Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu

doi:10.1016/j.arr.2012.11.004

Cited by 180Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulation

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2012.11.004

Open this paper in CoChat — free account

Abstract

Autophagy and apoptosis are crucial cellular housekeeping and tissue survival mechanisms. There is emerging evidence of important crosstalk between apoptosis and autophagy which can be linked to inflammasome activation. Beclin 1 is a platform protein which assembles an interactome consisting of diverse proteins which control the initiation of autophagocytosis and distinct phases in endocytosis. Recent studies have demonstrated that the anti-apoptotic Bcl-2 family members can interact with Beclin 1 and inhibit autophagy. Consequently, impaired autophagy can trigger inflammasome activation. Interestingly, the hallmarks of the ageing process include a decline in autophagy, increased resistance to apoptosis and a low-grade inflammatory phenotype. Age-related stresses, e.g. genotoxic, metabolic and environmental insults, enhance the expression of NF-κB-driven anti-apoptotic Bcl-2 proteins which repress the Beclin 1-dependent autophagy. Suppression of autophagocytosis provokes inflammation including NF-κB activation which further potentiates anti-apoptotic defence. In a context-dependent manner, this feedback defence mechanism can enhance the aging process or provoke tumorigenesis or cellular senescence. We will review the role of Beclin 1 interactome in the crosstalk between apoptosis, autophagy and inflammasomes emphasizing that disturbances in Beclin 1-dependent autophagy can have a crucial impact on the aging process.

Integrity signals

Registry

Crossref · 10.1016/j.arr.2012.11.004

Cites

246 of 246 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Downregulation of beclin 1 increases the aggregation of amyloid beta plaques and tau aggregates in Alzheimer's disease.
“In line with these findings, the downregulation of beclin 1 (BECN1) increases the aggregation of Aβ plaques and tau aggregates in AD [48].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [48]

Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
The Inflammasomes
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Regulation mechanisms and signaling pathways of autophagy
He, C., & Klionsky, D. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-114910 · Cited by 3,609 · see citing works
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536 · see citing works
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works
The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
Apoptosis: controlled demolition at the cellular level
Taylor, R. C., Cullen, S. P., & Martin, S. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2312 · Cited by 2,617 · see citing works
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485 · see citing works
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works
Autophagy and Aging
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
Tschopp, J., & Schroder, K. (2010) · Nature reviews. Immunology · doi:10.1038/nri2725 · Cited by 1,859 · see citing works
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcı́a-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,726 · see citing works
Deconvoluting the context-dependent role for autophagy in cancer
White, E. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3262 · Cited by 1,698 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works
JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329 · see citing works
Autophagy is required to maintain muscle mass.
Masiero, E., Agatea, L., Mammucari, C., Blaauw, B., Loro, E., Komatsu, M., Metzger, D., Reggiani, C., Schiaffino, S., & Sandri, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.008 · Cited by 1,282 · see citing works
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans
Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Matsunaga, K., Saitoh, T., Tabata, K., Omori, H., Satoh, T., Kurotori, N., Maejima, I., Shirahama-Noda, K., Ichimura, T., Isobe, T., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1846 · Cited by 1,235 · see citing works
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,186 · see citing works
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176 · see citing works
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works
Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein
Liang, X. H., Kleeman, L. K., Jiang, H., Gordon, G. W., Goldman, J. E., Berry, G., Herman, B. A., & Levine, B. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8586-8596.1998 · Cited by 1,128 · see citing works
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
Maiuri, M. C., Toumelin-Braizat, G. L., Criollo, A., Rain, J., Gautier, F., Juin, P. P., Tasdemir, E., Pierron, G., Troulinaki, K., Tavernarakis, N., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601689 · Cited by 1,107 · see citing works
Autophagy mediates the mitotic senescence transition
Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works
Endogenous HMGB1 regulates autophagy
Tang, D., Kang, R., Livesey, K. M., Cheh, C.-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M. E., Tracey, K. J., Zeh, H. J., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911078 · Cited by 951 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
Takahashi, Y., Coppola, D., Matsushita, N., Cualing, H. D., Sun, M., Sato, Y., Liang, C., Jung, J. U., Cheng, J. Q., Mul, J. J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1634 · Cited by 928 · see citing works
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Murakami, T., Öckinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117765109 · Cited by 926 · see citing works
Bcl-2 family proteins and cancer
Yip, K. W., & Reed, J. C. (2008) · Oncogene · doi:10.1038/onc.2008.307 · Cited by 883 · see citing works
Inflammatory markers in population studies of aging
Singh, T., & Newman, A. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.11.002 · Cited by 866 · see citing works
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Liang, C., Lee, J.-S., Inn, K.-S., Gack, M. U., Li, Q., Roberts, E. A., Vergne, I., Deretic, V., Feng, P., Akazawa, C., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1740 · Cited by 792 · see citing works
The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond
Funderburk, S. F., Wang, Q. J., & Yue, Z. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.002 · Cited by 778 · see citing works
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766 · see citing works
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763 · see citing works
The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x L
Chen, C., Edelstein, L. C., & Gélinas, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2687-2695.2000 · Cited by 760 · see citing works
Calcium and neurodegeneration
Mattson, M. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00275.x · Cited by 751 · see citing works
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
Esteller, M., & Herman, J. G. (2001) · The Journal of Pathology · doi:10.1002/path.1024 · Cited by 743 · see citing works
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp073 · Cited by 737 · see citing works
The mitochondrial‐lysosomal axis theory of aging
Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works
HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
Harris, H. E., Andersson, U., & Pisetsky, D. S. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.222 · Cited by 689 · see citing works
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
Rapp, P., & Gallagher, M. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.18.9926 · Cited by 687 · see citing works
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease
Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680 · see citing works
Age-related decline in chaperone-mediated autophagy
Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665 · see citing works
The Beclin 1 interactome
He, C., & Levine, B. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.01.001 · Cited by 659 · see citing works
BCL-2 family antagonists for cancer therapy
Lessène, G., Czabotar, P. E., & Colman, P. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2658 · Cited by 623 · see citing works
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death & Disease · doi:10.1038/cddis.2009.8 · Cited by 613 · see citing works
DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy
Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas‐Kramarski, R., & Kimchi, A. (2009) · The EMBO Reports · doi:10.1038/embor.2008.246 · Cited by 592 · see citing works
p16 INK4A is a robust in vivo biomarker of cellular aging in human skin
Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter‐Kochanek, K., Jansen‐Dürr, P., & Wlaschek, M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00231.x · Cited by 557 · see citing works
Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons
Tamatani, M., Ho, Y., Matsuzaki, H., Ogawa, S., Okado, H., Miyake, S., Mizuno, T., & Tohyama, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8531 · Cited by 549 · see citing works
Canonical and non-canonical autophagy: variations on a common theme of self-eating?
Codogno, P., Mehrpour, M., & Proikas‐Cezanne, T. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3249 · Cited by 545 · see citing works
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
Cao, Y., & Klionsky, D. J. (2007) · Cell Research · doi:10.1038/cr.2007.78 · Cited by 541 · see citing works
Aging as an event of proteostasis collapse
Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538 · see citing works
JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling
Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 537 · see citing works
Autophagy and aging: keeping that old broom working
Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
Gamerdinger, M., Hajieva, P., Kaya, A. M., Wolfrum, U., Hartl, F. U., & Behl, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.29 · Cited by 522 · see citing works
Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520 · see citing works
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
Bartolomeo, S. D., Corazzari, M., Nazio, F., Oliverio, S., Lisi, G., Antonioli, M., Pagliarini, V., Matteoni, S., Fuoco, C., Giunta, L., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201002100 · Cited by 519 · see citing works
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2012) · Aging · doi:10.18632/aging.100444 · Cited by 511 · see citing works
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-179 · Cited by 499 · see citing works
Untitled work
(1995) · PubMed · Cited by 496 · see citing works
Autophagosome Formation and Molecular Mechanism of Autophagy
Tanida, I. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3482 · Cited by 489 · see citing works
Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity
Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.02.055 · Cited by 488 · see citing works
Overview of macroautophagy regulation in mammalian cells
Mehrpour, M., Esclatine, A., Beau, I., & Codogno, P. (2010) · Cell Research · doi:10.1038/cr.2010.82 · Cited by 488 · see citing works
TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy
Shi, C.-S., & Kehrl, J. H. (2010) · Science Signaling · doi:10.1126/scisignal.2000751 · Cited by 472 · see citing works
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
Luciani, A., Villella, V. R., Esposito, S., Brunetti-Pierri, N., Medina, D., Settembre, C., Gavina, M., Pulze, L., Giardino, I., Pettoello-Mantovani, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2090 · Cited by 467 · see citing works
Motif module map reveals enforcement of aging by continual NF-κB activity
Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes & Development · doi:10.1101/gad.1588507 · Cited by 466 · see citing works
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., & Yuan, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600364200 · Cited by 458 · see citing works
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells
Hua Zhu, C., Wu, H., Liu, X., Li, B., Chen, Y., Ren, X., Liu, C., & Yang, J. (2009) · Autophagy · doi:10.4161/auto.9064 · Cited by 457 · see citing works
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Matsunaga, K., Morita, E., Saitoh, T., Akira, S., Ktistakis, N. T., Izumi, T., Noda, T., & Yoshimori, T. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911141 · Cited by 456 · see citing works
Can autophagy promote longevity?
Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 429 · see citing works
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
Sengupta, A., Molkentin, J. D., & Yutzey, K. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024406 · Cited by 428 · see citing works
Regulation of membrane traffic by phosphoinositide 3-kinases
Lindmo, K., & Stenmark, H. (2006) · Journal of Cell Science · doi:10.1242/jcs.02855 · Cited by 425 · see citing works
Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis
Zhou, F., Yang, Y., & Xing, D. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07965.x · Cited by 424 · see citing works
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Bishop, N. A., & Guarente, L. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2188 · Cited by 421 · see citing works
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
Chen, R., Valencia, I., Zhong, F., McColl, K. S., Roderick, H. L., Bootman, M. D., Berridge, M. J., Conway, S. J., Holmes, A. B., Mignery, G. A., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309146 · Cited by 403 · see citing works
Vascular endothelial senescence: from mechanisms to pathophysiology
Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399 · see citing works
Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis
Gareus, R., Kotsaki, E., Xanthoulea, S., van der Made, I., Gijbels, M. J., Kardakaris, R., Polykratis, A., Kollias, G. A., de Winther, M. P. J., & Pasparakis, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.016 · Cited by 382 · see citing works
Complex Inhibitory Effects of Nitric Oxide on Autophagy
Sarkar, S., Korolchuk, V. I., Renna, M., Imarisio, S., Fleming, A., Williams, A. J., Garcı́a-Arencibia, M., Rose, C., Luo, S., Underwood, B. R., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.029 · Cited by 381 · see citing works
The autophagy effector Beclin 1: a novel BH3-only protein
Sinha, S. C., & Levine, B. (2008) · Oncogene · doi:10.1038/onc.2009.51 · Cited by 376 · see citing works
Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch.
Marquez, R. T., & Xu, L. (2012) · PubMed · Cited by 364 · see citing works
Neuronal Calcium Homeostasis and Dysregulation
Gleichmann, M., & Mattson, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3386 · Cited by 360 · see citing works
Interleukin-1 (IL-1) Pathway
Weber, A., Wasiliew, P., & Kracht, M. (2010) · Science Signaling · doi:10.1126/scisignal.3105cm1 · Cited by 353 · see citing works
Autophagy is Required for Dietary Restriction-Mediated Life Span Extension inC. elegans
Jia, K., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.4989 · Cited by 341 · see citing works
The role of CD8+ T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Aging of the human cerebellum: A stereological study
Andersen, B. B., Gundersen, H. J. G., & Pakkenberg, B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10884 · Cited by 334 · see citing works
Autophagic cell death: Loch Ness monster or endangered species?
Shen, H., & Codogno, P. (2011) · Autophagy · doi:10.4161/auto.7.5.14226 · Cited by 330 · see citing works
The crosstalk between autophagy and apoptosis: where does this lead?
Gordy, C. L., & He, Y.-W. (2012) · Protein & Cell · doi:10.1007/s13238-011-1127-x · Cited by 322 · see citing works
Aging of the Immune System as a Prognostic Factor for Human Longevity
Larbi, A., Franceschi, C., Mazzatti, D. J., Solana, R., Wikby, A., & Pawelec, G. (2008) · Physiology · doi:10.1152/physiol.00040.2007 · Cited by 316 · see citing works
BAG3: a multifaceted protein that regulates major cell pathways
Rosati, A., Graziano, V., Laurenzi, V. D., Pascale, M. C., & Turco, M. C. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.24 · Cited by 314 · see citing works
Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy
Brack, A. S., Bildsoe, H., & Hughes, S. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02602 · Cited by 308 · see citing works
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
Rong, Y.-P., Bultynck, G., Aromolaran, A. S., Zhong, F., Parys, J. B., SMEDT, H. D., Mignery, G. A., Roderick, H. L., Bootman, M. D., & Distelhorst, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907555106 · Cited by 306 · see citing works
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
Wu, J., Quijano, C., Chen, E., Liu, H., Cao, L., Fergusson, M. M., Rovira, I. I., Gutkind, S., Daniels, M. P., Komatsu, M., et al. (2009) · Aging · doi:10.18632/aging.100038 · Cited by 305 · see citing works
Regulation of autophagy by the inositol trisphosphate receptor
Criollo, A., Maiuri, M. C., Tasdemir, E., Vitale, I., Fiebig, A. A., Andrews, D. W., Molgó, J., Dı́az, J., Lavandero, S., Harper, F., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402099 · Cited by 305 · see citing works
Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases
Salminen, A., Ojala, J. O., Kaarniranta, K., & Kauppinen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0962-0 · Cited by 304 · see citing works
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in micePreprint
Chen, Y., Kao, C., Chen, Y.-T., Wang, C., Wu, C.-Y., Tsai, C., Liu, F.-C., Yang, C.-W., Wei, Y., Hsu, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1779509 · Cited by 304 · see citing works
Oxidative stress, inflamm-aging and immunosenescence
Cannizzo, E. S., Clement, C. C., Sahu, R. K., Follo, C., & Santambrogio, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.005 · Cited by 303 · see citing works
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Differential Interactions Between Beclin 1 and Bcl-2 Family Members
Erlich, S., Mizrachy, L., Segev, O., Lindenboim, L., Zmira, O., Adi-Harel, S., Hirsch, J. A., Stein, R., & Pinkas‐Kramarski, R. (2007) · Autophagy · doi:10.4161/auto.4713 · Cited by 292 · see citing works
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
Vicencio, J. M., Ortiz, C., Criollo, A., Jones, A. W. E., Kepp, O., Galluzzi, L., Joza, N., Vitale, I., Morselli, E., Tailler, M., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.34 · Cited by 289 · see citing works
Parkin Interacts with Ambra1 to Induce Mitophagy
Van Humbeeck, C., Cornelissen, T., Hofkens, H., Mandemakers, W., Gevaert, K., De Strooper, B., & Vandenberghe, W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1917-11.2011 · Cited by 287 · see citing works
A Homozygous Mutation in a Novel Zinc-Finger Protein, ERIS, Is Responsible for Wolfram Syndrome 2
Amr, S. S., Heisey, C., Zhang, M., Xia, X.-J., Shows, K. H., Ajlouni, K. M., Pandya, A., Satin, L. S., El‐Shanti, H., & Shiang, R. (2007) · The American Journal of Human Genetics · doi:10.1086/520961 · Cited by 284 · see citing works
Antagonism of Beclin 1‐dependent autophagy by BCL‐2 at the endoplasmic reticulum requires NAF‐1
Chang, N. C., Nguyen, M., Germain, M., & Shore, G. C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.369 · Cited by 281 · see citing works
Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy
Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., & Codogno, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805920200 · Cited by 280 · see citing works
A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis
Brunk, U. T., Jones, C. B., & Sohal, R. S. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90042-n · Cited by 274 · see citing works
Regulation of the aging process by autophagy.
Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270 · see citing works
Self-citation
The number of p16INK4a positive cells in human skin reflects biological age
Waaijer, M. E. C., Parish, W. E., Strongitharm, B. H., van Heemst, D., Slagboom, P. E., de Craen, A. J. M., Sedivy, J. M., Westendorp, R. G. J., Gunn, D. A., & Maier, A. B. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00837.x · Cited by 264 · see citing works
Impact of cellular senescence signature on ageing research
Sikora, E., Arendt, T., Bennett, M., & Narita, M. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.002 · Cited by 264 · see citing works
p53/HMGB1 Complexes Regulate Autophagy and Apoptosis
Livesey, K. M., Kang, R., Vernon, P. J., Buchser, W., Loughran, P., Watkins, S. C., Zhang, L., Manfredi, J. J., Zeh, H. J., Li, L., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2291 · Cited by 261 · see citing works
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
Michiorri, S., Gelmetti, V, Giarda, E., Lombardi, F., Romano, F., Marongiu, R., Nerini-Molteni, S., Sale, P., Vago, R., Arena, G., et al. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.200 · Cited by 260 · see citing works
Autophagy induction by the pathogen receptor CD46.
Joubert, P.-E., Meiffren, G., Grégoire, I., Pontini, G., Richetta, C., Flacher, M., Azocar, O., Vidalain, P.-O., Vidal, M., Lotteau, V., et al. (2009) · Cell Host and Microbe · doi:10.1016/j.chom.2009.09.006 · Cited by 259 · see citing works
A dual role for Ca2+ in autophagy regulation
Decuypere, J.-P., Bultynck, G., & Parys, J. B. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.04.001 · Cited by 257 · see citing works
Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
Zalckvar, E., Berissi, H., Eisenstein, M., & Kimchi, A. (2009) · Autophagy · doi:10.4161/auto.5.5.8625 · Cited by 254 · see citing works
Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R., & Park, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023367 · Cited by 254 · see citing works
Aging: Central role for autophagy and the lysosomal degradative system
Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 247 · see citing works
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
Korkmaz, G., le Sage, C., Tekirdağ, K. A., Agami, R., & Gözüaçık, D. (2012) · Autophagy · doi:10.4161/auto.8.2.18351 · Cited by 246 · see citing works
Differences in signaling pathways by IL-1β and IL-18
Lee, J.-K., Kim, S.-H., Lewis, E. C., Azam, T., Reznikov, L. L., & Dinarello, C. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402800101 · Cited by 237 · see citing works
The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
Papa, S., Bubici, C., Zazzeroni, F., Pham, C. G., Kuntzen, C., Knabb, J. R., Dean, K., & Franzoso, G. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401865 · Cited by 236 · see citing works
Regulation of autophagy by phosphatidylinositol 3‐phosphate
Burman, C., & Ktistakis, N. T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.011 · Cited by 234 · see citing works
Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
Helenius, M., Hänninen, M., Lehtinen, S. K., & Salminen, A. (1996) · Biochemical Journal · doi:10.1042/bj3180603 · Cited by 232 · see citing works
Oxidative Stress, Inflammaging, and Immunosenescence
Bauer, M. E., & la Fuente, M. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229 · see citing works
Autophagy and cancer – issues we need to digest
Liu, E. Y., & Ryan, K. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.093708 · Cited by 219 · see citing works
Aging-induced Up-regulation of Nuclear Binding Activities of Oxidative Stress Responsive NF-kB Transcription Factor in Mouse Cardiac Muscle
Helenius, M. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0045 · Cited by 217 · see citing works
Oxidative Stress Induces Parallel Autophagy and Mitochondria Dysfunction in Human Glioma U251 Cells
Zhang, H., Kong, X., Kang, J., Su, J., Yang, L., Zhong, J., & Sun, L. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp101 · Cited by 209 · see citing works
Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation
Geeraert, C., Ratier, A., Pfisterer, S. G., Perdiz, D., Cantaloube, I., Rouault, A., Pattingre, S., Proikas‐Cezanne, T., Codogno, P., & Poüs, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091553 · Cited by 204 · see citing works
Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
Luo, S., Garcı́a-Arencibia, M., Zhao, R., Puri, C., Toh, P. P. C., Sadiq, O., & Rubinsztein, D. C. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.040 · Cited by 203 · see citing works
Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
Lee, J., Takahashi, T., Yasuhara, N., Inazawa, J., Kamada, S., & Tsujimoto, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203043 · Cited by 197 · see citing works
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
Thoresen, S. B., Pedersen, N. M., Liestøl, K., & Stenmark, H. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.07.008 · Cited by 192 · see citing works
Negative Regulation of Vps34 by Cdk Mediated Phosphorylation
Furuya, T., Kim, M., Lipinski, M. M., Li, J., Kim, D., Lu, T., Shen, Y., Rameh, L. E., Yankner, B. A., Tsai, L., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.009 · Cited by 186 · see citing works
NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1
Jounai, N., Kobiyama, K., Shiina, M., Ogata, K., Ishii, K. J., & Takeshita, F. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001654 · Cited by 184 · see citing works
Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
Ciechomska, I. A., Goemans, G. C., Skepper, J. N., & Tolkovsky, A. M. (2009) · Oncogene · doi:10.1038/onc.2009.60 · Cited by 180 · see citing works
Beclin 1-independent autophagy contributes to apoptosis in cortical neurons
Grishchuk, Y., Ginet, V., Truttmann, A. C., Clarke, P. G. H., & Puyal, J. (2011) · Autophagy · doi:10.4161/auto.7.10.16608 · Cited by 179 · see citing works
Autophagy in the heart and liver during normal aging and calorie restriction
Wohlgemuth, S. E., Julian, D., Akin, D. E., Fried, J., Toscano, K., Leeuwenburgh, C., & Dunn, Jr. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0535 · Cited by 179 · see citing works
Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB
Badrichani, A. Z., Stroka, D., Bilbao, G., Curiel, D. T., Bach, F. H., & Ferran, C. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci2517 · Cited by 174 · see citing works
NF-κB2/p100 induces Bcl-2 expression
Viatour, P., Bentires‐Alj, M., Chariot, A., Deregowski, V., de Leval, L., Merville, M. P., & Bours, V. (2003) · Leukemia · doi:10.1038/sj.leu.2402982 · Cited by 167 · see citing works
A Novel Role for Interleukin-18 in Adhesion Molecule Induction through NFκB and Phosphatidylinositol (PI) 3-Kinase-dependent Signal Transduction Pathways
Morel, J., Park, C. C., Woods, J. M., & Koch, A. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103574200 · Cited by 165 · see citing works
The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
Terman, A. (2009) · Gerontology · doi:10.1159/000213753 · Cited by 162 · see citing works
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
Rodríguez, D. A., Rojas‐Rivera, D., & Hetz, C. A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.012 · Cited by 160 · see citing works
Ins(1,4,5) P 3 receptor-mediated Ca 2+ signaling and autophagy induction are interrelated
Decuypere, J.-P., Welkenhuyzen, K., Luyten, T., Ponsaerts, R., Dewaele, M., Molgó, J., Agostinis, P., Missiaen, L., De Smedt, H., Parys, J. B., et al. (2011) · Autophagy · doi:10.4161/auto.7.12.17909 · Cited by 159 · see citing works
Apoptosis and aging: increased resistance to apoptosis enhances the aging process
Salminen, A., Ojala, J., & Kaarniranta, K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0597-y · Cited by 158 · see citing works
Autophagy: An Emerging Immunological Paradigm
Deretic, V. P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102108 · Cited by 154 · see citing works
TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3
Besse, A., Lamothe, B., Campos, A. D., Webster, W. K., Maddineni, U., Lin, S., Wu, H., & Darnay, B. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608867200 · Cited by 145 · see citing works
Bcl-2 Activates the Transcription Factor NFκB through the Degradation of the Cytoplasmic Inhibitor IκBα
de Moissac, D., Mustapha, S., Greenberg, A. H., & Kirshenbaum, L. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23946 · Cited by 145 · see citing works
Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation
Vairo, G., Soos, T. J., Upton, T. M., Zalvide, J. B., DeCaprio, J. A., Ewen, M. E., Koff, A., & Adams, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4745-4753.2000 · Cited by 144 · see citing works
The role of PI3P phosphatases in the regulation of autophagy
Vergne, I., & Deretic, V. P. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.054 · Cited by 143 · see citing works
Age-Related Changes in the Autophagic Proteolysis of Rat Isolated Liver Cells: Effects of Antiaging Dietary Restrictions
Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z., & Bergamini, E. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.9.b375 · Cited by 142 · see citing works
The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.007 · Cited by 142 · see citing works
MicroRNA-modulated autophagic signaling networks in cancer
Fu, L., Wen, X., Bao, J., & Liu, B. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.02.004 · Cited by 141 · see citing works
Nuclear domains during muscle atrophy: nuclei lost or paradigm lost?
Gundersen, K., & Bruusgaard, J. C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.154369 · Cited by 140 · see citing works
PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk
Eisenberg‐Lerner, A., & Kimchi, A. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.149 · Cited by 136 · see citing works
Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors
Li, Z., Chen, B., Wu, Y., Jin, F., Xia, Y., & Liu, X. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-98 · Cited by 134 · see citing works
Association of increased autophagic inclusions labeled for β-galactosidase with fibroblastic aging
Gerland, L.-M., Peyrol, S., Lallemand, C., Branche, R., Magaud, J.-P., & Ffrench, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00132-3 · Cited by 130 · see citing works
Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity
Satou, T., Cummings, B. J., & Cotman, C. W. (1995) · Brain Research · doi:10.1016/0006-8993(95)00748-f · Cited by 129 · see citing works
NF-κB Signaling in the Aging Process
Salminen, A., & Kaarniranta, K. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9296-6 · Cited by 123 · see citing works
IP3Receptors, Mitochondria, and Ca2+Signaling: Implications for Aging
Decuypere, J.-P., Monaco, G., Missiaen, L., SMEDT, H. D., Parys, J. B., & Bultynck, G. (2011) · Journal of Aging Research · doi:10.4061/2011/920178 · Cited by 122 · see citing works
HMGB1 release by inflammasomes
Walle, L. V., Kanneganti, T., & Lamkanfi, M. (2011) · Virulence · doi:10.4161/viru.2.2.15480 · Cited by 122 · see citing works
BH3 mimetics activate multiple pro-autophagic pathways
Malik, S. A., Orhon, I., Morselli, E., Criollo, A., Shen, S., Mariño, G., BenYounès, A., Bénit, P., Rustin, P., Maiuri, M. C., et al. (2011) · Oncogene · doi:10.1038/onc.2011.104 · Cited by 120 · see citing works
Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats
Merrill, D. A., Chiba, A. A., & Tuszynski, M. H. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1327 · Cited by 118 · see citing works
Autophagic activity dictates the cellular response to oncogenic RAS
Wang, Y., Wang, X. D., Lapi, E., Sullivan, A., Jia, W., He, Y.-W., Ratnayaka, I., Zhong, S., Goldin, R. D., Goemans, C. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120193109 · Cited by 117 · see citing works
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation
Mauthe, M., Jacob, A., Freiberger, S., Hentschel, K., Stierhof, Y.-D., Codogno, P., & Proikas-Cezanne, T. (2011) · Autophagy · doi:10.4161/auto.7.12.17802 · Cited by 116 · see citing works
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans
Ruck, A., Attonito, J. D., Garces, K. T., Núñez, L., Palmisano, N. J., Rubel, Z., Bai, Z., Nguyen, K. C. Q., Sun, L., Grant, B. D., et al. (2011) · Autophagy · doi:10.4161/auto.7.4.14391 · Cited by 114 · see citing works
Aging alters the apoptotic response to genotoxic stress
Suh, Y., Lee, K.-A., Kim, W. H., Han, B. G., Vijg, J., & Park, S. C. (2002) · Nature Medicine · doi:10.1038/nm0102-3 · Cited by 114 · see citing works
Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
Ryu, S. J., Oh, Y. S., & Park, S. C. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402091 · Cited by 114 · see citing works
Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle
Chang, N. C., Nguyen, M., Bourdon, J., Risse, P., Martin, J. G., Danialou, G., Rizzuto, R., Petrof, B. J., & Shore, G. C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds048 · Cited by 113 · see citing works
Non‐apoptotic functions of apoptosis‐regulatory proteins
Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · The EMBO Reports · doi:10.1038/embor.2012.19 · Cited by 109 · see citing works
NF-κB and JNK: An Intricate Affair
Bubici, C., Papa, S., Pham, C. G., Zazzeroni, F., & Franzoso, G. (2004) · Cell Cycle · doi:10.4161/cc.3.12.1321 · Cited by 108 · see citing works
Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer
Won, K. Y., Kim, G. Y., Kim, Y. W., Song, J. Y., & Lim, S. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.07.006 · Cited by 108 · see citing works
NF‐κB p50/RelA and c‐Rel‐containing dimers: opposite regulators of neuron vulnerability to ischaemia
Sarnico, I., Lanzillotta, A., Boroni, F., Benarese, M., Alghisi, M., Schwaninger, M., Inta, I. M., Battistin, L., Spano, P., & Pizzi, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05783.x · Cited by 106 · see citing works
DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress
Eisenberg‐Lerner, A., & Kimchi, A. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402212 · Cited by 104 · see citing works
Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells
Zhang, X.-Y., Wu, X.-Q., Deng, R., Sun, T., Feng, G., & Zhu, X. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.004 · Cited by 102 · see citing works
Inhibition of autophagy by TAB2 and TAB3
Criollo, A., Niso‐Santano, M., Malik, S. A., Michaud, M., Morselli, E., Mariño, G., Lachkar, S., Arkhipenko, A., Harper, F., Pierron, G., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.413 · Cited by 101 · see citing works
Death‐associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death
Lin, Y.-N., Hupp, T., & Stevens, C. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07411.x · Cited by 100 · see citing works
Regulation of membrane biogenesis in autophagy via PI3P dynamics
Noda, T., Matsunaga, K., Taguchi‐Atarashi, N., & Yoshimori, T. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.04.002 · Cited by 100 · see citing works
A persistent level of Cisd2 extends healthy lifespan and delays aging in mice
Wu, C.-Y., Chen, Y., Wang, C., Kao, C., Zhuang, H.-W., Chen, C., Chen, L., Kirby, R., Wei, Y., Tsai, S., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds210 · Cited by 99 · see citing works
Protein transamidation by transglutaminase 2 in cells: a disputed Ca 2+ ‐dependent action of a multifunctional protein
Király, R., Demény, M. Á., & Fésüs, L. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08345.x · Cited by 98 · see citing works
Protein Kinase D Specifically Mediates Apoptosis Signal-regulating Kinase 1-JNK Signaling Induced by H2O2 but Not Tumor Necrosis Factor
Zhang, W., Zheng, S., Störz, P., & Wang, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414674200 · Cited by 98 · see citing works
Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy
Parys, J. B., Decuypere, J.-P., & Bultynck, G. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-17 · Cited by 98 · see citing works
Characterization of Aging-Associated Up-Regulation of Constitutive Nuclear Factor-κB Binding Activity
Helenius, M., Kyrylenko, S., Vehviläinen, P., & Salminen, A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100669 · Cited by 97 · see citing works
Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion
Kim, M., Jang, H.-R., Kim, J., Noh, S.-M., Song, K.-S., Cho, J.-S., Jeong, H. Y., Norman, J. C., Caswell, P. T., Kang, G. H., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm291 · Cited by 95 · see citing works
ARF Induces Autophagy by Virtue of Interaction with Bcl-xl
Pimkina, J. S., Humbey, O., Zilfou, J. T., Jarník, M., & Murphy, M. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804705200 · Cited by 93 · see citing works
NF-κB-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1
Edelstein, L. C., Lagos, L., Simmons, M. J., Tirumalai, H., & Gélinas, C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2749-2761.2003 · Cited by 89 · see citing works
Mechanism of Bcl-2 and Bcl-X L inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization
Faustin, B., Chen, Y., Zhai, D., Negrate, G. L., Lartigue, L., Satterthwait, A. C., & Reed, J. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809414106 · Cited by 86 · see citing works
Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions
Lawan, A., Shi, H., Gatzke, F., & Bennett, A. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1041-2 · Cited by 81 · see citing works
Age-related change of the neuronal number in the human medial vestibular nucleus: A stereological investigation
Tang, Y. C., López, I. A., & Baloh, R. W. (2002) · Journal of Vestibular Research · doi:10.3233/ves-2002-11602 · Cited by 78 · see citing works
Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas
Nicotra, G., Mercalli, F., Peracchio, C., Castino, R., Follo, C., Valente, G., & Isidoro, C. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.80 · Cited by 78 · see citing works
Oxidative‐stress‐dependent up‐regulation of Bcl‐2 expression in the central nervous system of aged Fisher‐344 rats
Kaufmann, J. A., Bickford, P. C., & Taglialatela, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00118.x · Cited by 76 · see citing works
Identification and Characterization of Nuclear Factor κB Binding Sites in the Murine bcl‐χ Promoter
Glasgow, J. N., Wood, T., & Perez-Polo, J. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751377.x · Cited by 73 · see citing works
The ER and ageing II: Calcium homeostasis
Puzianowska-Kuznicka, M., & Kuznicki, J. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.002 · Cited by 73 · see citing works
Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins
D’Eletto, M., Farrace, M. G., Rossin, F., Strappazzon, F., Giacomo, G. D., Cecconi, F., Melino, G., Sepe, S., Moreno, S., Fimia, G. M., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.2 · Cited by 71 · see citing works
bcl-2 protein expression in aged brain and neurodegenerative diseases
Migheli, A., Cavalla, P., Piva, R., Giordana, M. T., & Schiffer, D. (1994) · Neuroreport · doi:10.1097/00001756-199410000-00016 · Cited by 70 · see citing works

Flagged first, then by citations

6 of the 252 references couldn’t be matched to a known paper.

Sorted by citations

The Roles of Autophagy in Cancer
Yun, C. W., & Lee, S. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113466 · Cited by 965 · see citing works
Broad targeting of resistance to apoptosis in cancer
Mohammad, R. M., Muqbil, I., Lowe, L. J., Yedjou, C. G., Hsu, H.-Y., Lin, L., Siegelin, M. D., Fimognari, C., Kumar, N. B., Dou, Q. P., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.001 · Cited by 876 · see citing works
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J., Grune, T., & Castro, J. P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.001 · Cited by 368 · see citing works
MitomiRs in human inflamm-aging: A hypothesis involving miR-181a, miR-34a and miR-146a
Rippo, M. R., Olivieri, F., Monsurrò, V., Prattichizzo, F., Albertini, M. C., & Procopio, A. D. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.002 · Cited by 209 · see citing works
Autophagy in the physiology and pathology of the central nervous system
Nikoletopoulou, V., Papandreou, M. E., & Tavernarakis, N. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.204 · Cited by 206 · see citing works
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
Xu, T., Li, H., Dai, Z., Lau, G. K., Li, B., Zhu, W., Liu, X.-Q., Liu, H.-F., Cai, W.-W., Huang, S., et al. (2020) · Aging · doi:10.18632/aging.103035 · Cited by 204 · see citing works
Autophagy and apoptosis cascade: which is more prominent in neuronal death?
Gupta, R. V., Ambasta, R. K., & Kumar, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04004-4 · Cited by 171 · see citing works
Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
Jenwitheesuk, A., Nopparat, C., Mukda, S., Wongchitrat, P., & Govitrapong, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916848 · Cited by 161 · see citing works
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease
Liu, X., Jiang, L., Li, Y., Huang, Y., Hu, X.-R., Zhu, W., Wang, X., Wu, Y., Meng, X., & Qi, X. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00721-5 · Cited by 157 · see citing works
The Therapeutic and Pathogenic Role of Autophagy in Autoimmune Diseases
Yin, H., Wu, H., Chen, Y., Zhang, J., Zheng, M., Chen, G., Li, L., & Lu, Q. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01512 · Cited by 154 · see citing works
Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases
Li, M., Gao, P., & Zhang, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030332 · Cited by 152 · see citing works
Flavonoids as promising molecules in the cancer therapy: An insight
Mir, S. A., Dar, A., Hamid, L., Nisar, N., Malik, J. A., Ali, T., & Bader, G. N. (2023) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2023.100167 · Cited by 158 · see citing works
Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity
Carter, H. N., Kim, Y., Erlich, A. T., Zarrin‐khat, D., & Hood, D. A. (2018) · The Journal of Physiology · doi:10.1113/jp275998 · Cited by 136 · see citing works
The interplay between autophagy and apoptosis in the diabetic heart
Ouyang, C., You, J., & Xie, Z. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.10.014 · Cited by 136 · see citing works
Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway
Lin, Y., Jiao, Y., Yuan, Y., Zhou, Z., Zheng, Y., Xiao, J., Li, C., Chen, Z., & Cao, P. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-017-0002-0 · Cited by 134 · see citing works
Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells
Salimi, L., Akbari, A., Jabbari, N., Mojarad, B., Vahhabi, A., Szafert, S., Kalashani, S. A., Soraya, H., Nawaz, M., & Rezaie, J. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00426-y · Cited by 129 · see citing works
Mechanisms of Radiation Toxicity in Transformed and Non-Transformed Cells
Panganiban, R. A. M., Snow, A. L., & Day, R. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815931 · Cited by 122 · see citing works
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017) · Aging · doi:10.18632/aging.101167 · Cited by 102 · see citing works
“In fact, impaired autophagy can trigger the appearance of a pro-inflammatory phenotype tissue (or inflammaging) and the inflammasome activation [10, 11].”
BackgroundInfluential
Autophagy core machinery: overcoming spatial barriers in neurons
Ariosa, A., & Klionsky, D. J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1461-9 · Cited by 100 · see citing works
Preantral follicular atresia occurs mainly through autophagy, while antral follicles degenerate mostly through apoptosis
Li, M., Jan, S. Z., Hamer, G., van Pelt, A. M. M., van der Stelt, I., Keijer, J., & Teerds, K. J. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy116 · Cited by 95 · see citing works
Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice
François, A., Bilan, A. R., Quellard, N., Fernandez, B., Janet, T., Chassaing, D., Paccalin, M., Terro, F., & Page, G. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0139-x · Cited by 95 · see citing works
Contribution of the inflammasome to inflammaging
Mejias, N. H., Martinez, C. C., Stephens, M. E., & Vaccari, J. P. D. R. (2018) · Journal of Inflammation · doi:10.1186/s12950-018-0198-3 · Cited by 91 · see citing works
Melatonin reverses H2O2‐induced senescence in SH ‐ SY 5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF ‐κB
Nopparat, C., Sinjanakhom, P., & Govitrapong, P. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12407 · Cited by 90 · see citing works
Hydrogen Peroxide-Induced Change in Meat Quality of the Breast Muscle of Broilers Is Mediated by ROS Generation, Apoptosis, and Autophagy in the NF-κB Signal Pathway
Chen, X., Zhang, L., Li, J., Gao, F., & Zhou, G. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01267 · Cited by 90 · see citing works
Enhancing autophagy in Alzheimer's disease through drug repositioning
Eshraghi, M., Ahmadi, M., Afshar, S., Lorzadeh, S., Adlimoghaddam, A., Rezvani Jalal, N., West, R., Dastghaib, S., Igder, S., Torshizi, S. R. N., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108171 · Cited by 89 · see citing works
Autophagy Protects Against Senescence and Apoptosis via the RAS-Mitochondria in High-Glucose-Induced Endothelial Cells
Chen, F., Chen, B., Xiao, F.-Q., Wu, Y., Wang, R.-H., Sun, Z., Fu, G., Mou, Y., Tao, W., Hu, X., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358676 · Cited by 85 · see citing works
Long-term exposure to 835 MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice
Kim, J. H., Yu, D.-H., Huh, Y. H., Lee, E., Kim, H., & Kim, H. R. (2017) · Scientific Reports · doi:10.1038/srep41129 · Cited by 84 · see citing works
Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy
Pan, P., Zhang, H., Su, L., Wang, X., & Liu, D. (2018) · Molecules · doi:10.3390/molecules23030675 · Cited by 84 · see citing works
Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review
Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 82 · see citing works
Autophagy and Inflammatory Response in the Tumor Microenvironment
Ngabire, D., & Kim, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18092016 · Cited by 75 · see citing works
The role of autophagy in cancer: from molecular mechanism to therapeutic window
Jalali, P., Shahmoradi, A., Samii, A., Mazloomnejad, R., Hatamnejad, M. R., Saeed, A., Namdar, A., & Salehi, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1528230 · Cited by 81 · see citing works
Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling pathway
Wang, X., Jiang, L., Liu, X., Huang, Y., Wang, A., Zeng, H.-X., Gao, L., Zhu, Q., Xia, L., & Wu, Y.-G. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154400 · Cited by 74 · see citing works
HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells
Ma, H., Su, L., Yue, H.-W., Yin, X., Zhao, J., Zhang, S., Kung, H., Xu, Z., & Miao, J. (2015) · Scientific Reports · doi:10.1038/srep15121 · Cited by 69 · see citing works
Autophagy and mitochondrial dysfunction in adjuvant-arthritis rats treatment with resveratrol
Zhang, J., Song, X., Cao, W., Lu, J., Wang, X., Wang, G., Wang, Z., & Chen, X. (2016) · Scientific Reports · doi:10.1038/srep32928 · Cited by 69 · see citing works
Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress
Nah, J., Yoo, S., Jung, S., Jeong, E. I., Park, M., Kaang, B., & Jung, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.71 · Cited by 68 · see citing works
Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor
Lu, R., Zhang, Y., Xia, Y., & Sun, J. (2019) · The FASEB Journal · doi:10.1096/fj.201900727r · Cited by 67 · see citing works
Transcriptomic profiles of aging in purified human immune cells
Reynolds, L. M., Ding, J., Taylor, J. R., Lohman, K., Soranzo, N., de la Fuente, A., Liu, T. F., Johnson, C., Barr, R. G., Register, T. C., et al. (2015) · BMC Genomics · doi:10.1186/s12864-015-1522-4 · Cited by 62 · see citing works
Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity
Raz, Y., Guerrero‐Ros, I., Maier, A. B., Slagboom, P. E., Atzmon, G., Barzilai, N., & Macián, F. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx020 · Cited by 63 · see citing works
Apoptosis, Autophagy, Necrosis and Their Multi Galore Crosstalk in Neurodegeneration
Saleem, S. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.06.023 · Cited by 62 · see citing works
Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells
Giuliani, A., Cirilli, I., Prattichizzo, F., Mensa’, E., Fulgenzi, G., Sabbatinelli, J., Graciotti, L., Olivieri, F., Procopio, A. D., Tiano, L., et al. (2018) · Aging · doi:10.18632/aging.101591 · Cited by 58 · see citing works
Autophagy and Inflammasome Interplay
Martins, J. D., Liberal, J. M. T., da Silva, A. B. G., Ferreira, I., Neves, B. M., & Cruz, M. T. (2015) · DNA and Cell Biology · doi:10.1089/dna.2014.2752 · Cited by 56 · see citing works
Diosgenin-induced autophagy and apoptosis in a human prostate cancer cell line
Nie, C., Zhou, J., Qin, X., Shi, X., Zeng, Q., Liu, J., Yan, S., & Zhang, L. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5750 · Cited by 56 · see citing works
Autophagy in Multiple Sclerosis: Two Sides of the Same Coin
Misrielal, C., Mauthe, M., Reggiori, F., & Eggen, B. J. L. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.603710 · Cited by 54 · see citing works
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells
Li, Z., Li, Q., Lv, W., Jiang, L., Geng, C., Yao, X., Shi, X., Liu, Y., & Cao, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.020 · Cited by 52 · see citing works
RETRACTED: A shared comparison of diabetes mellitus and neurodegenerative disorders
Morsi, M., Maher, A., Aboelmagd, O., Johar, D., & Bernstein, L. H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26261 · Cited by 49 · see citing works
Retracted
FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia
Jiang, X., Niu, X., Guo, Q., Dong, Y., Xu, J., Yin, N., Qi, Q., Jia, Y., Gao, L., He, Q., et al. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.023 · Cited by 49 · see citing works
The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
Rahmani, A. H., Almatroudi, A., Khan, A. A., Babiker, A. Y., Alanezi, M., & Allemailem, K. S. (2022) · Molecules · doi:10.3390/molecules27228023 · Cited by 47 · see citing works
Knockdown of ZFAS1 Inhibits Hippocampal Neurons Apoptosis and Autophagy by Activating the PI3K/AKT Pathway via Up-regulating miR-421 in Epilepsy
Hu, F., Shao, L., Zhang, J., Zhang, H., An, W., & Zhang, P. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03103-1 · Cited by 46 · see citing works
Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review
Asadi, M. R., Rahmanpour, D., Moslehian, M. S., Sabaie, H., Hassani, M., Ghafouri‐Fard, S., Taheri, M. N., & Rezazadeh, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.745394 · Cited by 46 · see citing works
Icariin Attenuates OGD/R‐Induced Autophagy via Bcl‐2‐Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells
Mo, Z., Li, W.-N., Zhai, Y.-R., & Gong, Q. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/4343084 · Cited by 46 · see citing works
Tongxinluo exerts protective effects via anti‐apoptotic and pro‐autophagic mechanisms by activating AMPK pathway in infarcted rat hearts
Li, Q., Li, N., Cui, H., Tian, X., Chen, J., Chen, G.-H., & Yang, Y. (2017) · Experimental Physiology · doi:10.1113/ep086192 · Cited by 45 · see citing works
Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury
Li, X., Huang, Q., Wang, M., Yan, X., Song, X., Ma, R., Jiang, R., Zhao, D., & Sun, L. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491655 · Cited by 49 · see citing works
Long-term exposure to the fluoride blocks the development of chondrocytes in the ducks: The molecular mechanism of fluoride regulating autophagy and apoptosis
Wang, Y., Li, J., Mehmood, K., Hussain, R., Abbas, R. Z., Javed, M. T., Chang, Y.-F., Hu, L., Pan, J., Li, Y., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112225 · Cited by 46 · see citing works
HSPB8 over‐expression prevents disruption of blood–brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury
Li, F., Yang, B., Li, T., Gong, X., Zhou, F., & Hu, Z. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14626 · Cited by 46 · see citing works
Two Faces of Autophagy in the Struggle against Cancer
Kubicka, A., Matczak, K., & Marczak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062981 · Cited by 43 · see citing works
Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer
Gu, Y., Chen, T., Li, G., Xu, C., Xu, Z., Zhang, J., He, K., Zheng, L., Guan, Z., Su, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11044 · Cited by 42 · see citing works
Moonlighting functions of the NRZ (mammalian Dsl1) complex
Tagaya, M., Arasaki, K., Inoue, H., & Kimura, H. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00025 · Cited by 42 · see citing works
What modulates animal longevity? Fast and slow aging in bivalves as a model for the study of lifespan
Blier, P. U., Abele, D., Munro, D., Dégletagne, C., Rodríguez, E., & Hagen, T. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.046 · Cited by 41 · see citing works
Arsenic trioxide induces autophagy and antitumor effects in Burkitt’s lymphoma Raji cells
Li, C.-L., Wei, H., Chen, J., Wang, B., Xie, B., Fan, L.-L., & Li, L.-J. (2014) · Oncology Reports · doi:10.3892/or.2014.3369 · Cited by 40 · see citing works
Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus
Kim, J. H., Sohn, U. D., Kim, H., & Kim, H. R. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.3.277 · Cited by 38 · see citing works
Regulation of Autophagy Progress via Lysosomal Depletion by Fluvastatin Nanoparticle Treatment in Breast Cancer Cells
Elimam, H., El‐Say, K. M., Cybulsky, A. V., & Khalil, H. (2020) · ACS Omega · doi:10.1021/acsomega.0c01618 · Cited by 36 · see citing works
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary
Hense, J. D., Garcia, D. N., Isola, J. V. V., Rincón, J. A. A., Zanini, B. M., Prosczek, J. B., Stout, M. B., Mason, J. B., Walsh, P. T., Brieño‐Enríquez, M. A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00573-9 · Cited by 36 · see citing works
Methods for the discovery of new anti-aging products – targeted approaches
Manayi, A., Saeidnia, S., Gohari, A. R., & Abdollahi, M. R. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.885014 · Cited by 32 · see citing works
Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren’s syndrome
Zong, Y., Yang, Y., Zhao, J., Li, L., Luo, D., Hu, J., Gao, Y., Li, W., Li, N., & Jiang, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1292146 · Cited by 32 · see citing works
Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis
Shen, D., Liu, K., Wang, H., & Wang, H. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac017 · Cited by 31 · see citing works
Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats
Liu, H., Lei, H., Shi, Y., Wang, J.-J., Chen, N., Li, Z.-H., Chen, Y.-F., Ye, Q.-F., & Yang, Y. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.169 · Cited by 28 · see citing works
Enhancing endometrial receptivity: the roles of human chorionic gonadotropin in autophagy and apoptosis regulation in endometrial stromal cells
Wang, B., Gao, M., Yao, Y., Shen, H., Li, H., Sun, J., Wang, L., & Zhang, X. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01205-x · Cited by 30 · see citing works
Veratramine suppresses human HepG2 liver cancer cell growth in vitro and in vivo by inducing autophagic cell death
Yin, L., Xia, Y., Xu, P., Zheng, W., Gao, Y., Xie, F., & Zhao-ning, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7622 · Cited by 30 · see citing works
Crocin exerts anti-proliferative and apoptotic effects on cutaneous squamous cell carcinoma via miR-320a/ATG2B
Bi, X., Jiang, Z., Luan, Z., & Qiu, D. (2021) · Bioengineered · doi:10.1080/21655979.2021.1955175 · Cited by 30 · see citing works
Regulatory mechanism of icariin in cardiovascular and neurological diseases
Wang, Y., Shang, C., Zhang, Y., Xin, L., Jiao, L., Xiang, M., Shen, Z., Chen, C., Ding, F., Lu, Y., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114156 · Cited by 27 · see citing works
Exposure to 835 MHz radiofrequency electromagnetic field induces autophagy in hippocampus but not in brain stem of mice
Kim, J. H., Yu, D.-H., Kim, H., Huh, Y. H., Cho, S., Lee, J.-K., Kim, H., & Kim, H. R. (2017) · Toxicology and Industrial Health · doi:10.1177/0748233717740066 · Cited by 28 · see citing works
Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats
Wang, H., Liu, Y., Guo, Z., Cui, M., Pang, P., Yang, J., & Wu, C. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.03.014 · Cited by 27 · see citing works
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
Vartak-Sharma, N., Nooka, S., & Ghorpade, A. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.006 · Cited by 27 · see citing works
Early-life bisphenol A exposure causes neuronal pyroptosis in juvenile and adult male rats through the NF-κB/IL-1β/NLRP3/caspase-1 signaling pathway: exploration of age and dose as effective covariates using an in vivo and in silico modeling approach
Al‐Shami, A. S., Elkader, H. A. E. A., Moussa, N., Essawy, A. E., & Haroun, M. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05039-4 · Cited by 26 · see citing works
Molecular characterization and expression analysis of the autophagic gene Beclin 1 from the purse red common carp (Cyprinus carpio) exposed to cadmium
Gao, D., Xu, Z., Kuang, X., Qiao, P., Liu, S., Zhang, L., He, P., Jadwiga, W. S., Wang, Y., & Min, W. (2013) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2013.11.004 · Cited by 26 · see citing works
Silencing of RpATG6 impaired the yolk accumulation and the biogenesis of the yolk organelles in the insect vector R. prolixus
Vieira, P. H., Bomfim, L., Atella, G. C., Masuda, H., & Ramos, I. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006507 · Cited by 25 · see citing works
Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse
Lapierre, J., Rodriguez, M., Ojha, C. R., & El‐Hage, N. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9788-3 · Cited by 23 · see citing works
Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX
Kaverina, N. V., Григорьевна, К. З., Borovjagin, A. V., Karseladze, A. I., Kim, C. K., Lesniak, M. S., Miska, J. M., Zhang, P., Baryshnikova, M. A., Xiao, T., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0395-9 · Cited by 24 · see citing works
A shared comparison of diabetes mellitus and neurodegenerative disorders
Morsi, M., Kobeissy, F. H., Magdeldin, S., Maher, A., Aboelmagd, O., Johar, D., & Bernstein, L. H. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28094 · Cited by 24 · see citing works
H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer
Chowdhury, P. R., Salvamani, S., Gunasekaran, B., Peng, H. B., & Ulaganathan, V. (2023) · The Yale Journal of Biology and Medicine · doi:10.59249/tdbj7410 · Cited by 24 · see citing works
Activation of Alpha-7 Nicotinic Acetylcholine Receptors (α7nAchR) Promotes the Protective Autophagy in LPS-Induced Acute Lung Injury (ALI) In Vitro and In Vivo
Zhao, X., Yu, Z., Lv, Z., Meng, L., Xu, J., Yuan, S., & Fu, Z. (2019) · Inflammation · doi:10.1007/s10753-019-01088-w · Cited by 23 · see citing works
Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
Das, N., Mukherjee, S., Das, A., Gupta, P., Bandyopadhyay, A., & Chattopadhyay, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23870 · Cited by 24 · see citing works
Neural Stem Cells from Shank3-ko Mouse Model Autism Spectrum Disorders
Grasselli, C., Carbone, A., Panelli, P., Giambra, V., Bossi, M., Mazzoccoli, G., & Filippis, L. D. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01811-6 · Cited by 21 · see citing works
Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb
Zhang, J., Li, Y., Chen, Y., Yu, X., Wang, S., Sun, H., Zheng, X., Zhang, L., Wang, Y., & Zhu, D. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.01.009 · Cited by 20 · see citing works
Triggering of Autophagy by Baicalein in Response to Apoptosis after Spinal Cord Injury: Possible Involvement of the PI3K Activation
Li, Y., Lin, S., Xu, C., Zhang, P., & Mei, X. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00768 · Cited by 20 · see citing works
Ursolic Acid Suppresses Hepatitis B Virus X Protein-mediated Autophagy and Chemotherapeutic Drug Resistance
Chang, C., Lin, P., Hsu, J., & Shih, W. (2016) · Anticancer Research · doi:10.21873/anticanres.11079 · Cited by 20 · see citing works
Induction of Autophagy in the Striatum and Hypothalamus of Mice after 835 MHz Radiofrequency Exposure
Kim, J. H., Huh, Y. H., & Kim, H. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153308 · Cited by 18 · see citing works
Effect of PI3K-mediated autophagy in human osteosarcoma MG63 cells on sensitivity to chemotherapy with cisplatin
Miao, X.-D., Cao, L., Zhang, Q., Hu, X.-Y., & Zhang, Y. (2015) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2015.07.024 · Cited by 17 · see citing works
The Role of Death-Associated Protein Kinase-1 in Cell Homeostasis-Related Processes
Makgoo, L., Mosebi, S., & Mbita, Z. (2023) · Genes · doi:10.3390/genes14061274 · Cited by 17 · see citing works
Effects of endurance training on autophagy and apoptotic signaling in visceral adipose tissue of prolonged high fat diet-fed rats
Rocha‐Rodrigues, S., Gonçalves, I. O., Beleza, J., Ascensão, A. A. M. R., & Magalhães, J. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1500-5 · Cited by 16 · see citing works
GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway
Li, C., Li, Z., Song, L., Meng, L., Xu, G., Zhang, H., Hu, J., Li, F., & Liu, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.656608 · Cited by 16 · see citing works
Redox-sensitive high mobility group box 1 (HMGB1) is a multifunctional regulator of cellular senescence, inflammation, and immunosuppression: Impact on the aging process
Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102926 · Cited by 15 · see citing works
Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
Fader, C. M., Aguilera, M. O., & Colombo, M. I. (2014) · Amino Acids · doi:10.1007/s00726-014-1835-7 · Cited by 15 · see citing works
Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up
François, A., Julian, A., Ragot, S., Dugast, E., Blanchard, L., Brishoual, S., Chassaing, D., Page, G., & Paccalin, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138326 · Cited by 15 · see citing works
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary
Zhan, X.-Z., Luo, P., Zhang, C., Zhang, L.-J., Shen, X., Jiang, D., & Liu, W.-J. (2024) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2024.107540 · Cited by 15 · see citing works
Paeoniflorin ameliorates reperfusion injury in H9C2 cells through SIRT1-PINK1/parkin-mediated mitochondrial autophagy
Chen, X., Sun, T., Qi, Y., Zhu, B., Li, L., Yu, J., Ding, Z., & Zhou, F. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.12.003 · Cited by 14 · see citing works
Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese Frailty
Ji, F., Park, J. H., Rheem, H., & Kim, J.-H. (2024) · Bioscience Reports · doi:10.1042/bsr20240784 · Cited by 14 · see citing works
The Function of Autophagy in the Initiation, and Development of Breast Cancer
Beilankouhi, E. A. V., Valilo, M., Dastmalchi, N., Teimourian, S., & Safaralizadeh, R. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230503145319 · Cited by 13 · see citing works
Moschus ameliorates glutamate-induced cellular damage by regulating autophagy and apoptosis pathway
Xie, D., Song, C., Qin, T., Zhai, Z., Cai, J., Dai, J., Sun, T., & Xu, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-45878-7 · Cited by 13 · see citing works

The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485 · see citing works
Role of the Beclin 1 Network in the Cross-Regulation Between Autophagy and Apoptosis
Xie, Y., Kang, R., & Tang, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00002-8 · Cited by 6 · see citing works
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
Maiuri, M. C., Criollo, A., & Kroemer, G. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.377 · Cited by 247 · see citing works
Differential Interactions Between Beclin 1 and Bcl-2 Family Members
Erlich, S., Mizrachy, L., Segev, O., Lindenboim, L., Zmira, O., Adi-Harel, S., Hirsch, J. A., Stein, R., & Pinkas‐Kramarski, R. (2007) · Autophagy · doi:10.4161/auto.4713 · Cited by 292 · see citing works
The Antiapoptotic Protein BCL-2 Has Also an Antiautophagy Role Through Beclin 1 Inhibition
Pattingre, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802936-7.00008-8 · Cited by 3 · see citing works

Authors: Salminen, A., Kaarniranta, K., & Kauppinen, A.
Affiliations: University of Eastern Finland (FI)
Corresponding author: Salminen, Antero
ORCID: Salminen, Antero
Kaarniranta, Kai
Kauppinen, Anu
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-03
Volume: 12
Issue: 2
Pages: 520-534
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2012.11.004
OpenAlex: W1978917500
Cited by: 173
References: 252
Citations by year: 2026: 8 · 2025: 9 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 11 · 2020: 15 · 2019: 7 · 2018: 25 · 2017: 16 · 2016: 15 · 2015: 8 · 2014: 9 · 2013: 6
FWCI: 0.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: Beclin-1, autophagy, apoptosis, inflammasome activation, aging, Bcl-2 family proteins, NF-κB, endocytosis, low-grade inflammation, cellular senescence, carcinogenesis, autophagy-apoptosis crosstalk
MeSH terms: Beclin-1, Aged, Aging, Autophagy, Humans, Inflammation, Membrane Proteins, NF-kappa B, Cellular Senescence, Apoptosis, Apoptosis Regulatory Proteins, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks