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Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro
Abstract
Phospholipid transfer protein (PLTP) plays a pivotal role in cellular lipid efflux and modulation of lipoprotein metabolism. PLTP is distributed widely in the central nervous system (CNS), is synthesized by glia and neurons, and is active in cerebrospinal fluid (CSF). The aims of this study were to test the hypothesis that patients with Alzheimer's disease (AD) have altered PLTP‐mediated phospholipid transfer activity in CSF, and to examine the potential relationship between PLTP activity and apolipoprotein E (apoE) levels in CSF. We assessed PLTP activity and apoE concentration in CSF of patients with probable AD (n = 50), multiple sclerosis (MS; n = 9), other neurologic diseases (n = 21), and neurologically healthy controls (n = 40). PLTP activity in AD was reduced compared to that in controls (P < 0.001), with approximately half of the AD patients with PLTP activity values below all controls. Patients with MS had lower PLTP activity than AD patients (P < 0.001). PLTP activity was highly correlated with PLTP mass, as estimated by Western blot (r = 0.006; P < 0.01). CSF PLTP activity positively correlated with apoE concentration in AD (R = 0.435; P = 0.002) and controls (R = 0.456; P = 0.003). Anti‐apoE immunoaffinity chromatography and Western blot analyses indicated that some CSF PLTP is associated with apoE‐containing lipoproteins. Exogenous addition of recombinant PLTP to primary human astrocytes significantly increased apoE secretion to the conditioned medium. The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis. © 2005 Wiley‐Liss, Inc.
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PLTP has reduced activity in human Alzheimer's disease patient CSF.
“PLTP, which is reported to transfer phospholipids to HDL in plasma, has reduced activity in human AD patient CSF [101, 102].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [101]
PLTP transfers phospholipids to HDL in plasma.
“PLTP, which is reported to transfer phospholipids to HDL in plasma, has reduced activity in human AD patient CSF [101, 102].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [101]
Astrocytic LpE is enriched in phospholipid transfer protein (PLTP) and clusterin (Clu, also known as ApoJ).
“Astrocytic LpE was found to be enriched in proteins such as phospholipid transfer protein (PLTP) and clusterin (Clu, also known as ApoJ), both of which play a role in AD disease pathogenesis (Fig. 4A) [11, 19, 101].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [101]
PLTP and clusterin play a role in Alzheimer's disease pathogenesis.
“Astrocytic LpE was found to be enriched in proteins such as phospholipid transfer protein (PLTP) and clusterin (Clu, also known as ApoJ), both of which play a role in AD disease pathogenesis (Fig. 4A) [11, 19, 101].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [101]
In human CSF, PLTP is present on LpE.
“In human CSF, PLTP was also shown to be present on LpE based on immunoaffinity purification of ApoE [101].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [101]
Pltp is present in ApoE lipoprotein.
“Pltp is known to be present in ApoE lipoprotein, and Pltp activity is reduced in AD patients compared to controls (57).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [57]
Pltp activity is reduced in AD patients compared to controls.
“Pltp is known to be present in ApoE lipoprotein, and Pltp activity is reduced in AD patients compared to controls (57).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [57]
Pltp induces secretion of ApoE from astrocytes.
“Pltp was also enriched in astrocyte ApoE lipoproteins (Fig. 5B, Supplemental Table S8) and has been previously reported to induce secretion of ApoE from astrocytes (57).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [57]
PLTP has reduced activity in the context of AD.
“PLTP, which has been reported to have reduced activity in the context of AD”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [57]
Reduced PLTP activity has been reported in the CSF of multiple sclerosis patients.
“Reduced PLTP activity has also been reported in the CSF of multiple sclerosis patients (57).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [57]
PLTP induces the secretion of ApoE from astrocytes.
“and induces the secretion of ApoE from astrocytes (57, 89).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [57]
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Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942
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Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Metadata
- Authors
- Vuletic, S., Peskind, E. R., Marcovina, S. M., Quinn, J. F., Cheung, M. C., Kennedy, H., Kaye, J. A., Jin, L., & Albers, J. J.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2005-03-28
- Volume
- 80
- Issue
- 3
- Pages
- 406-413
- ISSN
- 0360-4012
- 1097-4547
- Cited by
- 43
- References
- 1
- Language
- en
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