Cited by 80Epilepsy research and treatmentNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats

Yang, Fang, Liu, Zhi‐Rong, Chen, Jing, Zhang, Shi‐Jun, Quan, Qing‐Yun, Huang, Yuan‐Gui, Jiang, Wen·2010·Journal of Neuroscience Research

Abstract

Recent evidence showed that epileptic seizures increase hippocampal neurogenesis in the adult rat, but prolonged seizures result in the aberrant hippocampal neurogenesis that often leads to a recurrent excitatory circuitry and thus contributes to epileptogenesis. However, the mechanism underlying the aberrant neurogenesis after prolonged seizures remains largely unclear. In this study, we examined the role of activated astrocytes and microglia in the aberrant hippocampal neurogenesis induced by status epilepticus. Using a lithium-pilocarpine model to mimic human temporal lobe epilepsy, we found that status epilepticus induced a prominent activation of astrocytes and microglia in the dentate gyrus 3, 7, 14, and 20 days after the initial seizures. Then, we injected fluorocitrate stereotaxicly into the dentate hilus to inhibit astrocytic metabolism and found that fluorocitrate failed to prevent the seizure-induced formation of ectopic hilar basal dendrites but instead promoted the degeneration of dentate granule cells after seizures. In contrast, a selective inhibitor of microglia activation, minocycline, inhibited the aberrant migration of newborn neurons at 14 days after status epilepticus. Furthermore, with stereotaxic injection of lipopolysaccharide into the intact dentate hilus to activate local microglia, we found that lipopolysaccharide promoted the development of ectopic hilar basal dendrites in the hippocampus. These results indicate that the activated microglia in the epileptic hilus may guide the aberrant migration of newborn neurons and that minocycline could be a potential drug to impede seizure-induced aberrant migration of newborn neurons.

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Crossref · 10.1002/jnr.22224

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  • Seizures stimulate adult neurogenesis and impair hippocampal function.

    “For example, seizures stimulate adult neurogenesis and impair hippocampal function.”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Yang et al., 2010

  • Seizure-induced reactive astrocytes, reactive microglia, and reduced expression of PNNs around postsynaptic neurons of adult-generated cells likely contribute to the functional impairments.

    “Seizure-induced reactive astrocytes (Shapiro et al., 2008; Yang et al., 2010), reactive microglia (Shapiro et al., 2008; Yang et al., 2010), and reduced the expression of PNNs (McRae and Porter, 2012; Rankin-Gee et al., 2015) around postsynaptic neurons of adult-generated cells likely contribute to the functional impairments.”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Yang et al., 2010

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Authors
Yang, F., Liu, Z., Chen, J., Zhang, S., Quan, Q., Huang, Y., & Jiang, W.
Affiliations
Xijing Hospital (CN)
Corresponding author
Jiang, Wen
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2009-09-22
Volume
88
Issue
3
Pages
519-529
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W2056705288
Cited by
80
References
69
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 10
FWCI
4.74
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
astrocytes, microglia, status epilepticus, epileptogenesis, lithium-pilocarpine model, temporal lobe epilepsy, dentate gyrus, fluorocitrate, minocycline, lipopolysaccharide, microglial activation
MeSH terms
Aging, Animals, Astrocytes, Cell Movement, Dendrites, Disease Models, Animal, Epilepsy, Temporal Lobe, Male, Nerve Degeneration, Neurons, Random Allocation, Seizures, Status Epilepticus, Time Factors, Rats, Sprague-Dawley, Microglia, Dentate Gyrus, Rats, Neurogenesis

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