate with major histocompatibility complex (MHC) molecules; and (3) Production of different type of cytokines, including interleukin-1 (IL-1), IL-6, tumor necrosis factor-α (TNF-α), and etc. (Sica, Erreni, Allavena, & Porta, 2015; Wynn et al., 2013).”
BackgroundInfluential
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166

Flagged first, then by citations

Show all 131 references

Sorted by citations

Items 401–500 of 1,012

Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance
de Macedo, G. H. R. V., Costa, G. D. E., Oliveira, E. R., Damasceno, G. V., Mendonça, J. S. P., Silva, L. D. S., Chagas, V. L., Bazán, J. M. N., Aliança, A. S. D. S., de Miranda, R. D. C. M., et al. (2021) · Pathogens · doi:10.3390/pathogens10020148 · Cited by 75
Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging
Guimarães, G. R., Almeida, P. P., Santos, L. D. O., Rodrigues, L. P., Carvalho, J. L., & Boroni, M. (2021) · Cells · doi:10.3390/cells10061323 · Cited by 79
Recent advances of cereal β-glucan on immunity with gut microbiota regulation functions and its intelligent gelling application
Zhang, Y., Li, Y., Xia, Q., Liu, L., Wu, Z., & Pan, D. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1995842 · Cited by 74
The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment
Lian, J., Liang, Y., Zhang, H., Lan, M., Ye, Z., Lin, B., Qiu, X., & Zeng, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.912279 · Cited by 75
Macrophage‐derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment
Xiao, Y., Peng, X., Peng, Y., Zhang, C., Liu, W. Y., Yang, W., Dou, X., Jiang, Y., Wang, Y., Yang, S., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1071 · Cited by 75
Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair
Wang, H., Yu, H., Huang, T., Wang, B., & Xiang, L. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.12.012 · Cited by 75
Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization
Liu, L., Wang, J., Wang, Y., Chen, L., Peng, L., Bin, Y., Ding, P., Zhang, R., Tong, F., & Dong, X. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03024-9 · Cited by 74
Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states
Rahimi, K., Ahmadi, A., Hassanzadeh, K., Soleimani, Z., Sathyapalan, T., Mohammadi, A., & Sahebkar, A. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.05.012 · Cited by 73
Self-citation
Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment
Li, X., Jolly, M. K., George, J. T., Pienta, K. J., & Levine, H. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00010 · Cited by 73
Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease
Yang, A. J. T., Bagit, A., & MacPherson, R. E. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094628 · Cited by 77
Therapeutic potentials of ginger for treatment of Multiple sclerosis: A review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties
Jafarzadeh, A., & Nemati, M. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.09.003 · Cited by 84
Monocytes and macrophages in ANCA-associated vasculitis
Vegting, Y., Vogt, L., Anders, H., de Winther, M. P. J., Bemelman, F. J., & Hilhorst, M. L. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102911 · Cited by 72
Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral Responses
Yu, S., Ge, H., Su, L., & Qiu, H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.839585 · Cited by 78
Acetylation of p65Lys310 by p300 in macrophages mediates anti-inflammatory property of berberine
Zhang, S., Xu, P., Zhu, Z., Zhou, L., Li, J., Zhou, R., Kan, Y., Li, Y., Yu, X., Zhao, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102704 · Cited by 73
Atherosclerosis: Insights into Vascular Pathobiology and Outlook to Novel Treatments
Wolf, M., & Hunziker, P. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-09961-y · Cited by 74
Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease
Caër, C., & Wick, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00410 · Cited by 76
The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
Shan, X., Zhang, C., Mai, C.-T., Hu, X., Cheng, N., Chen, W., Peng, D., Wang, L., Ji, Z., & Xie, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.715461 · Cited by 72
Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy
Yang, D., Dai, F., Yuan, M., Zheng, Y., Liu, S., Deng, Z., Tan, W., Chen, L., Zhang, Q., Zhao, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689181 · Cited by 83
3D Printed Dual‐Porosity Scaffolds: The Combined Effect of Stiffness and Porosity in the Modulation of Macrophage Polarization
Camarero‐Espinosa, S., Carlos‐Oliveira, M., Liu, H., Mano, J. F., Bouvy, N., & Moroni, L. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202101415 · Cited by 71
CD38: A Significant Regulator of Macrophage Function
Li, W., Li, Y., Jin, X., Liao, Q., Chen, Z., Peng, H., & Zhou, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.775649 · Cited by 71
Hydrogel-based immunoregulation of macrophages for tissue repair and regeneration
Nie, R., Zhang, Q., Feng, Z.-Y., Huang, K., Zou, C., Fan, M., Zhang, Y., Zhang, J.-Y., Li‐Ling, J., Tan, B., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131643 · Cited by 75
Macrophages: The Bridge between Inflammation Resolution and Tissue Repair?
Garlet, G. P., & Giannobile, W. V. (2018) · Journal of Dental Research · doi:10.1177/0022034518785857 · Cited by 73
Macrophages: The Potent Immunoregulatory Innate Immune Cells
Kumar, V. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88013 · Cited by 76
Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations
Reyna, S. J. L., Holbrook, J. A., Jarosz-Griffiths, H., Peckham, D. G., & McDermott, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03540-9 · Cited by 73
Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression
Bi, Y., Shirure, V. S., Liu, R., Cunningham, C., Ding, L., Meacham, J. M., Goedegebuure, S. P., George, S. C., & Fields, R. C. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa017 · Cited by 75
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
Schenkel, L. B., Molina, J. R., Swinger, K. K., Abo, R., Blackwell, D. J., Lu, A. Z., Cheung, A. E., Church, W. D., Kunii, K., Kuplast-Barr, K. G., et al. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.02.010 · Cited by 71
Detection of Immune Checkpoint Receptors – A Current Challenge in Clinical Flow Cytometry
Shibru, B., Fey, K., Fricke, S., Blaudszun, A., Fürst, F., Weise, M., Seiffert, S., Weyh, M. K., Koehl, U., Sack, U., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.694055 · Cited by 70
The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment
Li, L., & Tian, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114504 · Cited by 75
Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review
Mesgari, H., Esmaelian, S., Nasiri, K., Ghasemzadeh, S., Doroudgar, P., & Payandeh, Z. (2023) · Cancers · doi:10.3390/cancers15235600 · Cited by 87
Macrophage based drug delivery: Key challenges and strategies
Guo, Q., & Qian, Z. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.004 · Cited by 81
Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis
Lu, X., & Chen, J. (2019) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2019.035 · Cited by 72
Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells
Bazzoni, R., Kamga, P. T., Tanasi, I., & Krampera, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.596079 · Cited by 68
Macrophages in pancreatic cancer: An immunometabolic perspective
Yang, J. M., Li, Y., Sun, Z., & Zhan, H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.029 · Cited by 72
ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway
Xu, D., Wang, Y., Wu, J., Zhang, Z., Chen, J., Xie, M., Tang, R., Chen, C., Chen, L., Lin, S., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03450-z · Cited by 66
Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance
Li, X., Zhang, X., Xia, J., Zhang, L., Chen, B., Lian, G., Yun, C., Yang, J., Yan, Y., Wang, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109607 · Cited by 71
Immune Tolerance in the Oral Mucosa
Pelaez-Prestel, H. F., Sanchez‐Trincado, J. L., Lafuente, E. M., & Reche, P. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212149 · Cited by 69
Lipid-loaded macrophages as new therapeutic target in cancer
Marelli, G., Morina, N., Portale, F., Pandini, M., Iovino, M., Di Conza, G., Ho, P.-C., & Di Mitri, D. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004584 · Cited by 69
Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
Mamilos, A., Winter, L., Schmitt, V. H., Barsch, F., Grevenstein, D., Wagner, W. L., Babel, M., Keller, K., Schmitt, C., Gürtler, F., et al. (2023) · Cells · doi:10.3390/cells12020276 · Cited by 75
Effect of micro- and nanoplastic particles on human macrophages
Adler, M. Y., Issoual, I., Rückert, M., Deloch, L., Meier, C., Tschernig, T., Alexiou, C., Pfister, F., Ramsperger, A. F. R. M., Laforsch, C., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134253 · Cited by 74
Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88
Gong, J., Li, J., Dong, H., Chen, G., Qin, X., Hu, M., Yuan, F., Fang, K., Wang, D., Jiang, S., et al. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2710-6 · Cited by 68
Intercellular Communication between Hepatic Cells in Liver Diseases
Sato, K., Kennedy, L. L., Liangpunsakul, S., Kusumanchi, P., Yang, Z., Meng, F., Glaser, S. S., Francis, H., & Alpini, G. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092180 · Cited by 73
Salmonella finds a way: Metabolic versatility of Salmonella enterica serovar Typhimurium in diverse host environments
Taylor, S., & Winter, S. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008540 · Cited by 65
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats
Tang, C. S., Luo, Y., Li, S., Huang, B., 徐尚福, & Li, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111081 · Cited by 68
Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome
Toro-Pérez, J., & Rodrigo, R. (2021) · Redox Report · doi:10.1080/13510002.2021.1891808 · Cited by 68
Cardiac repair after myocardial infarction: A two-sided role of inflammation-mediated
Li, T., Yan, Z., Fan, Y., Fan, X., Li, A., Qi, Z., & Zhang, J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1077290 · Cited by 76
From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis
Liu, Z., Ting, Y., Li, M., Li, Y., Tan, Y., & Long, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1415274 · Cited by 81
Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment
Shi, X., Xu, C., Chen, Z., Li, M., Yin, Z., Wang, B., Li, Y., Wu, Y., Wu, X., & Xu, Y. (2025) · Bone Research · doi:10.1038/s41413-025-00471-8 · Cited by 77
The clinical dynamic changes of macrophage phenotype and function in different stages of human wound healing and hypertrophic scar formation
Chen, L., Wang, J., Li, S.-X., Yu, Z., Liu, B., Song, B.-Q., & Su, Y.-J. (2018) · International Wound Journal · doi:10.1111/iwj.13041 · Cited by 61
Targeted Delivery of miRNA 155 to Tumor Associated Macrophages for Tumor Immunotherapy
Zang, X., Zhang, X., Zhao, X., Hu, H., Qiao, M., Deng, Y., & Chen, D. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00065 · Cited by 68
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells
Wang, R., Dong, Z., Lan, X., Liao, Z., & Chen, M. (2019) · Molecules · doi:10.3390/molecules24050872 · Cited by 67
Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy
Plesca, I., Tunger, A., Müller, L., Wehner, R., Lai, X., Grimm, M., Rutella, S., Bachmann, M. P., & Schmitz, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00364 · Cited by 71
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer
Kooshki, L., Mahdavi, P., Fakhri, S., Akkol, E. K., & Khan, H. Z. (2021) · BioFactors · doi:10.1002/biof.1799 · Cited by 67
Insights into the Role of Macrophage Polarization in the Pathogenesis of Osteoporosis
Wang, W., Liu, H., Liu, T., Yang, H., & He, F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2485959 · Cited by 70
Oral delivery of layer-by-layer coated exosomes for colitis therapy
Deng, C., Hu, Y., Conceição, M., Wood, M. J. A., Zhong, H., Wang, Y., Shao, P., Chen, J., & Qiu, L. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.017 · Cited by 71
Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease
Lu, H., Suo, Z., Lin, J., Cong, Y., & Liu, Z. (2024) · Biomarker Research · doi:10.1186/s40364-024-00612-x · Cited by 77
Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties
Zielińska‐Bliźniewska, H., Sitarek, P., Merecz-Sadowska, A., Malinowska, K., Zajdel, K., Jabłońska, M. R., Śliwiński, T., & Zajdel, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184556 · Cited by 68
Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases
Moyse, E., Krantic, S. M., Djellouli, N., Roger, S., Angoulvant, D., Debacq, C., Leroy, V., Fougère, B., & Aïdoud, A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827263 · Cited by 72
Harnessing bacteria for tumor therapy: Current advances and challenges
Guo, L., Ding, J., & Zhou, W. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108557 · Cited by 69
Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications
Luo, Y., Liu, H., Zhang, Y., Liu, Y., Liu, X., Liu, X., & Luo, E. (2023) · Biomaterials Science · doi:10.1039/d3bm01146a · Cited by 67
Propionic Acid Driven by the Lactobacillus johnsonii Culture Supernatant Alleviates Colitis by Inhibiting M1 Macrophage Polarization by Modulating the MAPK Pathway in Mice
Wu, Z., He, J., Zhang, Z., Li, J., Zou, H., Tan, X., Wang, Y., Yao, Y., & Xiong, W. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00278 · Cited by 67
Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3
Zhang, L., Zhang, J., Li, P., Li, T., Zhou, Z., & Wu, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04345-9 · Cited by 65
Dysfunction of low-density neutrophils in peripheral circulation in patients with sepsis
Sun, R., Huang, J., Yang, Y., Liu, L., Shao, Y., Li, L., & Sun, B. (2022) · Scientific Reports · doi:10.1038/s41598-021-04682-x · Cited by 65
Appropriate Size of Fe 3 O 4 Nanoparticles for Cancer Therapy by Ferroptosis
Tian, X., Ruan, L., Zhou, S., Wu, L. H., Cao, J., Qi, X., Zhang, X., & Shen, S. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00068 · Cited by 65
Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells
Huang, J., Chen, P., Xiang, Y., Liang, Q., Wu, T., Liu, J., Zeng, Y., Zeng, H., Liang, X., & Zhou, C. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108717 · Cited by 68
Immunomodulation Effect of Biomaterials on Bone Formation
Zhao, T., Chu, Z., Ma, J., & Ouyang, L. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13030103 · Cited by 69
The macrophage polarization in inflammatory dermatosis and its potential drug candidates
Sun, Q., Hu, S., Lou, Z., & Gao, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114469 · Cited by 66
Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment
Deng, Y., Chen, Q., Yang, X., Sun, Y., Zhang, B., Wei, W., Deng, S., Meng, J., Hu, Y., Wang, Y., et al. (2024) · Theranostics · doi:10.7150/thno.91119 · Cited by 71
The role of macrophages in fibrosis of chronic kidney disease
Li, G., Yang, H., Zhang, D., Zhang, Y., Liu, B., Wang, Y.-X., Zhou, H., Xu, Z.-X., & Wang, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117079 · Cited by 73
Hypoxia conduces the glioma progression by inducing M2 macrophage polarization via elevating TNFSF9 level in a histone-lactylation-dependent manner
Li, M., Sun, P., Tu, B., Deng, G., Li, D., & He, W. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00124.2024 · Cited by 68
Luteolin inhibits inflammation and M1 macrophage polarization in the treatment of Pseudomonas aeruginosa-induced acute pneumonia through suppressing EGFR/PI3K/AKT/NF-κB and EGFR/ERK/AP-1 signaling pathways
Gu, M., & Pang, Z. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156663 · Cited by 75
Hypoxia decreases macrophage glycolysis and M1 percentage by targeting microRNA‐30c and mTOR in human gastric cancer
Yun, Z., Yulin, T., Wang, Y., Wei, D., Yin, C., Xu, J.-H., Jiang, R., & Xu, X. (2019) · Cancer Science · doi:10.1111/cas.14110 · Cited by 65
How the redox state regulates immunity
Mullen, L., Mengozzi, M., Hanschmann, E.-M., Alberts, B. M., & Ghezzi, P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.022 · Cited by 66
Spousal bereavement is associated with more pronounced ex vivo cytokine production and lower heart rate variability: Mechanisms underlying cardiovascular risk?
Fagundes, C. P., Murdock, K. W., LeRoy, A. S., Baameur, F., Thayer, J. F., & Heijnen, C. J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.010 · Cited by 64
Dendritic cell/cytokine‐induced killer cell‐based immunotherapy in lung cancer: What we know and future landscape
Mohsenzadegan, M., Peng, R., & Roudi, R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28977 · Cited by 66
Estrogen receptor α promotes lung cancer cell invasion via increase of and cross‐talk with infiltrated macrophages through the CCL2/CCR2/MMP9 and CXCL12/CXCR4 signaling pathways
He, M., Yu, W., Chang, C., Miyamoto, H., Liu, X., Jiang, K., & Yeh, S. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12701 · Cited by 64
The complex roles of efferocytosis in cancer development, metastasis, and treatment
Tajbakhsh, A., Gheibi hayat, S. M., Movahedpour, A., Savardashtaki, A., Loveless, R., Barreto, G. E., Teng, Y., & Sahebkar, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111776 · Cited by 64
Self-citation
Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing
Szondi, D. C., Wong, J. K. F., Vardy, L. A., & Cruickshank, S. M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.773866 · Cited by 64
Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression
Watanabe, Y., Fukuda, T., Hayashi, C., Nakao, Y., Toyoda, M., Kawakami, K., Shinjo, T., Iwashita, M., Yamato, H., Yotsumoto, K., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17692-0 · Cited by 67
Metabolic reprogramming of immune cells in pancreatic cancer progression
Xiang, H., Yang, R., Tu, J., Yan, X., Yang, S., Lv, L., Zhai, X., Zhu, Y., Dong, D., & Tao, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113992 · Cited by 64
Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments
Liu, X., Wang, M., Jiang, Y., Zhang, X., Shi, C., Zeng, F., Qin, Y., Ye, J., Hu, J., & Zhou, Z. (2023) · ACS Nano · doi:10.1021/acsnano.3c05627 · Cited by 64
Dynamic interactions in the tumor niche: how the cross-talk between CAFs and the tumor microenvironment impacts resistance to therapy
Piwócka, O., Piotrowski, I., Suchorska, W. M., & Kulcenty, K. I. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1343523 · Cited by 69
Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles
Yang, J., Wang, Z., Liang, X., Wang, W., & Wang, S. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103155 · Cited by 64
The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression
Nie, F., Zhang, J., Tian, H., Zhao, J., Gong, P., Wang, H., Wang, S., Yang, P., & Yang, C. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06640-7 · Cited by 68
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
Cao, L., Li, K., Li, Q., Tong, Q., Wang, Y., & Huang, L. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02475-8 · Cited by 79
Expression of pro‐inflammatory cytokines and mediators induced by Bisphenol A via ERK‐NFκB and JAK1/2‐STAT3 pathways in macrophages
Huang, F., Chang, Y., Lee, S., Yang, M., & Kuan, Y. (2019) · Environmental Toxicology · doi:10.1002/tox.22702 · Cited by 64
Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy
Faria, S. S., Corrêa, L. H., Cardoso, G. S. H. R., de Sant’Ana, L. P., Almeida, R. D. N., & Magalhães, K. G. (2020) · Journal of Breast Cancer · doi:10.4048/jbc.2020.23.e35 · Cited by 72
Advanced Glycation End Products Enhance M1 Macrophage Polarization by Activating the MAPK Pathway
He, S., Hu, Q., Xu, X., Niu, Y., Chen, Y.-M., Lu, Y., Su, Q., & Qin, L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.053 · Cited by 64
The spectrum of macrophage activation by immunometabolism
Kang, S., & Kumanogoh, A. (2020) · International Immunology · doi:10.1093/intimm/dxaa017 · Cited by 64
Glucose Metabolism: The Metabolic Signature of Tumor Associated Macrophage
Zhang, Q., Wang, J., Yadav, D. K., Bai, X., & Liang, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702580 · Cited by 67
Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages
Wang, H., Zheng, X., Liu, B., Xia, Y., Xin, Z., Deng, B., He, L., Deng, J., & Ren, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.753092 · Cited by 68
Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond
Yu, W., Xie, D., Yamamoto, T., Koyama, H., & Cheng, J. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09787-4 · Cited by 64
The markers to delineate different phenotypes of macrophages related to metabolic disorders
Wei, Q., Deng, Y., Yang, Q., Zhan, A., & Wang, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1084636 · Cited by 66
Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization
Ko, C., Lin, Y., Achudhan, D., Chang, J., Liu, S., Lai, C.-Y., Huang, Y., Tsai, C., Fong, Y., Chen, H.-T., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.86701 · Cited by 63
The role of liver microenvironment in hepatic metastasis
Williamson, T., Sultanpuram, N., & Sendi, H. (2019) · Clinical and Translational Medicine · doi:10.1186/s40169-019-0237-6 · Cited by 65
Exosomes from mmu_circ_0001359-Modified ADSCs Attenuate Airway Remodeling by Enhancing FoxO1 Signaling-Mediated M2-like Macrophage Activation
Shang, Y., Sun, Y., Xu, J., Ge, X., Hu, Z., Xiao, J., Ning, Y., Dong, Y., & Bai, C. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.10.049 · Cited by 65
The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia
VanderVeen, B. N., Murphy, E. A., & Carson, J. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01037 · Cited by 61
Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
Wang, L., Li, H., Tang, Y., & Yao, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.585285 · Cited by 67
Fatty Acid Metabolism and Idiopathic Pulmonary Fibrosis
Geng, J., Liu, Y., Dai, H., & Wang, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.794629 · Cited by 61
Challenging the Paradigm: Anti-Inflammatory Interleukins and Angiogenesis
Peluzzo, A. M., & Autieri, M. V. (2022) · Cells · doi:10.3390/cells11030587 · Cited by 64
Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis
Wang, M., Tang, G., Zhou, C., Guo, H., Hu, Z., Hu, Q., & Li, G. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110387 · Cited by 62

Authors: Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A.
Affiliations: Faculty of Medicine Department of Immunology BuAli Research Institute Mashhad University of Medical Sciences Mashhad Iran
Faculty of Medicine Student Research Committee Immunology Research Center BuAli Research Institute Mashhad University of Medical Sciences Mashhad Iran
Islamic Azad University of Hamedan (IR)
Kermanshah University of Medical Sciences (IR)
Mashhad University of Medical Sciences (IR)
Islamic Azad University, Mashhad (IR)
Corresponding author: Sahebkar, Amirhossein
ORCID: Taghadosi, Mahdi
Esmaeili, Seyed‐Alireza
Mardani, Fatemeh
Mohammadi, Asadollah
Afshari, Jalil T.
Sahebkar, Amirhossein
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2018-03-01
Volume: 233
Issue: 9
Pages: 6425-6440
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.26429
PMC: PMC13482560
OpenAlex: W2782685575
Cited by: 4,930
References: 131
Citations by year: 2026: 477 · 2025: 876 · 2024: 898 · 2023: 783 · 2022: 666 · 2021: 564 · 2020: 399 · 2019: 183 · 2018: 77
FWCI: 31.37
Type: journal article
Language: en
Open access: green
pmc.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: macrophages, macrophage polarization, M1 macrophages, M2 macrophages, macrophage plasticity, macrophage migration, antigen presentation, cytokine and chemokine production, macrophage metabolism, microRNA, tissue repair, inflammation, pregnancy, antimicrobial defense, antitumor immunity, obesity, asthma, allergy, atherosclerosis, fibrosis, wound healing, autoimmunity
MeSH terms: Animals, Cell Differentiation, Humans, Inflammation, Macrophages, Phenotype, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Macrophage plasticity, polarization, and function in health and disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks