Exercise induces BDNF and synapsin I to specific hippocampal subfields
Abstract
To assess the relationship between brain-derived neurotrophic factor (BDNF) and synapsin I in the hippocampus during exercise, we employed a novel microsphere injection method to block the action of BDNF through its tyrosine kinase (Trk) receptor and subsequently measure the mRNA levels of synapsin I, using real-time TaqMan RT-PCR for RNA quantification. After establishing a causal link between BDNF and exercise-induced synapsin I mRNA levels, we studied the exercise-induced distribution of BDNF and synapsin I in the rodent hippocampus. Quantitative immunohistochemical analysis revealed increases of BDNF and synapsin I in CA3 stratum lucidum and dentate gyrus, and synapsin I alone in CA1 stratum radiatum and stratum laconosum moleculare. These results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin I regulation by BDNF.
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BDNF is mechanistically linked to exercise-induced improvement in cognitive functions, such as memory and learning.
“Furthermore, BDNF has been shown to be mechanistically linked to exercise-induced improvement in cognitive functions, such as memory and learning (93, 94).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [94]
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- Authors
- Vaynman, S., Ying, Z., & Gómez‐Pinilla, F.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Gómez‐Pinilla, Fernando
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2004-03-22
- Volume
- 76
- Issue
- 3
- Pages
- 356-362
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2115565337
- Cited by
- 203
- References
- 51
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 5 · 2023: 13 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 13 · 2018: 7 · 2017: 14 · 2016: 9 · 2015: 19 · 2014: 7 · 2013: 16 · 2012: 12
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (NS 38978, NS 39522)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- physical activity, brain-derived neurotrophic factor, synapsin I, hippocampus, hippocampal subfields, Trk receptors, dentate gyrus, CA1, synaptic plasticity
- MeSH terms
- Animals, Carbazoles, Enzyme Inhibitors, Hippocampus, Male, Microspheres, Neuronal Plasticity, Physical Conditioning, Animal, Protein Kinase C, Random Allocation, Signal Transduction, Synapsins, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, Receptor, trkB, Indole Alkaloids, Rats
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