The DOI matches its Crossref record.
Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli
Abstract
CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bight CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony-stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes. In contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-4) for dendritic differentiation down-regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon-γ (IFN-γ), and tumor necrosis factor α, whereas IL-6 and the antiinflammatory cytokine interleukin-10 (IL-10) strongly up-regulate CD163 mRNA in monocytes and macrophages. The effects of the immunosuppressants dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to influence CD163 mRNA levels. Our results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators. This expression pattern implies a functional role of CD163 in the antiinflammatory response of monocytes. J. Leukoc. Biol. 67: 97–103; 2000.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190
Microglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
Identification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649
Macrophage activation switching: an asset for the resolution of inflammation
Porcheray, F., Viaud, S., Rimaniol, A.-C., Léone, C., Samah, B., Dereuddre-Bosquet, N., Dormont, D., & Gras, G. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02934.x · Cited by 840
Scavenger receptors in homeostasis and immunity
Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3515 · Cited by 838
Regulation of Muscle Growth and Regeneration by the Immune System
Tidball, J. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.150 · Cited by 740
Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas
Komohara, Y., Ohnishi, K., Kuratsu, J., & Takeya, M. (2008) · The Journal of Pathology · doi:10.1002/path.2370 · Cited by 738
Macrophage phenotypes during tissue repair
Novak, M. L., & Koh, T. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012512 · Cited by 658
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606
Villalta, S. A., Nguyen, H. X., Deng, B., Gotoh, T., & Tidball, J. G. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn376 · Cited by 512
Philippidis, P., Mason, J. C., Evans, B. J., Nadra, I., Taylor, K. M., Haskard, D. O., & Landis, R. C. (2004) · Circulation Research · doi:10.1161/01.res.0000109414.78907.f9 · Cited by 476
Microglia in ALS: The Good, The Bad, and The Resting
Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353
Liver fibrosis: cellular mechanisms of progression and resolution
Henderson, N. C., & Iredale, J. P. (2007) · Clinical Science · doi:10.1042/cs20060242 · Cited by 270
Dayan, V., Yannarelli, G., Billia, F., Filomeno, P., Wang, X.-H., Davies, J. E., & Keating, A. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0221-9 · Cited by 249
Fall, N., Barnes, M., Thornton, S., Luyrink, L., Olson, J., Ilowite, N. T., Gottlieb, B. S., Griffin, T., Sherry, D. D., Thompson, S., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22981 · Cited by 245
Kim, W.-K., Alvarez, X., Fisher, J., Bronfin, B., Westmoreland, S., McLaurin, J., & Williams, K. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050215 · Cited by 225
Hemoglobin and Heme Scavenger Receptors
Nielsen, M. J., Møller, H. J., & Moestrup, S. K. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2792 · Cited by 172
Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., & Takeda, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3650 · Cited by 167
CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages
Gleissner, C. A., Shaked, I., Erbel, C., Böckler, D., Katus, H. A., & Ley, K. (2010) · Circulation Research · doi:10.1161/circresaha.109.199505 · Cited by 165
Wolfs, I., Donners, M., & de Winther, M. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0320 · Cited by 157
Lim, J. E., Chung, E., & Son, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09639-7 · Cited by 136
Jahagirdar, R., Zhang, H., Azhar, S., Tobin, J., Attwell, S., Yu, R., Wu, J., McLure, K. G., Hansen, H. C., Wagner, G. S., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.06.008 · Cited by 134
Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors
Weaver, L. K., Pioli, P. A., Wardwell, K., Vogel, S. N., & Guyre, P. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706428 · Cited by 133
Pey, P., Pearce, R. K., Kalaitzakis, M. E., Griffin, W. S. T., & Gentleman, S. M. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-21 · Cited by 128
Borda, J. T., Alvarez, X., Mohan, M., Hasegawa, A., Bernardino, A., Jean, S., Aye, P., & Lackner, A. A. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070848 · Cited by 115
Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury
Zhang, Z., Zhang, Z.-Y., Wu, Y., & Schluesener, H. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.038 · Cited by 83
Pellizzari, G., Hoskin, C., Crescioli, S., Mele, S., Gotovina, J., Chiaruttini, G., Bianchini, R., Ilieva, K., Bax, H. J., Papa, S., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.080 · Cited by 77
Mendonça, V. R. R., Luz, N. F., Santos, N. J. G., Borges, V. M., Gonçalves, M. S., Andrade, B. B., & Barral-Netto, M. (2012) · Infection and Immunity · doi:10.1128/iai.05933-11 · Cited by 72
Kraaij, M. D., van der Kooij, S. W., Reinders, M. E. J., Koekkoek, K., Rabelink, T. J., van Kooten, C., & Gelderman, K. A. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.10.002 · Cited by 69
Solís-Martínez, R., Cancino-Marentes, M., Hernández-Flores, G., Ortiz-Lazareno, P., Mandujano-Álvarez, G., Cruz-Gálvez, C., Sierra-Díaz, E., Rodríguez-Padilla, C., Jave-Suárez, L. F., Aguilar-Lemarroy, A., et al. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.02.009 · Cited by 47
Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans
Warren, C. J., Yu, S., Peters, D. K., Barbachano-Guerrero, A., Yang, Q., Burris, B. L., Worwa, G., Huang, I.-C., Wilkerson, G. K., Goldberg, T. L., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.022 · Cited by 42
Rezaie, P., & Male, D. (2003) · Neuroembryology and Aging · doi:10.1159/000074192 · Cited by 12
Metadata
- Authors
- Buechler, C., Ritter, M., Orsó, E., Langmann, T., Klucken, J., & Schmitz, G.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 67
- Issue
- 1
- Pages
- 97-103
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2133950776
- Cited by
- 704
- References
- 0
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
