The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The spleen contributes to stroke‐induced neurodegeneration
Open accessAbstract
Stroke, a cerebrovascular injury, is the leading cause of disability and third leading cause of death in the world. Recent reports indicate that inhibiting the inflammatory response to stroke enhances neurosurvival and limits expansion of the infarction. The immune response that is initiated in the spleen has been linked to the systemic inflammatory response to stroke, contributing to neurodegeneration. Here we show that removal of the spleen significantly reduces neurodegeneration after ischemic insult. Rats splenectomized 2 weeks before permanent middle cerebral artery occlusion had a >80% decrease in infarction volume in the brain compared with those rats that were subjected to the stroke surgery alone. Splenectomy also resulted in decreased numbers of activated microglia, macrophages, and neutrophils present in the brain tissue. Our results demonstrate that the peripheral immune response as mediated by the spleen is a major contributor to the inflammation that enhances neurodegeneration after stroke. © 2008 Wiley‐Liss, Inc.
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The role of inflammation in CNS injury and disease
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Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics
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Wohleb, E. S., McKim, D. B., Sheridan, J. F., & Godbout, J. P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00447 · Cited by 420
Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke
Ren, X., Akiyoshi, K., Dziennis, S., Vandenbark, A. A., Herson, P. S., Hurn, P. D., & Offner, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1623-11.2011 · Cited by 300
Chen, H., He, Y., Chen, S., Qi, S., & Shen, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104877 · Cited by 282
Reader, B. F., Jarrett, B. L., McKim, D. B., Wohleb, E. S., Godbout, J. P., & Sheridan, J. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.001 · Cited by 179
“This increased egress was associated with more severe pathology (Ajmo et al., 2008) that was dependent upon peripheral noradrenergic signaling (Ajmo et al., 2009).”
Background
Metadata
- Authors
- Ajmo, C. T., Vernon, D. O. L., Collier, L., Hall, A. A., Garbuzova‐Davis, S., Willing, A., & Pennypacker, K. R.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2008-04
- Volume
- 86
- Issue
- 10
- Pages
- 2227-2234
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1966194847
- Cited by
- 272
- References
- 44
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Ajmo, C. T., Vernon, D. O. L., Collier, L., Hall, A. A., Garbuzova‐Davis, S., Willing, A., & Pennypacker, K. R. (2008). The spleen contributes to stroke‐induced neurodegeneration. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.21661
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