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Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease

Demeester, N., Castro, G., Desrumaux, C., De Geitere, C., Fruchart, J.C., Santens, P., Mulleners, E., Engelborghs, S., De Deyn, P.P., Vandekerckhove, J., Rosseneu, M., Labeur, C.·2000·Journal of Lipid Research
DOI 10.1016/s0022-2275(20)32039-3
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  • PLTP induces the secretion of ApoE from astrocytes.

    “and induces the secretion of ApoE from astrocytes (57, 89).”

    From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [89]

    The section on lipid transfer proteins reports PLTP activity in CSF, while the discussion of astrocytes addresses ApoE synthesis and cholesterol efflux. Neither passage says that PLTP induces ApoE secretion from astrocytes; the paper says that the form in which astrocytes secrete ApoE has not been elucidated. Searched for PLTP-induced ApoE secretion and the relationship between phospholipid transfer protein and astrocytes. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • PLTP has reduced activity in the context of AD.

    “PLTP, which has been reported to have reduced activity in the context of AD”

    From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [89]

    The Activity measurements section reports PLTP activity in CSF but does not compare PLTP activity between AD patients and controls; Table 4 gives only a combined mean. The AD-associated reduction reported in that section and in Lipid transfer proteins and LCAT in human CSF concerns LCAT, not PLTP. Our copy therefore does not establish reduced PLTP activity in AD. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • LCAT activity has been reported to be significantly reduced in the CSF of AD patients compared to control patients.

    “Furthermore, LCAT activity has been reported to be significantly reduced in the CSF of AD patients compared to control patients [76, 77].”

    From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [76]

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Research works printed but not linked: 60

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Metadata

Authors
Demeester, N., Castro, G., Desrumaux, C., De Geitere, C., Fruchart, J. C., Santens, P., Mulleners, E., Engelborghs, S., De Deyn, P. P., Vandekerckhove, J., Rosseneu, M., & Labeur, C.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2000-06
Volume
41
Issue
6
Pages
963-974
ISSN
0022-2275
DOI
10.1016/s0022-2275(20)32039-3
Cited by
140
References
1
Language
en
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