Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health

Raony, Ícaro; de Figueiredo, Camila Saggioro; Pandolfo, Pablo; Giestal-de-Araujo, Elizabeth; Oliveira-Silva Bomfim, Priscilla; Savino, Wilson

doi:10.3389/fimmu.2020.01170

Cited by 185COVID-19 and Mental HealthLong-Term Effects of COVID-19Stress Responses and Cortisol

Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health

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Raony, Ícaro, de Figueiredo, Camila Saggioro, Pandolfo, Pablo, Giestal-de-Araujo, Elizabeth, Oliveira-Silva Bomfim, Priscilla, Savino, Wilson·2020·Frontiers in Immunology

DOI 10.3389/fimmu.2020.01170PMC PMC7267025

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Abstract

Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond the respiratory system, also affecting mental health. Several factors may be involved in the association between COVID-19 and psychiatric outcomes, such as fear inherent in the pandemic, adverse effects of treatments, as well as financial stress, and social isolation. Herein we discuss the growing evidence suggesting that the relationship between SARS-CoV-2 and host may also trigger changes in brain and behavior. Based on the similarity of SARS-CoV-2 with other coronaviruses, it is conceivable that changes in endocrine and immune response in the periphery or in the central nervous system may be involved in the association between SARS-CoV-2 infection and impaired mental health. This is likely to be further enhanced, since millions of people worldwide are isolated in quarantine to minimize the transmission of SARS-CoV-2 and social isolation can also lead to neuroendocrine-immune changes. Accordingly, we highlight here the hypothesis that neuroendocrine-immune interactions may be involved in negative impacts of SARS-CoV-2 infection and social isolation on psychiatric issues.

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The HPA axis is also activated for counteracting tissue damage evoked by cytokine storms in SARS-CoV-2 infection.
“This axis is also activated for counteracting tissue damage, evoked by cytokine storms, in SARS-CoV-2 infection, as previously reviewed [165].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [165]

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Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
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Biomarkers of post-covid depression
Lorkiewicz, P., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184142 · Cited by 102 · see citing works
SARS-CoV-2 Targeting the Retina: Host-virus Interaction and Possible Mechanisms of Viral Tropism
de Figueiredo, C. S., Raony, Í., & Giestal-de-Araujo, E. (2020) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2020.1799037 · Cited by 32 · see citing works
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Prior pandemics. looking to the past for insight into the COVID-19 pandemic
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Designing a Science-based Strategy to Prepare For the Next Pandemic
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PREVENT SOCIAL ISOLATION BEFORE IT STARTS
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Veterans and animals: A review of the literature on well-being and social isolation and recommendations during COVID-19
Krause‐Parello, C. A., Pratt, B. A., Meyer, E. G., & Browne-Banic, L. (2021) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh-2020-0059 · Cited by 6 · see citing works
СТРУКТУРНО-КОМПОЗИЦІЙНІ ОСОБЛИВОСТІ ДИСКУРСИВНОГО РОЗГОРТАННЯ НАРАТИВУ “CORONAVIRUS PANDEMIC” (НА МАТЕРІАЛІ ІНФОРМАЦІЙНОГО ПОРТАЛУ BBC NEWS)
Aleksenko, S., & Приходько, М. В. (2021) · Collection of scientific works Visnyk of Zaporizhzhya National University Philological Sciences · doi:10.26661/2414-9594-2021-1-1

Authors: Raony, Í., de Figueiredo, C. S., Pandolfo, P., Giestal-de-Araujo, E., Oliveira-Silva Bomfim, P., & Savino, W.
Affiliations: Universidade Federal Fluminense (BR)
Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação (BR)
Corresponding author: Savino, Wilson
ORCID: Raony, Ícaro
Pandolfo, Pablo
Savino, Wilson
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2020-05-27
Volume: 11
Pages: 1170-1170
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2020.01170
PMC: PMC7267025
OpenAlex: W3027541845
Cited by: 185
References: 156
Citations by year: 2026: 3 · 2025: 4 · 2024: 22 · 2023: 33 · 2022: 56 · 2021: 44 · 2020: 22 · 2013: 1
FWCI: 15.62
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Topics: Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: COVID-19 pandemic, SARS-CoV-2, mental health, mental health outcomes, social isolation, quarantine, neuroendocrine-immune interaction, endocrine response, immune response, financial stress, fear of infection
MeSH terms: COVID-19, Mental Disorders, Brain, Endocrine System Diseases, Humans, Mental Health, Nervous System Diseases, Neurosecretory Systems, Pneumonia, Viral, Social Isolation, Coronavirus Infections, Pandemics

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Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health

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