Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

Wolfs, Ine; Donners, Marjo; de Winther, Menno

doi:10.1160/th11-05-0320

Cited by 157

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

Wolfs, Ine, Donners, Marjo, de Winther, Menno·2011·Thrombosis and Haemostasis

DOI 10.1160/th11-05-0320

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Abstract

Summary: The phenotype of macrophages in atherosclerotic lesions can vary dramatically, from a large lipid laden foam cell to a small inflammatory cell. Classically, the concept of macrophage heterogeneity discriminates between two extremes called either pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. Polarisation of plaque macrophages is predominantly determined by the local micro-environment present in the atherosclerotic lesion and is rather more complex than typically described by the M1/M2 paradigm. In this review we will discuss the role of various polarising factors in regulating the phenotypical state of plaque macrophages. We will focus on two main levels of phenotype regulation, one determined by differentiation factors produced in the lesion and the other determined by T-cell-derived polarising cytokines. With foam cell formation being a key characteristic of macrophages during atherosclerosis initiation and progression, these polarisation factors will also be linked to lipid handling of macrophages.

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Background
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Di Gregoli, K., & Johnson, J. L. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328357ca6e · Cited by 55
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Self-citation
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Authors: Wolfs, I., Donners, M., & de Winther, M.
Venue: Thrombosis and Haemostasis
Publisher: Georg Thieme Verlag KG
Published: 2011
Volume: 106
Issue: 11
Pages: 763-771
ISSN: 0340-6245
2567-689X
DOI: 10.1160/th11-05-0320
Cited by: 157
References: 8
Language: en
Funders: Netherlands Organization for Scientific Research ((grants 2007T067 and 2010B022))

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Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

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