Gender‐specific differences in the development of sarcopenia in the rodent model of the ageing high‐fat rat
Open accessAbstract
Background: Sarcopenia is linked to functional impairments, loss of independence, and mortality. In the past few years, obesity has been established as being a risk factor for a decline in muscle mass and function. There are several molecular pathological mechanisms, which have been under discussion that might explain this relationship. However, most studies were conducted using male animals and for a short period of time. Methods: In this study, the gender‐specific effect of long‐term, high‐fat content feeding in Sprague–Dawley rats was examined. Development of the quadriceps muscle of the animals was monitored in vivo using magnetic resonance. The results of these measurements and of the biochemical analysis of the aged muscle were compared. Results: Surprisingly, only male but not female rats showed a decline in muscle cross‐sectional area at 16 months of age as a result of a chronic oversupply of dietary fats. This loss of muscle mass could not be explained by either de‐regulation of the anabolic Akt pathway or by up‐regulation of the main ubiquitin ligases of muscle, MAFbx and MuRF‐1. However, fusion of satellite cells to myotubes was induced by the high‐fat diet in male rats, possibly as a result of an increased need for compensatory regeneration processes. Caspase‐3‐dependent apoptosis induction, irrespective of diet, seems to be the major determinant of muscle decline during ageing in male but not female rats. Conclusion: Taken together, activation of the apoptosis‐inducing Caspase‐3 seems to be the most important trigger for the age‐related muscle loss. Male rats were more prone to the decline of muscle during ageing than female animals, which was further enforced by a long‐term, high fat diet.
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Loss of muscle leads to weakness, loss of independence, and increased risk of death.
“Loss of muscle has a serious consequence on many chronic diseases, and on ageing itself, because it leads to weakness, loss of independence, and increased risk of death.[ 4 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [4]
Full-blown sarcopenia often leads to loss of respiratory function, and increased risk of death.
“Full‐blown sarcopenia, on the other hand, often leads to loss of respiratory function, and increased risk of death.[ 4 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [4]
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Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626 · see citing works
The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles
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- Authors
- Kob, R., Fellner, C., Bertsch, T., Wittmann, A., Mishura, D., Sieber, C. C., Fischer, B. E., Stroszczynski, C., & Bollheimer, C. L.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Regensburg (DE)
- Paracelsus Medical University (AT)
- Corresponding author
- Kob, Robert
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2015-04-30
- Volume
- 6
- Issue
- 2
- Pages
- 181-191
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC4458084
- OpenAlex
- W1919082278
- Cited by
- 48
- References
- 52
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2014: 1
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Funders
- Bayerische Forschungsstiftung (FORMOsA)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, aging, high-fat diet, obesity, sex differences, muscle mass loss, quadriceps, magnetic resonance imaging, AKT pathway, atrogin-1, MuRF1, caspase-3, apoptosis, muscle atrophy
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