Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19
Open accessAbstract
The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID‐19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID‐19 patients. We investigated 43 adult patients with COVID‐19. The patients were classified into mild group (28 patients) and severe group (15 patients). A comparison of the hematological parameters between the mild and severe groups showed significant differences in interleukin‐6 (IL‐6), d‐dimer (d‐D), glucose, thrombin time, fibrinogen, and C‐reactive protein (P < .05). The optimal threshold and area under the receiver operator characteristic curve (ROC) of IL‐6 were 24.3 and 0.795 µg/L, respectively, while those of d‐D were 0.28 and 0.750 µg/L, respectively. The area under the ROC curve of IL‐6 combined with d‐D was 0.840. The specificity of predicting the severity of COVID‐19 during IL‐6 and d‐D tandem testing was up to 93.3%, while the sensitivity of IL‐6 and d‐D by parallel test in the severe COVID‐19 was 96.4%. IL‐6 and d‐D were closely related to the occurrence of severe COVID‐19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID‐19 patients, which has important clinical value.
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Patients infected with SARS-CoV-2 present elevated levels of IL-6, IL-10, IL-1β, INF-γ, CCL2, TNF-α, CXCL10, CCL7, IL-1 receptor antagonist and IL-2 receptor, supposedly associated with disease severity.
“Patients infected with SARS-CoV-2 present elevated levels of IL-6, IL-10, IL-1β, INF-γ, CCL2, TNF-α, CXCL10, CCL7, IL-1 receptor antagonist and IL-2 receptor, supposedly associated with disease severity [9, 98–105].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [103]
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- Authors
- Gao, Y., Li, T., Han, M., Li, X., Wu, D., Xu, Y., Zhu, Y., Liu, Y., Wang, X., & Wang, L.
- Affiliations
- Fuyang Second People's Hospital (CN)
- Department of Pharmacy Fuyang People's Hospital Fuyang Anhui China
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Medical University (CN)
- Corresponding author
- Wang, Xiaowu
- Wang, Linding
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2020-04-10
- Volume
- 92
- Issue
- 7
- Pages
- 791-796
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC7228247
- OpenAlex
- W3012422150
- Cited by
- 1,047
- References
- 14
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 59 · 2023: 104 · 2022: 191 · 2021: 310 · 2020: 350 · 2019: 1
- FWCI
- 31.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Anhui Province (1708085MH193)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- severe COVID-19, interleukin-6, D-dimer, disease severity prediction, diagnostic biomarkers, thrombin time, fibrinogen, C-reactive protein, hematological parameters, combined biomarker detection
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Adult, Aged, Blood Glucose, C-Reactive Protein, Cardiovascular Diseases, Diabetes Mellitus, Female, Fibrin Fibrinogen Degradation Products, Fibrinogen, Humans, Male, Middle Aged, Pneumonia, Viral, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Thrombin Time, Biomarkers, Interleukin-6, Coronavirus Infections, Clinical Laboratory Techniques, Area Under Curve, Pulmonary Disease, Chronic Obstructive, Diabetes Complications, Pandemics
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